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The map label for this gene is thrS

Identifier: 78357681

GI number: 78357681

Start: 2655216

End: 2657150

Strand: Reverse

Name: thrS

Synonym: Dde_2639

Alternate gene names: 78357681

Gene position: 2657150-2655216 (Counterclockwise)

Preceding gene: 78357682

Following gene: 304570590

Centisome position: 71.23

GC content: 56.12

Gene sequence:

>1935_bases
GTGAAGGTTTCCATCGAAGGATCAGTGGTGGAGGTCGAGTCCGGCGCAAGCTGCCGGGACGTGCTCAAGCAGGCCTTGAG
CGGCAAGAAATTTAAAAAAGTGCTGGCTGCCCGTTGCGGCGGCACCATGCTCGATCTGACCGCGACCGTTCCGACCGCCT
GCGAAACCCTTGAGCCTGTCTATGCAGACTCGCCCGAAGGGCTTGGTCTTATCCGCCACAGTGCGGCCCACGTAATGGCC
GATGCCGTGCAGCGCCTTTTCCCCGGCGTAAAGGTGACCATCGGGCCTGCCATTGAAAACGGCTTCTATTACGATTTCGA
CTACGAGCGTCCGTTCACCGCAGATGATCTTGAAGCCATCGAAGCAGAGATGGACAAGATCATCAAGGCGGCGCATCCGT
TCGAGCGCAGTGTCATGTCCAAGGATGAGGCAAAGAAAATGTTTGCCGACATGGGCGAGACCTACAAGCTTGAGCTTATC
GACGCCGTGCCCGACGATATTGTTTCCATTTACCGCAGCGGCGACTTTGTCGACCTGTGCCGCGGTCCTCATATTCCCGA
TACCGGCTGTATCAATGCCTTCAAGCTGATGTCCGTTGCCGGCGCCTACTGGCGCGGTGATGAAAAGAATGCCATGCTTT
CGCGTGTGTACGGCACGGCTTTTCCTGATGAAAAAGAGCTGAAAAGCTATCTGAACAGAATAGAGGAAGCGAAAAAGCGT
GACCACCGCAAGCTGGGCACGCAGCTTGACCTGTTCAGCTTTCAGGAAGAAGGCGGCTCGGGCATGGTGTACTGGCATCC
CAAAGGGGCGCTTGTGCGCGCCATTCTGGAAGACTTCGAGCGTAAGGAACACCTGAAGCGCGGCTACCAGATTGTGCAGA
CGCCGCAGATTTTGCGCCGCGAGCTGTGGGAAAAATCCGGTCACTATGACAACTACCGTGAAAACATGTATTTTACGGAT
ATTGATGAGCAGCCCTACGGCGTAAAGCCCATGAACTGCGTGGCTCATATGCTCATCTATAAATCACGCAGCCACAGCTA
CCGCGACCTGCCCGTACGCCTTTTTGAGCTGGGCGTGGTGCACCGCCATGAAAAAAGCGGTGTTCTGCACGGATTGCTGC
GGGTGCGCCAGTTCACGCAGGATGATGCGCACATCATCTGCACTCCTGACCAGCTGGAAAGCGAAATCGTGGGTGTGCTG
AATTTTGTGCGGGATGTCATGGGCGTGTTCGGCTTTGAATATTCCATGGAAGTGAGCACCCGTCCCGAAAAGTCCATCGG
TTCCGACGAAGACTGGGACCGCGCCACCAGCGCGCTTGTGAAGGCGCTGGAAGGGCAGGGACTGCCCTACGAGATTAACG
AGGGCGACGGCGCCTTTTACGGGCCTAAAATTGACGTAAAACTGCGCGACTGCCTGGGCAGAGAGTGGCAGTGCGCCACG
GTGCAGTGTGATTTCACCTTGCCTGACCGCTTTGATCTGGTGTACATCGGACAGGATGGTGAACGCCATCGACCGGTTAT
GGTGCATCGCGTCATTCTTGGCTCGGTTGAGCGTTTCATCGGTGTGCTTACAGAGCATTTTGCCGGTGCCTTCCCCACGT
GGCTGGCTCCTGTTCAGGCACGTCTGCTCACCGTGACGGACGCCCAGAACGAGTTTGCCGAAGAAGCCCGCGCCGCTCTT
ATGGCGCAGGGTATCCGCGTGGAAGTGGACACCCGCAATGAAAAACTCGGCTACAAGGTACGTGAGGCACAGCTGGAAAA
GATTCCCTACATTCTCGTCATCGGTGACAAGGAAGTGGAAGCCCGCGGCGTGAACGTGCGCCTGAGAAAGGGTGATAATC
TTGGCCTTAAGACGCTGGATGAGGTAGTGGACATCATCAGGGCCGATTGTGAGGAACCGTTTAAAAGTGGAGGGATGCGC
TATAGCTTCTCCTAA

Upstream 100 bases:

>100_bases
CTGCCCGTGCCTACCACATCGAACAAAGCAGGGGGAGGCCCGTAGCCTCCCCCTTTTTGTCATTGGTGGCGGATAAATTG
ATTAGCAAGGAGTTTGCAAG

Downstream 100 bases:

>100_bases
GTTTCGTCGGCAGGAGCCGCAGGACGTGACGCGTCGCAACGAGCAGATTCGTGCACGCGAAGTTCGTGTCATCGATGCAG
ATGGCAGCCAGCTTGGTATT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MKVSIEGSVVEVESGASCRDVLKQALSGKKFKKVLAARCGGTMLDLTATVPTACETLEPVYADSPEGLGLIRHSAAHVMA
DAVQRLFPGVKVTIGPAIENGFYYDFDYERPFTADDLEAIEAEMDKIIKAAHPFERSVMSKDEAKKMFADMGETYKLELI
DAVPDDIVSIYRSGDFVDLCRGPHIPDTGCINAFKLMSVAGAYWRGDEKNAMLSRVYGTAFPDEKELKSYLNRIEEAKKR
DHRKLGTQLDLFSFQEEGGSGMVYWHPKGALVRAILEDFERKEHLKRGYQIVQTPQILRRELWEKSGHYDNYRENMYFTD
IDEQPYGVKPMNCVAHMLIYKSRSHSYRDLPVRLFELGVVHRHEKSGVLHGLLRVRQFTQDDAHIICTPDQLESEIVGVL
NFVRDVMGVFGFEYSMEVSTRPEKSIGSDEDWDRATSALVKALEGQGLPYEINEGDGAFYGPKIDVKLRDCLGREWQCAT
VQCDFTLPDRFDLVYIGQDGERHRPVMVHRVILGSVERFIGVLTEHFAGAFPTWLAPVQARLLTVTDAQNEFAEEARAAL
MAQGIRVEVDTRNEKLGYKVREAQLEKIPYILVIGDKEVEARGVNVRLRKGDNLGLKTLDEVVDIIRADCEEPFKSGGMR
YSFS

Sequences:

>Translated_644_residues
MKVSIEGSVVEVESGASCRDVLKQALSGKKFKKVLAARCGGTMLDLTATVPTACETLEPVYADSPEGLGLIRHSAAHVMA
DAVQRLFPGVKVTIGPAIENGFYYDFDYERPFTADDLEAIEAEMDKIIKAAHPFERSVMSKDEAKKMFADMGETYKLELI
DAVPDDIVSIYRSGDFVDLCRGPHIPDTGCINAFKLMSVAGAYWRGDEKNAMLSRVYGTAFPDEKELKSYLNRIEEAKKR
DHRKLGTQLDLFSFQEEGGSGMVYWHPKGALVRAILEDFERKEHLKRGYQIVQTPQILRRELWEKSGHYDNYRENMYFTD
IDEQPYGVKPMNCVAHMLIYKSRSHSYRDLPVRLFELGVVHRHEKSGVLHGLLRVRQFTQDDAHIICTPDQLESEIVGVL
NFVRDVMGVFGFEYSMEVSTRPEKSIGSDEDWDRATSALVKALEGQGLPYEINEGDGAFYGPKIDVKLRDCLGREWQCAT
VQCDFTLPDRFDLVYIGQDGERHRPVMVHRVILGSVERFIGVLTEHFAGAFPTWLAPVQARLLTVTDAQNEFAEEARAAL
MAQGIRVEVDTRNEKLGYKVREAQLEKIPYILVIGDKEVEARGVNVRLRKGDNLGLKTLDEVVDIIRADCEEPFKSGGMR
YSFS
>Mature_644_residues
MKVSIEGSVVEVESGASCRDVLKQALSGKKFKKVLAARCGGTMLDLTATVPTACETLEPVYADSPEGLGLIRHSAAHVMA
DAVQRLFPGVKVTIGPAIENGFYYDFDYERPFTADDLEAIEAEMDKIIKAAHPFERSVMSKDEAKKMFADMGETYKLELI
DAVPDDIVSIYRSGDFVDLCRGPHIPDTGCINAFKLMSVAGAYWRGDEKNAMLSRVYGTAFPDEKELKSYLNRIEEAKKR
DHRKLGTQLDLFSFQEEGGSGMVYWHPKGALVRAILEDFERKEHLKRGYQIVQTPQILRRELWEKSGHYDNYRENMYFTD
IDEQPYGVKPMNCVAHMLIYKSRSHSYRDLPVRLFELGVVHRHEKSGVLHGLLRVRQFTQDDAHIICTPDQLESEIVGVL
NFVRDVMGVFGFEYSMEVSTRPEKSIGSDEDWDRATSALVKALEGQGLPYEINEGDGAFYGPKIDVKLRDCLGREWQCAT
VQCDFTLPDRFDLVYIGQDGERHRPVMVHRVILGSVERFIGVLTEHFAGAFPTWLAPVQARLLTVTDAQNEFAEEARAAL
MAQGIRVEVDTRNEKLGYKVREAQLEKIPYILVIGDKEVEARGVNVRLRKGDNLGLKTLDEVVDIIRADCEEPFKSGGMR
YSFS

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=629, Percent_Identity=40.6995230524642, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI38570111, Length=626, Percent_Identity=38.6581469648562, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI20070344, Length=623, Percent_Identity=40.4494382022472, Blast_Score=433, Evalue=1e-121,
Organism=Escherichia coli, GI1788013, Length=601, Percent_Identity=49.0848585690516, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71984184, Length=603, Percent_Identity=40.1326699834162, Blast_Score=477, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=603, Percent_Identity=40.1326699834162, Blast_Score=477, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322112, Length=646, Percent_Identity=41.7956656346749, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322654, Length=380, Percent_Identity=38.6842105263158, Blast_Score=287, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24583839, Length=627, Percent_Identity=40.6698564593301, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24583842, Length=627, Percent_Identity=40.6698564593301, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI28574141, Length=627, Percent_Identity=40.6698564593301, Blast_Score=499, Evalue=1e-141,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_DESDG (Q30Y11)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389130.1
- ProteinModelPortal:   Q30Y11
- SMR:   Q30Y11
- STRING:   Q30Y11
- GeneID:   3757661
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2639
- NMPDR:   fig|207559.3.peg.2856
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK12305
- BioCyc:   DDES207559:DDE_2639-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72729; Mature: 72729

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSIEGSVVEVESGASCRDVLKQALSGKKFKKVLAARCGGTMLDLTATVPTACETLEPV
CEEEECCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCC
YADSPEGLGLIRHSAAHVMADAVQRLFPGVKVTIGPAIENGFYYDFDYERPFTADDLEAI
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCHHHHHHH
EAEMDKIIKAAHPFERSVMSKDEAKKMFADMGETYKLELIDAVPDDIVSIYRSGDFVDLC
HHHHHHHHHHCCCHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHH
RGPHIPDTGCINAFKLMSVAGAYWRGDEKNAMLSRVYGTAFPDEKELKSYLNRIEEAKKR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DHRKLGTQLDLFSFQEEGGSGMVYWHPKGALVRAILEDFERKEHLKRGYQIVQTPQILRR
HHHHHCCEEEEEEHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHH
ELWEKSGHYDNYRENMYFTDIDEQPYGVKPMNCVAHMLIYKSRSHSYRDLPVRLFELGVV
HHHHHCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
HRHEKSGVLHGLLRVRQFTQDDAHIICTPDQLESEIVGVLNFVRDVMGVFGFEYSMEVST
HCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RPEKSIGSDEDWDRATSALVKALEGQGLPYEINEGDGAFYGPKIDVKLRDCLGREWQCAT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEECCEEEEEHHHHCCCCEEEEE
VQCDFTLPDRFDLVYIGQDGERHRPVMVHRVILGSVERFIGVLTEHFAGAFPTWLAPVQA
EEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RLLTVTDAQNEFAEEARAALMAQGIRVEVDTRNEKLGYKVREAQLEKIPYILVIGDKEVE
EEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCCEE
ARGVNVRLRKGDNLGLKTLDEVVDIIRADCEEPFKSGGMRYSFS
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MKVSIEGSVVEVESGASCRDVLKQALSGKKFKKVLAARCGGTMLDLTATVPTACETLEPV
CEEEECCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCC
YADSPEGLGLIRHSAAHVMADAVQRLFPGVKVTIGPAIENGFYYDFDYERPFTADDLEAI
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCHHHHHHH
EAEMDKIIKAAHPFERSVMSKDEAKKMFADMGETYKLELIDAVPDDIVSIYRSGDFVDLC
HHHHHHHHHHCCCHHHHHHCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHH
RGPHIPDTGCINAFKLMSVAGAYWRGDEKNAMLSRVYGTAFPDEKELKSYLNRIEEAKKR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DHRKLGTQLDLFSFQEEGGSGMVYWHPKGALVRAILEDFERKEHLKRGYQIVQTPQILRR
HHHHHCCEEEEEEHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHH
ELWEKSGHYDNYRENMYFTDIDEQPYGVKPMNCVAHMLIYKSRSHSYRDLPVRLFELGVV
HHHHHCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
HRHEKSGVLHGLLRVRQFTQDDAHIICTPDQLESEIVGVLNFVRDVMGVFGFEYSMEVST
HCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RPEKSIGSDEDWDRATSALVKALEGQGLPYEINEGDGAFYGPKIDVKLRDCLGREWQCAT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEECCEEEEEHHHHCCCCEEEEE
VQCDFTLPDRFDLVYIGQDGERHRPVMVHRVILGSVERFIGVLTEHFAGAFPTWLAPVQA
EEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RLLTVTDAQNEFAEEARAALMAQGIRVEVDTRNEKLGYKVREAQLEKIPYILVIGDKEVE
EEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCCEE
ARGVNVRLRKGDNLGLKTLDEVVDIIRADCEEPFKSGGMRYSFS
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA