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The map label for this gene is csrD [H]

Identifier: 78484553

GI number: 78484553

Start: 246535

End: 248472

Strand: Reverse

Name: csrD [H]

Synonym: Tcr_0208

Alternate gene names: 78484553

Gene position: 248472-246535 (Counterclockwise)

Preceding gene: 78484554

Following gene: 78484552

Centisome position: 10.23

GC content: 42.98

Gene sequence:

>1938_bases
ATGAGCTTGAGTAAACAAATGATGCTTTTTATCACGGCAATGCTAATTATTTTGCTACTGGGAACCTTTTTACTCAATTT
AAACAATACCCGCTCCTTTTTAGAAACTCAGCTACAGTCTCATGCCCAAGATACGGCCACCTCTTTGGGGTTATCTCTAA
GCTCTGTTGCCAACCAGGAAGATTCTTCCAGCATGGAAACCATGATTAACGCGGTGTTTGACCGTGGTTATTACTCGCAC
ATCACCATGCGAGATATGGATGGCGAACTGATTTATGAAAAAAGCAATGCACAGAAAATAAACGGCATACCGAATTGGTT
CATTGGTCTGATTTCAATTGAAGCGCCCGATGCTGAAGCTTTAGTTCAATCTGGCTGGGTTCCGATGGGGCATCTGATTG
TGCAAAGTCACCCAGGCTATGCTTATATTGAGCTGTGGAAAACGGCCATTGCATTATTGCTCTGGTTTTTATTGGCCGCC
GCGATTGCCATCGGGTTTGCCGCCTACGCCTTGCGCGTCATGCTGGCCCCTCTAAAAGAAATGGAAAAACAAGCCGAAGC
GATTGTGCGCAAAGAATATCTTTTACAAGATTCGTTACCTGGCACCATTGAATTCAAACGTGTGGTCTCGGCCATGAATG
CGATGGTGCATAAAATGAAAACCGTTTTTGACCGAGACGCACAACATGCCGACAAACTACAAAAACTGGCCTATCAGGAC
AGTGTCACCGGGTTAAGTAACCGTCGACACTTTGAAATGAACATCGATGCCTTGCTGGACAAACAAGCCGAAGCCTCGCC
AGGTGCTATCTGTCTTGTCCGCATTCATCATTTAAAAGAATTAAATGATCAGTTCGGCTATATGACAGGGGACAATCTAG
TCAAAGCGTTAGCCGATAAAATGACGCATAATTTGAACTTTGAAAACAGCTTTTATGCCCGTCTGAACGGCTCGGAATTG
CTGACAATTATGCCGACCATCTCTGGTAAAAAATTATCCAAACCTGTTTCGGAAATATGCAAAGCCGTGCCGAAAGTTTT
AAAACACTTAAAAGCCTCCGAATCAAAAATCAGTATATCTGTCGCTTACCTTGACTATTTGCCAGGAAATGATCGCAGCC
AATTATTGGCGCAATTGGACTTTGCCACCAAGGAGGCCAGTCAACTGGGACAAAATGAATTCTTCTATTACCAGCCTGAA
AAAGCTCATGCTGAAGAGGATACTCGCTGGAAAAGCATGCTCAACAACGCCATCGAAGACAAGCGGTTTATTTTATTCCA
GCAAGCGGCTTATGATGAAAATCGAAAAATTCATAACCGAGAAGCCTTGCTGCGGTTAAAAGATGAAAACAACGCCATTC
ATTCTGCCAGCTTTTTTATTCCCGCCATCCGAAAACTGAACAAAATGGATGAAATTGATAAACTCGCTGTCTCTTTGGCT
GTGACCTACCTGTCAAACCATCGTTTATTCCATGGAGAACGGCTTGCCATTAACCTTGGGCAATGCGTTATTCGTGATCA
AACATTACAGGACTGGTTATTCCAACAACTTGAAACGGTGGACACGAATCAGATTGCCATCGAAATTCCTGAAGCCATTA
TCCACGCCAACCGAAACGAAGCCCGCCCCCTGATCGAAAAAATTAAAAACGCAGGCATTCACTTTGGGTTAGATAATTTT
GGTAATCGTTTTACCAACATGAATTACATTCAAGAATTCCGTCCGGACTATATCAAGCTGGACACATCGTTCTCAAAGGC
CATTGAAGAAGATGATCAGACCCGATATTACGTTTCCAGCGTGTGCGATATGTCAGAAAGTTTGGACATTCAAATCATTG
CCATGTCGATTGAAACTGAAACACAATTGCAAGCATTTAAAGAATTAGGCATTCATCATTTTCAAGGGTATTATTTCGGA
GCGCCAAAACCCTTATAA

Upstream 100 bases:

>100_bases
AAGTTAGAAAATTGGAATCGATTACTCAAAAGGATGCAGCAATGAAACAATATCAACAGGCTGCCTTTGACCACATTACT
CTACTAAAAGGAAGCAACTC

Downstream 100 bases:

>100_bases
AAAATAGGTGTAAGAAAAATATACTCTAACTAAAAACGTAAAATTATTTTATACTCAACGTCTTAAAAAGACTGGATAGG
AAACCGCTAAGCTTATGGAA

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MSLSKQMMLFITAMLIILLLGTFLLNLNNTRSFLETQLQSHAQDTATSLGLSLSSVANQEDSSSMETMINAVFDRGYYSH
ITMRDMDGELIYEKSNAQKINGIPNWFIGLISIEAPDAEALVQSGWVPMGHLIVQSHPGYAYIELWKTAIALLLWFLLAA
AIAIGFAAYALRVMLAPLKEMEKQAEAIVRKEYLLQDSLPGTIEFKRVVSAMNAMVHKMKTVFDRDAQHADKLQKLAYQD
SVTGLSNRRHFEMNIDALLDKQAEASPGAICLVRIHHLKELNDQFGYMTGDNLVKALADKMTHNLNFENSFYARLNGSEL
LTIMPTISGKKLSKPVSEICKAVPKVLKHLKASESKISISVAYLDYLPGNDRSQLLAQLDFATKEASQLGQNEFFYYQPE
KAHAEEDTRWKSMLNNAIEDKRFILFQQAAYDENRKIHNREALLRLKDENNAIHSASFFIPAIRKLNKMDEIDKLAVSLA
VTYLSNHRLFHGERLAINLGQCVIRDQTLQDWLFQQLETVDTNQIAIEIPEAIIHANRNEARPLIEKIKNAGIHFGLDNF
GNRFTNMNYIQEFRPDYIKLDTSFSKAIEEDDQTRYYVSSVCDMSESLDIQIIAMSIETETQLQAFKELGIHHFQGYYFG
APKPL

Sequences:

>Translated_645_residues
MSLSKQMMLFITAMLIILLLGTFLLNLNNTRSFLETQLQSHAQDTATSLGLSLSSVANQEDSSSMETMINAVFDRGYYSH
ITMRDMDGELIYEKSNAQKINGIPNWFIGLISIEAPDAEALVQSGWVPMGHLIVQSHPGYAYIELWKTAIALLLWFLLAA
AIAIGFAAYALRVMLAPLKEMEKQAEAIVRKEYLLQDSLPGTIEFKRVVSAMNAMVHKMKTVFDRDAQHADKLQKLAYQD
SVTGLSNRRHFEMNIDALLDKQAEASPGAICLVRIHHLKELNDQFGYMTGDNLVKALADKMTHNLNFENSFYARLNGSEL
LTIMPTISGKKLSKPVSEICKAVPKVLKHLKASESKISISVAYLDYLPGNDRSQLLAQLDFATKEASQLGQNEFFYYQPE
KAHAEEDTRWKSMLNNAIEDKRFILFQQAAYDENRKIHNREALLRLKDENNAIHSASFFIPAIRKLNKMDEIDKLAVSLA
VTYLSNHRLFHGERLAINLGQCVIRDQTLQDWLFQQLETVDTNQIAIEIPEAIIHANRNEARPLIEKIKNAGIHFGLDNF
GNRFTNMNYIQEFRPDYIKLDTSFSKAIEEDDQTRYYVSSVCDMSESLDIQIIAMSIETETQLQAFKELGIHHFQGYYFG
APKPL
>Mature_644_residues
SLSKQMMLFITAMLIILLLGTFLLNLNNTRSFLETQLQSHAQDTATSLGLSLSSVANQEDSSSMETMINAVFDRGYYSHI
TMRDMDGELIYEKSNAQKINGIPNWFIGLISIEAPDAEALVQSGWVPMGHLIVQSHPGYAYIELWKTAIALLLWFLLAAA
IAIGFAAYALRVMLAPLKEMEKQAEAIVRKEYLLQDSLPGTIEFKRVVSAMNAMVHKMKTVFDRDAQHADKLQKLAYQDS
VTGLSNRRHFEMNIDALLDKQAEASPGAICLVRIHHLKELNDQFGYMTGDNLVKALADKMTHNLNFENSFYARLNGSELL
TIMPTISGKKLSKPVSEICKAVPKVLKHLKASESKISISVAYLDYLPGNDRSQLLAQLDFATKEASQLGQNEFFYYQPEK
AHAEEDTRWKSMLNNAIEDKRFILFQQAAYDENRKIHNREALLRLKDENNAIHSASFFIPAIRKLNKMDEIDKLAVSLAV
TYLSNHRLFHGERLAINLGQCVIRDQTLQDWLFQQLETVDTNQIAIEIPEAIIHANRNEARPLIEKIKNAGIHFGLDNFG
NRFTNMNYIQEFRPDYIKLDTSFSKAIEEDDQTRYYVSSVCDMSESLDIQIIAMSIETETQLQAFKELGIHHFQGYYFGA
PKPL

