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The map label for this gene is hemB [H]

Identifier: 78484499

GI number: 78484499

Start: 186250

End: 187251

Strand: Reverse

Name: hemB [H]

Synonym: Tcr_0154

Alternate gene names: 78484499

Gene position: 187251-186250 (Counterclockwise)

Preceding gene: 78484508

Following gene: 78484498

Centisome position: 7.71

GC content: 47.11

Gene sequence:

>1002_bases
ATGATCGAACGCCAGTTTCCCATTACACGTATGCGCCGCATGCGAAAAGATCCCTTCTCTCGTCGGCTTATGCGTGAGCA
TGTTTTAACGACGAACGACTTGATTTACCCGATGTTTGTCATAGAAGGACAAAACCGCCGTGAGCCGGTTAAATCCATGC
CGGACATTGAACGTTTGAGTATAGATCTATTGATTACTGAAGCTCAAGAACTTTTTGAACTTGGCATCCCAATGATTGCG
CTTTTTCCAGTGCCAGATCCAGAAACCAAATCTCTGGATGCAGCAGAAGCTTACAACCCGGATGGATTAGCTCAAAGAGC
CGTTCGCGCCCTTAAAGAAGCCATTCCAGACATGGGCATTATGACGGACATTGCCCTAGACCCTTACACGACACATGGTC
AAGACGGTATTATTGATGAAAATGGTTATGTCCTGAATGACGACACCATTGATGTACTCATGCAACAAGCCATTTCACAC
GCTGAAGCTGGGGCAGATGTTGTGGCGCCATCAGACATGATGGATGGTCGAATCATAGAAATTCGTGAACATTTGGAAGA
GCACGGTCATATCCATACCCGTATTATGGCTTACTCGGCGAAGTACGCTTCGTCGTATTATGGGCCATTCCGAGATGCAG
TCGGTTCGGCGGGCAATTTAGGCGCTGGTAATAAACACACCTATCAAATGGACCCAGCGAACAGCAACGAAGCATTGCAT
GAGGTCGCGATGGACATTAACGAAGGCGCAGACATGGTAATGATCAAGCCCGGCCTGCCATATCTTGATATTGTTTATCG
TGTGAAACAAGAATTCCAAGCCCCCACATTTGTCTACCATGTTAGCGGTGAATATGCCATGCTCAAAGCAGCGGCTTTAA
ATGGTTGGATCAACGAAAAAGACGTCGTCTTGGAGACCTTATTAAGCTGTAAACGTGCAGGGGCAGACGGCATCCTGACC
TATTACGCCAAGGTCGTCGCACAATGGTTAGCGGAAAAATAA

Upstream 100 bases:

>100_bases
TAAATCGTGTATCTCACCCTTTTCTGGCAAGCTCGACTTCGCTTTATTTTTTGAGTCGACAAGAGTATCATTCTTCCATC
ACAAACATCAGGAGCTCTTC

Downstream 100 bases:

>100_bases
TGCCATGACAGATTTATATGCCGTAGTGGGCAACCCGATTGCCCATTCAAAGTCGCCTCTGATCCATCGTCTATTTGCAG
AACAAACCGATCAGGATCTG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIERQFPITRMRRMRKDPFSRRLMREHVLTTNDLIYPMFVIEGQNRREPVKSMPDIERLSIDLLITEAQELFELGIPMIA
LFPVPDPETKSLDAAEAYNPDGLAQRAVRALKEAIPDMGIMTDIALDPYTTHGQDGIIDENGYVLNDDTIDVLMQQAISH
AEAGADVVAPSDMMDGRIIEIREHLEEHGHIHTRIMAYSAKYASSYYGPFRDAVGSAGNLGAGNKHTYQMDPANSNEALH
EVAMDINEGADMVMIKPGLPYLDIVYRVKQEFQAPTFVYHVSGEYAMLKAAALNGWINEKDVVLETLLSCKRAGADGILT
YYAKVVAQWLAEK

Sequences:

>Translated_333_residues
MIERQFPITRMRRMRKDPFSRRLMREHVLTTNDLIYPMFVIEGQNRREPVKSMPDIERLSIDLLITEAQELFELGIPMIA
LFPVPDPETKSLDAAEAYNPDGLAQRAVRALKEAIPDMGIMTDIALDPYTTHGQDGIIDENGYVLNDDTIDVLMQQAISH
AEAGADVVAPSDMMDGRIIEIREHLEEHGHIHTRIMAYSAKYASSYYGPFRDAVGSAGNLGAGNKHTYQMDPANSNEALH
EVAMDINEGADMVMIKPGLPYLDIVYRVKQEFQAPTFVYHVSGEYAMLKAAALNGWINEKDVVLETLLSCKRAGADGILT
YYAKVVAQWLAEK
>Mature_333_residues
MIERQFPITRMRRMRKDPFSRRLMREHVLTTNDLIYPMFVIEGQNRREPVKSMPDIERLSIDLLITEAQELFELGIPMIA
LFPVPDPETKSLDAAEAYNPDGLAQRAVRALKEAIPDMGIMTDIALDPYTTHGQDGIIDENGYVLNDDTIDVLMQQAISH
AEAGADVVAPSDMMDGRIIEIREHLEEHGHIHTRIMAYSAKYASSYYGPFRDAVGSAGNLGAGNKHTYQMDPANSNEALH
EVAMDINEGADMVMIKPGLPYLDIVYRVKQEFQAPTFVYHVSGEYAMLKAAALNGWINEKDVVLETLLSCKRAGADGILT
YYAKVVAQWLAEK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=40.9090909090909, Blast_Score=234, Evalue=8e-62,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=42.6791277258567, Blast_Score=240, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=36.0501567398119, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=38.6440677966102, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37331; Mature: 37331

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERQFPITRMRRMRKDPFSRRLMREHVLTTNDLIYPMFVIEGQNRREPVKSMPDIERLS
CCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHCCCHHHHE
IDLLITEAQELFELGIPMIALFPVPDPETKSLDAAEAYNPDGLAQRAVRALKEAIPDMGI
EHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCC
MTDIALDPYTTHGQDGIIDENGYVLNDDTIDVLMQQAISHAEAGADVVAPSDMMDGRIIE
CHHEECCCCCCCCCCCEECCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHH
IREHLEEHGHIHTRIMAYSAKYASSYYGPFRDAVGSAGNLGAGNKHTYQMDPANSNEALH
HHHHHHHCCCEEEHHEEHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHH
EVAMDINEGADMVMIKPGLPYLDIVYRVKQEFQAPTFVYHVSGEYAMLKAAALNGWINEK
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCH
DVVLETLLSCKRAGADGILTYYAKVVAQWLAEK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIERQFPITRMRRMRKDPFSRRLMREHVLTTNDLIYPMFVIEGQNRREPVKSMPDIERLS
CCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHCCCHHHHE
IDLLITEAQELFELGIPMIALFPVPDPETKSLDAAEAYNPDGLAQRAVRALKEAIPDMGI
EHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCC
MTDIALDPYTTHGQDGIIDENGYVLNDDTIDVLMQQAISHAEAGADVVAPSDMMDGRIIE
CHHEECCCCCCCCCCCEECCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHH
IREHLEEHGHIHTRIMAYSAKYASSYYGPFRDAVGSAGNLGAGNKHTYQMDPANSNEALH
HHHHHHHCCCEEEHHEEHHHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHH
EVAMDINEGADMVMIKPGLPYLDIVYRVKQEFQAPTFVYHVSGEYAMLKAAALNGWINEK
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCH
DVVLETLLSCKRAGADGILTYYAKVVAQWLAEK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]