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The map label for this gene is dxs [H]

Identifier: 161350036

GI number: 161350036

Start: 825089

End: 826978

Strand: Direct

Name: dxs [H]

Synonym: PMT9312_0893

Alternate gene names: 161350036

Gene position: 825089-826978 (Clockwise)

Preceding gene: 78779273

Following gene: 78779287

Centisome position: 48.27

GC content: 35.45

Gene sequence:

>1890_bases
ATGCTTTTAAGTGAGTTAAGCCATCCGAATGAACTACATGGCTTAACAGTTTCACAATTAGAGGAAATTGCTTGTCAAAT
TAGAGAAAGACATCTCCAAGTAGTATCTACAAGTGGTGGACACCTTGGCCCTGGATTAGGTGTAGTCGAATTGACATTGG
CTTTATATCAAACTCTAGATCTTGATAGCGACAGGGTTGTTTGGGATGTTGGTCATCAAGGTTATCCTCATAAATTAATA
ACAGGTCGTTTCAGTCAATTTGATTCACTTAGACAACAAAATGGAGTAGCAGGATATCTTAAAAGAAGTGAAAGTAAATT
TGACCATTTTGGTGCAGGTCATGCAAGTACATCAATTTCAGCTGCTTTAGGAATGGCAATAGCAAGAGATAGAAAAGGTG
AAAATCATAAATGTGTAGCAGTTATAGGAGATGGAGCATTAACTGGTGGAATGGCTTTAGAAGCTATAAATCATGCCGGA
CATTTACCTAATACTCCATTAGTTGTAGTTTTAAATGATAATGACATGTCAATATCGCCTCCAGTTGGAGCACTTTCTTC
TTATTTAAATAAAGTTAGACTTAGTCCTCCATTACAATTTTTATCAGATAGTGTGCAGGAAAGTGTAAAAAATATTCCGT
TAATTGGTAAGGATATTCCAGAAGAATTAAAAAATATTAAGGGCAGTGTGAGACGTTTAGCTGTTCCTAAGGTTGGAGCA
GTTTTTGAAGAACTCGGATTTACATATATGGGCCCAATTGATGGTCATGATATTGAAAATTTAATTAATACATTTAATGC
TGCGCATAGACTTAAAAAACCTGTTCTCGTTCATATTGTTACAACAAAGGGTAAGGGTTATCCTTATGCAGAAGCAGATC
AAGTTGGATACCATGCTCAGTCTGCATTTGACCTGACGACAGGTAAATCTATCCCATCAAAAAAACCAAAGCCCGTAAGT
TATAGCAAAATATTTGGTCAAACATTATTAAAAATATGTGAACAAGATAGCAAAGTTATTGGTATAACAGCAGCTATGGC
TACTGGCACAGGATTAGATATATTGCAAAAGAATATTCCAGAGCAATACGTTGATGTAGGCATAGCTGAGCAGCATGCAG
TTACTCTTGCCGCAGGAATGTCGTGCGATGGTCTTAAACCTGTTGTTGCTATTTATAGCACTTTCCTGCAACGTGCTTTT
GATCAATTAATTCATGATGTAGGGATACAAAATTTACCTGTATCTTTTGTACTTGATAGAGCTGGAATTGTTGGAGCTGA
CGGCCCTACTCACCAAGGGCAATACGATATTAGTTATATGAGATCCATACCAAATTTTGTCTTAATGGCCCCAAAAGATG
AGTCTGAATTGCAGAGAATGTTAATAACATCAATTAACCATAAGGGACCTACAGCATTAAGAATACCTAGAGGTTCTGGA
TTAGGTGTTGCTGTAATGGATGAAGGTTGGGAACCATTGAATATAGGTGAGGCTGAAATACTAGAAGAGGGAAATGATAT
TTTAATTATTGCTTATGGATCAATGGTCGCTTCAGCTATTGAAACAGCAGAGATATTAAAAGGTATGAACATTAATACTT
GTATTGTAAATGCAAGATTTGTTAAACCTCTCGATAAAAATCTTATTATTCCTTTGGCAAGTAGGATTCAAAAAGTGGTA
ACGATGGAAGAAGGAACCTTAATAGGTGGTTTTGGTTCAGCTATCGTTGAATTATTTAACGATAATGAAGTAAATATTCC
TGTATATAGAATAGGTATACCTGATGTTTTAGTTGATCATGCATCACCTGATCAGAGTAAAGAAAAATTAGGTCTTATGC
CTGATCAGATGGCAGATAAAATAATTCAGAAATTTAAATTAAATAATTAA

Upstream 100 bases:

>100_bases
TTAATTATTAATCTAATAAAACATTACATGATCGATTTCATAAAAATTACTCATTTTGCACCTCGGCGTTTTAAATTATA
TGTATAACTATTTTTATGTA

Downstream 100 bases:

>100_bases
AAATTTATTTTATAAATTTCTATAAAACACCACGTGATGCTAATCCAAGGATGGCACCTATTCCGAATATGTGACCTAGG
CAATTAGCTCCAACAACAGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MLLSELSHPNELHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDSDRVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENHKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRLSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLAVPKVGA
VFEELGFTYMGPIDGHDIENLINTFNAAHRLKKPVLVHIVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPEQYVDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHKGPTALRIPRGSG
LGVAVMDEGWEPLNIGEAEILEEGNDILIIAYGSMVASAIETAEILKGMNINTCIVNARFVKPLDKNLIIPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEVNIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADKIIQKFKLNN

Sequences:

>Translated_629_residues
MLLSELSHPNELHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDSDRVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENHKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRLSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLAVPKVGA
VFEELGFTYMGPIDGHDIENLINTFNAAHRLKKPVLVHIVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPEQYVDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHKGPTALRIPRGSG
LGVAVMDEGWEPLNIGEAEILEEGNDILIIAYGSMVASAIETAEILKGMNINTCIVNARFVKPLDKNLIIPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEVNIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADKIIQKFKLNN
>Mature_629_residues
MLLSELSHPNELHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDSDRVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGENHKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRLSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLAVPKVGA
VFEELGFTYMGPIDGHDIENLINTFNAAHRLKKPVLVHIVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIPEQYVDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHKGPTALRIPRGSG
LGVAVMDEGWEPLNIGEAEILEEGNDILIIAYGSMVASAIETAEILKGMNINTCIVNARFVKPLDKNLIIPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEVNIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADKIIQKFKLNN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=593, Percent_Identity=23.2715008431703, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4507521, Length=593, Percent_Identity=23.2715008431703, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI133778974, Length=640, Percent_Identity=22.8125, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI225637459, Length=377, Percent_Identity=25.4641909814324, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=377, Percent_Identity=25.4641909814324, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637463, Length=377, Percent_Identity=25.4641909814324, Blast_Score=101, Evalue=3e-21,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=43.3931484502447, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=27.4509803921569, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319698, Length=317, Percent_Identity=25.2365930599369, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=23.8095238095238, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=23.8095238095238, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=24.2174629324547, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24666278, Length=654, Percent_Identity=24.4648318042813, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=23.4939759036145, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=23.4939759036145, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68009; Mature: 68009

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSELSHPNELHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDSDRVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGENHKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRLSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLAVPKVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPIDGHDIENLINTFNAAHRLKKPVLVHIVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
EQYVDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHKGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
LGVAVMDEGWEPLNIGEAEILEEGNDILIIAYGSMVASAIETAEILKGMNINTCIVNARF
CEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEHH
VKPLDKNLIIPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEVNIPVYRIGIPDVLVDH
HCCCCCCEEEHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCEEEEECCCHHHHCC
ASPDQSKEKLGLMPDQMADKIIQKFKLNN
CCCCCHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLSELSHPNELHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDSDRVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCCCCEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGENHKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRLSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLAVPKVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPIDGHDIENLINTFNAAHRLKKPVLVHIVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVIGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
EQYVDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHHCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHKGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
LGVAVMDEGWEPLNIGEAEILEEGNDILIIAYGSMVASAIETAEILKGMNINTCIVNARF
CEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEHH
VKPLDKNLIIPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEVNIPVYRIGIPDVLVDH
HCCCCCCEEEHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCEEEEECCCHHHHCC
ASPDQSKEKLGLMPDQMADKIIQKFKLNN
CCCCCHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA