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The map label for this gene is atoC [H]

Identifier: 78358274

GI number: 78358274

Start: 3225340

End: 3226767

Strand: Direct

Name: atoC [H]

Synonym: Dde_3234

Alternate gene names: 78358274

Gene position: 3225340-3226767 (Clockwise)

Preceding gene: 78358273

Following gene: 78358275

Centisome position: 86.46

GC content: 59.38

Gene sequence:

>1428_bases
ATGCCCAGAATACTGGTCATAGACGACGACACCATCGTTTGCGAAACCATCGAAAGCCTGCTTTCGCGCCTGCAGTACCA
GAGCCGCTCGGCCCATACGCTGGAACAGGGTCTGCAGCTGCTTGCCGCGGAAGAATTTGACGTGGTGTTTCTGGACGTGC
GCCTGCCCGACGGTAACGGACTGGAGGCTCTGCCGCGAATCCGCAGTCACGAAAACAGCCCGGAAGTAATAATACTGACC
GGCGAAGGCGACCCCGACGGAGCGGAGCTGGCCATACAGGGCGGCGTGTGGGACTATCTGGTCAAACCCACGCCCATCAA
GCAGACCACCCTTACCCTGAACAGGGCGCTGCAGTACCGGCAGGAAAAACTGAACAAGCAGGCGGCGCCGCCCGTGGCGC
TTAATCTGGACGGCGTGGTGGGCAGCAGCGAACGCATCCGCGAATCGTTCGACATTGTGGCGCGTGCCGCATCCACTGAC
ACCAATGTGCTTATCACCGGCGAAACAGGCACCGGCAAAGAGCTTTTCGCCCGCACCATACACAGAAACTGCGGACGTGC
CGGCGGCCCTTTCGTGGTGGTGGACTGCGCGTCACTGACGGAAACCCTCATCGAATCAACACTGTTCGGGCATAAAAAAG
GCGCTTTCACAGGGGCCGAAGCTGATCAGGAAGGGCTGGCCAAACTGGCCGACGGCGGCACTCTTTTTCTGGACGAAGTA
GGGGAAATGCCCCTTTCGCTGCAACGGTCCTTTCTGCGTTTTTTGCAGGAACGCACCTTCAGACCGGTGGGCGGCACACA
GGAAGTGAAAAGCGACTTCAGGCTTATTTCGGCCACAAACAGAGATCTGGATGCCATGGTGGAACGCGGAGAGTTCCGCA
AGGACCTGCTTTTCCGGCTCAAGACGCTGCACGTGGTGCTGCCCCCGCTGCGACAGCGCCTGACCGACCTGAAACCCCTT
GCCATGTACTACATCGACAAACTGTGCGAGCAGTACAACGTGCCCAACAAGGGTTTCAGCTCCGACTTTTTCACCCTGCT
TGCACGCCATGACTGGCCGGGCAACGTCCGCGAGCTTTTCAACGTGCTGGAGCGGGCGTTTGTGGCTTCCGGGCTGGAAA
GCATGCTGTACGCCATGCATCTGCCGCAGGACCTGCGCATCAAGGCGGCCAAGGCGCACCTGCTGCGCGAACAGCCGGAC
GAACTGCCCGCCCGCGGACAGACCGGCTGCGCCCGCAATCAGCAGGATGCCGACGGGCTGCCCTGTCCGCTGCCGGACAT
GCGGTCGTTCAAGCACATGATGGAACGAAAATATCTGGAAAGCGTCATAGCGCGCCACAAAGGTGATCTGCCCGCGATTC
TGGAGACTTCCGGTCTGTCCCGTTCGCATTTTTATGCGTTGCTGAAAAAGAACAACATTGTGCTTTGA

Upstream 100 bases:

>100_bases
GGCATTTCCCAACATCAAAGCCATTGTTCCCAAGCCGTACAACCGCAACATCCTTTCCGAAACCATCCGCAAGGTTCTCG
GGTAATCAACGGAACGCACC

Downstream 100 bases:

>100_bases
TTGTTGGCGCCATGCTGTTGTATGCTGTACCTGACGGACGTTCCCGTGAACTTGCGCTGTCCTGTTTTTCAGACACGACA
CCAGTCCGCTTTTTCAGACA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MPRILVIDDDTIVCETIESLLSRLQYQSRSAHTLEQGLQLLAAEEFDVVFLDVRLPDGNGLEALPRIRSHENSPEVIILT
GEGDPDGAELAIQGGVWDYLVKPTPIKQTTLTLNRALQYRQEKLNKQAAPPVALNLDGVVGSSERIRESFDIVARAASTD
TNVLITGETGTGKELFARTIHRNCGRAGGPFVVVDCASLTETLIESTLFGHKKGAFTGAEADQEGLAKLADGGTLFLDEV
GEMPLSLQRSFLRFLQERTFRPVGGTQEVKSDFRLISATNRDLDAMVERGEFRKDLLFRLKTLHVVLPPLRQRLTDLKPL
AMYYIDKLCEQYNVPNKGFSSDFFTLLARHDWPGNVRELFNVLERAFVASGLESMLYAMHLPQDLRIKAAKAHLLREQPD
ELPARGQTGCARNQQDADGLPCPLPDMRSFKHMMERKYLESVIARHKGDLPAILETSGLSRSHFYALLKKNNIVL

Sequences:

>Translated_475_residues
MPRILVIDDDTIVCETIESLLSRLQYQSRSAHTLEQGLQLLAAEEFDVVFLDVRLPDGNGLEALPRIRSHENSPEVIILT
GEGDPDGAELAIQGGVWDYLVKPTPIKQTTLTLNRALQYRQEKLNKQAAPPVALNLDGVVGSSERIRESFDIVARAASTD
TNVLITGETGTGKELFARTIHRNCGRAGGPFVVVDCASLTETLIESTLFGHKKGAFTGAEADQEGLAKLADGGTLFLDEV
GEMPLSLQRSFLRFLQERTFRPVGGTQEVKSDFRLISATNRDLDAMVERGEFRKDLLFRLKTLHVVLPPLRQRLTDLKPL
AMYYIDKLCEQYNVPNKGFSSDFFTLLARHDWPGNVRELFNVLERAFVASGLESMLYAMHLPQDLRIKAAKAHLLREQPD
ELPARGQTGCARNQQDADGLPCPLPDMRSFKHMMERKYLESVIARHKGDLPAILETSGLSRSHFYALLKKNNIVL
>Mature_474_residues
PRILVIDDDTIVCETIESLLSRLQYQSRSAHTLEQGLQLLAAEEFDVVFLDVRLPDGNGLEALPRIRSHENSPEVIILTG
EGDPDGAELAIQGGVWDYLVKPTPIKQTTLTLNRALQYRQEKLNKQAAPPVALNLDGVVGSSERIRESFDIVARAASTDT
NVLITGETGTGKELFARTIHRNCGRAGGPFVVVDCASLTETLIESTLFGHKKGAFTGAEADQEGLAKLADGGTLFLDEVG
EMPLSLQRSFLRFLQERTFRPVGGTQEVKSDFRLISATNRDLDAMVERGEFRKDLLFRLKTLHVVLPPLRQRLTDLKPLA
MYYIDKLCEQYNVPNKGFSSDFFTLLARHDWPGNVRELFNVLERAFVASGLESMLYAMHLPQDLRIKAAKAHLLREQPDE
LPARGQTGCARNQQDADGLPCPLPDMRSFKHMMERKYLESVIARHKGDLPAILETSGLSRSHFYALLKKNNIVL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=400, Percent_Identity=40, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1790437, Length=365, Percent_Identity=40.2739726027397, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1790299, Length=402, Percent_Identity=37.3134328358209, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788905, Length=483, Percent_Identity=32.712215320911, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI87082117, Length=256, Percent_Identity=43.359375, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1789233, Length=238, Percent_Identity=41.1764705882353, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI87081872, Length=338, Percent_Identity=38.1656804733728, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789087, Length=230, Percent_Identity=46.5217391304348, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786524, Length=236, Percent_Identity=44.0677966101695, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082152, Length=269, Percent_Identity=42.0074349442379, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1787583, Length=229, Percent_Identity=40.174672489083, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789828, Length=220, Percent_Identity=40, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=216, Percent_Identity=28.7037037037037, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53004; Mature: 52873

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRILVIDDDTIVCETIESLLSRLQYQSRSAHTLEQGLQLLAAEEFDVVFLDVRLPDGNG
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
LEALPRIRSHENSPEVIILTGEGDPDGAELAIQGGVWDYLVKPTPIKQTTLTLNRALQYR
HHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHH
QEKLNKQAAPPVALNLDGVVGSSERIRESFDIVARAASTDTNVLITGETGTGKELFARTI
HHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HRNCGRAGGPFVVVDCASLTETLIESTLFGHKKGAFTGAEADQEGLAKLADGGTLFLDEV
HHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEHHHH
GEMPLSLQRSFLRFLQERTFRPVGGTQEVKSDFRLISATNRDLDAMVERGEFRKDLLFRL
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
KTLHVVLPPLRQRLTDLKPLAMYYIDKLCEQYNVPNKGFSSDFFTLLARHDWPGNVRELF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHH
NVLERAFVASGLESMLYAMHLPQDLRIKAAKAHLLREQPDELPARGQTGCARNQQDADGL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PCPLPDMRSFKHMMERKYLESVIARHKGDLPAILETSGLSRSHFYALLKKNNIVL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PRILVIDDDTIVCETIESLLSRLQYQSRSAHTLEQGLQLLAAEEFDVVFLDVRLPDGNG
CEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
LEALPRIRSHENSPEVIILTGEGDPDGAELAIQGGVWDYLVKPTPIKQTTLTLNRALQYR
HHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHH
QEKLNKQAAPPVALNLDGVVGSSERIRESFDIVARAASTDTNVLITGETGTGKELFARTI
HHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
HRNCGRAGGPFVVVDCASLTETLIESTLFGHKKGAFTGAEADQEGLAKLADGGTLFLDEV
HHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEHHHH
GEMPLSLQRSFLRFLQERTFRPVGGTQEVKSDFRLISATNRDLDAMVERGEFRKDLLFRL
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
KTLHVVLPPLRQRLTDLKPLAMYYIDKLCEQYNVPNKGFSSDFFTLLARHDWPGNVRELF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHH
NVLERAFVASGLESMLYAMHLPQDLRIKAAKAHLLREQPDELPARGQTGCARNQQDADGL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PCPLPDMRSFKHMMERKYLESVIARHKGDLPAILETSGLSRSHFYALLKKNNIVL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]