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The map label for this gene is serA [H]

Identifier: 78358728

GI number: 78358728

Start: 3649373

End: 3650290

Strand: Direct

Name: serA [H]

Synonym: Dde_3689

Alternate gene names: 78358728

Gene position: 3649373-3650290 (Clockwise)

Preceding gene: 78358727

Following gene: 78358729

Centisome position: 97.83

GC content: 62.42

Gene sequence:

>918_bases
ATGAAAATAGCCATAACAACGTCGTCATTCGCCCGCTTCAGCGAGGCACCGCTGCAGCTGCTGCGGCAGGAGCACATAGA
CTATGTGCTGAACCCGCTGGGCCGCAAACTGACCGAAAACGAAACCATAGACCTGCTGCAGGACTGCGTGGCCGTGGCGG
CAGGCACAGAACCGCTCACAGCCCGCGTCATGGACGCGCTGCCCGGCCTCAAGGTCATCTCCCGCTGCGGCACCGGCATG
GACAACGTGGACATGGAAGCCGCACGCGCACGCGGCATCGCCGTACGCAACACGCCGGACGGCCCCACGCAGGCAGTGGC
GGAACTGACCCTCGGACTGGCTCTAGATCTTATGCGTCAGGTTTCGCGCATGGACAGGGAACTGCGTTCCGGCGTGTGGA
AAAAACGCATGGGCAACCTGCTGGGGGGCAAGCGGCTGGGTATTGTCGGCATGGGTCGCATAGGCCGCGCCGTGGCAGAT
ATTTTCACTCCGCTGGGAGTACAGGTGGCCTTCAACGATCCGGTATCCTGCTGCGGTGATTATCCCTGCATGCCCGTGGA
AGAACTGCTCGGCTGGGCCGATATTCTGAGCCTGCACTGCTCCATGACGGGCGGCGAATGTTCGCTTTTCACCGCGGAAC
ACCTGCGGCGCATGAAACGCGGCAGCTGGGTGATCAACGTGGCCCGCGGCGGCCTGATAGATGAGCAGGCGCTGTACGAA
GCCCTTGCCGACGGCCATCTGGCCGGCGCCGCCGTGGATGTTTTCGGCAACGAACCCTACACCGGACCGCTGAGTTCGCT
GGACAACGTCATCCTGACTCCGCACATCGGGTCTTACGCCAAGGAGGCCCGCATACGCATGGAAACCGATACCATTGCCA
ATCTCATCGACGCGCTGCGCGCCGCCGGAGTGAAATAA

Upstream 100 bases:

>100_bases
CCGGCGTACCGGCGCGTGTCACCGGCAGCCGCTCCGACCGCTGAACGCGCCATCAAACCCGTGCGCATGGCGCACAATAT
CTGCTTTACGGATAAACAGC

Downstream 100 bases:

>100_bases
TGGCGCTGGAACTGGTTGTCTTTGACTGCGACGGAGTTCTGCTGGAAAGCGTGGAGGTAAAAACCCGCGCCTTTGCCCGC
ACGGTGGAAGAGTACGGTCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIAITTSSFARFSEAPLQLLRQEHIDYVLNPLGRKLTENETIDLLQDCVAVAAGTEPLTARVMDALPGLKVISRCGTGM
DNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLMRQVSRMDRELRSGVWKKRMGNLLGGKRLGIVGMGRIGRAVAD
IFTPLGVQVAFNDPVSCCGDYPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLIDEQALYE
ALADGHLAGAAVDVFGNEPYTGPLSSLDNVILTPHIGSYAKEARIRMETDTIANLIDALRAAGVK

Sequences:

>Translated_305_residues
MKIAITTSSFARFSEAPLQLLRQEHIDYVLNPLGRKLTENETIDLLQDCVAVAAGTEPLTARVMDALPGLKVISRCGTGM
DNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLMRQVSRMDRELRSGVWKKRMGNLLGGKRLGIVGMGRIGRAVAD
IFTPLGVQVAFNDPVSCCGDYPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLIDEQALYE
ALADGHLAGAAVDVFGNEPYTGPLSSLDNVILTPHIGSYAKEARIRMETDTIANLIDALRAAGVK
>Mature_305_residues
MKIAITTSSFARFSEAPLQLLRQEHIDYVLNPLGRKLTENETIDLLQDCVAVAAGTEPLTARVMDALPGLKVISRCGTGM
DNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLMRQVSRMDRELRSGVWKKRMGNLLGGKRLGIVGMGRIGRAVAD
IFTPLGVQVAFNDPVSCCGDYPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLIDEQALYE
ALADGHLAGAAVDVFGNEPYTGPLSSLDNVILTPHIGSYAKEARIRMETDTIANLIDALRAAGVK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=276, Percent_Identity=39.1304347826087, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=33.6, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=33.6, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI145580578, Length=247, Percent_Identity=34.412955465587, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557499, Length=247, Percent_Identity=34.412955465587, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=34.412955465587, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=32.9411764705882, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=37.3493975903614, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI87082289, Length=310, Percent_Identity=32.5806451612903, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787645, Length=322, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17532191, Length=295, Percent_Identity=33.8983050847458, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=225, Percent_Identity=34.6666666666667, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=303, Percent_Identity=30.6930693069307, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=268, Percent_Identity=32.4626865671642, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=34.0163934426229, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=249, Percent_Identity=26.5060240963855, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921140, Length=250, Percent_Identity=37.2, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646446, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646448, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646452, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646450, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472511, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=35, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=30.8943089430894, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24585516, Length=259, Percent_Identity=29.3436293436293, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32859; Mature: 32859

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAITTSSFARFSEAPLQLLRQEHIDYVLNPLGRKLTENETIDLLQDCVAVAAGTEPLT
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
ARVMDALPGLKVISRCGTGMDNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLMRQ
HHHHHHCCHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
VSRMDRELRSGVWKKRMGNLLGGKRLGIVGMGRIGRAVADIFTPLGVQVAFNDPVSCCGD
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCHHHHCC
YPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLIDEQALYE
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ALADGHLAGAAVDVFGNEPYTGPLSSLDNVILTPHIGSYAKEARIRMETDTIANLIDALR
HHHCCCCCCCEEEECCCCCCCCCHHHCCCEEECCCCCHHHHHHHHEEHHHHHHHHHHHHH
AAGVK
HCCCC
>Mature Secondary Structure
MKIAITTSSFARFSEAPLQLLRQEHIDYVLNPLGRKLTENETIDLLQDCVAVAAGTEPLT
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
ARVMDALPGLKVISRCGTGMDNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLMRQ
HHHHHHCCHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
VSRMDRELRSGVWKKRMGNLLGGKRLGIVGMGRIGRAVADIFTPLGVQVAFNDPVSCCGD
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCHHHHCC
YPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSWVINVARGGLIDEQALYE
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ALADGHLAGAAVDVFGNEPYTGPLSSLDNVILTPHIGSYAKEARIRMETDTIANLIDALR
HHHCCCCCCCEEEECCCCCCCCCHHHCCCEEECCCCCHHHHHHHHEEHHHHHHHHHHHHH
AAGVK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]