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The map label for this gene is argH

Identifier: 78357573

GI number: 78357573

Start: 2548903

End: 2550285

Strand: Reverse

Name: argH

Synonym: Dde_2530

Alternate gene names: 78357573

Gene position: 2550285-2548903 (Counterclockwise)

Preceding gene: 78357574

Following gene: 78357572

Centisome position: 68.37

GC content: 59.36

Gene sequence:

>1383_bases
ATGACTGCGGGCAAGCTGTGGGGCGGGCGTTTTCGTGAGCGCACCGCCGGATTGGTGGAGGAATACACCGAGTCCGTTTC
GTACGACCGCGCGTTGTACGCTCAGGATATCGCCGGTTCCAAGGCTCATGCCCGTATGCTGGCGCGGCAGGGAGTCATTT
CCGCCGGGGATGCCGGACGCATAACCGAAGGGCTGGAACAGATACGCAAAGAGATTGAATCCGGTGAGTTTGTGTGGCGT
ACCGAGATGGAAGACGTGCACATGAACATTGAAAGCCGCCTTACCGAACTGGTGGGTGACGCCGGAAGACGCCTGCATAC
CGGCCGCAGCCGCAACGATCAGGTGGCCCTTGATTTCCGGCTGTTTGTTTCGGACAGAATCCGCGTATGGAAGAATCTGG
TACGGGGTGTCATTGCCGCGCTGACTGCTCAGGCGCATGAACACAAAGACACGCTGCTGCCCGGTTGCACGCATCTGCAG
GCGGCTCAGCCTGTCAGTCTTGCCCAGCATCTGCTTGCCTACGCATGGATGTTGCGGCGGGATTACGACCGGCTGGAAGA
CTGCGACCGGCGTGTGCGCATATGCCCGCTGGGGGCTGCGGCACTGGCCGGTACGACGTATCCGCTTGATCCGCAGTCCG
TTGCCGCCGAACTGGACATGTACGGTGTGTTCAACAACTCCATGGATGCCGTTTCCGACAGGGACTTCGCGCTGGAAGCA
CAGTTCTGCGGTTCGCTGATCATGGCGCATATGTCGCGCCTGTGTGAAGAGATAATCCTCTGGGCCAATCCCAACTTCGG
GTACATATTTCTGCCTGATGCCTATGCCACCGGTTCCAGCATCATGCCGCAGAAAAAGAACCCCGATGTGGCGGAAATAA
TGCGCGGCAAGACCGGTCGCGTCTACGGCGGGCTCATGTCGCTGCTGACCACGCTCAAGGGACTGCCCATGACGTACAAC
CGTGACCTGCAGGAAGACAAAGAGCCTTTCATCGACACGGACCGGACGGTTTCGGCTTCGCTGGAAATAATGGCCGGCAT
GGTAGAAGCACTGCGCTTCAACACGCGGCGCATGGAAAATGCGCTTCGGGCGGGTTTTCTCAATGCCACCGAACTTGCCG
ATTATCTGGTCGGTAAAGGAGTGCCCTTCCGCGACGCGCACCATATCACCGGCAATGCCGTGGCGCTGGCAGAAGACAGG
GGCAAAGGGCTTGAAGACCTTACCCTTGAGGAATTCCATTCGGTATCGGACCTGATCGGCGAAGATGTTTTCGCCGTGCT
GGATTACCGTGCCGCTGTGGAACGCCGCTGCACACACGGCGGCACCGGACCGGCATCGGTGGCGGCTCAGCTGGCTGCTT
TGCAGCAATGGCTTTCCAGCTGA

Upstream 100 bases:

>100_bases
GCGACCTTTGAGGAAGATGAAGTTTACAATCAGGCAGACGCCGCCGGCTTTATCCGCCTGAACAGTCTGCGCATTCAGGG
TTACGGCAGGAGAAGCTGAC

Downstream 100 bases:

>100_bases
GCAGTTCCGGCGCTGCATTAATGTATGTGACAGGCCGTCCGCATGCGGGCGGCCTTTTTGTATGCGCAGTTGACGGTGAG
CAGAAGGGACCGGAAGGGGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTAGKLWGGRFRERTAGLVEEYTESVSYDRALYAQDIAGSKAHARMLARQGVISAGDAGRITEGLEQIRKEIESGEFVWR
TEMEDVHMNIESRLTELVGDAGRRLHTGRSRNDQVALDFRLFVSDRIRVWKNLVRGVIAALTAQAHEHKDTLLPGCTHLQ
AAQPVSLAQHLLAYAWMLRRDYDRLEDCDRRVRICPLGAAALAGTTYPLDPQSVAAELDMYGVFNNSMDAVSDRDFALEA
QFCGSLIMAHMSRLCEEIILWANPNFGYIFLPDAYATGSSIMPQKKNPDVAEIMRGKTGRVYGGLMSLLTTLKGLPMTYN
RDLQEDKEPFIDTDRTVSASLEIMAGMVEALRFNTRRMENALRAGFLNATELADYLVGKGVPFRDAHHITGNAVALAEDR
GKGLEDLTLEEFHSVSDLIGEDVFAVLDYRAAVERRCTHGGTGPASVAAQLAALQQWLSS

Sequences:

>Translated_460_residues
MTAGKLWGGRFRERTAGLVEEYTESVSYDRALYAQDIAGSKAHARMLARQGVISAGDAGRITEGLEQIRKEIESGEFVWR
TEMEDVHMNIESRLTELVGDAGRRLHTGRSRNDQVALDFRLFVSDRIRVWKNLVRGVIAALTAQAHEHKDTLLPGCTHLQ
AAQPVSLAQHLLAYAWMLRRDYDRLEDCDRRVRICPLGAAALAGTTYPLDPQSVAAELDMYGVFNNSMDAVSDRDFALEA
QFCGSLIMAHMSRLCEEIILWANPNFGYIFLPDAYATGSSIMPQKKNPDVAEIMRGKTGRVYGGLMSLLTTLKGLPMTYN
RDLQEDKEPFIDTDRTVSASLEIMAGMVEALRFNTRRMENALRAGFLNATELADYLVGKGVPFRDAHHITGNAVALAEDR
GKGLEDLTLEEFHSVSDLIGEDVFAVLDYRAAVERRCTHGGTGPASVAAQLAALQQWLSS
>Mature_459_residues
TAGKLWGGRFRERTAGLVEEYTESVSYDRALYAQDIAGSKAHARMLARQGVISAGDAGRITEGLEQIRKEIESGEFVWRT
EMEDVHMNIESRLTELVGDAGRRLHTGRSRNDQVALDFRLFVSDRIRVWKNLVRGVIAALTAQAHEHKDTLLPGCTHLQA
AQPVSLAQHLLAYAWMLRRDYDRLEDCDRRVRICPLGAAALAGTTYPLDPQSVAAELDMYGVFNNSMDAVSDRDFALEAQ
FCGSLIMAHMSRLCEEIILWANPNFGYIFLPDAYATGSSIMPQKKNPDVAEIMRGKTGRVYGGLMSLLTTLKGLPMTYNR
DLQEDKEPFIDTDRTVSASLEIMAGMVEALRFNTRRMENALRAGFLNATELADYLVGKGVPFRDAHHITGNAVALAEDRG
KGLEDLTLEEFHSVSDLIGEDVFAVLDYRAAVERRCTHGGTGPASVAAQLAALQQWLSS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=449, Percent_Identity=43.2071269487751, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=449, Percent_Identity=43.2071269487751, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI68303549, Length=449, Percent_Identity=41.2026726057906, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=40.0890868596882, Blast_Score=339, Evalue=3e-93,
Organism=Escherichia coli, GI1790398, Length=451, Percent_Identity=41.9068736141907, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=44.1048034934498, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=41.3716814159292, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=41.3716814159292, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_DESDG (Q30YB9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389022.1
- ProteinModelPortal:   Q30YB9
- SMR:   Q30YB9
- STRING:   Q30YB9
- GeneID:   3757547
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2530
- NMPDR:   fig|207559.3.peg.3468
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   DDES207559:DDE_2530-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50976; Mature: 50844

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGKLWGGRFRERTAGLVEEYTESVSYDRALYAQDIAGSKAHARMLARQGVISAGDAGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHH
ITEGLEQIRKEIESGEFVWRTEMEDVHMNIESRLTELVGDAGRRLHTGRSRNDQVALDFR
HHHHHHHHHHHHCCCCEEEEECHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEH
LFVSDRIRVWKNLVRGVIAALTAQAHEHKDTLLPGCTHLQAAQPVSLAQHLLAYAWMLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHH
DYDRLEDCDRRVRICPLGAAALAGTTYPLDPQSVAAELDMYGVFNNSMDAVSDRDFALEA
HHHHHHHHHCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
QFCGSLIMAHMSRLCEEIILWANPNFGYIFLPDAYATGSSIMPQKKNPDVAEIMRGKTGR
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGGLMSLLTTLKGLPMTYNRDLQEDKEPFIDTDRTVSASLEIMAGMVEALRFNTRRMEN
HHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALRAGFLNATELADYLVGKGVPFRDAHHITGNAVALAEDRGKGLEDLTLEEFHSVSDLIG
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
EDVFAVLDYRAAVERRCTHGGTGPASVAAQLAALQQWLSS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAGKLWGGRFRERTAGLVEEYTESVSYDRALYAQDIAGSKAHARMLARQGVISAGDAGR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHH
ITEGLEQIRKEIESGEFVWRTEMEDVHMNIESRLTELVGDAGRRLHTGRSRNDQVALDFR
HHHHHHHHHHHHCCCCEEEEECHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEH
LFVSDRIRVWKNLVRGVIAALTAQAHEHKDTLLPGCTHLQAAQPVSLAQHLLAYAWMLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHH
DYDRLEDCDRRVRICPLGAAALAGTTYPLDPQSVAAELDMYGVFNNSMDAVSDRDFALEA
HHHHHHHHHCCEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHH
QFCGSLIMAHMSRLCEEIILWANPNFGYIFLPDAYATGSSIMPQKKNPDVAEIMRGKTGR
HHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGGLMSLLTTLKGLPMTYNRDLQEDKEPFIDTDRTVSASLEIMAGMVEALRFNTRRMEN
HHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALRAGFLNATELADYLVGKGVPFRDAHHITGNAVALAEDRGKGLEDLTLEEFHSVSDLIG
HHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
EDVFAVLDYRAAVERRCTHGGTGPASVAAQLAALQQWLSS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA