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The map label for this gene is ribBA [H]

Identifier: 78779291

GI number: 78779291

Start: 837353

End: 839077

Strand: Reverse

Name: ribBA [H]

Synonym: PMT9312_0907

Alternate gene names: 78779291

Gene position: 839077-837353 (Counterclockwise)

Preceding gene: 78779293

Following gene: 78779286

Centisome position: 49.09

GC content: 31.83

Gene sequence:

>1725_bases
ATGAAAGAAACAAGTCCCAAATCAAATAATGGAACAATTTTGGATATAAATGAATCTTTTAAAATTGAATTTGATCCTAT
AAGCGATGCATTAGCTGCAATAAGAAATGGTGAATGCATAATTGTGGTAGATGATGAAAGAAGAGAAAATGAGGGTGATT
TAATTTGCGCCGCTCAGTTTGCTACTCCTCAACAAATTAATTTTATGGCTACTGAGGGAAGGGGCCTTATATGCCTAGCT
ATGCAAGGAGAAAAACTTGACTCCTTAGATTTACCCTTAATGGTGGATAGAAACACAGACAAGAATCAAACAGCTTTTAC
GATATCAATTGATGCTGGCCCTGAAAATAATGTATCGACTGGTATTTCAGCTGAAGACAGAGCCAAAACAATACAAGTTG
CTATAAATCCAAATACAAAACCTGATGATTTAAGGAGGCCAGGACATATTTTTCCATTAAGAGCTAAAAAAGGGGGAGTT
TTAAAAAGGGCAGGACATACAGAAGCGGCAGTAGATATTGCAGCAATGTCAGGACTATATCCAGCTGGAGTAATTTGTGA
AATACAAAATCCTGATGGTTCAATGTCAAGACTTCCACAACTTAAAGAGTATGCAAAACAGTGGGGGATGAAATTAATAT
CAATAGCCGATTTAATAAGTTATCGATTTCAAACTGAAAGATTTGTTTTTAGAAAATCCGATGCTGTTCTTCCAAGTATT
TTTGGAAATTTCAAAGCATATGGATACATTAATGAACTTGATGGTTCAGAGCACGTTGCATTAGTTAAACAAAAATCAAA
AAAATTAAGCGAACCTGTATTAGTAAGAATGCATTCAGAATGCCTAACTGGCGATGCTTTTGGTTCATTACGTTGCGATT
GTAGACCACAGTTAGAGGCTGCTTTATCAAGGATAGAAAAGGAAGAAGAGGGCGTTGTTGTTTACTTGAGACAAGAAGGT
AGAGGTATTGGTCTTATAAATAAATTAAAAGCTTACAGCTTACAGGATGGTGGATTAGACACAGTAGAAGCTAATGAAAA
ATTAGGATTTCCTGCTGATCTAAGAAATTATGGAGTAGGAGCACAGATATTAACTGATCTAGGTATAAAAAAATTAAAAT
TATTAACAAATAATCCTAGAAAGATTGCTGGATTAGGAGGTTATGGAATTGAAGTTATTGAGAGAGTTCCATTAATGATT
TGTCCAAATGATAATAATGCTGAATATTTAAGTGTTAAGAGAACAAAGCTTGGCCATATGATTGATGTAGATAATTCTAA
TTTCAGGAATATTGATCCATTTATATCTATTTTTCTTGACGGAAACTATAAATCAATTCATCTAGTTCCAATAAAAAATA
AGGTTAATAAATTCTGTAAGGATCAAAACATTAATATTAAACTGGAAAGTACTCCAAGATTATTGGCTTTTTGGAATCGA
CCAAAATTAGTATGGAGAATCATACACGATCGAAATAGAACTAATACTAATATTACCGACGAAGAAATAAAGAATATAGA
ATTATTAATTGAGTTTTTATCTAAATACGAAGATAGTAAAAAAATTGGGATTATTGTTTCTAGAAATATTGAACAAGCAT
TACATCCCAAAAATAGCATCAAACTTATCAATACTAAATTTACTATTAATAATGAAATTCTATATTCATCTACAAGAAAA
TTTAATTTAGATAAAGAGACATTTAGTATAGTTTTTGAAGGCTAA

Upstream 100 bases:

>100_bases
TGCAACATTCATTTCTTTGAATTGGCAGAATTTGAGATAGGATTATAAAGTGTTGAATTTAGGATAACTAACACACTATT
TTTCTATATTGATAGGAATA

Downstream 100 bases:

>100_bases
AATTACTACTTTAGAGTTGCCTTTAGAATTTTTGAACCGTTAGTAAGCTTAAGCACGACATCCATATCTTCTGTCTTACC
AAAAACAGTATGAACTCCAT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDKNQTAFTISIDAGPENNVSTGISAEDRAKTIQVAINPNTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYINELDGSEHVALVKQKSKKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLMI
CPNDNNAEYLSVKRTKLGHMIDVDNSNFRNIDPFISIFLDGNYKSIHLVPIKNKVNKFCKDQNINIKLESTPRLLAFWNR
PKLVWRIIHDRNRTNTNITDEEIKNIELLIEFLSKYEDSKKIGIIVSRNIEQALHPKNSIKLINTKFTINNEILYSSTRK
FNLDKETFSIVFEG

Sequences:

>Translated_574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDKNQTAFTISIDAGPENNVSTGISAEDRAKTIQVAINPNTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYINELDGSEHVALVKQKSKKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLMI
CPNDNNAEYLSVKRTKLGHMIDVDNSNFRNIDPFISIFLDGNYKSIHLVPIKNKVNKFCKDQNINIKLESTPRLLAFWNR
PKLVWRIIHDRNRTNTNITDEEIKNIELLIEFLSKYEDSKKIGIIVSRNIEQALHPKNSIKLINTKFTINNEILYSSTRK
FNLDKETFSIVFEG
>Mature_574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDKNQTAFTISIDAGPENNVSTGISAEDRAKTIQVAINPNTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYINELDGSEHVALVKQKSKKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLMI
CPNDNNAEYLSVKRTKLGHMIDVDNSNFRNIDPFISIFLDGNYKSIHLVPIKNKVNKFCKDQNINIKLESTPRLLAFWNR
PKLVWRIIHDRNRTNTNITDEEIKNIELLIEFLSKYEDSKKIGIIVSRNIEQALHPKNSIKLINTKFTINNEILYSSTRK
FNLDKETFSIVFEG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=209, Percent_Identity=46.88995215311, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=50.5208333333333, Blast_Score=194, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=41.747572815534, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=44.7058823529412, Blast_Score=129, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 64290; Mature: 64290

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQF
CCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
ATPQQINFMATEGRGLICLAMQGEKLDSLDLPLMVDRNTDKNQTAFTISIDAGPENNVST
CCCCEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCC
GISAEDRAKTIQVAINPNTKPDDLRRPGHIFPLRAKKGGVLKRAGHTEAAVDIAAMSGLY
CCCCCCCCEEEEEEECCCCCHHHHCCCCCEEEEECCCCCCEEECCCCHHHEEHHHHCCCC
PAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
CCCEEEEEECCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
FGNFKAYGYINELDGSEHVALVKQKSKKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEA
HCCCEEEEEEECCCCCCEEEEEHHHHHHCCCCEEEEEHHHHCCCCCCCCEEECCCHHHHH
ALSRIEKEEEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVG
HHHHHCCCCCCEEEEEEECCCCCCCHHHHEEEEECCCCCCEEECCCCCCCCHHHHHCCCC
AQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLMICPNDNNAEYLSVKRTKLGHM
HHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHCCCEEEECCCCCCEEEEEEECCCCCE
IDVDNSNFRNIDPFISIFLDGNYKSIHLVPIKNKVNKFCKDQNINIKLESTPRLLAFWNR
EECCCCCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHCCCCCEEEECCCCCEEEEECC
PKLVWRIIHDRNRTNTNITDEEIKNIELLIEFLSKYEDSKKIGIIVSRNIEQALHPKNSI
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCE
KLINTKFTINNEILYSSTRKFNLDKETFSIVFEG
EEEEEEEEECCEEEEECCCEECCCCEEEEEEEEC
>Mature Secondary Structure
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQF
CCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
ATPQQINFMATEGRGLICLAMQGEKLDSLDLPLMVDRNTDKNQTAFTISIDAGPENNVST
CCCCEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCC
GISAEDRAKTIQVAINPNTKPDDLRRPGHIFPLRAKKGGVLKRAGHTEAAVDIAAMSGLY
CCCCCCCCEEEEEEECCCCCHHHHCCCCCEEEEECCCCCCEEECCCCHHHEEHHHHCCCC
PAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
CCCEEEEEECCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
FGNFKAYGYINELDGSEHVALVKQKSKKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEA
HCCCEEEEEEECCCCCCEEEEEHHHHHHCCCCEEEEEHHHHCCCCCCCCEEECCCHHHHH
ALSRIEKEEEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVG
HHHHHCCCCCCEEEEEEECCCCCCCHHHHEEEEECCCCCCEEECCCCCCCCHHHHHCCCC
AQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLMICPNDNNAEYLSVKRTKLGHM
HHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHCCCEEEECCCCCCEEEEEEECCCCCE
IDVDNSNFRNIDPFISIFLDGNYKSIHLVPIKNKVNKFCKDQNINIKLESTPRLLAFWNR
EECCCCCCCCCCCEEEEEECCCCCEEEEEECHHHHHHHHCCCCCEEEECCCCCEEEEECC
PKLVWRIIHDRNRTNTNITDEEIKNIELLIEFLSKYEDSKKIGIIVSRNIEQALHPKNSI
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCCCE
KLINTKFTINNEILYSSTRKFNLDKETFSIVFEG
EEEEEEEEECCEEEEECCCEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]