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The map label for this gene is purE [H]

Identifier: 78358498

GI number: 78358498

Start: 3420694

End: 3421200

Strand: Direct

Name: purE [H]

Synonym: Dde_3459

Alternate gene names: 78358498

Gene position: 3420694-3421200 (Clockwise)

Preceding gene: 78358497

Following gene: 78358501

Centisome position: 91.7

GC content: 62.13

Gene sequence:

>507_bases
ATGCCTCAGGTCGGCATTTTCATCGGAAGCATCTCTGACGAGGAAACCCTGCGCCCCTGCACCGAGGTGCTGGACAAGCT
GGGCATCAGCTATCTGTTTACTGTCAGTTCCGCGCACCGTACCCCTGAACGCACGGAATCGCTGGTGGATACGCTGGAAA
AAGACGGCTGTCAGGTCTTTATCTGTGCCGCAGGCATGGCCGCCCATCTGGCGGGCGCCGTGGCCGCACGCACTCTGCGC
CCTGTCATCGGGGTACCTGTCACCGCCTCAAAACTGGGCGGCATGGATGCGCTGCTGGCAACGGTGCAGATGCCTCCCGG
ATATCCGGTGGGCACCGTGGCACTGGACAAGGCAGGCGCCAAAAACGCAGGCTGGTTTGCCGCGCAGATAATCGCCCTGA
ACAACCCGGAACTGGCACAGCGCCTTGCCGCGGCACGCAAGGAGTTCACCGCCGAGGTGATACGCGCCGGAGAAGATCTG
GAACGCCGTATGGCACAGGGCAGATAA

Upstream 100 bases:

>100_bases
GCGTAATACATCTTCAGCGGGGCACAGCTCCGCAACCGGGACTGCGGGCCGCCTGTGCGGCCCGCTCTGATATCCACCAT
CAACCTGTATGGAGTAGACA

Downstream 100 bases:

>100_bases
TCCCTGTCCTCAGACCGAAAGCAAGGGCCGTGATCGCATGCGATCACGGCCCTTTTCTGCTTTTCTGCACAGGTTGCCTT
TACGCCGTGCCGAAAACATC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MPQVGIFIGSISDEETLRPCTEVLDKLGISYLFTVSSAHRTPERTESLVDTLEKDGCQVFICAAGMAAHLAGAVAARTLR
PVIGVPVTASKLGGMDALLATVQMPPGYPVGTVALDKAGAKNAGWFAAQIIALNNPELAQRLAAARKEFTAEVIRAGEDL
ERRMAQGR

Sequences:

>Translated_168_residues
MPQVGIFIGSISDEETLRPCTEVLDKLGISYLFTVSSAHRTPERTESLVDTLEKDGCQVFICAAGMAAHLAGAVAARTLR
PVIGVPVTASKLGGMDALLATVQMPPGYPVGTVALDKAGAKNAGWFAAQIIALNNPELAQRLAAARKEFTAEVIRAGEDL
ERRMAQGR
>Mature_167_residues
PQVGIFIGSISDEETLRPCTEVLDKLGISYLFTVSSAHRTPERTESLVDTLEKDGCQVFICAAGMAAHLAGAVAARTLRP
VIGVPVTASKLGGMDALLATVQMPPGYPVGTVALDKAGAKNAGWFAAQIIALNNPELAQRLAAARKEFTAEVIRAGEDLE
RRMAQGR

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=152, Percent_Identity=48.6842105263158, Blast_Score=112, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=160, Percent_Identity=38.75, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17748; Mature: 17617

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVGIFIGSISDEETLRPCTEVLDKLGISYLFTVSSAHRTPERTESLVDTLEKDGCQVF
CCCCEEEEECCCCCHHHHHHHHHHHHCCHHHEEEEHHCCCCHHHHHHHHHHHHHCCCEEE
ICAAGMAAHLAGAVAARTLRPVIGVPVTASKLGGMDALLATVQMPPGYPVGTVALDKAGA
EECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCCCCCEEECCCCC
KNAGWFAAQIIALNNPELAQRLAAARKEFTAEVIRAGEDLERRMAQGR
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
PQVGIFIGSISDEETLRPCTEVLDKLGISYLFTVSSAHRTPERTESLVDTLEKDGCQVF
CCCEEEEECCCCCHHHHHHHHHHHHCCHHHEEEEHHCCCCHHHHHHHHHHHHHCCCEEE
ICAAGMAAHLAGAVAARTLRPVIGVPVTASKLGGMDALLATVQMPPGYPVGTVALDKAGA
EECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCCCCCEEECCCCC
KNAGWFAAQIIALNNPELAQRLAAARKEFTAEVIRAGEDLERRMAQGR
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]