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The map label for this gene is rmlA [H]

Identifier: 78357735

GI number: 78357735

Start: 2699335

End: 2700210

Strand: Direct

Name: rmlA [H]

Synonym: Dde_2693

Alternate gene names: 78357735

Gene position: 2699335-2700210 (Clockwise)

Preceding gene: 78357727

Following gene: 78357736

Centisome position: 72.36

GC content: 58.11

Gene sequence:

>876_bases
ATGAAAGGCATCATTCTGGCGGGCGGTTCAGGCACGCGCCTGTACCCCATCACCCGCGGCGCCTGCAAACAGCTGCTGCC
GGTATATGACAAGCCCATGATATATTATCCGCTTTCCGTGCTGATGCTGGCAGGCATCCGCGAGGTGTGCATCATCTCCA
CGCCTGCCGACCTGCCGCGTTTCCGCGATATTCTGGGCGACGGTTCCGCGCTGGGGCTCAGCTTTTCCTACATTGAACAG
TCAAGCCCCGACGGACTGGCTCAGGCTTTTGTACTGGCACGCGACTTCATTGCCGGTCAGCCTGTCTGCCTTATACTGGG
CGACAACCTGTTTTACGGCACCGGACTTGCCACCCTGCTCGAAAATTCCGCACGCCTGCAGCAGGGGGGCATCGTTTTCG
GCTACAAGGTGCGCGACCCCGAACGATACGGCGTGGTGGAATTTGATAAAAACGCGCGTGTGATCAGCATAGAAGAAAAG
CCGCAGAGCCCCAAGTCGCGCTATGCCGTCACCGGACTGTATTTTTATGACGGCCGTGTGGCCGATGTGGCGGCCGGGCT
GACTCCGTCTGCCAGAGGCGAGCTGGAAATAACCGACCTGAACAACGAGTACCTGAAACAAGGCAGGCTGCAGGTGGAAT
TTCTGGGACGCGGCGTGGCATGGCTGGACACCGGCACATTTGAGTCACTGCATCAGGCATCGTCTTTTGTACGCGCGGTA
CAGGACAGACAGGGCCTGAAAATAGCCTGCATTGAAGAAATCGCCTACCGCAAAGGATACATCTGCGCCGACAGACTGCG
CGAACTGGCAGCCCCCATGATGAAAAACGAATACGGCAAGTACCTCATGGAGGTCGCCTCCGAAGCGGTGCGCTAG

Upstream 100 bases:

>100_bases
TTTCTCCCCCTTTCATTATCTCTTTATTCCACGCCATGTTTTGCGTATGTATGACGTTCTGCACGTCTGCATACCACATC
AATGAACACGAGGTTTTGGA

Downstream 100 bases:

>100_bases
CCGCAGGCCTGCCACCGGAAATCACGGCGCAGACGTGTTTTGCGCCAGATGAGGTGCATGGCGGCGCGGCATCGCCTGTC
ACGCGCCGTACGCGCCCCGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGSGTRLYPITRGACKQLLPVYDKPMIYYPLSVLMLAGIREVCIISTPADLPRFRDILGDGSALGLSFSYIEQ
SSPDGLAQAFVLARDFIAGQPVCLILGDNLFYGTGLATLLENSARLQQGGIVFGYKVRDPERYGVVEFDKNARVISIEEK
PQSPKSRYAVTGLYFYDGRVADVAAGLTPSARGELEITDLNNEYLKQGRLQVEFLGRGVAWLDTGTFESLHQASSFVRAV
QDRQGLKIACIEEIAYRKGYICADRLRELAAPMMKNEYGKYLMEVASEAVR

Sequences:

>Translated_291_residues
MKGIILAGGSGTRLYPITRGACKQLLPVYDKPMIYYPLSVLMLAGIREVCIISTPADLPRFRDILGDGSALGLSFSYIEQ
SSPDGLAQAFVLARDFIAGQPVCLILGDNLFYGTGLATLLENSARLQQGGIVFGYKVRDPERYGVVEFDKNARVISIEEK
PQSPKSRYAVTGLYFYDGRVADVAAGLTPSARGELEITDLNNEYLKQGRLQVEFLGRGVAWLDTGTFESLHQASSFVRAV
QDRQGLKIACIEEIAYRKGYICADRLRELAAPMMKNEYGKYLMEVASEAVR
>Mature_291_residues
MKGIILAGGSGTRLYPITRGACKQLLPVYDKPMIYYPLSVLMLAGIREVCIISTPADLPRFRDILGDGSALGLSFSYIEQ
SSPDGLAQAFVLARDFIAGQPVCLILGDNLFYGTGLATLLENSARLQQGGIVFGYKVRDPERYGVVEFDKNARVISIEEK
PQSPKSRYAVTGLYFYDGRVADVAAGLTPSARGELEITDLNNEYLKQGRLQVEFLGRGVAWLDTGTFESLHQASSFVRAV
QDRQGLKIACIEEIAYRKGYICADRLRELAAPMMKNEYGKYLMEVASEAVR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=235, Percent_Identity=26.8085106382979, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=235, Percent_Identity=26.8085106382979, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=61.8055555555556, Blast_Score=383, Evalue=1e-108,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=61.0526315789474, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1787488, Length=234, Percent_Identity=25.2136752136752, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788355, Length=245, Percent_Identity=24.0816326530612, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=242, Percent_Identity=24.3801652892562, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=25.8771929824561, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=25.8771929824561, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32060; Mature: 32060

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITRGACKQLLPVYDKPMIYYPLSVLMLAGIREVCIISTPADLPR
CCCEEEECCCCCEEEEECHHHHHHHHHHCCCCEEEHHHHHHHHHCCHHEEEEECCCCCHH
FRDILGDGSALGLSFSYIEQSSPDGLAQAFVLARDFIAGQPVCLILGDNLFYGTGLATLL
HHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHH
ENSARLQQGGIVFGYKVRDPERYGVVEFDKNARVISIEEKPQSPKSRYAVTGLYFYDGRV
HCHHHHHCCCEEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCCH
ADVAAGLTPSARGELEITDLNNEYLKQGRLQVEFLGRGVAWLDTGTFESLHQASSFVRAV
HHHHCCCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QDRQGLKIACIEEIAYRKGYICADRLRELAAPMMKNEYGKYLMEVASEAVR
HHCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITRGACKQLLPVYDKPMIYYPLSVLMLAGIREVCIISTPADLPR
CCCEEEECCCCCEEEEECHHHHHHHHHHCCCCEEEHHHHHHHHHCCHHEEEEECCCCCHH
FRDILGDGSALGLSFSYIEQSSPDGLAQAFVLARDFIAGQPVCLILGDNLFYGTGLATLL
HHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHH
ENSARLQQGGIVFGYKVRDPERYGVVEFDKNARVISIEEKPQSPKSRYAVTGLYFYDGRV
HCHHHHHCCCEEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCCH
ADVAAGLTPSARGELEITDLNNEYLKQGRLQVEFLGRGVAWLDTGTFESLHQASSFVRAV
HHHHCCCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QDRQGLKIACIEEIAYRKGYICADRLRELAAPMMKNEYGKYLMEVASEAVR
HHCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]