Click here to switch to the map view.

The map label for this gene is yiaY [H]

Identifier: 78358562

GI number: 78358562

Start: 3482018

End: 3483199

Strand: Direct

Name: yiaY [H]

Synonym: Dde_3523

Alternate gene names: 78358562

Gene position: 3482018-3483199 (Clockwise)

Preceding gene: 78358559

Following gene: 78358563

Centisome position: 93.35

GC content: 59.64

Gene sequence:

>1182_bases
ATGGCAGTACGTGAAGAAGTTTACGGCTTTTTTATTCCCAGCGTCACCCTGATGGGCATCGGTAGCCACAAGGAAATCCC
GGCCAAGATCAAGGCTCTGGGCGGCAAGAAGCCTCTGCTCGTAACTGACAAAGGTATCACCAAGGTCGGCCTGACCGAAA
AAATCGTCAAGCTGCTGAAAGACAACAAAATGGACTGCGTTGTCTACGATGAAACCATTCCCAACCCCACCGATGAAAAC
GTGCATGCCGGCGTGGACGTGTACAAGAAAAACAAGTGCGACTCGCTGATCACTCTGGGCGGCGGCAGCTCCCACGACTG
CGGCAAGGGTATCGGCCTTGTGGTCGCCAACGGCGGCAAAATTCATGATTTCGAAGGCGTGGACAAGTCCACCAAGCCCA
TGCCCCCCTACGTTGCCGTGAACACCACGGCGGGCACCGCCTCTGAAATGACCCGCTTCTGCATCATCACCGACACCTCC
CGCAAGGTCAAAATGGCCATCGTCGACTGGCGTGTTACTCCCACCATCGCCCTTGACGACCCGCTGCTGATGATGGGCAT
GCCCCCCGCACTGACCGCAGCCACCGGCATGGACGCCCTGACCCACGCCGTGGAAGCCTATGTTTCCACCATTGCCACCC
CCATGACCGACGCCTGCGCCGAAAAAGCCATCAAGCTTATCTTCCAGCACCTGCGTGCCGCAGTGGCCAACGGACAGGAC
GTGGTAGCCCGCGAAGGCATGTGCTACGCCCAGTACCTTGCCGGTATGGCGTTCAACAACGCAAGCGTGGGGCATGTGCA
CGCCATGGCGCACCAGCTGGGCGGTTTCTACGACCTGCCGCACGGCGAATGCAACGCCATCCTGCTGCCCCACGTGGAAA
AATTCAACCTGATAGCCAAGGTTGAGCGCTTTGCCGAAATGGCCCGCTGGATGGGCGAAAACACCGAAGGCCTGAGCCCC
CGCGCCGCAGCCGAAAAGTGCCTCGACGCCATCCGCCAGCTTTCCGCCGACGTGGGTATCCCCTCCGGCCTTATCGAGCT
GGGCAAGCGCTACGGCAAGGATGTGAAGGAATCTGATATTCCGACCATGACCGCCAACGCCCAGAAGGACGCCTGCGGTC
TTACCAACCCCCGCTGCCCCACCGATGCCGACGTGATGGCCATCTACAAGGCTGCTCTGTAA

Upstream 100 bases:

>100_bases
ACTTTGGCCCGTTCCTTGCCTATGGGAGAGCAACACTAATGCTCACGGCAAAGTCCACAGTTTTGCCACCAACACACAAA
CGGTAAGGATGGATAAAGTT

Downstream 100 bases:

>100_bases
CGCCTGCTTACAGCGGGGGAAAACCCCTTTTTTTCCCGCTGCCCTGCATATCCGCAGAACCCGCCGCCGGGGTCATCCTT
GGCCCCGGCGGTAATCTTTC

Product: alcohol dehydrogenase, iron-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MAVREEVYGFFIPSVTLMGIGSHKEIPAKIKALGGKKPLLVTDKGITKVGLTEKIVKLLKDNKMDCVVYDETIPNPTDEN
VHAGVDVYKKNKCDSLITLGGGSSHDCGKGIGLVVANGGKIHDFEGVDKSTKPMPPYVAVNTTAGTASEMTRFCIITDTS
RKVKMAIVDWRVTPTIALDDPLLMMGMPPALTAATGMDALTHAVEAYVSTIATPMTDACAEKAIKLIFQHLRAAVANGQD
VVAREGMCYAQYLAGMAFNNASVGHVHAMAHQLGGFYDLPHGECNAILLPHVEKFNLIAKVERFAEMARWMGENTEGLSP
RAAAEKCLDAIRQLSADVGIPSGLIELGKRYGKDVKESDIPTMTANAQKDACGLTNPRCPTDADVMAIYKAAL

Sequences:

>Translated_393_residues
MAVREEVYGFFIPSVTLMGIGSHKEIPAKIKALGGKKPLLVTDKGITKVGLTEKIVKLLKDNKMDCVVYDETIPNPTDEN
VHAGVDVYKKNKCDSLITLGGGSSHDCGKGIGLVVANGGKIHDFEGVDKSTKPMPPYVAVNTTAGTASEMTRFCIITDTS
RKVKMAIVDWRVTPTIALDDPLLMMGMPPALTAATGMDALTHAVEAYVSTIATPMTDACAEKAIKLIFQHLRAAVANGQD
VVAREGMCYAQYLAGMAFNNASVGHVHAMAHQLGGFYDLPHGECNAILLPHVEKFNLIAKVERFAEMARWMGENTEGLSP
RAAAEKCLDAIRQLSADVGIPSGLIELGKRYGKDVKESDIPTMTANAQKDACGLTNPRCPTDADVMAIYKAAL
>Mature_392_residues
AVREEVYGFFIPSVTLMGIGSHKEIPAKIKALGGKKPLLVTDKGITKVGLTEKIVKLLKDNKMDCVVYDETIPNPTDENV
HAGVDVYKKNKCDSLITLGGGSSHDCGKGIGLVVANGGKIHDFEGVDKSTKPMPPYVAVNTTAGTASEMTRFCIITDTSR
KVKMAIVDWRVTPTIALDDPLLMMGMPPALTAATGMDALTHAVEAYVSTIATPMTDACAEKAIKLIFQHLRAAVANGQDV
VAREGMCYAQYLAGMAFNNASVGHVHAMAHQLGGFYDLPHGECNAILLPHVEKFNLIAKVERFAEMARWMGENTEGLSPR
AAAEKCLDAIRQLSADVGIPSGLIELGKRYGKDVKESDIPTMTANAQKDACGLTNPRCPTDADVMAIYKAAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=416, Percent_Identity=27.4038461538462, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994951, Length=384, Percent_Identity=55.9895833333333, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1789163, Length=377, Percent_Identity=40.3183023872679, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082107, Length=389, Percent_Identity=34.4473007712082, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1787493, Length=387, Percent_Identity=33.5917312661499, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789386, Length=354, Percent_Identity=24.5762711864407, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=26.463700234192, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321181, Length=389, Percent_Identity=49.8714652956298, Blast_Score=372, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24657991, Length=428, Percent_Identity=26.4018691588785, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 42078; Mature: 41947

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVREEVYGFFIPSVTLMGIGSHKEIPAKIKALGGKKPLLVTDKGITKVGLTEKIVKLLK
CCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
DNKMDCVVYDETIPNPTDENVHAGVDVYKKNKCDSLITLGGGSSHDCGKGIGLVVANGGK
CCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCCE
IHDFEGVDKSTKPMPPYVAVNTTAGTASEMTRFCIITDTSRKVKMAIVDWRVTPTIALDD
EECCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEEECCEEEECC
PLLMMGMPPALTAATGMDALTHAVEAYVSTIATPMTDACAEKAIKLIFQHLRAAVANGQD
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
VVAREGMCYAQYLAGMAFNNASVGHVHAMAHQLGGFYDLPHGECNAILLPHVEKFNLIAK
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEECCCCCCCCEEECCCCHHHHHHHH
VERFAEMARWMGENTEGLSPRAAAEKCLDAIRQLSADVGIPSGLIELGKRYGKDVKESDI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
PTMTANAQKDACGLTNPRCPTDADVMAIYKAAL
CCEECCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AVREEVYGFFIPSVTLMGIGSHKEIPAKIKALGGKKPLLVTDKGITKVGLTEKIVKLLK
CCHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHH
DNKMDCVVYDETIPNPTDENVHAGVDVYKKNKCDSLITLGGGSSHDCGKGIGLVVANGGK
CCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCCE
IHDFEGVDKSTKPMPPYVAVNTTAGTASEMTRFCIITDTSRKVKMAIVDWRVTPTIALDD
EECCCCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEEEEECCEEEECC
PLLMMGMPPALTAATGMDALTHAVEAYVSTIATPMTDACAEKAIKLIFQHLRAAVANGQD
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH
VVAREGMCYAQYLAGMAFNNASVGHVHAMAHQLGGFYDLPHGECNAILLPHVEKFNLIAK
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEECCCCCCCCEEECCCCHHHHHHHH
VERFAEMARWMGENTEGLSPRAAAEKCLDAIRQLSADVGIPSGLIELGKRYGKDVKESDI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
PTMTANAQKDACGLTNPRCPTDADVMAIYKAAL
CCEECCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]