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The map label for this gene is gmk

Identifier: 78778852

GI number: 78778852

Start: 440400

End: 440954

Strand: Direct

Name: gmk

Synonym: PMT9312_0467

Alternate gene names: 78778852

Gene position: 440400-440954 (Clockwise)

Preceding gene: 78778848

Following gene: 78778855

Centisome position: 25.77

GC content: 33.69

Gene sequence:

>555_bases
ATGAAAAATCAAAAAAAACTCATTATCCTTACCGGACCTAGCGGGGTAGGCAAAGGAACTGTTATTAAAGAAATATTAGG
TAAAGATAAAAATATTTGGCTTTCAATATCTGCAACTACAAGGGAACCCAGAGAGGGAGAGCAGGAGGGAGAAAATTATT
ACTTTTTGAAGCAAGAAAAGTTCAAAGAAATGATTGAAAAAAACCTTTTTCTTGAATGGGCTCAATTTGCTGGGAACTAT
TATGGAACTCCTTTATCTTCTGTCAATGAGAAAATCACAAAGGGATTTACCGTTTTACTTGAAATTGAGGTGGAAGGTGC
AAAGCAAATAAAGGAAAAGTTTCCTGAGTCCCTTTCAATATTTTTACTCCCTCCGGATAAAGCAGAGTTAGAGAGAAGAA
TAAGAAATAGGGGTACAGAAAAAGAAGAGGCAATTAAAAAAAGACTCTTAAGGGCTAGTTATGAGATTTCTGCATCAAAT
CAATTTGATTTTGAATTAACAAATCACAATGTTGATGAAACAGCTAAGAGAATAATCAAGTTAATACAAACTTGA

Upstream 100 bases:

>100_bases
ACAGATCTAATCGATGTAATATCCATTATCTGCGGCACACCTTTTTGCATTATTTCTTTTTAATTCACAAGAAGTCCATT
TTACTGTAAAACTTTTTTAT

Downstream 100 bases:

>100_bases
CTATTCTCTCTTTAATCAGCTCATTGGATGGAATAATAAGTCTGGGAAAAATCTATTAAATTCAATGATGATTCCTGCAG
TCATAGTAATCCAAGCCGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEKFKEMIEKNLFLEWAQFAGNY
YGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSIFLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASN
QFDFELTNHNVDETAKRIIKLIQT

Sequences:

>Translated_184_residues
MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEKFKEMIEKNLFLEWAQFAGNY
YGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSIFLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASN
QFDFELTNHNVDETAKRIIKLIQT
>Mature_184_residues
MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEKFKEMIEKNLFLEWAQFAGNY
YGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSIFLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASN
QFDFELTNHNVDETAKRIIKLIQT

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=171, Percent_Identity=35.672514619883, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI226874833, Length=171, Percent_Identity=35.672514619883, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4504221, Length=171, Percent_Identity=35.672514619883, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=26.775956284153, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=26.7045454545455, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=26.7045454545455, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=26.7045454545455, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=26.7045454545455, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI186700629, Length=183, Percent_Identity=23.4972677595628, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186972120, Length=183, Percent_Identity=23.4972677595628, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186700627, Length=183, Percent_Identity=23.4972677595628, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI52630447, Length=186, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21361598, Length=184, Percent_Identity=23.3695652173913, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=171, Percent_Identity=42.6900584795322, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=38.6740331491713, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=38.6740331491713, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=24.5901639344262, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=24.5901639344262, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71984092, Length=179, Percent_Identity=25.6983240223464, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=180, Percent_Identity=38.8888888888889, Blast_Score=135, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356141, Length=164, Percent_Identity=41.4634146341463, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=22.9508196721311, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=22.9508196721311, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=22.9508196721311, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=22.9508196721311, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=22.9508196721311, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=22.9508196721311, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI85816281, Length=215, Percent_Identity=26.5116279069767, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551002, Length=216, Percent_Identity=26.3888888888889, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816106, Length=215, Percent_Identity=26.5116279069767, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362232, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161078485, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648810, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362230, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648808, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_PROM9 (Q31C67)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_396964.1
- HSSP:   P60546
- ProteinModelPortal:   Q31C67
- SMR:   Q31C67
- STRING:   Q31C67
- GeneID:   3765264
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0467
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   PMAR74546:PMT9312_0467-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21199; Mature: 21199

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEK
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCEEEECHHH
FKEMIEKNLFLEWAQFAGNYYGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHCCCCEEE
FLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASNQFDFELTNHNVDETAKRIIK
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
LIQT
HHCC
>Mature Secondary Structure
MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEK
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCEEEECHHH
FKEMIEKNLFLEWAQFAGNYYGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHCCCCEEE
FLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASNQFDFELTNHNVDETAKRIIK
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
LIQT
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA