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The map label for this gene is ubiE

Identifier: 78484747

GI number: 78484747

Start: 453597

End: 454361

Strand: Reverse

Name: ubiE

Synonym: Tcr_0402

Alternate gene names: 78484747

Gene position: 454361-453597 (Counterclockwise)

Preceding gene: 78484748

Following gene: 78484746

Centisome position: 18.72

GC content: 46.93

Gene sequence:

>765_bases
ATGACAACAGAGCATTCACAATCCAAAAAAACCATTGATTTTGGCTTTAGCGAAGTGCCGCTAGAAGAGAAAGTTAAAAA
AGTTAAAGGCGTGTTTGATTCGGTGGCCGGCAATTACGACATTATGAACGATGTAATGTCATTCGGCATTCATCGTCTAT
GGAAACGCCATGCGATTGAACTCAGCGGCATTCGTCCGGGCAACGTTGTGTTGGATTTAGCCGGTGGAACGGGCGATTTA
ACCAAAGCCTTTGCCAAACGCGTCGGTAAAACCGGGCGCGTGGTGTTGGCCGACATTAATGAAAGCATGGTGCGTGTCGG
GCGTGATCGCCTCACCAATGAAGGCATCATCGGCAATGTGGATTACACCATCACCAATGCCGAAGCACTGACCTATCCGG
ACAACACTTTTGATTTGGTCACCATCTCATTCGGGCTACGCAACGTCACCAATAAAGACAAGGCGCTTGAAGAAATCTAC
CGTGTCTTAAAACCGGGTGGGCAACTTATGGTGCTGGAATTTTCCAAAGTGACTCAACCCCTGCTGGCAAAAGCATACGA
TTTTTACTCCTTCAATATCTTGCCAAAAATGGGCAAACTCATTGCCGATGATGAAGCCAGCTATCAATACTTGGCCGAAT
CGATCCGCATGCACCCCGATCAGGAAACCCTCAAAAAAATGATGCTGGAGGCCGGTTTTGATAAAGCCGAATACCTCAAT
ATGTCTGAAGGCATTGTGGCATTGCATCGTGGTTGGAAATACTAA

Upstream 100 bases:

>100_bases
GCCGGGCACAAACACCCGGATATTGAACCAACCGACTTAACCCAATTACTGTAATTTCGCTTGTGCATTGAGTGAACCCA
TTTCAACTAGGACGCCTTTT

Downstream 100 bases:

>100_bases
AAGGAATCGGAATGGACACGTCAGAAAATTCACCAGGCCTGGTCAAAACATCGTTATCCAAGTTCTTTGAAACACTGCTT
AATCAAGCGATTCAACTGGA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTTEHSQSKKTIDFGFSEVPLEEKVKKVKGVFDSVAGNYDIMNDVMSFGIHRLWKRHAIELSGIRPGNVVLDLAGGTGDL
TKAFAKRVGKTGRVVLADINESMVRVGRDRLTNEGIIGNVDYTITNAEALTYPDNTFDLVTISFGLRNVTNKDKALEEIY
RVLKPGGQLMVLEFSKVTQPLLAKAYDFYSFNILPKMGKLIADDEASYQYLAESIRMHPDQETLKKMMLEAGFDKAEYLN
MSEGIVALHRGWKY

Sequences:

>Translated_254_residues
MTTEHSQSKKTIDFGFSEVPLEEKVKKVKGVFDSVAGNYDIMNDVMSFGIHRLWKRHAIELSGIRPGNVVLDLAGGTGDL
TKAFAKRVGKTGRVVLADINESMVRVGRDRLTNEGIIGNVDYTITNAEALTYPDNTFDLVTISFGLRNVTNKDKALEEIY
RVLKPGGQLMVLEFSKVTQPLLAKAYDFYSFNILPKMGKLIADDEASYQYLAESIRMHPDQETLKKMMLEAGFDKAEYLN
MSEGIVALHRGWKY
>Mature_253_residues
TTEHSQSKKTIDFGFSEVPLEEKVKKVKGVFDSVAGNYDIMNDVMSFGIHRLWKRHAIELSGIRPGNVVLDLAGGTGDLT
KAFAKRVGKTGRVVLADINESMVRVGRDRLTNEGIIGNVDYTITNAEALTYPDNTFDLVTISFGLRNVTNKDKALEEIYR
VLKPGGQLMVLEFSKVTQPLLAKAYDFYSFNILPKMGKLIADDEASYQYLAESIRMHPDQETLKKMMLEAGFDKAEYLNM
SEGIVALHRGWKY

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=283, Percent_Identity=42.4028268551237, Blast_Score=228, Evalue=4e-60,
Organism=Escherichia coli, GI48994983, Length=248, Percent_Identity=64.1129032258064, Blast_Score=343, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI17557039, Length=256, Percent_Identity=44.53125, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=260, Percent_Identity=43.0769230769231, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641702, Length=261, Percent_Identity=43.6781609195402, Blast_Score=227, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_THICR (Q31IM5)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390672.1
- ProteinModelPortal:   Q31IM5
- STRING:   Q31IM5
- GeneID:   3761183
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0402
- NMPDR:   fig|317025.3.peg.12
- eggNOG:   COG2226
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- PhylomeDB:   Q31IM5
- BioCyc:   TCRU317025:TCR_0402-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 28497; Mature: 28366

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEHSQSKKTIDFGFSEVPLEEKVKKVKGVFDSVAGNYDIMNDVMSFGIHRLWKRHAIE
CCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEE
LSGIRPGNVVLDLAGGTGDLTKAFAKRVGKTGRVVLADINESMVRVGRDRLTNEGIIGNV
ECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEECC
DYTITNAEALTYPDNTFDLVTISFGLRNVTNKDKALEEIYRVLKPGGQLMVLEFSKVTQP
EEEEECCEEEECCCCCEEEEEEEECHHCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHH
LLAKAYDFYSFNILPKMGKLIADDEASYQYLAESIRMHPDQETLKKMMLEAGFDKAEYLN
HHHHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCC
MSEGIVALHRGWKY
CCCCHHEECCCCCC
>Mature Secondary Structure 
TTEHSQSKKTIDFGFSEVPLEEKVKKVKGVFDSVAGNYDIMNDVMSFGIHRLWKRHAIE
CCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCEE
LSGIRPGNVVLDLAGGTGDLTKAFAKRVGKTGRVVLADINESMVRVGRDRLTNEGIIGNV
ECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEECC
DYTITNAEALTYPDNTFDLVTISFGLRNVTNKDKALEEIYRVLKPGGQLMVLEFSKVTQP
EEEEECCEEEECCCCCEEEEEEEECHHCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHH
LLAKAYDFYSFNILPKMGKLIADDEASYQYLAESIRMHPDQETLKKMMLEAGFDKAEYLN
HHHHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHCC
MSEGIVALHRGWKY
CCCCHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA