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The map label for this gene is hemD [H]

Identifier: 78357878

GI number: 78357878

Start: 2823488

End: 2824999

Strand: Reverse

Name: hemD [H]

Synonym: Dde_2837

Alternate gene names: 78357878

Gene position: 2824999-2823488 (Counterclockwise)

Preceding gene: 78357879

Following gene: 78357877

Centisome position: 75.73

GC content: 58.6

Gene sequence:

>1512_bases
ATGAAAGTTTACCTGATCGGTGCCGGTCCCGGCGACCCCGGACTGCTGACCATCAAGGGCCGTGATATTTTGAAGCGCGC
CGATGTCATTGTGTACGACTATCTGGCCAACGACGCTTTTCTGAATTACGCGGCCCCCGGCGCGGAAATCATCTATGTGG
GCAAAAAAGGCGGCGACCATACCCTGTCTCAGGAAGGCATCAACAGGTTGATTGTTGAGAAGGCCAGAGAAGGCAAGGTG
GTGGCGCGTCTCAAGGGCGGCGATCCCTATGTGTTCGGACGGGGTGGCGAAGAAGCGGAAGAACTGCTTGACGCCGGCGT
GAACTTCGAGGTTGTGCCGGGAGTCACTTCGGCTGTGGCAGGCCCCGCATACGCCGGTATTCCGCTGACGCACCGCAGCT
ATTCCTCCTCCGTTTCATTCATAACCGGCCACGAAGATCCTTCTAAGCCCGAATCGGCTCATAACTGGAAGGCGCTGGCC
GCCAGTGCCAGCACGCTGGTGTTCTTTATGGGCATGAAAAATCTGCCCGAAATTTCGCGCAAGCTCATTGAGGCCGGCAT
GGACCCCGATACGCCTGCGGCACTTGTGCGCTGGGGTACCACATCGCGCCACCGCAGTCTGGCAGCCACCATTGCCACCC
TGCCGGAAGAAGGCAAAAAAGCGGGATTTTCTTCTCCCAGCCTTATTGTTGTGGGGCATGTGGTCAAACTGCGCGACCGG
CTGAACTGGTTTGAGCAGCTGCCGCTGCTGGGCAGGGGCATTGTGGTTACCCGCGCCCGCGAACAGGCCAGCGGACTGGC
AGCCAGCCTGACGCAGCTGGGAGCGGAGGTCATTCAGTTTCCCACCATTCTCATCCGCCCGCTGGAAGATTATGCTCCCG
TGCATGACGCCATTCGCAGGCTTGCCGAATATGACTGGCTTGTTTTCACTTCTGTGAACGGCGTGAAACATTTCTGGCAG
CAAATGGGCCTGCTGGGGCTGGACAGCAGAGCGCTGGGCGGTGTGAAAGTGGCTGCCATCGGACCGGCAACGGCGGACGT
GCTGCGTGAAAAAGGGATAGAGCCTGATTTTATTCCTGAAAAATATGTGGCCGAAGGCGTGGTCAAGGGAATGATAGAGC
GCGGAATGGACGGCAGCAGGGTGCTGCTGCCCCGTGCGCGTGTGGCTCGCGAAGTGCTGCCGGAAGAGCTTGCCCGTGCC
GGTGCGCGTGTGGATGTGCTGCCGGTATACGAAACCGTGCCGGGCGACGCCAACCGCAGTCACGTGCTTGAAATGCTGGA
AGAGGGCCGCATTGACTGCATCACCTTCGGCAGTTCTTCCACTGTGGACAATTTCTTTTCACTGGTTGAACCGGAAGCCA
TGCGCCGGTACGAACATGTGCATATGGCCTGCATAGGACCGGTAACCCGTAAGACTCTGGAACGCTACGGTTTCACCTGT
TCCATCCAGCCGGAAGATTATACCATTCCGGCACTGGTGGATGAACTGGTGCGTCAGCTTGGCGCGCAGTAG

Upstream 100 bases:

>100_bases
CAGGTCGGACAGACCGTTCCGGACGCAAGCACCGCGCGGGGCATACGCCGCACAGAGCATTTTATAGACGCCGGAGCGCT
CCGGCCCATACGGAGGAAGG

Downstream 100 bases:

>100_bases
CGCATCGCTGCTCAGCTGTCTGGCGGGCCGGTTTTCCGGCCCGCTTTGTTTTAACAGCCTGCAACTGCGGCGCGGCTGCC
TTTTTCTTGCGGCCCGGGCC

Product: uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKVYLIGAGPGDPGLLTIKGRDILKRADVIVYDYLANDAFLNYAAPGAEIIYVGKKGGDHTLSQEGINRLIVEKAREGKV
VARLKGGDPYVFGRGGEEAEELLDAGVNFEVVPGVTSAVAGPAYAGIPLTHRSYSSSVSFITGHEDPSKPESAHNWKALA
ASASTLVFFMGMKNLPEISRKLIEAGMDPDTPAALVRWGTTSRHRSLAATIATLPEEGKKAGFSSPSLIVVGHVVKLRDR
LNWFEQLPLLGRGIVVTRAREQASGLAASLTQLGAEVIQFPTILIRPLEDYAPVHDAIRRLAEYDWLVFTSVNGVKHFWQ
QMGLLGLDSRALGGVKVAAIGPATADVLREKGIEPDFIPEKYVAEGVVKGMIERGMDGSRVLLPRARVAREVLPEELARA
GARVDVLPVYETVPGDANRSHVLEMLEEGRIDCITFGSSSTVDNFFSLVEPEAMRRYEHVHMACIGPVTRKTLERYGFTC
SIQPEDYTIPALVDELVRQLGAQ

