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The map label for this gene is maeB [H]

Identifier: 78358676

GI number: 78358676

Start: 3600764

End: 3602083

Strand: Reverse

Name: maeB [H]

Synonym: Dde_3637

Alternate gene names: 78358676

Gene position: 3602083-3600764 (Counterclockwise)

Preceding gene: 78358677

Following gene: 78358675

Centisome position: 96.56

GC content: 57.05

Gene sequence:

>1320_bases
ATGGCTCTTTTCACAAAAGAAGAAGCACTGAAATATCATGAGGCTCCGCGCCCCGGTAAGCTGGAAGTCGTTCCCGCAAA
GCCCTGCAGAAACCAGAAAGATCTTTCAATGGCGTATTCGCCCGGCGTGGCCGAAGCCTGCAAAGCCATCCGCGAAGATC
CGGCAAAGGCCGCGCTGTATACCGGCCGTTCCAACCTTGTGGGCGTGGTTTCAGACGGTTCCGCGGTTCTGGGGCTGGGT
AACATCGGCCCGCTGGCAGGAAAGCCGGTTATGGAAGGCAAAGGCGTGCTGTTCAAAACCTTTGCCGACATCGACGTGTT
TGACATCAATCTGGACGTGCGCAGCGCCGATCAGCTTATCGAGGTGGTGAAAACGCTGGAGCCCACCTTCGGCGGGATCA
ATCTGGAAGACATCAAGGCTCCGGAATGCTTTTACATCGAAGAGACGCTCAAACGCGAGATGAATATTCCCGTGTTTCAT
GATGATCAGCACGGCACCGCCGTGATTTCCGGAGCGGGGCTGCTCAACGCGCTGGATATAACCAACCGCAGGGCCGAAGA
CATGAAGGTTGTGATTGTGGGAGCCGGAGCTGCAGGCATTGCCTGTGCCACATTCTATGTTGCACTCGGCGTCGATCCTG
CAAATATCTACATGTTCGACTCGCGGGGGCTTATCCATGCCGGACGCAGCGATCTGAACAGCTACAAGAAACGGTTTGCT
CAGAAAAAAGATGCCGGAAGTCTTGAAGATGTGATGAAAGGGGCGGACATGTTCCTTGGTCTGTCCACAAAAGACCTTGT
TTCCAAAGACATGGTGCGGGCCATGGCAAAGGATCCGGTGCTGTTCGCCATGGCAAATCCCGATCCGGAAATTGCATATC
CCGATGCCAAAGAAGCCTGCCCCGGCTGCATCATGGGTACAGGGCGTTCCGATTTTCCCAATCAGGTGAACAATGTTTCC
GGTTTTCCGTATATTTTCCGCGGAGCACTGGACGTGGGCGCCACGGAAATCAACGAGGCCATGAAAATCGCCGCTGCCAG
ATCGCTGGCGGCGCTGGCGCGCGAGCCTGTTCCTGCAGAAATCTGCGCATTGTACGGTGTGGATTCTCTGGAGTTCGGCG
TGGACTATGTCATACCGAAGCCGCTGGACCCGCGTGTGCTGGAGTGGGAAACTCCCGCCGTGGCGCAGGCGGCCATGGAT
TCCGGCGTGGCCACGGTACCTGTGGCTGATATGAAAGCGTATGCCGCTTCGCTGCGGGTCCGCGTGGATGCTGCGGCGCG
CCGTGCGGCAGCCGTGGTGGACAGTTATTCCGGCGTCTGA

Upstream 100 bases:

>100_bases
GAAGGTGCGTGATTTTCCGCTGCTGGTGATCAACGATGCCTGCGGCGGCGAGCTGTATGTAACCCCCAAACTTGATCTGT
GACCACTCAGGAGGCTGACA

Downstream 100 bases:

>100_bases
TTTCTGCCGCTGCCTGCATCCTGCGGCGGTCGTGCAGAATGCAGGCAGAAAAATACCGTTGCTTGCGCATCTTCTGCGGC
AGCGTAATAATACTCGTTGC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MALFTKEEALKYHEAPRPGKLEVVPAKPCRNQKDLSMAYSPGVAEACKAIREDPAKAALYTGRSNLVGVVSDGSAVLGLG
NIGPLAGKPVMEGKGVLFKTFADIDVFDINLDVRSADQLIEVVKTLEPTFGGINLEDIKAPECFYIEETLKREMNIPVFH
DDQHGTAVISGAGLLNALDITNRRAEDMKVVIVGAGAAGIACATFYVALGVDPANIYMFDSRGLIHAGRSDLNSYKKRFA
QKKDAGSLEDVMKGADMFLGLSTKDLVSKDMVRAMAKDPVLFAMANPDPEIAYPDAKEACPGCIMGTGRSDFPNQVNNVS
GFPYIFRGALDVGATEINEAMKIAAARSLAALAREPVPAEICALYGVDSLEFGVDYVIPKPLDPRVLEWETPAVAQAAMD
SGVATVPVADMKAYAASLRVRVDAAARRAAAVVDSYSGV

Sequences:

