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The map label for this gene is ygcA [C]

Identifier: 78357737

GI number: 78357737

Start: 2700875

End: 2702248

Strand: Direct

Name: ygcA [C]

Synonym: Dde_2695

Alternate gene names: 78357737

Gene position: 2700875-2702248 (Clockwise)

Preceding gene: 78357736

Following gene: 78357738

Centisome position: 72.41

GC content: 59.39

Gene sequence:

>1374_bases
ATGAACACCCCGACCACTCCCGCCGAAGGCGACATACTGCACCTGCAGCCGCACACACTGACCACCGGAGGCCGCGCTCT
GGCCCGCCACGGCAGACTGGCCGTTTTCATCGACAACGCGCTGCCCGGCCAGACAGTGACAGCCCGCGTGACCAGATGCC
GCAAAAATTATGCTGAAGCCACACTGCTTGGCGTTACCGCTGCCGCAGACTATCAGACCGAGCCTTTTTGCCGCCATTTT
GCAGAATGCGGCGGGTGCAGCTGGCAGCACATGCCGTATGCCATGCAGCTGGAATGGAAGCAGCGTCTGGTGCACGACGC
TTTTGTGCGCATCGGCAGAATTGCGGAACCGCCCGTCCTGCCCGCGCTGGCATCGCCCGCACAGCGCTTCTTTCGCAATA
AAATGGAATTTGCTTTTGAAAATGACAGTCCGCAGGGAATCCGCCTTGGTCTGCGCGCCAGAGGTTCGCATGACGTGATC
AATATAAGCGAGTGCCATCTGCAGTCGCAGCGCTGCGTGCGCATCGTGGATTCGGTAAGGCGCTGGGCCGCACAGACCGG
ACTGACAGCATGGGACGTGCGCAGCGGAGAAGGATTTTTCCGCTATCTTGTCATCCGCGAAACTCTGTATACCGGCCAGT
GCATGGTACAGCTGATTACCGGTCCGGAAAAAACCGGCGGCAATGCGGGAGCCCGTGCGGTCAGACAGCTCGGCGATCTG
CTGGCAGAGAGCGGCGAAGGTATCACATCCTTTATACATGGCGAACGCCGCTCGCCCGTACAGGCCGCGTATGCCGAAAA
GACCCTGTACAGCACAGGAGACAGCCACCTGACGGAACAACTGAACGGCAGGACGTTCACCATGGCTCCGCATGCCTTTT
TCCAGACCAACACAGCGGCGACGGAGATTCTGAGCAGAACCGCCGCTGACTATGCCGGTCAGGGCGGCGTACTGTGGGAC
CTGTACTGCGGAGTGGGCACCATGGGACTGGGCATGGCTGATCAGGTAACGTCGGTGACGGGCATGGAAGTATCTGAAGA
AGCCGTACAGTTCGCCACACTGAACGCCCGTAATCAGCAGGTGCCGCAGGCCCGTTTTTTGGCGGGCGATGTACGCAGAC
TGCTTATCAGGCACAAGGAAAAACCCGACATAGTCATCACGGACCCGCCCCGCGCCGGCATGCATCCCGATGTGCTCTCG
GCTCTTATATCCCGCGCACCGCGCAAAATTGTCTACATATCGTGCGATCCGGCCACGCAGGCGCGTGACGCAGCGGCTCT
GACAGACAGCTACCGGCTTGAAGCTGTGCAGCCCGTTGATATGTTTCCTCATTCTGCGCATATAGAAAGCGTCGCCCTGT
TTTCAATACGATGA

Upstream 100 bases:

>100_bases
GTTCCGTTTTGTGATTTTGCGCACAAATAAAACATAGCATACGATAATTACAGAACATTCCTGAACGAGCAAACACTCGC
TTTATAAGAGCAGCACAAAC

Downstream 100 bases:

>100_bases
CGGCATGGGCGGGAATATCCTCGCCGGACTGATTCTGCAGGATTTACCGGACTGCCCCGCTGCCCTTTCCGGCGCACCTT
ATGGCGCGGCAGCATGCGCT

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNTPTTPAEGDILHLQPHTLTTGGRALARHGRLAVFIDNALPGQTVTARVTRCRKNYAEATLLGVTAAADYQTEPFCRHF
AECGGCSWQHMPYAMQLEWKQRLVHDAFVRIGRIAEPPVLPALASPAQRFFRNKMEFAFENDSPQGIRLGLRARGSHDVI
NISECHLQSQRCVRIVDSVRRWAAQTGLTAWDVRSGEGFFRYLVIRETLYTGQCMVQLITGPEKTGGNAGARAVRQLGDL
LAESGEGITSFIHGERRSPVQAAYAEKTLYSTGDSHLTEQLNGRTFTMAPHAFFQTNTAATEILSRTAADYAGQGGVLWD
LYCGVGTMGLGMADQVTSVTGMEVSEEAVQFATLNARNQQVPQARFLAGDVRRLLIRHKEKPDIVITDPPRAGMHPDVLS
ALISRAPRKIVYISCDPATQARDAAALTDSYRLEAVQPVDMFPHSAHIESVALFSIR

Sequences:

