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The map label for this gene is dhaT [H]

Identifier: 78358573

GI number: 78358573

Start: 3491618

End: 3492760

Strand: Direct

Name: dhaT [H]

Synonym: Dde_3534

Alternate gene names: 78358573

Gene position: 3491618-3492760 (Clockwise)

Preceding gene: 78358572

Following gene: 78358574

Centisome position: 93.6

GC content: 59.49

Gene sequence:

>1143_bases
ATGTCGGTAACGAAGTTCGCTATTCCGGAAGTCATCTTCGGCAACTCCAGCCTGCGGTATCTTGCACAGTGTGCGCTGCG
GCTCGGAGCAAGACGGATATTTCTGGTAAGTGATCCCGGGCTGGAAAAGGCGGGCTGGGTGCAGCACGTCATTGACATTC
TTTCCGAAGACCGGCTGGAATGCGTCTATTACAACGATGTGGATTCCAACCCCCGAGACTGGCAGGTGCACGAGGGCGCC
CGTCTGTACACTGAAGAACGCGCCGATCTCATCATCGGTCTCGGCGGCGGCAGCCCCATTGACGCCGCCAAGGGCATTGC
CACCATTGCCAGCAACGGCGGGCGGATTCATGATTACGAGGGCGCCAACCGCATCATGCGTCCCCTGCCGCCCATGATTT
TCATCCCCACCACGGCGGGCAGCGGCTCTGACATTTCACAGTACTGTATTATCACCGACGTGGAGCGGCAGCTCAAAATG
TCCATCATCAGCCGCTCGCTGGTGCCCAACGTCTCCATCATAGACCCTTCTCTTCTGCTCACAAAAACCGTGGAACTGAT
TCTTGCTTCGGCCATAGACGCACTGGCCCACGCGGTTGAATCCTATGTATCACGGCTGGCTTCTCCGTTTACGGAGACGC
AGGCGCTGTATGCCATCCGGCTGATCATGGAAAATCTGGAAACGGCAGCCCGCACGCGCAACCCCGCGGCACTGGAAAAG
CTGAGCATCGCCAGTACCGCGGCGGGCATGTCTTTCAGCAATGCCGGGCTGGGCATAGGACATGCGCTGGCGCACTCGCT
GGGCGGACGCTACGACGTGCTGCACGGGCTGGTGCATCCGGTACTGCTGCCGCACGTCATGCGGTACAACCTGCCTGTGT
GCCGCGAAAAAATGGACAACATCGCCGCCGTGGTGCTGCAAAGCTGCGACACCGCCGGAACCGGCCGCGCACTGGAGGGC
ATAGAACAGCTGGAACACATGTTCCGTTCGCTGCAGGTCACCACCAGACTGCGTGATATTCTGCCCGACGACAGTCAGCT
GGAGCAGATATGCAAAATGGCGGTGCCGGACGAATGCGCACTTACCAACCCGCGCGAAGCCACCTGGGCTGACCTGATGG
GGATATGCAAAGAGGCCTGGTAA

Upstream 100 bases:

>100_bases
CCTGAAAAGCATAAGCAATTTTTGTTCACGGGCTTGCCCTAACGGGAGATAAGCGGGTATCAACAAGACTGATTTTCTTT
ATACGCTCCGAGGAGGCGGC

Downstream 100 bases:

>100_bases
TGAAAGGCAAAACAACCATAGAAGACCTTGTCGGCATTGAACACAGCAAGCTGAATTTTTTTCAGGAACTCCAGCAGAGC
ATTGAGGAACTGAAAGAAAG

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSVTKFAIPEVIFGNSSLRYLAQCALRLGARRIFLVSDPGLEKAGWVQHVIDILSEDRLECVYYNDVDSNPRDWQVHEGA
RLYTEERADLIIGLGGGSPIDAAKGIATIASNGGRIHDYEGANRIMRPLPPMIFIPTTAGSGSDISQYCIITDVERQLKM
SIISRSLVPNVSIIDPSLLLTKTVELILASAIDALAHAVESYVSRLASPFTETQALYAIRLIMENLETAARTRNPAALEK
LSIASTAAGMSFSNAGLGIGHALAHSLGGRYDVLHGLVHPVLLPHVMRYNLPVCREKMDNIAAVVLQSCDTAGTGRALEG
IEQLEHMFRSLQVTTRLRDILPDDSQLEQICKMAVPDECALTNPREATWADLMGICKEAW

Sequences:

>Translated_380_residues
MSVTKFAIPEVIFGNSSLRYLAQCALRLGARRIFLVSDPGLEKAGWVQHVIDILSEDRLECVYYNDVDSNPRDWQVHEGA
RLYTEERADLIIGLGGGSPIDAAKGIATIASNGGRIHDYEGANRIMRPLPPMIFIPTTAGSGSDISQYCIITDVERQLKM
SIISRSLVPNVSIIDPSLLLTKTVELILASAIDALAHAVESYVSRLASPFTETQALYAIRLIMENLETAARTRNPAALEK
LSIASTAAGMSFSNAGLGIGHALAHSLGGRYDVLHGLVHPVLLPHVMRYNLPVCREKMDNIAAVVLQSCDTAGTGRALEG
IEQLEHMFRSLQVTTRLRDILPDDSQLEQICKMAVPDECALTNPREATWADLMGICKEAW
>Mature_379_residues
SVTKFAIPEVIFGNSSLRYLAQCALRLGARRIFLVSDPGLEKAGWVQHVIDILSEDRLECVYYNDVDSNPRDWQVHEGAR
LYTEERADLIIGLGGGSPIDAAKGIATIASNGGRIHDYEGANRIMRPLPPMIFIPTTAGSGSDISQYCIITDVERQLKMS
IISRSLVPNVSIIDPSLLLTKTVELILASAIDALAHAVESYVSRLASPFTETQALYAIRLIMENLETAARTRNPAALEKL
SIASTAAGMSFSNAGLGIGHALAHSLGGRYDVLHGLVHPVLLPHVMRYNLPVCREKMDNIAAVVLQSCDTAGTGRALEGI
EQLEHMFRSLQVTTRLRDILPDDSQLEQICKMAVPDECALTNPREATWADLMGICKEAW

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=310, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI48994951, Length=386, Percent_Identity=37.8238341968912, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=32.2666666666667, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87082107, Length=383, Percent_Identity=30.5483028720627, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787493, Length=386, Percent_Identity=29.5336787564767, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789386, Length=352, Percent_Identity=21.875, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537053, Length=271, Percent_Identity=25.830258302583, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321181, Length=383, Percent_Identity=34.4647519582245, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24657991, Length=388, Percent_Identity=23.1958762886598, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41489; Mature: 41358

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTKFAIPEVIFGNSSLRYLAQCALRLGARRIFLVSDPGLEKAGWVQHVIDILSEDRLE
CCCCHHCCCHHEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEE
CVYYNDVDSNPRDWQVHEGARLYTEERADLIIGLGGGSPIDAAKGIATIASNGGRIHDYE
EEEECCCCCCCCCCEECCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCC
GANRIMRPLPPMIFIPTTAGSGSDISQYCIITDVERQLKMSIISRSLVPNVSIIDPSLLL
CHHHHHHCCCCEEEEECCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHCCCCEEECCHHHH
TKTVELILASAIDALAHAVESYVSRLASPFTETQALYAIRLIMENLETAARTRNPAALEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSIASTAAGMSFSNAGLGIGHALAHSLGGRYDVLHGLVHPVLLPHVMRYNLPVCREKMDN
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAAVVLQSCDTAGTGRALEGIEQLEHMFRSLQVTTRLRDILPDDSQLEQICKMAVPDECA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
LTNPREATWADLMGICKEAW
CCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVTKFAIPEVIFGNSSLRYLAQCALRLGARRIFLVSDPGLEKAGWVQHVIDILSEDRLE
CCCHHCCCHHEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEE
CVYYNDVDSNPRDWQVHEGARLYTEERADLIIGLGGGSPIDAAKGIATIASNGGRIHDYE
EEEECCCCCCCCCCEECCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCC
GANRIMRPLPPMIFIPTTAGSGSDISQYCIITDVERQLKMSIISRSLVPNVSIIDPSLLL
CHHHHHHCCCCEEEEECCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHCCCCEEECCHHHH
TKTVELILASAIDALAHAVESYVSRLASPFTETQALYAIRLIMENLETAARTRNPAALEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSIASTAAGMSFSNAGLGIGHALAHSLGGRYDVLHGLVHPVLLPHVMRYNLPVCREKMDN
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAAVVLQSCDTAGTGRALEGIEQLEHMFRSLQVTTRLRDILPDDSQLEQICKMAVPDECA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
LTNPREATWADLMGICKEAW
CCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]