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The map label for this gene is umuC [H]

Identifier: 78358013

GI number: 78358013

Start: 2955582

End: 2957060

Strand: Reverse

Name: umuC [H]

Synonym: Dde_2973

Alternate gene names: 78358013

Gene position: 2957060-2955582 (Counterclockwise)

Preceding gene: 78358014

Following gene: 78358012

Centisome position: 79.27

GC content: 63.02

Gene sequence:

>1479_bases
GTGTGCTTACACTTGCGGCAGTACCGGCATGCAGCGCCTGTGCGTGAAGGAGGGATGGCTGTGGATGTGACCGTACTGGG
CAGAGCTGCCTGTTCCCGCGTGCGGCATGACGGGGGAACACCGTCCGCACCCGCGGCACAGCGGCAGGGGCGTCCGTTGT
ATGCGCTTGTGGACTGCAACAGTTTTTATGTTTCCTGCGAGCGGGTTTTCAGGCCCGACCTTGTCCGCCGCCCCGTGGTT
GTGCTGTCCAACAACGACGGCTGCATCATTGCACGCTCGGCAGAGGCTAAAGCTCTGGGTATTCCCATGGGGGCCCCGTG
GTTCAAGGTGCGCAGACATGCTGAGTCCGCGGGGGTGACCGTGTTTTCGTCCAATTATGCCTTGTACGGTGATATGTCGT
CACGCGTCATGCGGGTGCTGGAGCGTTTCTGTCCGGATGTGCATGTGTATTCCATTGATGAGGCTTTTATGCGGCTGGAC
AGCCTGATCATGCCGCCGGGTATGTCGCCGGAGCGGTATGCGGCGTGTCTGCGGCGCGAGGTGTACCGGCGTACAGGCAT
TCCCGTGTCGGTGGGGCTGGGCTGCACCAAGACTCTTGCCAAGCTGGCAAACAGGCTGAGCAAACAGCAGAATGCCGGAG
CGCGGGCCATGGTGCCGGCGGCTTTCCGGTATGCCGGAGTATTCAACTTTGGAGCAGTGACAGATCCTGACGTTATGGAT
GCGTTGCTGGAAACGCTGGACGTGACGGATGTGTGGGGTGTGGGGGCGCGCCATGCGGGGCGTCTGCGGACATGGGGCAT
ACGCACCGCGCGGGCGCTGCGTGATGCACCGGATGACAGGGTGCGCAGATACATGAGCGTGACCGGTCTGCACACCGTGC
TGGAACTGCGCGGCATTTCGTGTCTGCCTCTGGATGATGCGCCGCCGTCGCGCAGGTCGGTTGTCTCTTCGCGGTCATTC
GGCACACTGGTGACGCACAAGGAGCATATGCTCGAAGCTGTCACGGCCTATATGACACGGGCCGCCGAAAAACTGCGGCG
CGAACAGCTTGAAGCGCACTGCGTGGGGGTTATGATCAGCACCCCGCGCCACGGCGACGGGCCGCGCTATGCCGACAGCG
CACAGGTGCAGCTTGCGGTGCCCACCAGCCATACGCCGCAGCTGATAGTCCGCGCCCGCGCCCTGCTGGAGAGTATATGG
CGCGACGGCTACCGGTACCAGAAGGCCGGCGTGATGCTTTCGGGGCTTGAATCTGCGGTATCCCGTCAGGTTTCCATGCT
GCCTGCCCTGCAGGGGACAGGGCGGGGACTGGAACGGGGAAGGCGGCTCATGGCGGCGGCCGATGCGGTGAATGCACGTT
TCGGAAGGGGAACGCTGGAATACGCGGCGGCCGGTCTGGGAAGGCCGTGGAGCATGAAACAGGAACACCTGTCGCCCCGC
TACACTTCGGACTGGAAAAAACTGCCGCTTGTGCGCTGA

Upstream 100 bases:

>100_bases
TTACAGTCCCGTTGATGTCAGCGGGCGCGAAGATTTTTCCGTCTGGGGGGTGGTAACCTGTGTGTTGCACAGGGTGTGAC
CTGTTCAGGGCTTCGCGCCG

Downstream 100 bases:

>100_bases
GCTTTTTTGGGGGAAGTTCCTACCTGACATGGCGTGTGCTGCCGTATACACTGTGCCGTCGCTGCGTACGGTGCGGCGGC
TGCGCGGCAACTGCACGGCA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MCLHLRQYRHAAPVREGGMAVDVTVLGRAACSRVRHDGGTPSAPAAQRQGRPLYALVDCNSFYVSCERVFRPDLVRRPVV
VLSNNDGCIIARSAEAKALGIPMGAPWFKVRRHAESAGVTVFSSNYALYGDMSSRVMRVLERFCPDVHVYSIDEAFMRLD
SLIMPPGMSPERYAACLRREVYRRTGIPVSVGLGCTKTLAKLANRLSKQQNAGARAMVPAAFRYAGVFNFGAVTDPDVMD
ALLETLDVTDVWGVGARHAGRLRTWGIRTARALRDAPDDRVRRYMSVTGLHTVLELRGISCLPLDDAPPSRRSVVSSRSF
GTLVTHKEHMLEAVTAYMTRAAEKLRREQLEAHCVGVMISTPRHGDGPRYADSAQVQLAVPTSHTPQLIVRARALLESIW
RDGYRYQKAGVMLSGLESAVSRQVSMLPALQGTGRGLERGRRLMAAADAVNARFGRGTLEYAAAGLGRPWSMKQEHLSPR
YTSDWKKLPLVR

Sequences:

>Translated_492_residues
MCLHLRQYRHAAPVREGGMAVDVTVLGRAACSRVRHDGGTPSAPAAQRQGRPLYALVDCNSFYVSCERVFRPDLVRRPVV
VLSNNDGCIIARSAEAKALGIPMGAPWFKVRRHAESAGVTVFSSNYALYGDMSSRVMRVLERFCPDVHVYSIDEAFMRLD
SLIMPPGMSPERYAACLRREVYRRTGIPVSVGLGCTKTLAKLANRLSKQQNAGARAMVPAAFRYAGVFNFGAVTDPDVMD
ALLETLDVTDVWGVGARHAGRLRTWGIRTARALRDAPDDRVRRYMSVTGLHTVLELRGISCLPLDDAPPSRRSVVSSRSF
GTLVTHKEHMLEAVTAYMTRAAEKLRREQLEAHCVGVMISTPRHGDGPRYADSAQVQLAVPTSHTPQLIVRARALLESIW
RDGYRYQKAGVMLSGLESAVSRQVSMLPALQGTGRGLERGRRLMAAADAVNARFGRGTLEYAAAGLGRPWSMKQEHLSPR
YTSDWKKLPLVR
>Mature_492_residues
MCLHLRQYRHAAPVREGGMAVDVTVLGRAACSRVRHDGGTPSAPAAQRQGRPLYALVDCNSFYVSCERVFRPDLVRRPVV
VLSNNDGCIIARSAEAKALGIPMGAPWFKVRRHAESAGVTVFSSNYALYGDMSSRVMRVLERFCPDVHVYSIDEAFMRLD
SLIMPPGMSPERYAACLRREVYRRTGIPVSVGLGCTKTLAKLANRLSKQQNAGARAMVPAAFRYAGVFNFGAVTDPDVMD
ALLETLDVTDVWGVGARHAGRLRTWGIRTARALRDAPDDRVRRYMSVTGLHTVLELRGISCLPLDDAPPSRRSVVSSRSF
GTLVTHKEHMLEAVTAYMTRAAEKLRREQLEAHCVGVMISTPRHGDGPRYADSAQVQLAVPTSHTPQLIVRARALLESIW
RDGYRYQKAGVMLSGLESAVSRQVSMLPALQGTGRGLERGRRLMAAADAVNARFGRGTLEYAAAGLGRPWSMKQEHLSPR
YTSDWKKLPLVR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=432, Percent_Identity=42.1296296296296, Blast_Score=317, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 54284; Mature: 54284

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLHLRQYRHAAPVREGGMAVDVTVLGRAACSRVRHDGGTPSAPAAQRQGRPLYALVDCN
CCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECC
SFYVSCERVFRPDLVRRPVVVLSNNDGCIIARSAEAKALGIPMGAPWFKVRRHAESAGVT
CHHHHHHHHHCCHHHHCCEEEEECCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHCCEE
VFSSNYALYGDMSSRVMRVLERFCPDVHVYSIDEAFMRLDSLIMPPGMSPERYAACLRRE
EEECCEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VYRRTGIPVSVGLGCTKTLAKLANRLSKQQNAGARAMVPAAFRYAGVFNFGAVTDPDVMD
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCEEECCCCCCHHHHH
ALLETLDVTDVWGVGARHAGRLRTWGIRTARALRDAPDDRVRRYMSVTGLHTVLELRGIS
HHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCE
CLPLDDAPPSRRSVVSSRSFGTLVTHKEHMLEAVTAYMTRAAEKLRREQLEAHCVGVMIS
EEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
TPRHGDGPRYADSAQVQLAVPTSHTPQLIVRARALLESIWRDGYRYQKAGVMLSGLESAV
CCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEHHHCHHHHHHHHHH
SRQVSMLPALQGTGRGLERGRRLMAAADAVNARFGRGTLEYAAAGLGRPWSMKQEHLSPR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHCCCC
YTSDWKKLPLVR
CCCCHHHCCCCC
>Mature Secondary Structure
MCLHLRQYRHAAPVREGGMAVDVTVLGRAACSRVRHDGGTPSAPAAQRQGRPLYALVDCN
CCCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECC
SFYVSCERVFRPDLVRRPVVVLSNNDGCIIARSAEAKALGIPMGAPWFKVRRHAESAGVT
CHHHHHHHHHCCHHHHCCEEEEECCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHCCEE
VFSSNYALYGDMSSRVMRVLERFCPDVHVYSIDEAFMRLDSLIMPPGMSPERYAACLRRE
EEECCEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VYRRTGIPVSVGLGCTKTLAKLANRLSKQQNAGARAMVPAAFRYAGVFNFGAVTDPDVMD
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCEEECCCCCCHHHHH
ALLETLDVTDVWGVGARHAGRLRTWGIRTARALRDAPDDRVRRYMSVTGLHTVLELRGIS
HHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCE
CLPLDDAPPSRRSVVSSRSFGTLVTHKEHMLEAVTAYMTRAAEKLRREQLEAHCVGVMIS
EEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
TPRHGDGPRYADSAQVQLAVPTSHTPQLIVRARALLESIWRDGYRYQKAGVMLSGLESAV
CCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEHHHCHHHHHHHHHH
SRQVSMLPALQGTGRGLERGRRLMAAADAVNARFGRGTLEYAAAGLGRPWSMKQEHLSPR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHCCCC
YTSDWKKLPLVR
CCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]