>Translated_457_residues
MNTPTTPAEGDILHLQPHTLTTGGRALARHGRLAVFIDNALPGQTVTARVTRCRKNYAEATLLGVTAAADYQTEPFCRHF
AECGGCSWQHMPYAMQLEWKQRLVHDAFVRIGRIAEPPVLPALASPAQRFFRNKMEFAFENDSPQGIRLGLRARGSHDVI
NISECHLQSQRCVRIVDSVRRWAAQTGLTAWDVRSGEGFFRYLVIRETLYTGQCMVQLITGPEKTGGNAGARAVRQLGDL
LAESGEGITSFIHGERRSPVQAAYAEKTLYSTGDSHLTEQLNGRTFTMAPHAFFQTNTAATEILSRTAADYAGQGGVLWD
LYCGVGTMGLGMADQVTSVTGMEVSEEAVQFATLNARNQQVPQARFLAGDVRRLLIRHKEKPDIVITDPPRAGMHPDVLS
ALISRAPRKIVYISCDPATQARDAAALTDSYRLEAVQPVDMFPHSAHIESVALFSIR
>Mature_457_residues
MNTPTTPAEGDILHLQPHTLTTGGRALARHGRLAVFIDNALPGQTVTARVTRCRKNYAEATLLGVTAAADYQTEPFCRHF
AECGGCSWQHMPYAMQLEWKQRLVHDAFVRIGRIAEPPVLPALASPAQRFFRNKMEFAFENDSPQGIRLGLRARGSHDVI
NISECHLQSQRCVRIVDSVRRWAAQTGLTAWDVRSGEGFFRYLVIRETLYTGQCMVQLITGPEKTGGNAGARAVRQLGDL
LAESGEGITSFIHGERRSPVQAAYAEKTLYSTGDSHLTEQLNGRTFTMAPHAFFQTNTAATEILSRTAADYAGQGGVLWD
LYCGVGTMGLGMADQVTSVTGMEVSEEAVQFATLNARNQQVPQARFLAGDVRRLLIRHKEKPDIVITDPPRAGMHPDVLS
ALISRAPRKIVYISCDPATQARDAAALTDSYRLEAVQPVDMFPHSAHIESVALFSIR

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=438, Percent_Identity=29.2237442922374, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI51173878, Length=438, Percent_Identity=29.2237442922374, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI269784680, Length=376, Percent_Identity=25.7978723404255, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI269784676, Length=376, Percent_Identity=25.7978723404255, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI20149688, Length=376, Percent_Identity=25.7978723404255, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI269784678, Length=394, Percent_Identity=26.1421319796954, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789148, Length=460, Percent_Identity=27.6086956521739, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1787083, Length=378, Percent_Identity=29.1005291005291, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790403, Length=243, Percent_Identity=21.8106995884774, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997438, Length=173, Percent_Identity=31.2138728323699, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=443, Percent_Identity=24.3792325056433, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24666579, Length=421, Percent_Identity=25.8907363420428, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 50231; Mature: 50231

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPTTPAEGDILHLQPHTLTTGGRALARHGRLAVFIDNALPGQTVTARVTRCRKNYAEA
CCCCCCCCCCCEEEECCCEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
TLLGVTAAADYQTEPFCRHFAECGGCSWQHMPYAMQLEWKQRLVHDAFVRIGRIAEPPVL
EEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC
PALASPAQRFFRNKMEFAFENDSPQGIRLGLRARGSHDVINISECHLQSQRCVRIVDSVR
HHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
RWAAQTGLTAWDVRSGEGFFRYLVIRETLYTGQCMVQLITGPEKTGGNAGARAVRQLGDL
HHHHHCCCEEEEECCCCCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LAESGEGITSFIHGERRSPVQAAYAEKTLYSTGDSHLTEQLNGRTFTMAPHAFFQTNTAA
HHHCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCHHHCCCHHH
TEILSRTAADYAGQGGVLWDLYCGVGTMGLGMADQVTSVTGMEVSEEAVQFATLNARNQQ
HHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHEECCCCCC
VPQARFLAGDVRRLLIRHKEKPDIVITDPPRAGMHPDVLSALISRAPRKIVYISCDPATQ
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
ARDAAALTDSYRLEAVQPVDMFPHSAHIESVALFSIR
HHHHHHHCCCHHEEEECCHHCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MNTPTTPAEGDILHLQPHTLTTGGRALARHGRLAVFIDNALPGQTVTARVTRCRKNYAEA
CCCCCCCCCCCEEEECCCEECCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
TLLGVTAAADYQTEPFCRHFAECGGCSWQHMPYAMQLEWKQRLVHDAFVRIGRIAEPPVL
EEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC
PALASPAQRFFRNKMEFAFENDSPQGIRLGLRARGSHDVINISECHLQSQRCVRIVDSVR
HHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
RWAAQTGLTAWDVRSGEGFFRYLVIRETLYTGQCMVQLITGPEKTGGNAGARAVRQLGDL
HHHHHCCCEEEEECCCCCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LAESGEGITSFIHGERRSPVQAAYAEKTLYSTGDSHLTEQLNGRTFTMAPHAFFQTNTAA
HHHCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCHHHCCCHHH
TEILSRTAADYAGQGGVLWDLYCGVGTMGLGMADQVTSVTGMEVSEEAVQFATLNARNQQ
HHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHEECCCCCC
VPQARFLAGDVRRLLIRHKEKPDIVITDPPRAGMHPDVLSALISRAPRKIVYISCDPATQ
CCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
ARDAAALTDSYRLEAVQPVDMFPHSAHIESVALFSIR
HHHHHHHCCCHHEEEECCHHCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA