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The map label for this gene is metH [H]

Identifier: 78484517

GI number: 78484517

Start: 203000

End: 206719

Strand: Reverse

Name: metH [H]

Synonym: Tcr_0172

Alternate gene names: 78484517

Gene position: 206719-203000 (Counterclockwise)

Preceding gene: 78484521

Following gene: 78484516

Centisome position: 8.51

GC content: 47.85

Gene sequence:

>3720_bases
ATGTCCGAATTTGAAAATCGTCCAACAAGAATTGCTCAATTAAGAAGCTTACTGAATCAGCGCATCGTGGTGCTGGATGG
CGCAATGGGAACAATGGTACAAGACCTAGCCCTCAGTGAAGAGGATTTCCGAGGAGATCGATTCACCGACTACCACATGG
ATATCAAAGGCAATAATGATATCTTGGTCATGACACAACCGGCAATGATTCGAGACATTCACTTGGCTTTTTTACGCCAA
GGGGCGGACATCATTGAAACCAATTCATTCAATGCCACCACCATCGCTCAAGCGGACTATGACATGCAAGACACTGTCAC
CGAGCTTAACATCGCGGCAGCAACCGTGGCACGCGAAGCGTGTCAAATCGCCGAAAAAGAAGATGGTAAGCCTCGCTTTG
TGGCCGGCGTGCTTGGGCCAACCAACCGAACTGCGTCGATTTCGCCAGATGTGAATGACCCCGGCAAACGAAATACCCAC
TTCGATGAGCTGGTCACCGCTTACAAGCAAGCCACTCACGCCTTATTAAAAGGTGGCGCAGACGTCATTCTGATTGAAAC
CATTTTCGACACGCTGAATGCCAAAGCCGCTATTTTTGCAGTGAAAGACGTGGAAGAAGAAATTGGCTATGAAGTACCGA
TTATGCTGTCGGGCACCATCACTGATGCGTCTGGACGCACCTTATCCGGGCAAACCACCGAAGCCTTTTATAACGCGGTT
GCCCATGCACAACCCTTATCCATCGGCTTAAACTGTGCCTTGGGGCCGGAAGAACTGCGCCAATATGTTGAAGAACTCAG
CCGCGTGTGTGAGACCTATGTCTCCGTGCACCCTAATGCTGGGTTGCCGAATGAGTTTGGAGAGTATGATGAAACCCCGG
AGCAAATGGCACATGAAATCGCCATTTGGGCCGAAAAAGGTTGGTTAAACATTATTGGCGGCTGTTGTGGCACCACCCCA
GACCATGTCGAAGCCATGGCAAATGCCGCATTGGCGCACCCGGCTCGCACTTTGCCTGAAATCGCCCCTGCGTGCCGTTT
ATCCGGTTTAGAACCGCTGAACATTGATGACAACAGTTTGTTTGTCAATATTGGTGAGCGTAACAATGTCACCGGTTCGG
CGAAGTTCAAACGTCTTATTATTGAAGAAAACTACAACGAAGCCATTGATATTGCCGTGAAGCAAGTGGAAGACGGCGCT
CAAATCATCGATGTCAATATGGATGAAGGAATGCTGGACGCAAAGGCCTGTATGGTGAAGTTTTTGAACCTATTGGCTTC
CGAACCCGAAGCCTCTCGTGTTCCGATTATGATCGACTCATCTAAATGGGAAGTGATTGAAGCCGGTTTAAAATGCATCC
AGGGTAAAGGCGTGGTGAATTCCATCTCCTTGAAAGAAGGGGAAGATGCCTTTATCCAGCAGGCCAGACTGGTCAAAAAA
TATGGTGCCGCGGCCATTGTGATGGCTTTTGATGAAGACGGACAAGCCGACACTCTGGAACGAAAAATTGAAATTTGTGA
ACGTTCTTACAATGTTCTGACGCAAAAAGTGGGCTTTTTACCCCAAGACATCATTTTTGACCCTAACATCTTCGCCGTGG
CCACCGGGATTGAAGAGCATAATAACTATGGTCTAGACTTTATCAATGCGGTCACTTGGATCAAACAAAACCTGCCTTAT
