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The map label for this gene is hup [H]

Identifier: 78357794

GI number: 78357794

Start: 2753210

End: 2753485

Strand: Reverse

Name: hup [H]

Synonym: Dde_2752

Alternate gene names: 78357794

Gene position: 2753485-2753210 (Counterclockwise)

Preceding gene: 78357802

Following gene: 78357792

Centisome position: 73.82

GC content: 56.52

Gene sequence:

>276_bases
ATGACCAAAGCTGAACTGGTTCAGAAGATTGCTGCCAAAGCCGGTATGAATTCCAAGACCCAGGCCGAATCTGCTCTGGA
CGCCACCATTGCCGTTATCACCGAAGCGCTGAGCGCCGGTGATTCCGTGACCTTCACCGGTTTCGGTTCTTTCAAGGTTG
CCGAACGCGCCGCCCGTAAAGGCCGCAACCCCCGCACCGGCGAAGAAATGACCATTCCCGCCAGCAAAGTGGTGAAGTTC
ACCCCCGGCAAGGCTCTGAAAGACGCCGTTAAATAA

Upstream 100 bases:

>100_bases
GACTGATGGTCTGAAAGAAGGGCTACCTCGTGATATCGCCTTTTCAGGCGGCGCCCGGCGTACGCCTTAATTTAACGTCA
TATAGAATCGGAGATTGAAA

Downstream 100 bases:

>100_bases
GCAGTCTTTCCGGAACCGGAATGCATGAACGCCCCGCTTTGCGGGGCGTTTTTTATTTATGCCTGTGGCGGTCCGCTCCG
GCGGCGGAGTCGGGCCATGC

Product: histone-like DNA-binding protein

Products: NA

Alternate protein names: DNA-binding protein II; HB [H]

Number of amino acids: Translated: 91; Mature: 90

Protein sequence:

>91_residues
MTKAELVQKIAAKAGMNSKTQAESALDATIAVITEALSAGDSVTFTGFGSFKVAERAARKGRNPRTGEEMTIPASKVVKF
TPGKALKDAVK

Sequences:

>Translated_91_residues
MTKAELVQKIAAKAGMNSKTQAESALDATIAVITEALSAGDSVTFTGFGSFKVAERAARKGRNPRTGEEMTIPASKVVKF
TPGKALKDAVK
>Mature_90_residues
TKAELVQKIAAKAGMNSKTQAESALDATIAVITEALSAGDSVTFTGFGSFKVAERAARKGRNPRTGEEMTIPASKVVKFT
PGKALKDAVK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=91, Percent_Identity=57.1428571428571, Blast_Score=100, Evalue=3e-23,
Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=60, Blast_Score=99, Evalue=4e-23,
Organism=Escherichia coli, GI1788005, Length=91, Percent_Identity=39.5604395604396, Blast_Score=72, Evalue=9e-15,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=35.2272727272727, Blast_Score=69, Evalue=8e-14,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9499; Mature: 9368

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAELVQKIAAKAGMNSKTQAESALDATIAVITEALSAGDSVTFTGFGSFKVAERAARK
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHC
GRNPRTGEEMTIPASKVVKFTPGKALKDAVK
CCCCCCCCEEECCHHHHEEECCCHHHHHHCC
>Mature Secondary Structure 
TKAELVQKIAAKAGMNSKTQAESALDATIAVITEALSAGDSVTFTGFGSFKVAERAARK
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHC
GRNPRTGEEMTIPASKVVKFTPGKALKDAVK
CCCCCCCCEEECCHHHHEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1644313 [H]