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The map label for this gene is atoC [H]

Identifier: 78357999

GI number: 78357999

Start: 2938958

End: 2939983

Strand: Direct

Name: atoC [H]

Synonym: Dde_2959

Alternate gene names: 78357999

Gene position: 2938958-2939983 (Clockwise)

Preceding gene: 78357998

Following gene: 78358000

Centisome position: 78.79

GC content: 59.26

Gene sequence:

>1026_bases
ATGGAGCTAAAGACAGCCGGCATTATCGGGCAAAGCTCTTCGCTCAGAGATCTTTTTCGCGTACTCGCCAAAGTGGCACC
CACCGACAGCACAGTACTGGTCACCGGAGAATCCGGTACCGGTAAAGAGCTGCTTGTCCGTGCGCTGCATATGAACAGCC
AGCGCGCGGACAAACCTTTTGTGCCCATAAACTGCGGCGCCATTCCGCGCGAGCTGCTCGAATCTGAACTCTTCGGACAC
GAAAAGGGAGCCTTCACCCACGCCATCCGCACGCGTCCCGGCCGCTTTGAAGTGGCGGACGGCGGCACTATTTTTCTGGA
CGAAATAGGCGAGATGGACCTGACGCTGCAGGTCAAGATACTTCGCGTATTGCAGGAAAAAGAAATCGAGCGCGTCGGCG
CCACAGCCACCCGCAAAGTCGATGTACGCATAGTGGCGGCCACCAACCGCGATCTGGAAACAGAAGTCCGCGAAGGCCGG
TTCCGCGAAGACCTGTACTACCGCCTCAACGTCATTCCGCTGCACCTGCCTCCGCTGCGCGAACGCGGCGCGGACATTCT
CATGCTTTCAGAGCACTTCCTGTGCAAATTCTGCCGCAGCAAAGGACGCACGGCTCTCCGGCTGGACGACGGCATCCGGC
GCATTCTGGCGGCCTACCCGTGGCCGGGCAACGTGCGTGAGCTGGAAAACTTCATGGAGCGGCTGAGCATACTGTGCGAC
GAAGACAGCGTGCGCCCCCACGACCTGCCCCGCAAAATTCTGGACGCAGTGGGAGATGTGGCACAGCTGCCCGAAGTGCC
CGAACCGGCCCCCGCGCCGGCACCGCAAGGCTTTGCGTGGCCGCGCATCGAAGACATGCAGCAGCGCGGGATGGACCTGA
AACAGTTCATAGACACCGTGGAGGAACGCCTGCTGCTGGAAGCACTGGAAAAAGCGGACGGCGTCAAAAATCAGGCCGCT
GAAATACTGGGGGTAAAGCGGACAACCCTCATCGAAAAATTGAAAAAACGTCAGCTGGACAAATAA

Upstream 100 bases:

>100_bases
TTTCTGATTTGGGTTGACTTTGCGTCATGTTTTTGACACGCATCGATGTGATACCTGTGATACCATTTCCCCGCAGCAGT
CATGCGGGTTCGGAGGCTCA

Downstream 100 bases:

>100_bases
TTCCGGCACACGGCCGTTATTACGCCGCCGGCATATATCCGGCTGCAGGCGGCGGTTGCAGCCCCCGCCGTCTGACCGAA
TACCGCGGGCCCGCAGCGAC

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MELKTAGIIGQSSSLRDLFRVLAKVAPTDSTVLVTGESGTGKELLVRALHMNSQRADKPFVPINCGAIPRELLESELFGH
EKGAFTHAIRTRPGRFEVADGGTIFLDEIGEMDLTLQVKILRVLQEKEIERVGATATRKVDVRIVAATNRDLETEVREGR
FREDLYYRLNVIPLHLPPLRERGADILMLSEHFLCKFCRSKGRTALRLDDGIRRILAAYPWPGNVRELENFMERLSILCD
EDSVRPHDLPRKILDAVGDVAQLPEVPEPAPAPAPQGFAWPRIEDMQQRGMDLKQFIDTVEERLLLEALEKADGVKNQAA
EILGVKRTTLIEKLKKRQLDK

Sequences:

>Translated_341_residues
MELKTAGIIGQSSSLRDLFRVLAKVAPTDSTVLVTGESGTGKELLVRALHMNSQRADKPFVPINCGAIPRELLESELFGH
EKGAFTHAIRTRPGRFEVADGGTIFLDEIGEMDLTLQVKILRVLQEKEIERVGATATRKVDVRIVAATNRDLETEVREGR
FREDLYYRLNVIPLHLPPLRERGADILMLSEHFLCKFCRSKGRTALRLDDGIRRILAAYPWPGNVRELENFMERLSILCD
EDSVRPHDLPRKILDAVGDVAQLPEVPEPAPAPAPQGFAWPRIEDMQQRGMDLKQFIDTVEERLLLEALEKADGVKNQAA
EILGVKRTTLIEKLKKRQLDK
>Mature_341_residues
MELKTAGIIGQSSSLRDLFRVLAKVAPTDSTVLVTGESGTGKELLVRALHMNSQRADKPFVPINCGAIPRELLESELFGH
EKGAFTHAIRTRPGRFEVADGGTIFLDEIGEMDLTLQVKILRVLQEKEIERVGATATRKVDVRIVAATNRDLETEVREGR
FREDLYYRLNVIPLHLPPLRERGADILMLSEHFLCKFCRSKGRTALRLDDGIRRILAAYPWPGNVRELENFMERLSILCD
EDSVRPHDLPRKILDAVGDVAQLPEVPEPAPAPAPQGFAWPRIEDMQQRGMDLKQFIDTVEERLLLEALEKADGVKNQAA
EILGVKRTTLIEKLKKRQLDK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=333, Percent_Identity=46.2462462462462, Blast_Score=294, Evalue=5e-81,
Organism=Escherichia coli, GI1790437, Length=330, Percent_Identity=44.2424242424242, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1790299, Length=337, Percent_Identity=45.1038575667656, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=349, Percent_Identity=45.5587392550143, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI1789087, Length=337, Percent_Identity=45.1038575667656, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI87082152, Length=238, Percent_Identity=52.1008403361345, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1789233, Length=335, Percent_Identity=41.4925373134328, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786524, Length=344, Percent_Identity=42.4418604651163, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI87081872, Length=346, Percent_Identity=39.0173410404624, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1788905, Length=216, Percent_Identity=50.462962962963, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1787583, Length=242, Percent_Identity=41.7355371900826, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI87081858, Length=325, Percent_Identity=29.2307692307692, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=32.5301204819277, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 38424; Mature: 38424

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKTAGIIGQSSSLRDLFRVLAKVAPTDSTVLVTGESGTGKELLVRALHMNSQRADKPF
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCC
VPINCGAIPRELLESELFGHEKGAFTHAIRTRPGRFEVADGGTIFLDEIGEMDLTLQVKI
CEEECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCCCCEEHHHHH
LRVLQEKEIERVGATATRKVDVRIVAATNRDLETEVREGRFREDLYYRLNVIPLHLPPLR
HHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHCCCHHHHHEEEEEEEEECCCCHH
ERGADILMLSEHFLCKFCRSKGRTALRLDDGIRRILAAYPWPGNVRELENFMERLSILCD
HCCCCEEEEHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
EDSVRPHDLPRKILDAVGDVAQLPEVPEPAPAPAPQGFAWPRIEDMQQRGMDLKQFIDTV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHH
EERLLLEALEKADGVKNQAAEILGVKRTTLIEKLKKRQLDK
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELKTAGIIGQSSSLRDLFRVLAKVAPTDSTVLVTGESGTGKELLVRALHMNSQRADKPF
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCC
VPINCGAIPRELLESELFGHEKGAFTHAIRTRPGRFEVADGGTIFLDEIGEMDLTLQVKI
CEEECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCCCCEEHHHHH
LRVLQEKEIERVGATATRKVDVRIVAATNRDLETEVREGRFREDLYYRLNVIPLHLPPLR
HHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHCCCHHHHHEEEEEEEEECCCCHH
ERGADILMLSEHFLCKFCRSKGRTALRLDDGIRRILAAYPWPGNVRELENFMERLSILCD
HCCCCEEEEHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
EDSVRPHDLPRKILDAVGDVAQLPEVPEPAPAPAPQGFAWPRIEDMQQRGMDLKQFIDTV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHH
EERLLLEALEKADGVKNQAAEILGVKRTTLIEKLKKRQLDK
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]