GCCAAAATTTCCGGCGGGGTATCCAACGTCTCTTTCTCTTTCCGAGGAAACAACCCGGTCCGTGAAGCCATTCACTCCGT
CTTTTTATACTATGCCATCAAAGAAGGCATGGATATGGGGATCGTGAATGCCGGCCAAATGGCTATTTATGACGACCTTC
CAGAAAAACTGCGTGTGGCGGTTGAAGATGTCATCCTCAATAAAGATCCAGAAGCAGGCGAACGCTTATTGGAAGTGGCC
GAAGAATATCGCGGCGACGGACAAGCCACGTCGAAAGTAACCGATACCGCCTGGCGTGAAACAACCGTTGAAAAACGATT
GGAACATTCTTTGGTAAAAGGCATCACCGATTACATTGAGGCGGATACCGAAGAAGCCTATCAAAAGCTAGGCGCACCGA
TTAATGTCATTGAAGGGCCGTTAATGGATGGCATGAATGTCGTCGGAGATTTGTTCGGTTCTGGGAAAATGTTTCTTCCT
CAAGTGGTGAAATCGGCTCGCGTCATGAAACGCGCGGTGGCGTATCTTGATCCTTATCTGGAAGCGGAAAAATCCGAAGG
ACAGGTGCAAGGTAAAATTGTCATGGCGACCGTTAAGGGAGATGTACACGATATCGGTAAAAACATTGTCGGCGTCGTTC
TGCAATGTAATAACTTCGAAGTCATCGACTTGGGGGTCATGGTGCCTGCTGAAAAAATCCTCGATACCGCCATTGAACAA
AATGCCAATGTCATCGGGCTATCAGGCCTCATCACCCCGTCTCTTGAAGAGATGGTCAATGTCGCGAAACTGATGAAAGA
ACGCGGCATGAATCTTCCTTTATTAATTGGGGGGGCCACCACGTCCAAGGCGCATACAGCCGTTAAGATCGAACCGCAAT
ACGATCATCCAGTGGTCTATGTAAAAGACGCATCACGTGCGGTTGGGGTAGCACAAAGCTTAATATCAAACGATTTGAAA
GAGACGTTTGCCGCTAAAATCAAAGCTGAGTACGAACAAGTTCGAGAAGAACGTAAGGCTCGCGCCAAACAGGTCAAGCG
TATCCCGATTAAACAAGCTCGATTGAATCCGGCGTTGGATGACCAGGCCTGGGAGAATTACACACCGGTTAAGCCAAGCT
TCCTCGGCACCAAAGTGCTTGAAAGCTTTCCATTGGAAAAACTGCTTGAACGCTTTGACTGGTCACCGTTCTTCCAATCC
TGGGAACTGCATGGCCTTTATCCGAGAATCTTAGACGATAAAGTGGTGGGGGACGAAGCACGCAAAGTCTTTGCGGATGC
CCAAGCATTGCTGAAAACCATTATCGATCAAAAATGGCTGACCGCAAAAGCCGTGTATGGATTCTACCCGGCCAATCGCG
TTGGGGATGACATAGAAGTCTACACGGATGAAAGCCGAACAGAAGTCCTTCATACCTTCCATCATTTGCGCCAACAAGCC
GAGAAAAAGCGTGGCGGTGCCAACAACTGTCTTTCCGACTTTATCGCTCCGAAAGAAAGTGGCGTCGCTGACTACATTGG
ATTCTTTGCGGTCACGGCGGGCATTGGTATTGAAGAGCATATCGCACGCTTTGAGAAAGAACATGATGACTATCATTCCA
TTATGTTAAAAGCACTCGCGGATCGATTTGCTGAAGCTTTTGCCGAAACATTGCATGAAATCGTTCGTAAAGAAGATTGG
GGTTATGCACCCAATGAACAGCTTGAGAACGAAGACATCATTCGTGAACGCTATCAAGGTATTCGTCCAGCCCCCGGTTA
CCCTGCCTGCCCGGATCATACCGAAAAAGGTATTCTCTGGGATTTAATAAAACCGGATGAGAAAATAGGTTTGGAAATTA
CCGAAAGTTTTGCCATGACCCCTACGGCCGCTGTTTCAGGAACCTATTTCGCCCATCCAAAATCCCGTTATTTTGGAGTC
GGTTCAATTGGTCGAGATCAAGTTGAGGACTACGCGATTCGAAAAGGATGGTCAATTGAAGAAACCGAAAAATGGTTGGC
ACCGAATTTAGGGTACGACCCTGAAGATTTTGCTAACTGA

Upstream 100 bases:

>100_bases
AACCATACTAAAGCAATGACTTTAAGGCATCGACTCCTTATGATGCCATCGTTTCAATTATGTTAAAATATCGCTTTTTC
ATTGCCTTAGAAGAAGTGTT

Downstream 100 bases:

>100_bases
TTTCAAAGTTATGAACGGAAACCGGGCATGGAAACGATTTGTTTTGAAGCGAGAGCTAGAACGTCAACATAAAACATGAC
CAACCCGGCTTTTCCTTTTG

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS [H]

Number of amino acids: Translated: 1239; Mature: 1238

Protein sequence:

>1239_residues
MSEFENRPTRIAQLRSLLNQRIVVLDGAMGTMVQDLALSEEDFRGDRFTDYHMDIKGNNDILVMTQPAMIRDIHLAFLRQ
GADIIETNSFNATTIAQADYDMQDTVTELNIAAATVAREACQIAEKEDGKPRFVAGVLGPTNRTASISPDVNDPGKRNTH
FDELVTAYKQATHALLKGGADVILIETIFDTLNAKAAIFAVKDVEEEIGYEVPIMLSGTITDASGRTLSGQTTEAFYNAV
AHAQPLSIGLNCALGPEELRQYVEELSRVCETYVSVHPNAGLPNEFGEYDETPEQMAHEIAIWAEKGWLNIIGGCCGTTP
DHVEAMANAALAHPARTLPEIAPACRLSGLEPLNIDDNSLFVNIGERNNVTGSAKFKRLIIEENYNEAIDIAVKQVEDGA
QIIDVNMDEGMLDAKACMVKFLNLLASEPEASRVPIMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEDAFIQQARLVKK
YGAAAIVMAFDEDGQADTLERKIEICERSYNVLTQKVGFLPQDIIFDPNIFAVATGIEEHNNYGLDFINAVTWIKQNLPY
AKISGGVSNVSFSFRGNNPVREAIHSVFLYYAIKEGMDMGIVNAGQMAIYDDLPEKLRVAVEDVILNKDPEAGERLLEVA
EEYRGDGQATSKVTDTAWRETTVEKRLEHSLVKGITDYIEADTEEAYQKLGAPINVIEGPLMDGMNVVGDLFGSGKMFLP
QVVKSARVMKRAVAYLDPYLEAEKSEGQVQGKIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPAEKILDTAIEQ
NANVIGLSGLITPSLEEMVNVAKLMKERGMNLPLLIGGATTSKAHTAVKIEPQYDHPVVYVKDASRAVGVAQSLISNDLK
ETFAAKIKAEYEQVREERKARAKQVKRIPIKQARLNPALDDQAWENYTPVKPSFLGTKVLESFPLEKLLERFDWSPFFQS
WELHGLYPRILDDKVVGDEARKVFADAQALLKTIIDQKWLTAKAVYGFYPANRVGDDIEVYTDESRTEVLHTFHHLRQQA
EKKRGGANNCLSDFIAPKESGVADYIGFFAVTAGIGIEEHIARFEKEHDDYHSIMLKALADRFAEAFAETLHEIVRKEDW
GYAPNEQLENEDIIRERYQGIRPAPGYPACPDHTEKGILWDLIKPDEKIGLEITESFAMTPTAAVSGTYFAHPKSRYFGV
GSIGRDQVEDYAIRKGWSIEETEKWLAPNLGYDPEDFAN

Sequences:

>Translated_1239_residues
MSEFENRPTRIAQLRSLLNQRIVVLDGAMGTMVQDLALSEEDFRGDRFTDYHMDIKGNNDILVMTQPAMIRDIHLAFLRQ
GADIIETNSFNATTIAQADYDMQDTVTELNIAAATVAREACQIAEKEDGKPRFVAGVLGPTNRTASISPDVNDPGKRNTH
FDELVTAYKQATHALLKGGADVILIETIFDTLNAKAAIFAVKDVEEEIGYEVPIMLSGTITDASGRTLSGQTTEAFYNAV
AHAQPLSIGLNCALGPEELRQYVEELSRVCETYVSVHPNAGLPNEFGEYDETPEQMAHEIAIWAEKGWLNIIGGCCGTTP
DHVEAMANAALAHPARTLPEIAPACRLSGLEPLNIDDNSLFVNIGERNNVTGSAKFKRLIIEENYNEAIDIAVKQVEDGA
QIIDVNMDEGMLDAKACMVKFLNLLASEPEASRVPIMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEDAFIQQARLVKK
YGAAAIVMAFDEDGQADTLERKIEICERSYNVLTQKVGFLPQDIIFDPNIFAVATGIEEHNNYGLDFINAVTWIKQNLPY
AKISGGVSNVSFSFRGNNPVREAIHSVFLYYAIKEGMDMGIVNAGQMAIYDDLPEKLRVAVEDVILNKDPEAGERLLEVA
EEYRGDGQATSKVTDTAWRETTVEKRLEHSLVKGITDYIEADTEEAYQKLGAPINVIEGPLMDGMNVVGDLFGSGKMFLP
QVVKSARVMKRAVAYLDPYLEAEKSEGQVQGKIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPAEKILDTAIEQ
NANVIGLSGLITPSLEEMVNVAKLMKERGMNLPLLIGGATTSKAHTAVKIEPQYDHPVVYVKDASRAVGVAQSLISNDLK
ETFAAKIKAEYEQVREERKARAKQVKRIPIKQARLNPALDDQAWENYTPVKPSFLGTKVLESFPLEKLLERFDWSPFFQS
WELHGLYPRILDDKVVGDEARKVFADAQALLKTIIDQKWLTAKAVYGFYPANRVGDDIEVYTDESRTEVLHTFHHLRQQA
EKKRGGANNCLSDFIAPKESGVADYIGFFAVTAGIGIEEHIARFEKEHDDYHSIMLKALADRFAEAFAETLHEIVRKEDW
GYAPNEQLENEDIIRERYQGIRPAPGYPACPDHTEKGILWDLIKPDEKIGLEITESFAMTPTAAVSGTYFAHPKSRYFGV
GSIGRDQVEDYAIRKGWSIEETEKWLAPNLGYDPEDFAN
>Mature_1238_residues
SEFENRPTRIAQLRSLLNQRIVVLDGAMGTMVQDLALSEEDFRGDRFTDYHMDIKGNNDILVMTQPAMIRDIHLAFLRQG
ADIIETNSFNATTIAQADYDMQDTVTELNIAAATVAREACQIAEKEDGKPRFVAGVLGPTNRTASISPDVNDPGKRNTHF
DELVTAYKQATHALLKGGADVILIETIFDTLNAKAAIFAVKDVEEEIGYEVPIMLSGTITDASGRTLSGQTTEAFYNAVA
HAQPLSIGLNCALGPEELRQYVEELSRVCETYVSVHPNAGLPNEFGEYDETPEQMAHEIAIWAEKGWLNIIGGCCGTTPD
HVEAMANAALAHPARTLPEIAPACRLSGLEPLNIDDNSLFVNIGERNNVTGSAKFKRLIIEENYNEAIDIAVKQVEDGAQ
IIDVNMDEGMLDAKACMVKFLNLLASEPEASRVPIMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEDAFIQQARLVKKY
GAAAIVMAFDEDGQADTLERKIEICERSYNVLTQKVGFLPQDIIFDPNIFAVATGIEEHNNYGLDFINAVTWIKQNLPYA
KISGGVSNVSFSFRGNNPVREAIHSVFLYYAIKEGMDMGIVNAGQMAIYDDLPEKLRVAVEDVILNKDPEAGERLLEVAE
EYRGDGQATSKVTDTAWRETTVEKRLEHSLVKGITDYIEADTEEAYQKLGAPINVIEGPLMDGMNVVGDLFGSGKMFLPQ
VVKSARVMKRAVAYLDPYLEAEKSEGQVQGKIVMATVKGDVHDIGKNIVGVVLQCNNFEVIDLGVMVPAEKILDTAIEQN
ANVIGLSGLITPSLEEMVNVAKLMKERGMNLPLLIGGATTSKAHTAVKIEPQYDHPVVYVKDASRAVGVAQSLISNDLKE
TFAAKIKAEYEQVREERKARAKQVKRIPIKQARLNPALDDQAWENYTPVKPSFLGTKVLESFPLEKLLERFDWSPFFQSW
ELHGLYPRILDDKVVGDEARKVFADAQALLKTIIDQKWLTAKAVYGFYPANRVGDDIEVYTDESRTEVLHTFHHLRQQAE
KKRGGANNCLSDFIAPKESGVADYIGFFAVTAGIGIEEHIARFEKEHDDYHSIMLKALADRFAEAFAETLHEIVRKEDWG
YAPNEQLENEDIIRERYQGIRPAPGYPACPDHTEKGILWDLIKPDEKIGLEITESFAMTPTAAVSGTYFAHPKSRYFGVG
SIGRDQVEDYAIRKGWSIEETEKWLAPNLGYDPEDFAN

