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The map label for this gene is rnhA

Identifier: 78357981

GI number: 78357981

Start: 2920672

End: 2921136

Strand: Reverse

Name: rnhA

Synonym: Dde_2941

Alternate gene names: 78357981

Gene position: 2921136-2920672 (Counterclockwise)

Preceding gene: 78357982

Following gene: 78357980

Centisome position: 78.31

GC content: 58.28

Gene sequence:

>465_bases
ATGAAACAAGTGGATATATTCACGGACGGGTCGTGCCTTGGCAACCCCGGTCCCGGAGGCTGGGCCGCGGTGTTGCGGTA
TGCCGGCACACAGAAGGAATTGGGGGGCGGTTTTTCGGGTACAACCAACAACCGCATGGAAATACTGGCTGTTATCGAAG
GGCTGGAAGCTCTGCAGGAGCCGTGTACTGTTAATTTGTACACCGATTCGCAGTATGTGCGGAATGCCGTTGAAAAAAAA
TGGCTTGATTCGTGGCAGCGCAACGGGTGGAAAACGGCCGCCCGGAAGCCGGTAAAAAATAAAGACCTGTGGCTGCGGCT
GCTGCCGCTGCTTGCCCGGCATACTGTCAAATTTCACTGGGTGCGCGGACACAGCGGGCATCCGGAAAACGAACTGTGCG
ATACCATTGCCCGCGGGCATGCTTCGCGTGGCGGGCTGCCGCCGGACACGCAGGCTGCAGGCTGA

Upstream 100 bases:

>100_bases
TTTATCCCTTATTTTGAAAACGGCCAGTGGGGACTGGCCCTTGCGGATGCACTCAAAAAAATATGGAGCGGCCTTGGCCG
CCCTTGACGGCGATACATTT

Downstream 100 bases:

>100_bases
ACAACAGACCCGGGTGTTTTCATAAGGGGTGTTTTTTATGCAGGCAGAAGCCATACCGGCACAGGCCAGACGCAGCGCCG
GAGTCAGTCTTTCCATCGGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKQVDIFTDGSCLGNPGPGGWAAVLRYAGTQKELGGGFSGTTNNRMEILAVIEGLEALQEPCTVNLYTDSQYVRNAVEKK
WLDSWQRNGWKTAARKPVKNKDLWLRLLPLLARHTVKFHWVRGHSGHPENELCDTIARGHASRGGLPPDTQAAG

Sequences:

>Translated_154_residues
MKQVDIFTDGSCLGNPGPGGWAAVLRYAGTQKELGGGFSGTTNNRMEILAVIEGLEALQEPCTVNLYTDSQYVRNAVEKK
WLDSWQRNGWKTAARKPVKNKDLWLRLLPLLARHTVKFHWVRGHSGHPENELCDTIARGHASRGGLPPDTQAAG
>Mature_154_residues
MKQVDIFTDGSCLGNPGPGGWAAVLRYAGTQKELGGGFSGTTNNRMEILAVIEGLEALQEPCTVNLYTDSQYVRNAVEKK
WLDSWQRNGWKTAARKPVKNKDLWLRLLPLLARHTVKFHWVRGHSGHPENELCDTIARGHASRGGLPPDTQAAG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=140, Percent_Identity=35, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786408, Length=141, Percent_Identity=59.5744680851064, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI115532542, Length=141, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17505482, Length=132, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552509, Length=145, Percent_Identity=34.4827586206897, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137476, Length=145, Percent_Identity=34.4827586206897, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_DESDG (Q30X61)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389430.1
- HSSP:   P0A7Y4
- ProteinModelPortal:   Q30X61
- SMR:   Q30X61
- STRING:   Q30X61
- GeneID:   3757946
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2941
- NMPDR:   fig|207559.3.peg.2927
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   DDES207559:DDE_2941-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16976; Mature: 16976

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVDIFTDGSCLGNPGPGGWAAVLRYAGTQKELGGGFSGTTNNRMEILAVIEGLEALQE
CCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
PCTVNLYTDSQYVRNAVEKKWLDSWQRNGWKTAARKPVKNKDLWLRLLPLLARHTVKFHW
CCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHEEEEE
VRGHSGHPENELCDTIARGHASRGGLPPDTQAAG
EECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQVDIFTDGSCLGNPGPGGWAAVLRYAGTQKELGGGFSGTTNNRMEILAVIEGLEALQE
CCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
PCTVNLYTDSQYVRNAVEKKWLDSWQRNGWKTAARKPVKNKDLWLRLLPLLARHTVKFHW
CCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHEEEEE
VRGHSGHPENELCDTIARGHASRGGLPPDTQAAG
EECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA