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The map label for this gene is can [H]

Identifier: 78484766

GI number: 78484766

Start: 471114

End: 471770

Strand: Reverse

Name: can [H]

Synonym: Tcr_0421

Alternate gene names: 78484766

Gene position: 471770-471114 (Counterclockwise)

Preceding gene: 78484767

Following gene: 78484764

Centisome position: 19.43

GC content: 42.62

Gene sequence:

>657_bases
ATGTGCCATCAATGTGACTGCGATACATCAATCGAGCAGCTGTTACAAAACAACCGTGATTGGGTGGATGAAATCAACGC
CATTCGTCCCGACTTTTTTGAAACCTTATCCCACCAACAAAAACCCGAATATCTCTGGATAGGTTGCTCCGATAGCCGAG
TTCCTGCAAACGAACTGGTTAAGATGGATCCAGGAACCATTTTTGTGCACCGAAACATCGCGAACCTAGTCAACTCAAGT
GACATGAATGTCCTTTCTGTTATTCAATACGCGGTGGAAATTCTAAAGGTCAAACACATCATCATTAATGGACATTACGG
CTGTGGTGGCGTTATCGCATCAATGGAAGAACACAATCCCAGTTTGATCGATCACTGGGTGCGCCCCATCCGTAAGTATT
ATCAACGCAAACAAACAGAACTGGATGCTCTTCCTTATGAAGAAAGAGTGAATCGGTTATGTGAAATCAACGTGGTGGAG
CAAGTTCGCAACATTTGTCATGTACCGGCGGTCAAAAATGCATGGAAAAAAGGACAACATCTAGCCATTCACGGCTTTAT
TTACAATATTAAAGATGGCCGTTTGAAAAATTTGAATGTCAGCATTGACGATATTGAATCGGCTGAAAAAGCGGTCTTAA
GAGCAACTGATAGCTAA

Upstream 100 bases:

>100_bases
AACGTGTATAATTTCCATTTTGAAGAAGCTTTAAAGTAAATGCCCTTACAATTTAAGGGCATTTTTGTATCCCCCAACAA
CTTCTCCAAAAGGATTCTTA

Downstream 100 bases:

>100_bases
AACTTAACTGTCTTTTCCAGCCAGAAAAGCTTGCATTAATGCTTGGTGCATCTTAGAGTTTTCTTCCAAAGAAGCGCCAA
GAATATTTTCTGAAACCTGA

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MCHQCDCDTSIEQLLQNNRDWVDEINAIRPDFFETLSHQQKPEYLWIGCSDSRVPANELVKMDPGTIFVHRNIANLVNSS
DMNVLSVIQYAVEILKVKHIIINGHYGCGGVIASMEEHNPSLIDHWVRPIRKYYQRKQTELDALPYEERVNRLCEINVVE
QVRNICHVPAVKNAWKKGQHLAIHGFIYNIKDGRLKNLNVSIDDIESAEKAVLRATDS

Sequences:

>Translated_218_residues
MCHQCDCDTSIEQLLQNNRDWVDEINAIRPDFFETLSHQQKPEYLWIGCSDSRVPANELVKMDPGTIFVHRNIANLVNSS
DMNVLSVIQYAVEILKVKHIIINGHYGCGGVIASMEEHNPSLIDHWVRPIRKYYQRKQTELDALPYEERVNRLCEINVVE
QVRNICHVPAVKNAWKKGQHLAIHGFIYNIKDGRLKNLNVSIDDIESAEKAVLRATDS
>Mature_218_residues
MCHQCDCDTSIEQLLQNNRDWVDEINAIRPDFFETLSHQQKPEYLWIGCSDSRVPANELVKMDPGTIFVHRNIANLVNSS
DMNVLSVIQYAVEILKVKHIIINGHYGCGGVIASMEEHNPSLIDHWVRPIRKYYQRKQTELDALPYEERVNRLCEINVVE
QVRNICHVPAVKNAWKKGQHLAIHGFIYNIKDGRLKNLNVSIDDIESAEKAVLRATDS

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=200, Percent_Identity=49, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1786534, Length=181, Percent_Identity=32.5966850828729, Blast_Score=95, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324292, Length=202, Percent_Identity=29.2079207920792, Blast_Score=101, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25058; Mature: 25058

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCHQCDCDTSIEQLLQNNRDWVDEINAIRPDFFETLSHQQKPEYLWIGCSDSRVPANELV
CCCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHE
KMDPGTIFVHRNIANLVNSSDMNVLSVIQYAVEILKVKHIIINGHYGCGGVIASMEEHNP
EECCCEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCH
SLIDHWVRPIRKYYQRKQTELDALPYEERVNRLCEINVVEQVRNICHVPAVKNAWKKGQH
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCE
LAIHGFIYNIKDGRLKNLNVSIDDIESAEKAVLRATDS
EEEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCHQCDCDTSIEQLLQNNRDWVDEINAIRPDFFETLSHQQKPEYLWIGCSDSRVPANELV
CCCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHE
KMDPGTIFVHRNIANLVNSSDMNVLSVIQYAVEILKVKHIIINGHYGCGGVIASMEEHNP
EECCCEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCH
SLIDHWVRPIRKYYQRKQTELDALPYEERVNRLCEINVVEQVRNICHVPAVKNAWKKGQH
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCE
LAIHGFIYNIKDGRLKNLNVSIDDIESAEKAVLRATDS
EEEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]