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The map label for this gene is ubiE [H]

Identifier: 78358225

GI number: 78358225

Start: 3173454

End: 3174176

Strand: Direct

Name: ubiE [H]

Synonym: Dde_3185

Alternate gene names: 78358225

Gene position: 3173454-3174176 (Clockwise)

Preceding gene: 78358224

Following gene: 78358227

Centisome position: 85.07

GC content: 58.37

Gene sequence:

>723_bases
ATGAAGCACACAGACAGTCAGGAACACGCCTGCAATGTTTCAGGCATGTTCGGCCGCATTGCAGGCTGCTACGATTTTCT
CAATCATTTTCTGAGCGTCGGCATGGACTACTGGTGGCGTTACGAACTCGTGCGTCAGATAATACCCGGCCCCACGGGGC
GGGTGCTTGATCTGGCCGCGGGCACGTACGACGTTTCGCTGGAAATAAGACGACAGTACCCGCACATGCGGGTTGCCGCG
CTGGATTACTGCCTGCCCATGCTGACCACGGGCAAAAAAAAGCTGCGCGGTCTCAAAGGCGCCGGAGTCTATCCCGCACA
GGGCGACGGCAGGCATCTGCCGCTCGCGGACAACAGCGTAGACTGCGCCACCATAGCCTTCGGCATACGCAACATCATTC
CCCGTGAAGAGGCCTTCCGCGAAATTCTGCGGGTGCTGGTACCCGGCGGCAGGCTTTGTGTGCTGGAATTCGGTTCAGGC
AAAAACAAGGTGTGGAAAGGGCTGTACAATTTTTACCTGCAACACGCCCTGCCCCGCATCGGCAAAATTTTTTCAGGCGA
CGACAGCGCGTACCGCTATCTGGCCGACACCATCATCGCCTTTCCCGATGCGCGGGAACTGGCGCAGGAAATGCGTGACG
CCGGTTTTGCACGGGTGCTTCACCGGCCGCTTACTTCGGGCATAGTCCAGCTGCATGTGGCGCAGAAGGCTAACCGGAAA
TGA

Upstream 100 bases:

>100_bases
AACTTCGGAGAAATGTTCCCCGCTGTATACAACGTGGTCTTTGAAACCATCTGCGCCGGCAGCAGCCAGCCCCAGCGCGA
AAGCGCGGAATAATCCGTCG

Downstream 100 bases:

>100_bases
AATAATAACGGGCCAGCGCCACAGCCCCGACGCCCAGCAGCATCATGACCAGACCGGTAATGCGCAGATGGGCGGTTCTG
GTTTCCGCAAGGGCGCGCAG

Product: demethylmenaquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKHTDSQEHACNVSGMFGRIAGCYDFLNHFLSVGMDYWWRYELVRQIIPGPTGRVLDLAAGTYDVSLEIRRQYPHMRVAA
LDYCLPMLTTGKKKLRGLKGAGVYPAQGDGRHLPLADNSVDCATIAFGIRNIIPREEAFREILRVLVPGGRLCVLEFGSG
KNKVWKGLYNFYLQHALPRIGKIFSGDDSAYRYLADTIIAFPDARELAQEMRDAGFARVLHRPLTSGIVQLHVAQKANRK

Sequences:

>Translated_240_residues
MKHTDSQEHACNVSGMFGRIAGCYDFLNHFLSVGMDYWWRYELVRQIIPGPTGRVLDLAAGTYDVSLEIRRQYPHMRVAA
LDYCLPMLTTGKKKLRGLKGAGVYPAQGDGRHLPLADNSVDCATIAFGIRNIIPREEAFREILRVLVPGGRLCVLEFGSG
KNKVWKGLYNFYLQHALPRIGKIFSGDDSAYRYLADTIIAFPDARELAQEMRDAGFARVLHRPLTSGIVQLHVAQKANRK
>Mature_240_residues
MKHTDSQEHACNVSGMFGRIAGCYDFLNHFLSVGMDYWWRYELVRQIIPGPTGRVLDLAAGTYDVSLEIRRQYPHMRVAA
LDYCLPMLTTGKKKLRGLKGAGVYPAQGDGRHLPLADNSVDCATIAFGIRNIIPREEAFREILRVLVPGGRLCVLEFGSG
KNKVWKGLYNFYLQHALPRIGKIFSGDDSAYRYLADTIIAFPDARELAQEMRDAGFARVLHRPLTSGIVQLHVAQKANRK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=32.4528301886792, Blast_Score=137, Evalue=7e-33,
Organism=Escherichia coli, GI48994983, Length=230, Percent_Identity=38.2608695652174, Blast_Score=147, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17557039, Length=237, Percent_Identity=33.7552742616034, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323526, Length=237, Percent_Identity=27.0042194092827, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641702, Length=240, Percent_Identity=32.0833333333333, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26968; Mature: 26968

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure
MKHTDSQEHACNVSGMFGRIAGCYDFLNHFLSVGMDYWWRYELVRQIIPGPTGRVLDLAA
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEEEC
GTYDVSLEIRRQYPHMRVAALDYCLPMLTTGKKKLRGLKGAGVYPAQGDGRHLPLADNSV
CCEEEEEHHHHHCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
DCATIAFGIRNIIPREEAFREILRVLVPGGRLCVLEFGSGKNKVWKGLYNFYLQHALPRI
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
GKIFSGDDSAYRYLADTIIAFPDARELAQEMRDAGFARVLHRPLTSGIVQLHVAQKANRK
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA