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The map label for this gene is capL [H]

Identifier: 78358227

GI number: 78358227

Start: 3174504

End: 3175817

Strand: Direct

Name: capL [H]

Synonym: Dde_3187

Alternate gene names: 78358227

Gene position: 3174504-3175817 (Clockwise)

Preceding gene: 78358225

Following gene: 78358228

Centisome position: 85.1

GC content: 59.82

Gene sequence:

>1314_bases
ATGATCAGGTTTGAAGAACTTACCGACGCAAATGCCGCCGTGGCCGTTGTGGGTCTCGGCTATGTTGGGCTGCCTCTTGC
CGTGGCCTTAAGCGAACACTTCCGCGTGATCGGCTTTGACATTTCGCAACGCCGCGTGGATGCCCTCATCAAAGGTGAAG
ACGCCACAGGCGAAGTGGAAAATTCCCGGCTGGCGGCGTGCAAGGCAGAATTTACCGCAGACCCCGCGCGCATAGGTCAG
GCGGACATTGTCATCGTGGCCGTGCCCACGCCCATCGACGGCAATCGCCGGCCCGATCTTTTTCCGGTGGAAAGCGCCTC
ACGCACTGTGGGCCGCACCATGAAAAAAGGCTGCGTGGTGGTATACGAATCCACGGTATACCCCGGCCTTACCGAAGAAA
TCTGCGTGCCCATTCTTGAAAAAGAATCGGGCATGAAATTCGGCACCGACTTCACCGTGGGCTATTCGCCCGAGCGCATC
AATCCGGGCGACAAAGTTCACACCCTCGAAACCATCGTCAAGGTTGTTTCCGGCAGCGATGAAGCCACGGCGGACCTGCT
GCAGCGCATGTACGGCACAGTGGTCACCGCCGGAACATTCCGCGCATCCAGCATCCGCGTTGCCGAGGCAGCAAAGGTCA
TCGAAAACACCCAGAGAGACCTGAACATCGCTCTTATGAACGAACTGGCGCTGCTGTTCGACCGCATGGACATCGACACG
CTGGAAGTGCTTGAAGCAGCCGGCACCAAATGGAATTTCCTGCCGTTCCGTCCCGGTCTCGTGGGCGGCCACTGCATCGG
CGTCGACCCGTACTATCTCACCTTCAAGGCCGAAGCGCTGGGACACCACCCGCAGGTCATTCTTGCCGGACGCCGCATCA
ATGACGGCATGGGCAAATTCGTGGCCGAAACCTGCGTGAAAAAAATGATCCGCAAAGGCAACGTGGTGGCCGGTTCCCGC
GTGGGCGTGCTGGGGCTTACCTTTAAGGAAAACGTACCCGACCTGCGCAACACCCGCGTGGTGGACGTGATTGACGAACT
GCGCGACTACGGCGTGCATGTGCTGGTGCACGACCCGCAGGCCGACCCCGCGGAAGCCCACGAAGAATACGGCCTGACCC
TGACCGGTCTGGACACCCTGCGCGAGCTGGATGCTGTTATTCTGGCCGTACCGCACGCGGAATACGACGCACTGCAGGCA
CAGGATATCCGCGGCTGGTTCCGCGATCCGCAAAAAGCCCTGCTGCTGGATATCAAAGGCGCAAAGTCGCCCGCCGCGTT
CACTGACGCCGGTTTTGACTACTGGCGCCTGTAA

Upstream 100 bases:

>100_bases
CCATGTCCAGCACGGGCTGCACGGACATTCCCGCGCGGCAGTGCAGGACAGACTCTGAACACCCCGACCGGACAATGCTT
TTTTTTCGGAGAAAACCGCA

Downstream 100 bases:

>100_bases
CGGCACCGTTTTGTTTGCGGCGCCTATGCCCCCGCACACCGCCCCTTCGCTTTACAGGAGGGGCGGTGCACTATAAAAGC
ACCGGAACTGCAACCCGTTA

Product: UDP-glucose/GDP-mannose dehydrogenase family protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MIRFEELTDANAAVAVVGLGYVGLPLAVALSEHFRVIGFDISQRRVDALIKGEDATGEVENSRLAACKAEFTADPARIGQ
ADIVIVAVPTPIDGNRRPDLFPVESASRTVGRTMKKGCVVVYESTVYPGLTEEICVPILEKESGMKFGTDFTVGYSPERI
NPGDKVHTLETIVKVVSGSDEATADLLQRMYGTVVTAGTFRASSIRVAEAAKVIENTQRDLNIALMNELALLFDRMDIDT
LEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEALGHHPQVILAGRRINDGMGKFVAETCVKKMIRKGNVVAGSR
VGVLGLTFKENVPDLRNTRVVDVIDELRDYGVHVLVHDPQADPAEAHEEYGLTLTGLDTLRELDAVILAVPHAEYDALQA
QDIRGWFRDPQKALLLDIKGAKSPAAFTDAGFDYWRL

