Click here to switch to the map view.

The map label for this gene is thiD [H]

Identifier: 78778747

GI number: 78778747

Start: 343491

End: 344270

Strand: Direct

Name: thiD [H]

Synonym: PMT9312_0362

Alternate gene names: 78778747

Gene position: 343491-344270 (Clockwise)

Preceding gene: 78778746

Following gene: 78778749

Centisome position: 20.1

GC content: 31.15

Gene sequence:

>780_bases
ATGTATTCTAAAGTTGTACTTTCAATAGGAGGTAGTGACTCCGGAGGTGGAGCAGGTATACAAGCTGACCTAAGAACTTT
TATGGCCCTTAAAGTACATGGATGTTCTGTTATTACATGTATTACTGCACAAAATAGTATTGCAGTTAATTGCGTTGAAG
CAGTAGAAAAGAATACTTTATTAAGTCAGTTAGATACTTTATTTTCTGATTTTGGCTTTGATGCTTTAAAAACTGGAATG
TTACTAAATGAAGGGATAATCATTGATACTGCATCAAAATTAAATAAATATAAAATAACCAAAATTATTGACCCAGTAAT
GGTTACAAGAACTGGTTCTAAATTACTGGAGGATTCTGCGATTAATGCTTATAAAAAATTCTTATTACCAATTGCGGATT
TAGTAACTCCAAATATTTATGAAGCAAATCTACTTTCTGGTTTAGAAATAAGGAATAAAGAAGATATCGAAAATTCCGCA
AGAAATATTATTAGTCTGGGAGCCAAGGCAGTACTTATAAAAGGTGGCGGTTTAAAAGAGATGAAAGGGAAAGATTTTTT
TCTTGATTTAAATGGTAGAAAAAAATGGTTAATTAATAATTTTATAAATACAAAAAATACCCATGGTAGTGGTTGTACTT
TAAGTGCAGCTATTTGCGGTTACAAAGCTTTAGGTTTTGATCTACTTGACTCTATCCAAAAAGCAAAATTTTTTGTTGAA
AAATCTTTAGAAAATTCTTACAAAATAGGATCTGGCCCTGGCCCCTTAGGTCATCATTAA

Upstream 100 bases:

>100_bases
GAGCAATTGAATTAGAATTAGATTTTTTTAATGCATATTCAGATTTCTAATTTAAATTAAAATCTATTTATAGTACTTTT
AAAGACGAGTTAATCAAATT

Downstream 100 bases:

>100_bases
TTAATTATTTATTTATGGAAGTGGATTTAGAACCACCATTTTCTGTAGGGCTTTTTTAAAAATAAGATTTCTTCTGTCTC
CCATCCACCCTCCAACCACT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MYSKVVLSIGGSDSGGGAGIQADLRTFMALKVHGCSVITCITAQNSIAVNCVEAVEKNTLLSQLDTLFSDFGFDALKTGM
LLNEGIIIDTASKLNKYKITKIIDPVMVTRTGSKLLEDSAINAYKKFLLPIADLVTPNIYEANLLSGLEIRNKEDIENSA
RNIISLGAKAVLIKGGGLKEMKGKDFFLDLNGRKKWLINNFINTKNTHGSGCTLSAAICGYKALGFDLLDSIQKAKFFVE
KSLENSYKIGSGPGPLGHH

Sequences:

>Translated_259_residues
MYSKVVLSIGGSDSGGGAGIQADLRTFMALKVHGCSVITCITAQNSIAVNCVEAVEKNTLLSQLDTLFSDFGFDALKTGM
LLNEGIIIDTASKLNKYKITKIIDPVMVTRTGSKLLEDSAINAYKKFLLPIADLVTPNIYEANLLSGLEIRNKEDIENSA
RNIISLGAKAVLIKGGGLKEMKGKDFFLDLNGRKKWLINNFINTKNTHGSGCTLSAAICGYKALGFDLLDSIQKAKFFVE
KSLENSYKIGSGPGPLGHH
>Mature_259_residues
MYSKVVLSIGGSDSGGGAGIQADLRTFMALKVHGCSVITCITAQNSIAVNCVEAVEKNTLLSQLDTLFSDFGFDALKTGM
LLNEGIIIDTASKLNKYKITKIIDPVMVTRTGSKLLEDSAINAYKKFLLPIADLVTPNIYEANLLSGLEIRNKEDIENSA
RNIISLGAKAVLIKGGGLKEMKGKDFFLDLNGRKKWLINNFINTKNTHGSGCTLSAAICGYKALGFDLLDSIQKAKFFVE
KSLENSYKIGSGPGPLGHH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=39.0625, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6325378, Length=267, Percent_Identity=29.2134831460674, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324517, Length=252, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324997, Length=252, Percent_Identity=32.9365079365079, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27882; Mature: 27882

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKVVLSIGGSDSGGGAGIQADLRTFMALKVHGCSVITCITAQNSIAVNCVEAVEKNTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCEEEEEEECCCCEEHHHHHHHHHHHH
LSQLDTLFSDFGFDALKTGMLLNEGIIIDTASKLNKYKITKIIDPVMVTRTGSKLLEDSA
HHHHHHHHHHCCHHHHHHCCEECCCEEEECHHHCCCEEHHHHHCCCEEECCCHHHHHHHH
INAYKKFLLPIADLVTPNIYEANLLSGLEIRNKEDIENSARNIISLGAKAVLIKGGGLKE
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
MKGKDFFLDLNGRKKWLINNFINTKNTHGSGCTLSAAICGYKALGFDLLDSIQKAKFFVE
CCCCEEEEEECCCCEEEHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLENSYKIGSGPGPLGHH
HHHCCCEECCCCCCCCCCC
>Mature Secondary Structure
MYSKVVLSIGGSDSGGGAGIQADLRTFMALKVHGCSVITCITAQNSIAVNCVEAVEKNTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCEEEEEEECCCCEEHHHHHHHHHHHH
LSQLDTLFSDFGFDALKTGMLLNEGIIIDTASKLNKYKITKIIDPVMVTRTGSKLLEDSA
HHHHHHHHHHCCHHHHHHCCEECCCEEEECHHHCCCEEHHHHHCCCEEECCCHHHHHHHH
INAYKKFLLPIADLVTPNIYEANLLSGLEIRNKEDIENSARNIISLGAKAVLIKGGGLKE
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCC
MKGKDFFLDLNGRKKWLINNFINTKNTHGSGCTLSAAICGYKALGFDLLDSIQKAKFFVE
CCCCEEEEEECCCCEEEHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLENSYKIGSGPGPLGHH
HHHCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA