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The map label for this gene is norD [H]

Identifier: 78484767

GI number: 78484767

Start: 471872

End: 474145

Strand: Reverse

Name: norD [H]

Synonym: Tcr_0422

Alternate gene names: 78484767

Gene position: 474145-471872 (Counterclockwise)

Preceding gene: 78484768

Following gene: 78484766

Centisome position: 19.53

GC content: 46.13

Gene sequence:

>2274_bases
ATGAATGCAGACCTCATAACAGAAGTCGTTTCTGAGTATCAAGACAAATTCACCTGTAATTTCCCCAAGGCGTTGGAGGT
TTTTCCGGTGTGCATCGAAGAGGCTGCCCAACAACTTTCAGACGAAGGGGTGACTGCCTATATTGATGGTGCCAACTTCC
TTTGTAAGATAGGCATGGGCGTTGAACCGGTTCTGGTCTACCTTGAGATCATGCCGGAAATCGCCTCTCATATTGGAAAA
GGCACCATGAAAATGGTGGCCGACTACGGCTATAAGTTAGCGCGCAGCCCTAACAAAAAAGCCTTAATTCCTTTTTTAGC
TTCACTCAGCAGTGTCTGCCGACGCATCGATACTTTGGAAGACCTTCAGCACTATCTGGACATTATTGATGAATACGTCG
ATAAAACACAAACCGTCATTCATGGTCATCACTCTTTGTATGAAAGCCCGGGCATGATTCCTTTATTGGAATCCATGCCC
CAACTGATTTCCAAATTGAGTCTGGCCGGAATCCGTAATTTTATTGATTATGGCGCACGCAACTATAATGATGCGCCCGA
CCAGCAAATTGCTTATTTCAGCTTAGAATCGCACGATGCCAAAAGTATCATTCAACGTGAACGTCAAGGCACAACGTTCA
AAGACGTGGAACGTCATTTGGATATGTTAAAAGACTGCATGTGGCATTGTGACCGCCCTTTTTCGGTTTTCTCCACCGCA
TTCGATCAACTTCGTAAACCCGTTCCGTATTTGGATGAAGAACTCATTGCCGTGCCAGATGTGTATGAAGATGAAAATGG
TGTTAGCGGTTTGGATCGCTATCGCGCCATGCTAGCGCATATGATGGCGCACAAAGAATGGTCAACCAAGTTGATGGCCG
ATAATTTCGCCCCCCATATGCAGCTTTTTATTTCCACCTTTGAAGACTGCCGAGTGGAAAGACTGGCCATTCAACGATTC
CCCGGGTTAAAACCCTTGTTTCTTGCACTCCACCCAGTGCCGGAAAAAGGCGCGTGCGACCCGATCCAACAGGCCTGTTT
AAGATATCGCTCTACACGCCTGTCTCGCGCCTTAATGGATGAAACATTTGACCCGGAAAACCCATTGATCGAAGACTTCC
GCACCCAGTTCAATGCCATTATGGCTGAAAAAGGCGACGCCTCCACCACACAAGACATGGCGAAACTGGGCACGAACTTC
TATGTCAAATCGCGTAAAAAAACCGACAGCTTGCCGAACGTTTTCTTTGACGACACCGAAGTCAGTTACCGAGATGACAA
TCGCTTTATCTGGTTCCATTACGAAGAGAATGACGAAGCGGAAGATTTCCATAACAACGAATATCACTCCGATGAAAAAA
TAGTCGACGACGCAAACAGTTTACCGCCTCGCCACTATGATGAATGGGATTATATTTCTGAAAGCTATCGTCCAGACTGG
GCGACGGTTTATGAACGCTTACACCCTTCTGGAGATTCAAATAAAATTGACCGCCTGATGGAAAAACATGACGGTTTGGC
CAAACGTTTGAAAAAAATGATTGAAGCCCTTAAACCTCAAAACAAAAAACGCATTCGGTTTCAGGAAGAAGGGGAAGAGC
TGGATTTGGACATCGCGATTCGTTCCGTCATTGATTTTAAAAGCGGGCAAGCACCCGACCCTCGCATCAACTACAGCCAT
ACCACTGACAGCCGAAACATTGCCGTCATGTTACTGGTGGACACCTCACAATCGTTAAAAGAGCGCAATCAGGAAACGGG
TCAAACTTTACTGGAATTAAGTGAAGAAGCTCTTGCCATCACCGCGTGGACCATTGAACAGCTAGGGGATAAGTTCGCCA
TTGCGGGCTTTTGCTCGGACACGCGTCATGAAGTTCGCTATCAGCATATCAAAGGCTATTCAGAGCATTATGGCGATGAG
GTCAAGTCTCGCATTGCCGCGATGGAAGCCTCTTATTCCACCCGAATGGGAGCCGCCATGCGTCATGCGGCACATTATCT
GGAAGCACAGCAGGCTGAGAAAAAACTGATGCTGATTTTAACCGATGGCGAGCCGGCGGATATTGACACCAAAGACCCAC
AGGTTCTTATTCAAGATACCCATAAAGCGGTCGAAGAACTGAAAAGCAAAGGAATCTATTCTTACTGCATTACCTTAGAT
CCGAATGCCGATGAATACGTTGAGACCATTTTTGACAACCACTATACCGTCATTGACCATGTTGATAAGCTGCCAGAAAA
ATTACCTCAAGTCTTTATGAAAATCACACAATAA