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1248, Percent_Identity=54.7275641025641, Blast_Score=1356, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1234, Percent_Identity=65.2350081037277, Blast_Score=1641, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=325, Percent_Identity=25.2307692307692, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535405, Length=1251, Percent_Identity=53.876898481215, Blast_Score=1325, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 137262; Mature: 137131

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING ; PS00530 RNASE_T2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFENRPTRIAQLRSLLNQRIVVLDGAMGTMVQDLALSEEDFRGDRFTDYHMDIKGNND
CCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCHHCCCCCCEEEEEEEECCCC
ILVMTQPAMIRDIHLAFLRQGADIIETNSFNATTIAQADYDMQDTVTELNIAAATVAREA
EEEEECCHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
CQIAEKEDGKPRFVAGVLGPTNRTASISPDVNDPGKRNTHFDELVTAYKQATHALLKGGA
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DVILIETIFDTLNAKAAIFAVKDVEEEIGYEVPIMLSGTITDASGRTLSGQTTEAFYNAV
CEEEHHHHHHHHCCCEEEEEEHHHHHHCCCCCCEEEEEEEECCCCCEECCCHHHHHHHHH
AHAQPLSIGLNCALGPEELRQYVEELSRVCETYVSVHPNAGLPNEFGEYDETPEQMAHEI
HHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
AIWAEKGWLNIIGGCCGTTPDHVEAMANAALAHPARTLPEIAPACRLSGLEPLNIDDNSL
HEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEE
FVNIGERNNVTGSAKFKRLIIEENYNEAIDIAVKQVEDGAQIIDVNMDEGMLDAKACMVK
EEEECCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
FLNLLASEPEASRVPIMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEDAFIQQARLVKK
HHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHH
YGAAAIVMAFDEDGQADTLERKIEICERSYNVLTQKVGFLPQDIIFDPNIFAVATGIEEH
HCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCEEEEEECCHHC
NNYGLDFINAVTWIKQNLPYAKISGGVSNVSFSFRGNNPVREAIHSVFLYYAIKEGMDMG
CCCCHHHHHHHHHHHHCCCHHEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
IVNAGQMAIYDDLPEKLRVAVEDVILNKDPEAGERLLEVAEEYRGDGQATSKVTDTAWRE
EECCCCEEEHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TTVEKRLEHSLVKGITDYIEADTEEAYQKLGAPINVIEGPLMDGMNVVGDLFGSGKMFLP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHH
QVVKSARVMKRAVAYLDPYLEAEKSEGQVQGKIVMATVKGDVHDIGKNIVGVVLQCNNFE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHEEEEEECCCEE
VIDLGVMVPAEKILDTAIEQNANVIGLSGLITPSLEEMVNVAKLMKERGMNLPLLIGGAT
EEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCC
TSKAHTAVKIEPQYDHPVVYVKDASRAVGVAQSLISNDLKETFAAKIKAEYEQVREERKA
CCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKQVKRIPIKQARLNPALDDQAWENYTPVKPSFLGTKVLESFPLEKLLERFDWSPFFQS
HHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHC
WELHGLYPRILDDKVVGDEARKVFADAQALLKTIIDQKWLTAKAVYGFYPANRVGDDIEV
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
YTDESRTEVLHTFHHLRQQAEKKRGGANNCLSDFIAPKESGVADYIGFFAVTAGIGIEEH
EECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHH
IARFEKEHDDYHSIMLKALADRFAEAFAETLHEIVRKEDWGYAPNEQLENEDIIRERYQG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
IRPAPGYPACPDHTEKGILWDLIKPDEKIGLEITESFAMTPTAAVSGTYFAHPKSRYFGV
CCCCCCCCCCCCCCCCCCEEECCCCCHHCCCEEEHHHCCCCCHHHCCCEEECCCCCEEEC
GSIGRDQVEDYAIRKGWSIEETEKWLAPNLGYDPEDFAN
CCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCC
>Mature Secondary Structure 
SEFENRPTRIAQLRSLLNQRIVVLDGAMGTMVQDLALSEEDFRGDRFTDYHMDIKGNND
CCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCHHCCCCCCEEEEEEEECCCC
ILVMTQPAMIRDIHLAFLRQGADIIETNSFNATTIAQADYDMQDTVTELNIAAATVAREA
EEEEECCHHHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
CQIAEKEDGKPRFVAGVLGPTNRTASISPDVNDPGKRNTHFDELVTAYKQATHALLKGGA
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DVILIETIFDTLNAKAAIFAVKDVEEEIGYEVPIMLSGTITDASGRTLSGQTTEAFYNAV
CEEEHHHHHHHHCCCEEEEEEHHHHHHCCCCCCEEEEEEEECCCCCEECCCHHHHHHHHH
AHAQPLSIGLNCALGPEELRQYVEELSRVCETYVSVHPNAGLPNEFGEYDETPEQMAHEI
HHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
AIWAEKGWLNIIGGCCGTTPDHVEAMANAALAHPARTLPEIAPACRLSGLEPLNIDDNSL
HEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEE
FVNIGERNNVTGSAKFKRLIIEENYNEAIDIAVKQVEDGAQIIDVNMDEGMLDAKACMVK
EEEECCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
FLNLLASEPEASRVPIMIDSSKWEVIEAGLKCIQGKGVVNSISLKEGEDAFIQQARLVKK
HHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHH
YGAAAIVMAFDEDGQADTLERKIEICERSYNVLTQKVGFLPQDIIFDPNIFAVATGIEEH
HCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCEEEEEECCHHC
NNYGLDFINAVTWIKQNLPYAKISGGVSNVSFSFRGNNPVREAIHSVFLYYAIKEGMDMG
CCCCHHHHHHHHHHHHCCCHHEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
IVNAGQMAIYDDLPEKLRVAVEDVILNKDPEAGERLLEVAEEYRGDGQATSKVTDTAWRE
EECCCCEEEHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TTVEKRLEHSLVKGITDYIEADTEEAYQKLGAPINVIEGPLMDGMNVVGDLFGSGKMFLP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCHHH
QVVKSARVMKRAVAYLDPYLEAEKSEGQVQGKIVMATVKGDVHDIGKNIVGVVLQCNNFE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHEEEEEECCCEE
VIDLGVMVPAEKILDTAIEQNANVIGLSGLITPSLEEMVNVAKLMKERGMNLPLLIGGAT
EEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCC
TSKAHTAVKIEPQYDHPVVYVKDASRAVGVAQSLISNDLKETFAAKIKAEYEQVREERKA
CCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKQVKRIPIKQARLNPALDDQAWENYTPVKPSFLGTKVLESFPLEKLLERFDWSPFFQS
HHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHC
WELHGLYPRILDDKVVGDEARKVFADAQALLKTIIDQKWLTAKAVYGFYPANRVGDDIEV
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
YTDESRTEVLHTFHHLRQQAEKKRGGANNCLSDFIAPKESGVADYIGFFAVTAGIGIEEH
EECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHH
IARFEKEHDDYHSIMLKALADRFAEAFAETLHEIVRKEDWGYAPNEQLENEDIIRERYQG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
IRPAPGYPACPDHTEKGILWDLIKPDEKIGLEITESFAMTPTAAVSGTYFAHPKSRYFGV
CCCCCCCCCCCCCCCCCCEEECCCCCHHCCCEEEHHHCCCCCHHHCCCEEECCCCCEEEC
GSIGRDQVEDYAIRKGWSIEETEKWLAPNLGYDPEDFAN
CCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751 [H]