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The map label for this gene is cobS [H]

Identifier: 78357962

GI number: 78357962

Start: 2901141

End: 2902157

Strand: Reverse

Name: cobS [H]

Synonym: Dde_2922

Alternate gene names: 78357962

Gene position: 2902157-2901141 (Counterclockwise)

Preceding gene: 78357963

Following gene: 78357961

Centisome position: 77.8

GC content: 55.16

Gene sequence:

>1017_bases
ATGATTACACATGAACTTGACACCCTCACCACTACGGATATGGACGCCGGCACTCTGTTCAGCGGCAAAGCATCCGGCCG
CATGATACGCGGATATAGCGCTCCATGCAGCTTTACCCCCAGGATTGATCCTGACTATCTGTTCCATGATTCCATGCGGG
ATATCGTAGTCTGGCTTTTATCAGGAACTGAAGAGAAAGCCGACCCGCTTTACATTTTCGGGCCAACAGGAAGCGGAAAA
ACAAGCCTTGTGCGACAGCTCGCTGCTCGCCTGAACTATCCAGTCTTTGATGTCACAGGGCACGGCAGACTGGAGTTCCC
GGACCTTGCCGGTCACCTGAGTGTGCAGAGCGGAAACATGGTTTATCAGTATGGTCCGCTTGCGCTGGCTATGCGTTACG
GCGGTCTTTTCCTGCTCAATGAGGCGGACCTGCTCGACCCTGCCACGGCCACAGGTTTGAATGGTGTGCTCGATGGCGGA
CCGCTCTGCATCCCGGAAAACGGTGGAGAGATTATCCAGCCGCATCCCATGTTCCGGTTTGTGGCTACCGCCAACACCAA
CGGCGCCTCAGACGAAAGTGGCCTGTATCAAGGAACCCTGCGGCAGAACATCGCCCTGATGGACAGGTTCTACCTCTGCG
AGGTTGGCTATCCTGCTCAGGAAACAGAAGTCATGCTTCTTGAACGGATAGCGCCTGATATTCCACAAGATATCCGTGAA
ACAATGGTAAGCTTTGCGGGAGAAGTGCGTCGACTGTTCATGGGTGAAAGCGAAAAGCAGAAATACGGCGAAACCATCGA
CATAACCTTTTCCACCCGCACGCTGATCCGCTGGGCCACGCTTGCCAGGCGATTCCAACCTCTGGCAAGGCAGGGAATCC
AGCCCATCGGCTACGCTCTGGACAGAGCTCTGGGATTTCGAGCCTCTCGGGAGACACGCGCCATGCTGCACGAGCTGGCG
CAGCGCATGTTTCCCACAGCGGAATCGCAACAGACTACAGACATAGAGAACACTTGA

Upstream 100 bases:

>100_bases
GTCACCAGAATAGGTGCCCCTTTTCAGCGGCTATATATCAGCCCCCGCATGCCGGAGGTTTCAGCAACCAATACTCTGCC
AACACAAAAGGAAGTATAAG

Downstream 100 bases:

>100_bases
AGGGAGCCCTGAGAGATCAGCGGCTCCCTTTCTTATTCAATATACAAAACAGGAGGACTACCATGCATACAGATATCACC
GTGCTCGATAACCTTGTGGC

Product: ATPase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMVSFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLARRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT

Sequences:

>Translated_338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMVSFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLARRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT
>Mature_338_residues
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLLSGTEEKADPLYIFGPTGSGK
TSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNMVYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGG
PLCIPENGGEIIQPHPMFRFVATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
TMVSFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLARRFQPLARQGIQPIGYALDRALGFRASRETRAMLHELA
QRMFPTAESQQTTDIENT

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=281, Percent_Identity=29.1814946619217, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI57863271, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI57863273, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323135, Length=245, Percent_Identity=31.4285714285714, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161076562, Length=215, Percent_Identity=26.5116279069767, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076560, Length=215, Percent_Identity=26.5116279069767, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 37477; Mature: 37477

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLL
CCCCCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SGTEEKADPLYIFGPTGSGKTSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNM
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEECCCE
VYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGGPLCIPENGGEIIQPHPMFRF
EEEECCHHEEHHHCCEEEEECCCCCCCCHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEE
VATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
TMVSFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLARRFQPLARQGIQPIGYAL
HHHHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DRALGFRASRETRAMLHELAQRMFPTAESQQTTDIENT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MITHELDTLTTTDMDAGTLFSGKASGRMIRGYSAPCSFTPRIDPDYLFHDSMRDIVVWLL
CCCCCCCCCEECCCCCCCEECCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
SGTEEKADPLYIFGPTGSGKTSLVRQLAARLNYPVFDVTGHGRLEFPDLAGHLSVQSGNM
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCEECCCCCCEEEEECCCE
VYQYGPLALAMRYGGLFLLNEADLLDPATATGLNGVLDGGPLCIPENGGEIIQPHPMFRF
EEEECCHHEEHHHCCEEEEECCCCCCCCHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEE
VATANTNGASDESGLYQGTLRQNIALMDRFYLCEVGYPAQETEVMLLERIAPDIPQDIRE
EEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
TMVSFAGEVRRLFMGESEKQKYGETIDITFSTRTLIRWATLARRFQPLARQGIQPIGYAL
HHHHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
DRALGFRASRETRAMLHELAQRMFPTAESQQTTDIENT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]