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The map label for this gene is galK [H]

Identifier: 78358692

GI number: 78358692

Start: 3615479

End: 3616783

Strand: Direct

Name: galK [H]

Synonym: Dde_3653

Alternate gene names: 78358692

Gene position: 3615479-3616783 (Clockwise)

Preceding gene: 78358691

Following gene: 78358693

Centisome position: 96.92

GC content: 65.59

Gene sequence:

>1305_bases
ATGATACCCGCGCTGCATACGCAGCAGGAAATGCTGAACGCCCTGCATAGGGGGGCGCTGGACGCGGGGCTGCGCGCCCT
GTACGCGCCGGACAGCGACAGCGGGCACACAGCCGCTGCGGCACGCATCCGGCTGGAAAACCTGCTGCATGAACATCTGC
ACCGCTACGGCCCGCGGCCTGTGGGTATTTTCAGCGCGCCCGGCCGTACGGAGCTGGCAGGCAACCATACCGACCACAAC
AAGGGTGTGGTGGTGGCGGCAGCAGTCACACTGGACTGTCTGGCCGTGGCTTCTGCCCGCGCCGACCTGCGCGTGCATCT
GGTTTCCGCCGGATTTGCCCGTCCGGTGGACCTGACACTGGATGACCTGCAGCCGCGCGCGGACGAAAAAGAAACCCCCG
CGGCCATCGTCAGAGGCATGGCTGCCGGCATACACGGCCTGATGCCCCTCTGCGGATTCGATGCCTGTGTGCACAGTACG
GTTCCCGTGGGTGCGGGACTCAGCTCCTCCGCAGCATTCGAGGTGCTCTGCGGCCGCATTTTTTCAGGCTGGCATTCCGG
TTACGTCCTCACTCAGCAAACGCTGGCGGCACTGGCCCATACCGCAGAATCCCGTTATTTCGGCAAGCCATGCGGCGAAA
TGGATCAACTGGCCTGTGCGGGCAGCGGAGCTTCGGTCATCCGCTTCGGCATGCCGCAGGGCAAAAACGTTGAAGCCGTG
CCCGTCAATATTGCGGAAGCCGGCTATCAGCTTGCGGTTGTAAACACGGGGGGCAGCCACGCCGACCTGACGGCGGAATA
CGCCGCCATACCCGCAGAGATGCGCCGCGCCGCGGCCGTACTGGGCAAGCAGCAGGCCCACGGCATCACCGCCGCAGAGG
TGCTGCGCCACGCCGCAGCCATCCGCAATGCGGCCGGAGACCGGGCCCTGCTGCGGCTGCTTCATTTTGCCGAAGAGACA
CAGCGTGCCGAAGCCGTGGCACAGGCGCTGCGTCACAACCGCACGCAGGAATTGCTGCGGCTGGTCAATGCCAGCGGCGA
TTCTTCGTGGCGGCTGCTGCAAAACTGCTACCCCGCCGGTGCGTCCGCCCAGCCCCTGCCCGTGGCGCTGGAAACGACCC
GCCTGCAACTGGACGGGCAAGGGGCATGGCGTGTGCACGGCGGAGGATTTGCCGGTACCATACAGGTCTATGTGCCGCAG
CGGCTCATGGCCGGCTACACAAAGTGCATGGAACAGCTTTTCGGCGACGGGTGTGTCATCCCGCTGGATATCCGCGGCAG
CGGCCTGCACCGGCTGCTCCCGTAA

Upstream 100 bases:

>100_bases
TGGGCAGCCCGCAGCGCGACCTGACTGCAGAGAGCGCGGCGGACAAGCTGCGCGCCCTTTCCGACGTGCATTACACGGAC
CTGCGGCAGGGGTCTGCAAC

Downstream 100 bases:

>100_bases
GTCAGCTCCGCAGGCAAAAAAAGCCGTGCCGCTTTTGACAAAACCATGTAAATGAGGTCAAACTGCAAACGTTTGCAGCA
ACTGCGGCACCCGCCGCAAA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MIPALHTQQEMLNALHRGALDAGLRALYAPDSDSGHTAAAARIRLENLLHEHLHRYGPRPVGIFSAPGRTELAGNHTDHN
KGVVVAAAVTLDCLAVASARADLRVHLVSAGFARPVDLTLDDLQPRADEKETPAAIVRGMAAGIHGLMPLCGFDACVHST
VPVGAGLSSSAAFEVLCGRIFSGWHSGYVLTQQTLAALAHTAESRYFGKPCGEMDQLACAGSGASVIRFGMPQGKNVEAV
PVNIAEAGYQLAVVNTGGSHADLTAEYAAIPAEMRRAAAVLGKQQAHGITAAEVLRHAAAIRNAAGDRALLRLLHFAEET
QRAEAVAQALRHNRTQELLRLVNASGDSSWRLLQNCYPAGASAQPLPVALETTRLQLDGQGAWRVHGGGFAGTIQVYVPQ
RLMAGYTKCMEQLFGDGCVIPLDIRGSGLHRLLP

Sequences:

>Translated_434_residues
MIPALHTQQEMLNALHRGALDAGLRALYAPDSDSGHTAAAARIRLENLLHEHLHRYGPRPVGIFSAPGRTELAGNHTDHN
KGVVVAAAVTLDCLAVASARADLRVHLVSAGFARPVDLTLDDLQPRADEKETPAAIVRGMAAGIHGLMPLCGFDACVHST
VPVGAGLSSSAAFEVLCGRIFSGWHSGYVLTQQTLAALAHTAESRYFGKPCGEMDQLACAGSGASVIRFGMPQGKNVEAV
PVNIAEAGYQLAVVNTGGSHADLTAEYAAIPAEMRRAAAVLGKQQAHGITAAEVLRHAAAIRNAAGDRALLRLLHFAEET
QRAEAVAQALRHNRTQELLRLVNASGDSSWRLLQNCYPAGASAQPLPVALETTRLQLDGQGAWRVHGGGFAGTIQVYVPQ
RLMAGYTKCMEQLFGDGCVIPLDIRGSGLHRLLP
>Mature_434_residues
MIPALHTQQEMLNALHRGALDAGLRALYAPDSDSGHTAAAARIRLENLLHEHLHRYGPRPVGIFSAPGRTELAGNHTDHN
KGVVVAAAVTLDCLAVASARADLRVHLVSAGFARPVDLTLDDLQPRADEKETPAAIVRGMAAGIHGLMPLCGFDACVHST
VPVGAGLSSSAAFEVLCGRIFSGWHSGYVLTQQTLAALAHTAESRYFGKPCGEMDQLACAGSGASVIRFGMPQGKNVEAV
PVNIAEAGYQLAVVNTGGSHADLTAEYAAIPAEMRRAAAVLGKQQAHGITAAEVLRHAAAIRNAAGDRALLRLLHFAEET
QRAEAVAQALRHNRTQELLRLVNASGDSSWRLLQNCYPAGASAQPLPVALETTRLQLDGQGAWRVHGGGFAGTIQVYVPQ
RLMAGYTKCMEQLFGDGCVIPLDIRGSGLHRLLP

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=354, Percent_Identity=29.9435028248588, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786972, Length=343, Percent_Identity=24.4897959183673, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 45874; Mature: 45874

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPALHTQQEMLNALHRGALDAGLRALYAPDSDSGHTAAAARIRLENLLHEHLHRYGPRP
CCCCCCCHHHHHHHHHHCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VGIFSAPGRTELAGNHTDHNKGVVVAAAVTLDCLAVASARADLRVHLVSAGFARPVDLTL
EEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCH
DDLQPRADEKETPAAIVRGMAAGIHGLMPLCGFDACVHSTVPVGAGLSSSAAFEVLCGRI
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FSGWHSGYVLTQQTLAALAHTAESRYFGKPCGEMDQLACAGSGASVIRFGMPQGKNVEAV
HHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCEEEE
PVNIAEAGYQLAVVNTGGSHADLTAEYAAIPAEMRRAAAVLGKQQAHGITAAEVLRHAAA
EEEHHHCCEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IRNAAGDRALLRLLHFAEETQRAEAVAQALRHNRTQELLRLVNASGDSSWRLLQNCYPAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCC
ASAQPLPVALETTRLQLDGQGAWRVHGGGFAGTIQVYVPQRLMAGYTKCMEQLFGDGCVI
CCCCCCEEEEEEEEEEECCCCEEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCEE
PLDIRGSGLHRLLP
EEEECCCCHHHCCC
>Mature Secondary Structure
MIPALHTQQEMLNALHRGALDAGLRALYAPDSDSGHTAAAARIRLENLLHEHLHRYGPRP
CCCCCCCHHHHHHHHHHCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VGIFSAPGRTELAGNHTDHNKGVVVAAAVTLDCLAVASARADLRVHLVSAGFARPVDLTL
EEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCH
DDLQPRADEKETPAAIVRGMAAGIHGLMPLCGFDACVHSTVPVGAGLSSSAAFEVLCGRI
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FSGWHSGYVLTQQTLAALAHTAESRYFGKPCGEMDQLACAGSGASVIRFGMPQGKNVEAV
HHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCEEEE
PVNIAEAGYQLAVVNTGGSHADLTAEYAAIPAEMRRAAAVLGKQQAHGITAAEVLRHAAA
EEEHHHCCEEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IRNAAGDRALLRLLHFAEETQRAEAVAQALRHNRTQELLRLVNASGDSSWRLLQNCYPAG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCC
ASAQPLPVALETTRLQLDGQGAWRVHGGGFAGTIQVYVPQRLMAGYTKCMEQLFGDGCVI
CCCCCCEEEEEEEEEEECCCCEEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHCCCCEE
PLDIRGSGLHRLLP
EEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]