Sequences:

>Translated_437_residues
MIRFEELTDANAAVAVVGLGYVGLPLAVALSEHFRVIGFDISQRRVDALIKGEDATGEVENSRLAACKAEFTADPARIGQ
ADIVIVAVPTPIDGNRRPDLFPVESASRTVGRTMKKGCVVVYESTVYPGLTEEICVPILEKESGMKFGTDFTVGYSPERI
NPGDKVHTLETIVKVVSGSDEATADLLQRMYGTVVTAGTFRASSIRVAEAAKVIENTQRDLNIALMNELALLFDRMDIDT
LEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEALGHHPQVILAGRRINDGMGKFVAETCVKKMIRKGNVVAGSR
VGVLGLTFKENVPDLRNTRVVDVIDELRDYGVHVLVHDPQADPAEAHEEYGLTLTGLDTLRELDAVILAVPHAEYDALQA
QDIRGWFRDPQKALLLDIKGAKSPAAFTDAGFDYWRL
>Mature_437_residues
MIRFEELTDANAAVAVVGLGYVGLPLAVALSEHFRVIGFDISQRRVDALIKGEDATGEVENSRLAACKAEFTADPARIGQ
ADIVIVAVPTPIDGNRRPDLFPVESASRTVGRTMKKGCVVVYESTVYPGLTEEICVPILEKESGMKFGTDFTVGYSPERI
NPGDKVHTLETIVKVVSGSDEATADLLQRMYGTVVTAGTFRASSIRVAEAAKVIENTQRDLNIALMNELALLFDRMDIDT
LEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEALGHHPQVILAGRRINDGMGKFVAETCVKKMIRKGNVVAGSR
VGVLGLTFKENVPDLRNTRVVDVIDELRDYGVHVLVHDPQADPAEAHEEYGLTLTGLDTLRELDAVILAVPHAEYDALQA
QDIRGWFRDPQKALLLDIKGAKSPAAFTDAGFDYWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=380, Percent_Identity=24.7368421052632, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI48994968, Length=422, Percent_Identity=29.3838862559242, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560350, Length=400, Percent_Identity=24.5, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47677; Mature: 47677

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFEELTDANAAVAVVGLGYVGLPLAVALSEHFRVIGFDISQRRVDALIKGEDATGEVE
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCEEEEECHHHHHHHHHEECCCCCCCCC
NSRLAACKAEFTADPARIGQADIVIVAVPTPIDGNRRPDLFPVESASRTVGRTMKKGCVV
CCEEEEEEHHCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEE
VYESTVYPGLTEEICVPILEKESGMKFGTDFTVGYSPERINPGDKVHTLETIVKVVSGSD
EEECCCCCCCHHHHHHHHHCCCCCCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
EATADLLQRMYGTVVTAGTFRASSIRVAEAAKVIENTQRDLNIALMNELALLFDRMDIDT
HHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHH
LEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEALGHHPQVILAGRRINDGMGKF
HHHHHHCCCCCCEECCCCCCCCCEEEECCCEEEEEEHHHCCCCCEEEEECCCCCCHHHHH
VAETCVKKMIRKGNVVAGSRVGVLGLTFKENVPDLRNTRVVDVIDELRDYGVHVLVHDPQ
HHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
ADPAEAHEEYGLTLTGLDTLRELDAVILAVPHAEYDALQAQDIRGWFRDPQKALLLDIKG
CCHHHHHHHCCCEEECHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECC
AKSPAAFTDAGFDYWRL
CCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MIRFEELTDANAAVAVVGLGYVGLPLAVALSEHFRVIGFDISQRRVDALIKGEDATGEVE
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCEEEEECHHHHHHHHHEECCCCCCCCC
NSRLAACKAEFTADPARIGQADIVIVAVPTPIDGNRRPDLFPVESASRTVGRTMKKGCVV
CCEEEEEEHHCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEE
VYESTVYPGLTEEICVPILEKESGMKFGTDFTVGYSPERINPGDKVHTLETIVKVVSGSD
EEECCCCCCCHHHHHHHHHCCCCCCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
EATADLLQRMYGTVVTAGTFRASSIRVAEAAKVIENTQRDLNIALMNELALLFDRMDIDT
HHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHH
LEVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTFKAEALGHHPQVILAGRRINDGMGKF
HHHHHHCCCCCCEECCCCCCCCCEEEECCCEEEEEEHHHCCCCCEEEEECCCCCCHHHHH
VAETCVKKMIRKGNVVAGSRVGVLGLTFKENVPDLRNTRVVDVIDELRDYGVHVLVHDPQ
HHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
ADPAEAHEEYGLTLTGLDTLRELDAVILAVPHAEYDALQAQDIRGWFRDPQKALLLDIKG
CCHHHHHHHCCCEEECHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECC
AKSPAAFTDAGFDYWRL
CCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]