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The map label for this gene is gapA [H]

Identifier: 78358775

GI number: 78358775

Start: 3693294

End: 3694313

Strand: Reverse

Name: gapA [H]

Synonym: Dde_3736

Alternate gene names: 78358775

Gene position: 3694313-3693294 (Counterclockwise)

Preceding gene: 78358776

Following gene: 78358774

Centisome position: 99.04

GC content: 57.55

Gene sequence:

>1020_bases
ATGAAAAAGGTAAGAGTCGGCATCAACGGCTTCGGCCGTATCGGCCGTCAGGTTCTTAAAACCATTTGGGAACGGCACAG
AGACACAGTGGACGTGGTGGCCGTGAACGACCTGTTCGATATCAACACCAACGCGCACCTGCTGAGCCACGACACCAACT
ACCGCGGCTTTGCGCCCGAAGTCTCCGTTGACGGCGACATCATGCGCGTAGGCGGCGACTTTGTGATTAAAAACTACGCA
GAGCGCGATCCCCGCGCCATTCCGTGGGGAGCCATGGACGTGGACATCGTCATCGAGTCCACCGGTATTTTTACTTCCGG
CCCCAAAGCCGCCATGCATCTGGAAGCAGGCGCCAAAAAAGTGGTCATCTCTGCCCCTGCCAAGGAAGAAGACATCACCG
TGGTGCTGGGTGTAAACCATCAGGATTACGACCCTGCAAAACACAGGATCATTTCCAACGCATCGTGCACCACAAACTGC
CTTGCTCCCGTGGTCAAGGTCATGCACGAAAACTTCGGCATCCAGAAAGGTGTGATGACCACCGTGCACTCATACACCAA
CGACCAGCGCATCCTTGACCAGCCGCACAGGGATATGCGCCGTGCACGGGCTGCCGCCTGCAACATGATTCCCACGTCCA
CCGGAGCCGCCAAGGCCGTGGCGCTGGTCATTCCCGAAATGAAGGGACGCTTTGAAGGGTATTCCGTGCGCGTACCCACG
CCCACGGTGTCGCTGGTGGACTTTGTGGCCATTCTGGAGCGCGAAACCACCACCGAAGAACTGCGCGCCACGCTGAAGAA
CGCGGCTCAGGGCAGCCTGAACGGCATTCTGGGGTACTCCGAACTGCCGCTGGTTTCTTCGGACTTCATCGGTGACCCGC
ATTCGGGTATTGTAGAGGCGGACTTCACTCTGGTGCAGACAGGCAATCTGGCCAAGGTGTATGTGTGGTACGATAACGAA
TGGGGTTATTCGTGCCGTGTGGCCGATCTTGTGGAATACATGAGGGAACGCGGCCTGTAG

Upstream 100 bases:

>100_bases
GAAGCGCGAAAACAGGCTGGCGGAAGAATACATCTACCGCGTTGATGAAAACTAGCAGTCACAGCAGCCAGCGCCATGCG
CTGCCCGCGGAGGATAGCAT

Downstream 100 bases:

>100_bases
GTGACGTGCTCCGTAAACGGAATGCGTCAGTTTGAGACGTAATGCTAAGGCCGCAACCGGGGGTTGCGGCCTTTTTTTTG
CGTGCTAAAAAGGATAGCAT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; GAPDH [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKKVRVGINGFGRIGRQVLKTIWERHRDTVDVVAVNDLFDINTNAHLLSHDTNYRGFAPEVSVDGDIMRVGGDFVIKNYA
ERDPRAIPWGAMDVDIVIESTGIFTSGPKAAMHLEAGAKKVVISAPAKEEDITVVLGVNHQDYDPAKHRIISNASCTTNC
LAPVVKVMHENFGIQKGVMTTVHSYTNDQRILDQPHRDMRRARAAACNMIPTSTGAAKAVALVIPEMKGRFEGYSVRVPT
PTVSLVDFVAILERETTTEELRATLKNAAQGSLNGILGYSELPLVSSDFIGDPHSGIVEADFTLVQTGNLAKVYVWYDNE
WGYSCRVADLVEYMRERGL

Sequences:

>Translated_339_residues
MKKVRVGINGFGRIGRQVLKTIWERHRDTVDVVAVNDLFDINTNAHLLSHDTNYRGFAPEVSVDGDIMRVGGDFVIKNYA
ERDPRAIPWGAMDVDIVIESTGIFTSGPKAAMHLEAGAKKVVISAPAKEEDITVVLGVNHQDYDPAKHRIISNASCTTNC
LAPVVKVMHENFGIQKGVMTTVHSYTNDQRILDQPHRDMRRARAAACNMIPTSTGAAKAVALVIPEMKGRFEGYSVRVPT
PTVSLVDFVAILERETTTEELRATLKNAAQGSLNGILGYSELPLVSSDFIGDPHSGIVEADFTLVQTGNLAKVYVWYDNE
WGYSCRVADLVEYMRERGL
>Mature_339_residues
MKKVRVGINGFGRIGRQVLKTIWERHRDTVDVVAVNDLFDINTNAHLLSHDTNYRGFAPEVSVDGDIMRVGGDFVIKNYA
ERDPRAIPWGAMDVDIVIESTGIFTSGPKAAMHLEAGAKKVVISAPAKEEDITVVLGVNHQDYDPAKHRIISNASCTTNC
LAPVVKVMHENFGIQKGVMTTVHSYTNDQRILDQPHRDMRRARAAACNMIPTSTGAAKAVALVIPEMKGRFEGYSVRVPT
PTVSLVDFVAILERETTTEELRATLKNAAQGSLNGILGYSELPLVSSDFIGDPHSGIVEADFTLVQTGNLAKVYVWYDNE
WGYSCRVADLVEYMRERGL

Specific function: More active in catabolism [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=339, Percent_Identity=45.7227138643068, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI7657116, Length=343, Percent_Identity=46.064139941691, Blast_Score=292, Evalue=2e-79,
Organism=Escherichia coli, GI1788079, Length=335, Percent_Identity=44.7761194029851, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1789295, Length=328, Percent_Identity=45.1219512195122, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17534677, Length=344, Percent_Identity=48.8372093023256, Blast_Score=324, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17534679, Length=344, Percent_Identity=48.8372093023256, Blast_Score=323, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI32566163, Length=343, Percent_Identity=48.3965014577259, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17568413, Length=343, Percent_Identity=48.3965014577259, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6322409, Length=333, Percent_Identity=47.4474474474475, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6321631, Length=333, Percent_Identity=49.2492492492492, Blast_Score=309, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6322468, Length=333, Percent_Identity=48.048048048048, Blast_Score=305, Evalue=7e-84,
Organism=Drosophila melanogaster, GI17933600, Length=335, Percent_Identity=45.0746268656716, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI18110149, Length=335, Percent_Identity=45.0746268656716, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI85725000, Length=335, Percent_Identity=45.0746268656716, Blast_Score=287, Evalue=6e-78,
Organism=Drosophila melanogaster, GI22023983, Length=335, Percent_Identity=45.0746268656716, Blast_Score=287, Evalue=6e-78,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=43.3734939759036, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 37358; Mature: 37358

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVRVGINGFGRIGRQVLKTIWERHRDTVDVVAVNDLFDINTNAHLLSHDTNYRGFAPE
CCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCEEEECCCCCCCCCCC
VSVDGDIMRVGGDFVIKNYAERDPRAIPWGAMDVDIVIESTGIFTSGPKAAMHLEAGAKK
CCCCCCEEEECCCEEEECHHCCCCCCCCCCCCEEEEEEEECCCEECCCCEEEEECCCCCE
VVISAPAKEEDITVVLGVNHQDYDPAKHRIISNASCTTNCLAPVVKVMHENFGIQKGVMT
EEEECCCCCCCEEEEEECCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
TVHSYTNDQRILDQPHRDMRRARAAACNMIPTSTGAAKAVALVIPEMKGRFEGYSVRVPT
HHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCCCEEEECCC
PTVSLVDFVAILERETTTEELRATLKNAAQGSLNGILGYSELPLVSSDFIGDPHSGIVEA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
DFTLVQTGNLAKVYVWYDNEWGYSCRVADLVEYMRERGL
CEEEEECCCEEEEEEEECCCCCCEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVRVGINGFGRIGRQVLKTIWERHRDTVDVVAVNDLFDINTNAHLLSHDTNYRGFAPE
CCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCEEEECCCCCCCCCCC
VSVDGDIMRVGGDFVIKNYAERDPRAIPWGAMDVDIVIESTGIFTSGPKAAMHLEAGAKK
CCCCCCEEEECCCEEEECHHCCCCCCCCCCCCEEEEEEEECCCEECCCCEEEEECCCCCE
VVISAPAKEEDITVVLGVNHQDYDPAKHRIISNASCTTNCLAPVVKVMHENFGIQKGVMT
EEEECCCCCCCEEEEEECCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
TVHSYTNDQRILDQPHRDMRRARAAACNMIPTSTGAAKAVALVIPEMKGRFEGYSVRVPT
HHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCCCCEEEECCC
PTVSLVDFVAILERETTTEELRATLKNAAQGSLNGILGYSELPLVSSDFIGDPHSGIVEA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
DFTLVQTGNLAKVYVWYDNEWGYSCRVADLVEYMRERGL
CEEEEECCCEEEEEEEECCCCCCEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493629; 9384377; 8755892; 10658653; 10799476 [H]