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The map label for this gene is recQ [H]

Identifier: 78357489

GI number: 78357489

Start: 2467747

End: 2469966

Strand: Direct

Name: recQ [H]

Synonym: Dde_2446

Alternate gene names: 78357489

Gene position: 2467747-2469966 (Clockwise)

Preceding gene: 78357488

Following gene: 78357493

Centisome position: 66.16

GC content: 59.91

Gene sequence:

>2220_bases
ATGCTCGACACAGCCCGGGAAATCCTCATCTCCACATACGGATTCCGCGACTTTCAGGGGCTGCAAAAAGATATCATAGA
ACACACCGCATCCGGCGGCGACGCGCTGGTGCTCATGCCCACAGGCGGCGGCAAGTCACTGTGCTACCAGATTCCCTCCA
TCATGCGGCAGGGCACCGGTATTGTCATATCGCCGCTTATCGCGCTTATGCAGGATCAGGTGGACAGCCTCACGCAGATG
GGAGTACGCGCGGCTTTTCTTAACTCCAGCCTGTCTCCTGAAAAACAGCGCGAGGTGGAAGCACGCCTACTGAGCGGCAT
GCTCGATCTCGTCTATGTAGCGCCCGAACGGCTGGTGCAGCCTGCTTTTCTGGGGCTGCTTGAAAGAATAACACCCGCGC
TGTTCGCCATTGACGAGGCGCATTGCGTTTCGCAGTGGGGGCATGATTTCAGGCCGGAATACACACGGCTGACCATTCTG
CATGAGCAGTTTCCGCATGTGCCCCGGATAGCTCTTACCGCCACGGCGGACGGGCCCACCAGACGCGACATCATCAGGCA
TCTGGACCTGCAGGACGCCACTGTTTTTTCTACGGGATTCGACCGCCCCAATATTTCGTACACCATACAGCCCAAAGACA
AGCCGCTGGAGCAGCTGCTGCATTTCATCCGCACACGCCACAAAGGACAGTCGGGCATAGTGTACCGGCTGAGCAGAAAA
AAAGTTGAAGAAACAGCAGCCTGGCTGTGTGCAAAAGGCATAGAAGCCCTGCCCTATCACGCAGGGCTCAACGCCATTCA
GCGTCATCACAATCAGGAACGGTTCATGCGTGAAGACGGGCTGGTCATGGTGGCTACCGTGGCCTTCGGCATGGGGGTGG
ACAAGCCGGATGTACGCTTTGTGGCACACCTTGAGCCGCCAAAAAGTCTGGAAGCCTATCATCAGGAAACCGGACGTGCG
GGACGTGACGGCCTGCCCGCCGATGCATGGATGACATACGGTCTGGCCGATGTGGTGCAATTGCGGCGCATGCTGGGCCA
AGGCGAAGAAGACAGCCCGCGGCGCATGGTCGAACTGCGCAAGCTGGATGCCATGCTCGCCTTTTGCGAAACAACCGAGT
GCCGCCGTAAAGTGCTGCTGGGCTATTTCGGCGAACACGACAGAGAACCCTGCGGAAACTGCGACACCTGTCAGTTTCCT
GTAGAGACATGGGACGGCACGGTGGCCGCCCAGAAAGCACTGAGCGCCGTATACCGCACCGGTCAGCGCTTCGGCGCCGC
ACACCTGACAGACATACTTACCGGCAAGCTGACCGACCGCATACGCAGCCACGGGCATAACGACCTGAAAACATTCGGCT
GCGGCAAAGAACTGGGTGCATCGCAATGGAAAGGCGTGTTCAGACAGCTGGCATGTCTGGGGCTGCTTGCCACCGATGCG
GACGGGCACGGCGGCCTGCGTCTGACACCGGAAAGCTGGCAGGTACTGCGCGGAGAACGCATGCTGAGCTTCCGGCGTGA
CATTCTGGGCCGCTCCGCCACACGTGCACTGGCAAAAACACAGGCCGACGCGGCTCTGCAGAATGCCCTGAACACGGAAG
AATCCAGACAGCTGTGGGATACCCTGCGCTCGTTACGGGGCAGGCTGGCACAGGAACGTGACGTGCCGCCCTACGCCGTT
TTTGCGGACAGGGCCCTGCTGGAGATGGTCTGCTTTCGGCCGCGCACGCCGGATGACCTGCAATGCATTCACGGCGTCGG
CAAAGCCAAGCTGTCCATGTTCGGGCAGGAATTTCTTGATGCGCTGCTCTCGCACGAAGCCGCCTGGGGCAGGCCGGACG
ATCTGCCCGCACTGCCCGAACGCAGACCGGCTACTGCCGCAAAAAAGGAAAACGGCCTTACCGACACCATACGCGAAACG
CTGCAGCTTTTTAACAAGCTGCAGGACATGCAGGCCGTGGCCGAGGCCCGCGCCCTGAAACCGGCCACCATATGCAATCA
TCTGGTACGGTGCATACGTCATGGCGAGCTGACCACGGAACAGGTGGTGCCCCTGCCCGCGCACGAGCTGGCAGAAATAC
GGGGAGTGCTGGGTGAAACAGCTTCGCTGGGCGGAGTTACCGCCGCGCACGGCAGACTGAAAGGCCGCTATGATTTTGAA
ACCCTGCGGCTGGTTCAGGCCGAGCTGTTCATCAGGCGGGGTGACGAGGAAGACTGGTAA

Upstream 100 bases:

>100_bases
CTGCGGCGGAACCTCCCGTTTTGCTCTTTGCGCCTGCCGCCGGCAGTGGTACAGTGCGCACGCCATGACGCAACAGACCC
ATACCACAACAGCTTCATCC

Downstream 100 bases:

>100_bases
GCCTGCCGCGGGTGCGCACAGCCGCCCGCACCGGCGCATCAGCCTGCCATGACGGGAAACACCGCACCGGCCGCATGCAT
GCGCAGCAGCCGCGACAGCC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MLDTAREILISTYGFRDFQGLQKDIIEHTASGGDALVLMPTGGGKSLCYQIPSIMRQGTGIVISPLIALMQDQVDSLTQM
GVRAAFLNSSLSPEKQREVEARLLSGMLDLVYVAPERLVQPAFLGLLERITPALFAIDEAHCVSQWGHDFRPEYTRLTIL
HEQFPHVPRIALTATADGPTRRDIIRHLDLQDATVFSTGFDRPNISYTIQPKDKPLEQLLHFIRTRHKGQSGIVYRLSRK
KVEETAAWLCAKGIEALPYHAGLNAIQRHHNQERFMREDGLVMVATVAFGMGVDKPDVRFVAHLEPPKSLEAYHQETGRA
GRDGLPADAWMTYGLADVVQLRRMLGQGEEDSPRRMVELRKLDAMLAFCETTECRRKVLLGYFGEHDREPCGNCDTCQFP
VETWDGTVAAQKALSAVYRTGQRFGAAHLTDILTGKLTDRIRSHGHNDLKTFGCGKELGASQWKGVFRQLACLGLLATDA
DGHGGLRLTPESWQVLRGERMLSFRRDILGRSATRALAKTQADAALQNALNTEESRQLWDTLRSLRGRLAQERDVPPYAV
FADRALLEMVCFRPRTPDDLQCIHGVGKAKLSMFGQEFLDALLSHEAAWGRPDDLPALPERRPATAAKKENGLTDTIRET
LQLFNKLQDMQAVAEARALKPATICNHLVRCIRHGELTTEQVVPLPAHELAEIRGVLGETASLGGVTAAHGRLKGRYDFE
TLRLVQAELFIRRGDEEDW

Sequences:

>Translated_739_residues
MLDTAREILISTYGFRDFQGLQKDIIEHTASGGDALVLMPTGGGKSLCYQIPSIMRQGTGIVISPLIALMQDQVDSLTQM
GVRAAFLNSSLSPEKQREVEARLLSGMLDLVYVAPERLVQPAFLGLLERITPALFAIDEAHCVSQWGHDFRPEYTRLTIL
HEQFPHVPRIALTATADGPTRRDIIRHLDLQDATVFSTGFDRPNISYTIQPKDKPLEQLLHFIRTRHKGQSGIVYRLSRK
KVEETAAWLCAKGIEALPYHAGLNAIQRHHNQERFMREDGLVMVATVAFGMGVDKPDVRFVAHLEPPKSLEAYHQETGRA
GRDGLPADAWMTYGLADVVQLRRMLGQGEEDSPRRMVELRKLDAMLAFCETTECRRKVLLGYFGEHDREPCGNCDTCQFP
VETWDGTVAAQKALSAVYRTGQRFGAAHLTDILTGKLTDRIRSHGHNDLKTFGCGKELGASQWKGVFRQLACLGLLATDA
DGHGGLRLTPESWQVLRGERMLSFRRDILGRSATRALAKTQADAALQNALNTEESRQLWDTLRSLRGRLAQERDVPPYAV
FADRALLEMVCFRPRTPDDLQCIHGVGKAKLSMFGQEFLDALLSHEAAWGRPDDLPALPERRPATAAKKENGLTDTIRET
LQLFNKLQDMQAVAEARALKPATICNHLVRCIRHGELTTEQVVPLPAHELAEIRGVLGETASLGGVTAAHGRLKGRYDFE
TLRLVQAELFIRRGDEEDW
>Mature_739_residues
MLDTAREILISTYGFRDFQGLQKDIIEHTASGGDALVLMPTGGGKSLCYQIPSIMRQGTGIVISPLIALMQDQVDSLTQM
GVRAAFLNSSLSPEKQREVEARLLSGMLDLVYVAPERLVQPAFLGLLERITPALFAIDEAHCVSQWGHDFRPEYTRLTIL
HEQFPHVPRIALTATADGPTRRDIIRHLDLQDATVFSTGFDRPNISYTIQPKDKPLEQLLHFIRTRHKGQSGIVYRLSRK
KVEETAAWLCAKGIEALPYHAGLNAIQRHHNQERFMREDGLVMVATVAFGMGVDKPDVRFVAHLEPPKSLEAYHQETGRA
GRDGLPADAWMTYGLADVVQLRRMLGQGEEDSPRRMVELRKLDAMLAFCETTECRRKVLLGYFGEHDREPCGNCDTCQFP
VETWDGTVAAQKALSAVYRTGQRFGAAHLTDILTGKLTDRIRSHGHNDLKTFGCGKELGASQWKGVFRQLACLGLLATDA
DGHGGLRLTPESWQVLRGERMLSFRRDILGRSATRALAKTQADAALQNALNTEESRQLWDTLRSLRGRLAQERDVPPYAV
FADRALLEMVCFRPRTPDDLQCIHGVGKAKLSMFGQEFLDALLSHEAAWGRPDDLPALPERRPATAAKKENGLTDTIRET
LQLFNKLQDMQAVAEARALKPATICNHLVRCIRHGELTTEQVVPLPAHELAEIRGVLGETASLGGVTAAHGRLKGRYDFE
TLRLVQAELFIRRGDEEDW

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=648, Percent_Identity=33.179012345679, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI14591902, Length=407, Percent_Identity=39.5577395577396, Blast_Score=299, Evalue=7e-81,
Organism=Homo sapiens, GI14591904, Length=407, Percent_Identity=39.5577395577396, Blast_Score=299, Evalue=7e-81,
Organism=Homo sapiens, GI148612816, Length=426, Percent_Identity=39.6713615023474, Blast_Score=271, Evalue=2e-72,
Organism=Homo sapiens, GI110735439, Length=500, Percent_Identity=34.6, Blast_Score=266, Evalue=7e-71,
Organism=Homo sapiens, GI169218196, Length=500, Percent_Identity=34.6, Blast_Score=266, Evalue=8e-71,
Organism=Homo sapiens, GI51242947, Length=395, Percent_Identity=40.253164556962, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI51242943, Length=395, Percent_Identity=40.253164556962, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI284005309, Length=370, Percent_Identity=34.0540540540541, Blast_Score=174, Evalue=3e-43,
Organism=Escherichia coli, GI48994977, Length=604, Percent_Identity=47.1854304635762, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25145561, Length=661, Percent_Identity=33.1316187594554, Blast_Score=327, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71987997, Length=411, Percent_Identity=39.1727493917275, Blast_Score=285, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI71987993, Length=411, Percent_Identity=39.1727493917275, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI32564293, Length=816, Percent_Identity=28.7990196078431, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17552866, Length=409, Percent_Identity=35.4523227383863, Blast_Score=248, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6323844, Length=478, Percent_Identity=37.8661087866109, Blast_Score=334, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24646066, Length=629, Percent_Identity=34.9761526232114, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24664226, Length=417, Percent_Identity=39.0887290167866, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24664230, Length=417, Percent_Identity=39.0887290167866, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI62472181, Length=417, Percent_Identity=39.0887290167866, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI21358123, Length=360, Percent_Identity=36.3888888888889, Blast_Score=199, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82492; Mature: 82492

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTAREILISTYGFRDFQGLQKDIIEHTASGGDALVLMPTGGGKSLCYQIPSIMRQGTG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
IVISPLIALMQDQVDSLTQMGVRAAFLNSSLSPEKQREVEARLLSGMLDLVYVAPERLVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
PAFLGLLERITPALFAIDEAHCVSQWGHDFRPEYTRLTILHEQFPHVPRIALTATADGPT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEHHHCCCCCCEEEEECCCCCH
RRDIIRHLDLQDATVFSTGFDRPNISYTIQPKDKPLEQLLHFIRTRHKGQSGIVYRLSRK
HHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHH
KVEETAAWLCAKGIEALPYHAGLNAIQRHHNQERFMREDGLVMVATVAFGMGVDKPDVRF
HHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCEE
VAHLEPPKSLEAYHQETGRAGRDGLPADAWMTYGLADVVQLRRMLGQGEEDSPRRMVELR
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KLDAMLAFCETTECRRKVLLGYFGEHDREPCGNCDTCQFPVETWDGTVAAQKALSAVYRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHH
GQRFGAAHLTDILTGKLTDRIRSHGHNDLKTFGCGKELGASQWKGVFRQLACLGLLATDA
HHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHHHHHHHHHHHEECC
DGHGGLRLTPESWQVLRGERMLSFRRDILGRSATRALAKTQADAALQNALNTEESRQLWD
CCCCCEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TLRSLRGRLAQERDVPPYAVFADRALLEMVCFRPRTPDDLQCIHGVGKAKLSMFGQEFLD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHH
ALLSHEAAWGRPDDLPALPERRPATAAKKENGLTDTIRETLQLFNKLQDMQAVAEARALK
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PATICNHLVRCIRHGELTTEQVVPLPAHELAEIRGVLGETASLGGVTAAHGRLKGRYDFE
HHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHCCCCCCCCCHH
TLRLVQAELFIRRGDEEDW
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDTAREILISTYGFRDFQGLQKDIIEHTASGGDALVLMPTGGGKSLCYQIPSIMRQGTG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
IVISPLIALMQDQVDSLTQMGVRAAFLNSSLSPEKQREVEARLLSGMLDLVYVAPERLVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
PAFLGLLERITPALFAIDEAHCVSQWGHDFRPEYTRLTILHEQFPHVPRIALTATADGPT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEHHHCCCCCCEEEEECCCCCH
RRDIIRHLDLQDATVFSTGFDRPNISYTIQPKDKPLEQLLHFIRTRHKGQSGIVYRLSRK
HHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHH
KVEETAAWLCAKGIEALPYHAGLNAIQRHHNQERFMREDGLVMVATVAFGMGVDKPDVRF
HHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCEE
VAHLEPPKSLEAYHQETGRAGRDGLPADAWMTYGLADVVQLRRMLGQGEEDSPRRMVELR
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KLDAMLAFCETTECRRKVLLGYFGEHDREPCGNCDTCQFPVETWDGTVAAQKALSAVYRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHH
GQRFGAAHLTDILTGKLTDRIRSHGHNDLKTFGCGKELGASQWKGVFRQLACLGLLATDA
HHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHCCHHHHHHHHHHHHHHHHHEECC
DGHGGLRLTPESWQVLRGERMLSFRRDILGRSATRALAKTQADAALQNALNTEESRQLWD
CCCCCEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TLRSLRGRLAQERDVPPYAVFADRALLEMVCFRPRTPDDLQCIHGVGKAKLSMFGQEFLD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHH
ALLSHEAAWGRPDDLPALPERRPATAAKKENGLTDTIRETLQLFNKLQDMQAVAEARALK
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PATICNHLVRCIRHGELTTEQVVPLPAHELAEIRGVLGETASLGGVTAAHGRLKGRYDFE
HHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHCCCCCCCCCHH
TLRLVQAELFIRRGDEEDW
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]