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The map label for this gene is umuD [H]

Identifier: 78358014

GI number: 78358014

Start: 2957082

End: 2957708

Strand: Reverse

Name: umuD [H]

Synonym: Dde_2974

Alternate gene names: 78358014

Gene position: 2957708-2957082 (Counterclockwise)

Preceding gene: 78358019

Following gene: 78358013

Centisome position: 79.29

GC content: 59.81

Gene sequence:

>627_bases
ATGCTGTTGTGCCGAAGCACGCAAATACCGGAGGATGACATGTCGTACCACAGCGGACTGCCCCAACAGCCTTACGGGGT
CAAGCTTTTTGCGGAAAAGATACCGGCGGCGCATGCATTGCGGCCTTCCCGCACCCGTGACGCCGTTCCGGCACATGCGC
ACACCGGCGGTGCTGACGGTCTGCATATGCTGGCGGGTGCGGTACCGCAGCATGAGGGGGCGGAGAAAATCCGTCATGCC
GCAGCGGACAGACCGCTTATGCTGTCCTGCGTGGCGGCCGGTTTTCCTTCACCGGCAGACGATTACATAGACAGGCGGCT
GGACCTGAACGAATATCTGGTGCGTAACCCCGAATCGACATTTTATGTGCGCGTCCACGGTGAATCCATGCGCGATGCCG
GTATCTGGGCCGGAGATATTCTGGTGGTGGACCGTGCCGTGCAGCCTGCCACCGGCCGGGTGGTGATAGCCGTGCTGGAC
GGGGAACTGACCGTAAAGCGGCTTAAAAAAGAAGGAGACCGTCTGCTGCTGGTTCCGGAAAATCCGGATTACAGTCCCGT
TGATGTCAGCGGGCGCGAAGATTTTTCCGTCTGGGGGGTGGTAACCTGTGTGTTGCACAGGGTGTGA

Upstream 100 bases:

>100_bases
GGTCTGTCTGCTGCTGAAGGTGCGGTGCCGGAAAAGTGTTCATGCGGTGTCCCGTCCGGGCAATGCGTTGCCGGTACTTG
TCTGAGGTGAGCCGGAGGAT

Downstream 100 bases:

>100_bases
CCTGTTCAGGGCTTCGCGCCGGTGTGCTTACACTTGCGGCAGTACCGGCATGCAGCGCCTGTGCGTGAAGGAGGGATGGC
TGTGGATGTGACCGTACTGG

Product: SOS mutagenesis protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLLCRSTQIPEDDMSYHSGLPQQPYGVKLFAEKIPAAHALRPSRTRDAVPAHAHTGGADGLHMLAGAVPQHEGAEKIRHA
AADRPLMLSCVAAGFPSPADDYIDRRLDLNEYLVRNPESTFYVRVHGESMRDAGIWAGDILVVDRAVQPATGRVVIAVLD
GELTVKRLKKEGDRLLLVPENPDYSPVDVSGREDFSVWGVVTCVLHRV

Sequences:

>Translated_208_residues
MLLCRSTQIPEDDMSYHSGLPQQPYGVKLFAEKIPAAHALRPSRTRDAVPAHAHTGGADGLHMLAGAVPQHEGAEKIRHA
AADRPLMLSCVAAGFPSPADDYIDRRLDLNEYLVRNPESTFYVRVHGESMRDAGIWAGDILVVDRAVQPATGRVVIAVLD
GELTVKRLKKEGDRLLLVPENPDYSPVDVSGREDFSVWGVVTCVLHRV
>Mature_208_residues
MLLCRSTQIPEDDMSYHSGLPQQPYGVKLFAEKIPAAHALRPSRTRDAVPAHAHTGGADGLHMLAGAVPQHEGAEKIRHA
AADRPLMLSCVAAGFPSPADDYIDRRLDLNEYLVRNPESTFYVRVHGESMRDAGIWAGDILVVDRAVQPATGRVVIAVLD
GELTVKRLKKEGDRLLLVPENPDYSPVDVSGREDFSVWGVVTCVLHRV

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=121, Percent_Identity=44.6280991735537, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790476, Length=120, Percent_Identity=38.3333333333333, Blast_Score=84, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 22777; Mature: 22777

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLCRSTQIPEDDMSYHSGLPQQPYGVKLFAEKIPAAHALRPSRTRDAVPAHAHTGGADG
CEEECCCCCCCHHHHHHCCCCCCCCCEEHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCH
LHMLAGAVPQHEGAEKIRHAAADRPLMLSCVAAGFPSPADDYIDRRLDLNEYLVRNPEST
HHHHHCCCCCCCCHHHHHHHHCCCCCEEHHHHCCCCCCHHHHHHHHCCCHHHHHCCCCCE
FYVRVHGESMRDAGIWAGDILVVDRAVQPATGRVVIAVLDGELTVKRLKKEGDRLLLVPE
EEEEEECCCCCCCCCEECCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHCCCEEEEEEC
NPDYSPVDVSGREDFSVWGVVTCVLHRV
CCCCCCEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLLCRSTQIPEDDMSYHSGLPQQPYGVKLFAEKIPAAHALRPSRTRDAVPAHAHTGGADG
CEEECCCCCCCHHHHHHCCCCCCCCCEEHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCH
LHMLAGAVPQHEGAEKIRHAAADRPLMLSCVAAGFPSPADDYIDRRLDLNEYLVRNPEST
HHHHHCCCCCCCCHHHHHHHHCCCCCEEHHHHCCCCCCHHHHHHHHCCCHHHHHCCCCCE
FYVRVHGESMRDAGIWAGDILVVDRAVQPATGRVVIAVLDGELTVKRLKKEGDRLLLVPE
EEEEEECCCCCCCCCEECCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHCCCEEEEEEC
NPDYSPVDVSGREDFSVWGVVTCVLHRV
CCCCCCEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]