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The map label for this gene is ilvE [H]

Identifier: 78779306

GI number: 78779306

Start: 857287

End: 858201

Strand: Direct

Name: ilvE [H]

Synonym: PMT9312_0922

Alternate gene names: 78779306

Gene position: 857287-858201 (Clockwise)

Preceding gene: 78779304

Following gene: 78779307

Centisome position: 50.16

GC content: 31.37

Gene sequence:

>915_bases
ATGCATGAATTTCTTCCATACGCCTGGTTCGAAGGTAAATGTATTCCATTTAAAGAAGCAAAAATATCAATAGCTACTCA
TGCACTACATTACGGTACTGCTGCATTTGGAGGAATGCGAGCGATACCTAACCCAACAAACAAAGAAGAATTTCTTTTGT
TTAGAACTGATAAACATATAAAAAGATTATCTCAAAGTGCAAAATTACTCTTAACTGAAATTTCTGAAGAATATATTTTT
AAAGCTTTAGAAGAAGTTATAAAAAGAAACAAGCCAGAAAAACCTATTTATATAAGACCATTTGTATATACAAGCGATTT
AGGTATAGCTCCAAGGTTACACAATATTGAAACAGATTTCTTTATTTATTGTATTGAACTAGGAGATTATTTATCCCCAG
ATGGTGTTTCTTGTAGAATGAGTAGTTGGACAAGACAAGAAGATAGATCTCTCCCCTTAAGAGGAAAAATAAGTGGAGCA
TATATTACTAGTTCATTAGCAAAAACAGAAGCTAGTTTATCTGGTTTTGATGAAGCCCTGCTATTAAATTCAAGTGGTAA
GGTAAGCGAAGCTAGTGGTATGAATTTATTTATTGTAAGGAATGGAGACTTAATCACTCCTGGTGTTGATCAAGATATCC
TTGAGGGGATTACTAGAGCTAGTGTAATTGAATTAGCAAAATCATTTGGAATAAATGTAATTGAGAGACCTGTTGATAAA
ACAGAATTATTAATAGCAGATGAAGTTTTTCTAACTGGTACAGCAGCAAAAATTACACCAGTTAAAAAAATCGAATCAAC
TGAATTAAATGTTGAAAGACCAATAATGAATAAATTAAAAAGTAAGCTTATAGAAATAACAGAAGGTCGTTCTCAAGACT
ATGATAATTGGGTAACAAGAATTTCACTAATATAA

Upstream 100 bases:

>100_bases
TTCCTGCTATATTTAATATCCTGTGCATTTTTATATATAAATAAGGTTTAGAATACGTACGTTGGATAAAACAAGTTTAC
CTTAATTAAATAAATTAAAT

Downstream 100 bases:

>100_bases
ATTTTTAGCTAAAAATGGAATCTTTCAGAACCTATCTAAATAGAGATGAAAAACCATTAATTATTTTTGACGGAGGTACT
GGAACATCTTTTCAGAACTT

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHEFLPYAWFEGKCIPFKEAKISIATHALHYGTAAFGGMRAIPNPTNKEEFLLFRTDKHIKRLSQSAKLLLTEISEEYIF
KALEEVIKRNKPEKPIYIRPFVYTSDLGIAPRLHNIETDFFIYCIELGDYLSPDGVSCRMSSWTRQEDRSLPLRGKISGA
YITSSLAKTEASLSGFDEALLLNSSGKVSEASGMNLFIVRNGDLITPGVDQDILEGITRASVIELAKSFGINVIERPVDK
TELLIADEVFLTGTAAKITPVKKIESTELNVERPIMNKLKSKLIEITEGRSQDYDNWVTRISLI

Sequences:

>Translated_304_residues
MHEFLPYAWFEGKCIPFKEAKISIATHALHYGTAAFGGMRAIPNPTNKEEFLLFRTDKHIKRLSQSAKLLLTEISEEYIF
KALEEVIKRNKPEKPIYIRPFVYTSDLGIAPRLHNIETDFFIYCIELGDYLSPDGVSCRMSSWTRQEDRSLPLRGKISGA
YITSSLAKTEASLSGFDEALLLNSSGKVSEASGMNLFIVRNGDLITPGVDQDILEGITRASVIELAKSFGINVIERPVDK
TELLIADEVFLTGTAAKITPVKKIESTELNVERPIMNKLKSKLIEITEGRSQDYDNWVTRISLI
>Mature_304_residues
MHEFLPYAWFEGKCIPFKEAKISIATHALHYGTAAFGGMRAIPNPTNKEEFLLFRTDKHIKRLSQSAKLLLTEISEEYIF
KALEEVIKRNKPEKPIYIRPFVYTSDLGIAPRLHNIETDFFIYCIELGDYLSPDGVSCRMSSWTRQEDRSLPLRGKISGA
YITSSLAKTEASLSGFDEALLLNSSGKVSEASGMNLFIVRNGDLITPGVDQDILEGITRASVIELAKSFGINVIERPVDK
TELLIADEVFLTGTAAKITPVKKIESTELNVERPIMNKLKSKLIEITEGRSQDYDNWVTRISLI

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI50658084, Length=332, Percent_Identity=24.0963855421687, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI296010906, Length=329, Percent_Identity=26.7477203647416, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI38176287, Length=329, Percent_Identity=26.7477203647416, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI296010904, Length=329, Percent_Identity=26.7477203647416, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI48994963, Length=305, Percent_Identity=33.1147540983607, Blast_Score=188, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6322608, Length=301, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322002, Length=334, Percent_Identity=23.6526946107784, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005785 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 34152; Mature: 34152

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00037 MYB_1 ; PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEFLPYAWFEGKCIPFKEAKISIATHALHYGTAAFGGMRAIPNPTNKEEFLLFRTDKHI
CCCCCCCCEECCEECCHHHCEEEEEHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCHHH
KRLSQSAKLLLTEISEEYIFKALEEVIKRNKPEKPIYIRPFVYTSDLGIAPRLHNIETDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCE
FIYCIELGDYLSPDGVSCRMSSWTRQEDRSLPLRGKISGAYITSSLAKTEASLSGFDEAL
EEEEEECCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
LLNSSGKVSEASGMNLFIVRNGDLITPGVDQDILEGITRASVIELAKSFGINVIERPVDK
EECCCCCCCCCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
TELLIADEVFLTGTAAKITPVKKIESTELNVERPIMNKLKSKLIEITEGRSQDYDNWVTR
HHEEEECCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEE
ISLI
EECC
>Mature Secondary Structure
MHEFLPYAWFEGKCIPFKEAKISIATHALHYGTAAFGGMRAIPNPTNKEEFLLFRTDKHI
CCCCCCCCEECCEECCHHHCEEEEEHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCHHH
KRLSQSAKLLLTEISEEYIFKALEEVIKRNKPEKPIYIRPFVYTSDLGIAPRLHNIETDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCE
FIYCIELGDYLSPDGVSCRMSSWTRQEDRSLPLRGKISGAYITSSLAKTEASLSGFDEAL
EEEEEECCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
LLNSSGKVSEASGMNLFIVRNGDLITPGVDQDILEGITRASVIELAKSFGINVIERPVDK
EECCCCCCCCCCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
TELLIADEVFLTGTAAKITPVKKIESTELNVERPIMNKLKSKLIEITEGRSQDYDNWVTR
HHEEEECCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEE
ISLI
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]