>Translated_439_residues
MALFTKEEALKYHEAPRPGKLEVVPAKPCRNQKDLSMAYSPGVAEACKAIREDPAKAALYTGRSNLVGVVSDGSAVLGLG
NIGPLAGKPVMEGKGVLFKTFADIDVFDINLDVRSADQLIEVVKTLEPTFGGINLEDIKAPECFYIEETLKREMNIPVFH
DDQHGTAVISGAGLLNALDITNRRAEDMKVVIVGAGAAGIACATFYVALGVDPANIYMFDSRGLIHAGRSDLNSYKKRFA
QKKDAGSLEDVMKGADMFLGLSTKDLVSKDMVRAMAKDPVLFAMANPDPEIAYPDAKEACPGCIMGTGRSDFPNQVNNVS
GFPYIFRGALDVGATEINEAMKIAAARSLAALAREPVPAEICALYGVDSLEFGVDYVIPKPLDPRVLEWETPAVAQAAMD
SGVATVPVADMKAYAASLRVRVDAAARRAAAVVDSYSGV
>Mature_438_residues
ALFTKEEALKYHEAPRPGKLEVVPAKPCRNQKDLSMAYSPGVAEACKAIREDPAKAALYTGRSNLVGVVSDGSAVLGLGN
IGPLAGKPVMEGKGVLFKTFADIDVFDINLDVRSADQLIEVVKTLEPTFGGINLEDIKAPECFYIEETLKREMNIPVFHD
DQHGTAVISGAGLLNALDITNRRAEDMKVVIVGAGAAGIACATFYVALGVDPANIYMFDSRGLIHAGRSDLNSYKKRFAQ
KKDAGSLEDVMKGADMFLGLSTKDLVSKDMVRAMAKDPVLFAMANPDPEIAYPDAKEACPGCIMGTGRSDFPNQVNNVSG
FPYIFRGALDVGATEINEAMKIAAARSLAALAREPVPAEICALYGVDSLEFGVDYVIPKPLDPRVLEWETPAVAQAAMDS
GVATVPVADMKAYAASLRVRVDAAARRAAAVVDSYSGV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=351, Percent_Identity=27.9202279202279, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI62420880, Length=351, Percent_Identity=27.9202279202279, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI239049447, Length=351, Percent_Identity=27.9202279202279, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4505143, Length=344, Percent_Identity=25, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4505145, Length=346, Percent_Identity=26.5895953757225, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=415, Percent_Identity=57.3493975903614, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17537199, Length=410, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=274, Percent_Identity=30.2919708029197, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362672, Length=414, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362674, Length=414, Percent_Identity=26.0869565217391, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356279, Length=414, Percent_Identity=26.0869565217391, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI78707242, Length=342, Percent_Identity=25.7309941520468, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI78707238, Length=342, Percent_Identity=25.7309941520468, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI78707240, Length=340, Percent_Identity=25.8823529411765, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 46754; Mature: 46623

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFTKEEALKYHEAPRPGKLEVVPAKPCRNQKDLSMAYSPGVAEACKAIREDPAKAALY
CCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEEE
TGRSNLVGVVSDGSAVLGLGNIGPLAGKPVMEGKGVLFKTFADIDVFDINLDVRSADQLI
ECCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHH
EVVKTLEPTFGGINLEDIKAPECFYIEETLKREMNIPVFHDDQHGTAVISGAGLLNALDI
HHHHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCEEEEECCCCHHHHHH
TNRRAEDMKVVIVGAGAAGIACATFYVALGVDPANIYMFDSRGLIHAGRSDLNSYKKRFA
CCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCHHHHHHHHHHHH
QKKDAGSLEDVMKGADMFLGLSTKDLVSKDMVRAMAKDPVLFAMANPDPEIAYPDAKEAC
HCCCCCCHHHHHCCCHHEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHC
PGCIMGTGRSDFPNQVNNVSGFPYIFRGALDVGATEINEAMKIAAARSLAALAREPVPAE
CCEEECCCCCCCCCHHHCCCCCCCEEECHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
ICALYGVDSLEFGVDYVIPKPLDPRVLEWETPAVAQAAMDSGVATVPVADMKAYAASLRV
HHHHHCCCHHHCCCEEECCCCCCCCEEECCCCHHHHHHHHCCCEEEEHHHHHHHHHHHEE
RVDAAARRAAAVVDSYSGV
EEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALFTKEEALKYHEAPRPGKLEVVPAKPCRNQKDLSMAYSPGVAEACKAIREDPAKAALY
CCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEEE
TGRSNLVGVVSDGSAVLGLGNIGPLAGKPVMEGKGVLFKTFADIDVFDINLDVRSADQLI
ECCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHH
EVVKTLEPTFGGINLEDIKAPECFYIEETLKREMNIPVFHDDQHGTAVISGAGLLNALDI
HHHHHHCCCCCCCCHHHCCCCCEEEHHHHHHHHCCCCEEECCCCCEEEEECCCCHHHHHH
TNRRAEDMKVVIVGAGAAGIACATFYVALGVDPANIYMFDSRGLIHAGRSDLNSYKKRFA
CCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCHHHHHHHHHHHH
QKKDAGSLEDVMKGADMFLGLSTKDLVSKDMVRAMAKDPVLFAMANPDPEIAYPDAKEAC
HCCCCCCHHHHHCCCHHEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHC
PGCIMGTGRSDFPNQVNNVSGFPYIFRGALDVGATEINEAMKIAAARSLAALAREPVPAE
CCEEECCCCCCCCCHHHCCCCCCCEEECHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
ICALYGVDSLEFGVDYVIPKPLDPRVLEWETPAVAQAAMDSGVATVPVADMKAYAASLRV
HHHHHCCCHHHCCCEEECCCCCCCCEEECCCCHHHHHHHHCCCEEEEHHHHHHHHHHHEE
RVDAAARRAAAVVDSYSGV
EEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]