Upstream 100 bases:

>100_bases
ATGATTTTTGGCTAAAAACAGCCAGGCCTGGTTATTTTTGCTAAGCCACCGCCCAAACATGAGCGGTGACGATTTATCAT
TCAATCAAATGAGTTAGATT

Downstream 100 bases:

>100_bases
AAACGTGTATAATTTCCATTTTGAAGAAGCTTTAAAGTAAATGCCCTTACAATTTAAGGGCATTTTTGTATCCCCCAACA
ACTTCTCCAAAAGGATTCTT

Product: von Willebrand factor, type A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MNADLITEVVSEYQDKFTCNFPKALEVFPVCIEEAAQQLSDEGVTAYIDGANFLCKIGMGVEPVLVYLEIMPEIASHIGK
GTMKMVADYGYKLARSPNKKALIPFLASLSSVCRRIDTLEDLQHYLDIIDEYVDKTQTVIHGHHSLYESPGMIPLLESMP
QLISKLSLAGIRNFIDYGARNYNDAPDQQIAYFSLESHDAKSIIQRERQGTTFKDVERHLDMLKDCMWHCDRPFSVFSTA
FDQLRKPVPYLDEELIAVPDVYEDENGVSGLDRYRAMLAHMMAHKEWSTKLMADNFAPHMQLFISTFEDCRVERLAIQRF
PGLKPLFLALHPVPEKGACDPIQQACLRYRSTRLSRALMDETFDPENPLIEDFRTQFNAIMAEKGDASTTQDMAKLGTNF
YVKSRKKTDSLPNVFFDDTEVSYRDDNRFIWFHYEENDEAEDFHNNEYHSDEKIVDDANSLPPRHYDEWDYISESYRPDW
ATVYERLHPSGDSNKIDRLMEKHDGLAKRLKKMIEALKPQNKKRIRFQEEGEELDLDIAIRSVIDFKSGQAPDPRINYSH
TTDSRNIAVMLLVDTSQSLKERNQETGQTLLELSEEALAITAWTIEQLGDKFAIAGFCSDTRHEVRYQHIKGYSEHYGDE
VKSRIAAMEASYSTRMGAAMRHAAHYLEAQQAEKKLMLILTDGEPADIDTKDPQVLIQDTHKAVEELKSKGIYSYCITLD
PNADEYVETIFDNHYTVIDHVDKLPEKLPQVFMKITQ

Sequences:

