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The map label for this gene is serS [H]

Identifier: 161350030

GI number: 161350030

Start: 1195448

End: 1196725

Strand: Direct

Name: serS [H]

Synonym: PMT9312_1289

Alternate gene names: 161350030

Gene position: 1195448-1196725 (Clockwise)

Preceding gene: 78779671

Following gene: 78779673

Centisome position: 69.94

GC content: 31.46

Gene sequence:

>1278_bases
GTGTTAGACCAAAAATTAATAAGAGAAAATCCAACGTCTGTTGAAGAGAATTTATCCTTAAGAGGAAAAGTTTACAAAAT
ATCCCACATTCACGAATTAACAGTTAAAAAAAAAGAAATTGATATAGAAATATCGAGCCTTCAATCCGAGAGTAAAAAAT
TAAGCAAATTAATCGGTCAAGTAATTGCAAAATCACAAAACACTAATTCACAAGAACTAAATGATTTAAAAAAAAGAGGA
AACGAATACAGAATCAAAATTTCTGAACTTGAAGAGAAACAAAGAATATTAGATAAACAAGTAGATGATGAGATTTATAA
TTTGCCAAATTTCTCTAGCAAAGAAGCACCTATTGGGAAAGATGAAAGTGATAATGTACAAATAAAAACTTGGGGAGACA
CTCTTATAAGGGAGAATATTAAATCACACTGGGAAATAGGAGAAAGTCTTAATATTTTTGACTCCGTAAAATCAACAAAA
ATATCAAAAAGTCGTTTTATCACTCTTATTGGTAATGGCGCCAAATTAGAGAGGGCATTGATTAATTTCATGCTCGATAT
TCATACTAAAAATGGTTATTTAGAGTTAATGCCTCCAGCTTTAGTAAATTCAGAAAGTCTTAGGGGATCTGGACAATTAC
CTAAATTTTCAAATGAAAGTTTTAAATGTTCTAATGATGATTTATGGCTTTCTCCAACAGCCGAAGTTCCACTCACTGCT
TTTCATAGAAATGAAATTATTGATCCTAAGCAGTTACCTATTAAGTATGTTGCATATAGTCCATGTTTCAGAAGAGAAGC
TGGTAGTTATGGTAGGGATACTAAGGGCTTAATACGACTTCATCAATTTAATAAGGTTGAGCTTTATTGGTTTTGTGATC
CAAGTAAATCTTTAGAAGCTCATAAAAAGATTACTTCTGATGCAGAAAGCATTTTAAAAAAGCTCAATTTACCATACAGA
TTAGTAGATATTTGTACTGGAGACTTAGGCTTTTCTTCTAGTAGAACTTTTGATCTTGAAGTCTGGCTGCCCAGTAGTAA
ATGTTATAGAGAAATTTCAAGTTGCAGTAATTGTCTAGACTTTCAAGCACGTAGATCATCAATAAGATCAAAAATTAATA
AAAAAAATACATATTTGCACACTTTAAATGGTAGTGGGCTTGCTATTGGAAGAACAATGGCCGCGATTCTTGAGAATGGC
CAACAAAAAGATGGTAGCGTTAAAATTCCAGATGCTCTTGTTCCATATTTTGGATCAAATTATTTAAAAACTGCTTAA

Upstream 100 bases:

>100_bases
TTGCATAAGTTAGGAATCATTAATTTAGTTAATTTTTCATCAAAAATCCCAAATAATGAATCGAGATTAACTATCTTTAT
TAATGTATAAAAAAAAAAGA

Downstream 100 bases:

>100_bases
TATAAAAAAATGAATGTTTTAACCTCAATAACAGTTCTTGGATTTCTCATTTTTTTTCATGAGATGGGCCATTTTCTTGC
AGCAATTTTACAAGGAATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIAKSQNTNSQELNDLKKRG
NEYRIKISELEEKQRILDKQVDDEIYNLPNFSSKEAPIGKDESDNVQIKTWGDTLIRENIKSHWEIGESLNIFDSVKSTK
ISKSRFITLIGNGAKLERALINFMLDIHTKNGYLELMPPALVNSESLRGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
FHRNEIIDPKQLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKINKKNTYLHTLNGSGLAIGRTMAAILENG
QQKDGSVKIPDALVPYFGSNYLKTA

Sequences:

>Translated_425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIAKSQNTNSQELNDLKKRG
NEYRIKISELEEKQRILDKQVDDEIYNLPNFSSKEAPIGKDESDNVQIKTWGDTLIRENIKSHWEIGESLNIFDSVKSTK
ISKSRFITLIGNGAKLERALINFMLDIHTKNGYLELMPPALVNSESLRGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
FHRNEIIDPKQLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKINKKNTYLHTLNGSGLAIGRTMAAILENG
QQKDGSVKIPDALVPYFGSNYLKTA
>Mature_425_residues
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIAKSQNTNSQELNDLKKRG
NEYRIKISELEEKQRILDKQVDDEIYNLPNFSSKEAPIGKDESDNVQIKTWGDTLIRENIKSHWEIGESLNIFDSVKSTK
ISKSRFITLIGNGAKLERALINFMLDIHTKNGYLELMPPALVNSESLRGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
FHRNEIIDPKQLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKINKKNTYLHTLNGSGLAIGRTMAAILENG
QQKDGSVKIPDALVPYFGSNYLKTA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=322, Percent_Identity=36.9565217391304, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI8923421, Length=395, Percent_Identity=31.1392405063291, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI225579074, Length=397, Percent_Identity=29.9748110831234, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=44.0366972477064, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539260, Length=436, Percent_Identity=32.1100917431193, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17542084, Length=329, Percent_Identity=30.3951367781155, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=394, Percent_Identity=34.010152284264, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6321799, Length=400, Percent_Identity=31.25, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24581334, Length=329, Percent_Identity=35.5623100303951, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737985, Length=396, Percent_Identity=28.5353535353535, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48245; Mature: 48245

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQ
CCCCHHHHCCCCCHHHCCCCCCEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIAKSQNTNSQELNDLKKRGNEYRIKISELEEKQRILDKQVDDEIYNLPNFSSKEAPIGK
HHHCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DESDNVQIKTWGDTLIRENIKSHWEIGESLNIFDSVKSTKISKSRFITLIGNGAKLERAL
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHH
INFMLDIHTKNGYLELMPPALVNSESLRGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
HHHHHEEECCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCEEE
FHRNEIIDPKQLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKKITSDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKINKKNTYLHTLNGSGLAIGRTMAAILENGQQKDGSVKIPDALVPYFGSN
HHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCC
YLKTA
CCCCC
>Mature Secondary Structure
MLDQKLIRENPTSVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQ
CCCCHHHHCCCCCHHHCCCCCCEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIAKSQNTNSQELNDLKKRGNEYRIKISELEEKQRILDKQVDDEIYNLPNFSSKEAPIGK
HHHCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DESDNVQIKTWGDTLIRENIKSHWEIGESLNIFDSVKSTKISKSRFITLIGNGAKLERAL
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHH
INFMLDIHTKNGYLELMPPALVNSESLRGSGQLPKFSNESFKCSNDDLWLSPTAEVPLTA
HHHHHEEECCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCEEE
FHRNEIIDPKQLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHCCCCCCCCCCCEEEEEECCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKKITSDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKINKKNTYLHTLNGSGLAIGRTMAAILENGQQKDGSVKIPDALVPYFGSN
HHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCC
YLKTA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA