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The map label for this gene is trxC [H]

Identifier: 78358455

GI number: 78358455

Start: 3377992

End: 3378432

Strand: Direct

Name: trxC [H]

Synonym: Dde_3416

Alternate gene names: 78358455

Gene position: 3377992-3378432 (Clockwise)

Preceding gene: 78358454

Following gene: 78358456

Centisome position: 90.56

GC content: 60.54

Gene sequence:

>441_bases
ATGAGTGACAGCATTCATATCGTCTGCCCACACTGCCAATCCATCAATCGCGTGCCAGCCAACAAGTTGGCAGAGAAGCC
CAATTGCGGGCGGTGCCAGCACCCGCTGTTCACCGGAGAACCCATTGATCTGACCACAGCGACCTTCGCCCGTCATCTGG
AGCGCAGTGACCTGCCGCTGCTGGTTGACTTTTGGGCGCCGTGGTGCGGGCCGTGCAAGATGATGGCGCCGCAGTTCGAG
CAGGCAGCCTCCCTGCTTGAACCCAAGGTGAGGTTGGCCAAGGTAAATACCGAGGCCGAGCCTCACCTGGCCGCCCAGTT
CGGTATTCGCAGCATTCCAACCCTGATTTTGTTCCGAGGGGGACATGAGGTTGCACGTCAGACGGGCGCCATGGGCGCGC
AGGACATTATGCGCTGGGTGACATCCCGCTTGCCGCAATGA

Upstream 100 bases:

>100_bases
GCATCCGGCAACTGACGCAAGGGCTACAGCTCGAATCCCCATGTCACAGCGGCCCAACTGCCGGAGCCATTACTTCCTCT
GTGTCCAAAGGAGCCGCCTC

Downstream 100 bases:

>100_bases
CGCGGCGCGAACCACCCTGCTTATCAGTTGTTCGATCCTTGAGGAAAGTGCGTAGCCGCGATGCATAGCGACCCCAACCA
CACAATCTTTGACGAAATGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MSDSIHIVCPHCQSINRVPANKLAEKPNCGRCQHPLFTGEPIDLTTATFARHLERSDLPLLVDFWAPWCGPCKMMAPQFE
QAASLLEPKVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQTGAMGAQDIMRWVTSRLPQ

Sequences:

>Translated_146_residues
MSDSIHIVCPHCQSINRVPANKLAEKPNCGRCQHPLFTGEPIDLTTATFARHLERSDLPLLVDFWAPWCGPCKMMAPQFE
QAASLLEPKVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQTGAMGAQDIMRWVTSRLPQ
>Mature_145_residues
SDSIHIVCPHCQSINRVPANKLAEKPNCGRCQHPLFTGEPIDLTTATFARHLERSDLPLLVDFWAPWCGPCKMMAPQFEQ
AASLLEPKVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQTGAMGAQDIMRWVTSRLPQ

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=89, Percent_Identity=42.6966292134831, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI94966757, Length=90, Percent_Identity=41.1111111111111, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI21361657, Length=78, Percent_Identity=42.3076923076923, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4758304, Length=81, Percent_Identity=44.4444444444444, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI224493972, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI42794771, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI5031973, Length=77, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI24308127, Length=76, Percent_Identity=38.1578947368421, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361403, Length=81, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=47.1428571428571, Blast_Score=145, Evalue=7e-37,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=39.8058252427184, Blast_Score=93, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17549970, Length=107, Percent_Identity=37.3831775700935, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25144092, Length=107, Percent_Identity=35.5140186915888, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=100, Percent_Identity=29, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=105, Percent_Identity=35.2380952380952, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=103, Percent_Identity=33.9805825242718, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=29.5238095238095, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=105, Percent_Identity=31.4285714285714, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=105, Percent_Identity=31.4285714285714, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=87, Percent_Identity=34.4827586206897, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=36.046511627907, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647799, Length=87, Percent_Identity=44.8275862068966, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=114, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921434, Length=106, Percent_Identity=35.8490566037736, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358065, Length=102, Percent_Identity=30.3921568627451, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859803, Length=107, Percent_Identity=30.8411214953271, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16237; Mature: 16106

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSIHIVCPHCQSINRVPANKLAEKPNCGRCQHPLFTGEPIDLTTATFARHLERSDLPL
CCCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
LVDFWAPWCGPCKMMAPQFEQAASLLEPKVRLAKVNTEAEPHLAAQFGIRSIPTLILFRG
EEECCCCCCCCHHHCCCCHHHHHHHHCCCHHEEECCCCCCCHHHHHHCHHHCCEEEEECC
GHEVARQTGAMGAQDIMRWVTSRLPQ
CHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDSIHIVCPHCQSINRVPANKLAEKPNCGRCQHPLFTGEPIDLTTATFARHLERSDLPL
CCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
LVDFWAPWCGPCKMMAPQFEQAASLLEPKVRLAKVNTEAEPHLAAQFGIRSIPTLILFRG
EEECCCCCCCCHHHCCCCHHHHHHHHCCCHHEEECCCCCCCHHHHHHCHHHCCEEEEECC
GHEVARQTGAMGAQDIMRWVTSRLPQ
CHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]