Sequences:

>Translated_503_residues
MKVYLIGAGPGDPGLLTIKGRDILKRADVIVYDYLANDAFLNYAAPGAEIIYVGKKGGDHTLSQEGINRLIVEKAREGKV
VARLKGGDPYVFGRGGEEAEELLDAGVNFEVVPGVTSAVAGPAYAGIPLTHRSYSSSVSFITGHEDPSKPESAHNWKALA
ASASTLVFFMGMKNLPEISRKLIEAGMDPDTPAALVRWGTTSRHRSLAATIATLPEEGKKAGFSSPSLIVVGHVVKLRDR
LNWFEQLPLLGRGIVVTRAREQASGLAASLTQLGAEVIQFPTILIRPLEDYAPVHDAIRRLAEYDWLVFTSVNGVKHFWQ
QMGLLGLDSRALGGVKVAAIGPATADVLREKGIEPDFIPEKYVAEGVVKGMIERGMDGSRVLLPRARVAREVLPEELARA
GARVDVLPVYETVPGDANRSHVLEMLEEGRIDCITFGSSSTVDNFFSLVEPEAMRRYEHVHMACIGPVTRKTLERYGFTC
SIQPEDYTIPALVDELVRQLGAQ
>Mature_503_residues
MKVYLIGAGPGDPGLLTIKGRDILKRADVIVYDYLANDAFLNYAAPGAEIIYVGKKGGDHTLSQEGINRLIVEKAREGKV
VARLKGGDPYVFGRGGEEAEELLDAGVNFEVVPGVTSAVAGPAYAGIPLTHRSYSSSVSFITGHEDPSKPESAHNWKALA
ASASTLVFFMGMKNLPEISRKLIEAGMDPDTPAALVRWGTTSRHRSLAATIATLPEEGKKAGFSSPSLIVVGHVVKLRDR
LNWFEQLPLLGRGIVVTRAREQASGLAASLTQLGAEVIQFPTILIRPLEDYAPVHDAIRRLAEYDWLVFTSVNGVKHFWQ
QMGLLGLDSRALGGVKVAAIGPATADVLREKGIEPDFIPEKYVAEGVVKGMIERGMDGSRVLLPRARVAREVLPEELARA
GARVDVLPVYETVPGDANRSHVLEMLEEGRIDCITFGSSSTVDNFFSLVEPEAMRRYEHVHMACIGPVTRKTLERYGFTC
SIQPEDYTIPALVDELVRQLGAQ

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=49.3827160493827, Blast_Score=241, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6322922, Length=251, Percent_Identity=32.6693227091633, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 54619; Mature: 54619

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYLIGAGPGDPGLLTIKGRDILKRADVIVYDYLANDAFLNYAAPGAEIIYVGKKGGDH
CEEEEEECCCCCCCEEEECCHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCC
TLSQEGINRLIVEKAREGKVVARLKGGDPYVFGRGGEEAEELLDAGVNFEVVPGVTSAVA
CHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCEEECCCCHHHHC
GPAYAGIPLTHRSYSSSVSFITGHEDPSKPESAHNWKALAASASTLVFFMGMKNLPEISR
CCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
KLIEAGMDPDTPAALVRWGTTSRHRSLAATIATLPEEGKKAGFSSPSLIVVGHVVKLRDR
HHHHCCCCCCCCHHEEECCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEHHHHHHHHHH
LNWFEQLPLLGRGIVVTRAREQASGLAASLTQLGAEVIQFPTILIRPLEDYAPVHDAIRR
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHCCCHHHHHHH
LAEYDWLVFTSVNGVKHFWQQMGLLGLDSRALGGVKVAAIGPATADVLREKGIEPDFIPE
HHHCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCH
KYVAEGVVKGMIERGMDGSRVLLPRARVAREVLPEELARAGARVDVLPVYETVPGDANRS
HHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
HVLEMLEEGRIDCITFGSSSTVDNFFSLVEPEAMRRYEHVHMACIGPVTRKTLERYGFTC
HHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCEE
SIQPEDYTIPALVDELVRQLGAQ
EECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVYLIGAGPGDPGLLTIKGRDILKRADVIVYDYLANDAFLNYAAPGAEIIYVGKKGGDH
CEEEEEECCCCCCCEEEECCHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCCCC
TLSQEGINRLIVEKAREGKVVARLKGGDPYVFGRGGEEAEELLDAGVNFEVVPGVTSAVA
CHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHCCCCEEECCCCHHHHC
GPAYAGIPLTHRSYSSSVSFITGHEDPSKPESAHNWKALAASASTLVFFMGMKNLPEISR
CCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
KLIEAGMDPDTPAALVRWGTTSRHRSLAATIATLPEEGKKAGFSSPSLIVVGHVVKLRDR
HHHHCCCCCCCCHHEEECCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEHHHHHHHHHH
LNWFEQLPLLGRGIVVTRAREQASGLAASLTQLGAEVIQFPTILIRPLEDYAPVHDAIRR
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHCCCHHHHHHH
LAEYDWLVFTSVNGVKHFWQQMGLLGLDSRALGGVKVAAIGPATADVLREKGIEPDFIPE
HHHCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCH
KYVAEGVVKGMIERGMDGSRVLLPRARVAREVLPEELARAGARVDVLPVYETVPGDANRS
HHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
HVLEMLEEGRIDCITFGSSSTVDNFFSLVEPEAMRRYEHVHMACIGPVTRKTLERYGFTC
HHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCEE
SIQPEDYTIPALVDELVRQLGAQ
EECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]