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=530, Percent_Identity=23.2075471698113, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081921, Length=428, Percent_Identity=21.9626168224299, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1787541, Length=426, Percent_Identity=23.7089201877934, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788849, Length=447, Percent_Identity=23.7136465324385, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082096, Length=447, Percent_Identity=21.4765100671141, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790496, Length=240, Percent_Identity=25.8333333333333, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081743, Length=235, Percent_Identity=25.531914893617, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786507, Length=105, Percent_Identity=30.4761904761905, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081980, Length=245, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788502, Length=122, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI226510982, Length=284, Percent_Identity=21.1267605633803, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI87081845, Length=247, Percent_Identity=24.6963562753036, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788956, Length=365, Percent_Identity=22.1917808219178, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 73241; Mature: 73110

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSKQMMLFITAMLIILLLGTFLLNLNNTRSFLETQLQSHAQDTATSLGLSLSSVANQE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
DSSSMETMINAVFDRGYYSHITMRDMDGELIYEKSNAQKINGIPNWFIGLISIEAPDAEA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCHHH
LVQSGWVPMGHLIVQSHPGYAYIELWKTAIALLLWFLLAAAIAIGFAAYALRVMLAPLKE
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEKQAEAIVRKEYLLQDSLPGTIEFKRVVSAMNAMVHKMKTVFDRDAQHADKLQKLAYQD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SVTGLSNRRHFEMNIDALLDKQAEASPGAICLVRIHHLKELNDQFGYMTGDNLVKALADK
HHCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
MTHNLNFENSFYARLNGSELLTIMPTISGKKLSKPVSEICKAVPKVLKHLKASESKISIS
HHHCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VAYLDYLPGNDRSQLLAQLDFATKEASQLGQNEFFYYQPEKAHAEEDTRWKSMLNNAIED
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHCCCHHHHHHHHHHHHHCC
KRFILFQQAAYDENRKIHNREALLRLKDENNAIHSASFFIPAIRKLNKMDEIDKLAVSLA
CCEEEEEHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTYLSNHRLFHGERLAINLGQCVIRDQTLQDWLFQQLETVDTNQIAIEIPEAIIHANRNE
HHHHHCCCEECCCEEEEECCHHHHCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCC
ARPLIEKIKNAGIHFGLDNFGNRFTNMNYIQEFRPDYIKLDTSFSKAIEEDDQTRYYVSS
HHHHHHHHHHCCCEECHHHHCCHHCCCHHHHHCCCCEEEECCHHHHHHCCCCCHHHHHHH
VCDMSESLDIQIIAMSIETETQLQAFKELGIHHFQGYYFGAPKPL
HHCCCCCCCEEEEEEEECCHHHHHHHHHHCHHHHCCEECCCCCCC
>Mature Secondary Structure 
SLSKQMMLFITAMLIILLLGTFLLNLNNTRSFLETQLQSHAQDTATSLGLSLSSVANQE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
DSSSMETMINAVFDRGYYSHITMRDMDGELIYEKSNAQKINGIPNWFIGLISIEAPDAEA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCHHH
LVQSGWVPMGHLIVQSHPGYAYIELWKTAIALLLWFLLAAAIAIGFAAYALRVMLAPLKE
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEKQAEAIVRKEYLLQDSLPGTIEFKRVVSAMNAMVHKMKTVFDRDAQHADKLQKLAYQD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SVTGLSNRRHFEMNIDALLDKQAEASPGAICLVRIHHLKELNDQFGYMTGDNLVKALADK
HHCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHH
MTHNLNFENSFYARLNGSELLTIMPTISGKKLSKPVSEICKAVPKVLKHLKASESKISIS
HHHCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VAYLDYLPGNDRSQLLAQLDFATKEASQLGQNEFFYYQPEKAHAEEDTRWKSMLNNAIED
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHCCCHHHHHHHHHHHHHCC
KRFILFQQAAYDENRKIHNREALLRLKDENNAIHSASFFIPAIRKLNKMDEIDKLAVSLA
CCEEEEEHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTYLSNHRLFHGERLAINLGQCVIRDQTLQDWLFQQLETVDTNQIAIEIPEAIIHANRNE
HHHHHCCCEECCCEEEEECCHHHHCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCC
ARPLIEKIKNAGIHFGLDNFGNRFTNMNYIQEFRPDYIKLDTSFSKAIEEDDQTRYYVSS
HHHHHHHHHHCCCEECHHHHCCHHCCCHHHHHCCCCEEEECCHHHHHHCCCCCHHHHHHH
VCDMSESLDIQIIAMSIETETQLQAFKELGIHHFQGYYFGAPKPL
HHCCCCCCCEEEEEEEECCHHHHHHHHHHCHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]