>Translated_757_residues
MNADLITEVVSEYQDKFTCNFPKALEVFPVCIEEAAQQLSDEGVTAYIDGANFLCKIGMGVEPVLVYLEIMPEIASHIGK
GTMKMVADYGYKLARSPNKKALIPFLASLSSVCRRIDTLEDLQHYLDIIDEYVDKTQTVIHGHHSLYESPGMIPLLESMP
QLISKLSLAGIRNFIDYGARNYNDAPDQQIAYFSLESHDAKSIIQRERQGTTFKDVERHLDMLKDCMWHCDRPFSVFSTA
FDQLRKPVPYLDEELIAVPDVYEDENGVSGLDRYRAMLAHMMAHKEWSTKLMADNFAPHMQLFISTFEDCRVERLAIQRF
PGLKPLFLALHPVPEKGACDPIQQACLRYRSTRLSRALMDETFDPENPLIEDFRTQFNAIMAEKGDASTTQDMAKLGTNF
YVKSRKKTDSLPNVFFDDTEVSYRDDNRFIWFHYEENDEAEDFHNNEYHSDEKIVDDANSLPPRHYDEWDYISESYRPDW
ATVYERLHPSGDSNKIDRLMEKHDGLAKRLKKMIEALKPQNKKRIRFQEEGEELDLDIAIRSVIDFKSGQAPDPRINYSH
TTDSRNIAVMLLVDTSQSLKERNQETGQTLLELSEEALAITAWTIEQLGDKFAIAGFCSDTRHEVRYQHIKGYSEHYGDE
VKSRIAAMEASYSTRMGAAMRHAAHYLEAQQAEKKLMLILTDGEPADIDTKDPQVLIQDTHKAVEELKSKGIYSYCITLD
PNADEYVETIFDNHYTVIDHVDKLPEKLPQVFMKITQ
>Mature_757_residues
MNADLITEVVSEYQDKFTCNFPKALEVFPVCIEEAAQQLSDEGVTAYIDGANFLCKIGMGVEPVLVYLEIMPEIASHIGK
GTMKMVADYGYKLARSPNKKALIPFLASLSSVCRRIDTLEDLQHYLDIIDEYVDKTQTVIHGHHSLYESPGMIPLLESMP
QLISKLSLAGIRNFIDYGARNYNDAPDQQIAYFSLESHDAKSIIQRERQGTTFKDVERHLDMLKDCMWHCDRPFSVFSTA
FDQLRKPVPYLDEELIAVPDVYEDENGVSGLDRYRAMLAHMMAHKEWSTKLMADNFAPHMQLFISTFEDCRVERLAIQRF
PGLKPLFLALHPVPEKGACDPIQQACLRYRSTRLSRALMDETFDPENPLIEDFRTQFNAIMAEKGDASTTQDMAKLGTNF
YVKSRKKTDSLPNVFFDDTEVSYRDDNRFIWFHYEENDEAEDFHNNEYHSDEKIVDDANSLPPRHYDEWDYISESYRPDW
ATVYERLHPSGDSNKIDRLMEKHDGLAKRLKKMIEALKPQNKKRIRFQEEGEELDLDIAIRSVIDFKSGQAPDPRINYSH
TTDSRNIAVMLLVDTSQSLKERNQETGQTLLELSEEALAITAWTIEQLGDKFAIAGFCSDTRHEVRYQHIKGYSEHYGDE
VKSRIAAMEASYSTRMGAAMRHAAHYLEAQQAEKKLMLILTDGEPADIDTKDPQVLIQDTHKAVEELKSKGIYSYCITLD
PNADEYVETIFDNHYTVIDHVDKLPEKLPQVFMKITQ

Specific function: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection [H]

COG id: COG4548

COG function: function code P; Nitric oxide reductase activation protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002035 [H]

Pfam domain/function: PF00092 VWA [H]

EC number: NA

Molecular weight: Translated: 86991; Mature: 86991

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADLITEVVSEYQDKFTCNFPKALEVFPVCIEEAAQQLSDEGVTAYIDGANFLCKIGMG
CCHHHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCC
VEPVLVYLEIMPEIASHIGKGTMKMVADYGYKLARSPNKKALIPFLASLSSVCRRIDTLE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DLQHYLDIIDEYVDKTQTVIHGHHSLYESPGMIPLLESMPQLISKLSLAGIRNFIDYGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
NYNDAPDQQIAYFSLESHDAKSIIQRERQGTTFKDVERHLDMLKDCMWHCDRPFSVFSTA
CCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FDQLRKPVPYLDEELIAVPDVYEDENGVSGLDRYRAMLAHMMAHKEWSTKLMADNFAPHM
HHHHCCCCCCCCHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QLFISTFEDCRVERLAIQRFPGLKPLFLALHPVPEKGACDPIQQACLRYRSTRLSRALMD
HHHHHHHHHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ETFDPENPLIEDFRTQFNAIMAEKGDASTTQDMAKLGTNFYVKSRKKTDSLPNVFFDDTE
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCEECCCC
VSYRDDNRFIWFHYEENDEAEDFHNNEYHSDEKIVDDANSLPPRHYDEWDYISESYRPDW
CCEECCCEEEEEEECCCCCHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCH
ATVYERLHPSGDSNKIDRLMEKHDGLAKRLKKMIEALKPQNKKRIRFQEEGEELDLDIAI
HHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHH
RSVIDFKSGQAPDPRINYSHTTDSRNIAVMLLVDTSQSLKERNQETGQTLLELSEEALAI
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
TAWTIEQLGDKFAIAGFCSDTRHEVRYQHIKGYSEHYGDEVKSRIAAMEASYSTRMGAAM
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHAAHYLEAQQAEKKLMLILTDGEPADIDTKDPQVLIQDTHKAVEELKSKGIYSYCITLD
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEC
PNADEYVETIFDNHYTVIDHVDKLPEKLPQVFMKITQ
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNADLITEVVSEYQDKFTCNFPKALEVFPVCIEEAAQQLSDEGVTAYIDGANFLCKIGMG
CCHHHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCC
VEPVLVYLEIMPEIASHIGKGTMKMVADYGYKLARSPNKKALIPFLASLSSVCRRIDTLE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DLQHYLDIIDEYVDKTQTVIHGHHSLYESPGMIPLLESMPQLISKLSLAGIRNFIDYGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
NYNDAPDQQIAYFSLESHDAKSIIQRERQGTTFKDVERHLDMLKDCMWHCDRPFSVFSTA
CCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
FDQLRKPVPYLDEELIAVPDVYEDENGVSGLDRYRAMLAHMMAHKEWSTKLMADNFAPHM
HHHHCCCCCCCCHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QLFISTFEDCRVERLAIQRFPGLKPLFLALHPVPEKGACDPIQQACLRYRSTRLSRALMD
HHHHHHHHHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ETFDPENPLIEDFRTQFNAIMAEKGDASTTQDMAKLGTNFYVKSRKKTDSLPNVFFDDTE
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCEECCCC
VSYRDDNRFIWFHYEENDEAEDFHNNEYHSDEKIVDDANSLPPRHYDEWDYISESYRPDW
CCEECCCEEEEEEECCCCCHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCH
ATVYERLHPSGDSNKIDRLMEKHDGLAKRLKKMIEALKPQNKKRIRFQEEGEELDLDIAI
HHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHH
RSVIDFKSGQAPDPRINYSHTTDSRNIAVMLLVDTSQSLKERNQETGQTLLELSEEALAI
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
TAWTIEQLGDKFAIAGFCSDTRHEVRYQHIKGYSEHYGDEVKSRIAAMEASYSTRMGAAM
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHAAHYLEAQQAEKKLMLILTDGEPADIDTKDPQVLIQDTHKAVEELKSKGIYSYCITLD
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEC
PNADEYVETIFDNHYTVIDHVDKLPEKLPQVFMKITQ
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA