| Definition | Desulfovibrio desulfuricans subsp. desulfuricans str. G20 chromosome, complete genome. |
|---|---|
| Accession | NC_007519 |
| Length | 3,730,232 |
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The map label for this gene is lon [H]
Identifier: 78357487
GI number: 78357487
Start: 2464574
End: 2467003
Strand: Direct
Name: lon [H]
Synonym: Dde_2444
Alternate gene names: 78357487
Gene position: 2464574-2467003 (Clockwise)
Preceding gene: 78357486
Following gene: 78357488
Centisome position: 66.07
GC content: 56.46
Gene sequence:
>2430_bases ATGGAAGGAGAAGGCATGAGCGACAGAAACGACGCAGAAAGCCTCGACATACACGAAAGCGGAGCTTCCATTGAGGAAGC CGCAGAGCATATGAACGAACTGCTGAATGATTTCCCCGCGGAACTGCCGGTGCTTGCCGTCCGCGATATTGTTGTATTCA ACTACATGATTCTGCCGCTTTTTGTGGGCAGAGAAAAATCGGTGCAGGCCGTGGATGCGGCGCTTAACGGCAGCCGCTAT ATGATGATCTGCACCCAGCACGACGAAGCCGTGGACGATCCCACAGGGGATGACCTGCACAAAACAGGCACCGTAGTCAT GATCATGCGCATGCTCAAGATGCCTGACGGCCGCCTGAAGGTTCTGGTGCAGGGCATCAGCCGTGCCAAGGTGAAAAACT TTGTTTCTGAAGACCCCTACCTGCTGGCCGAAGTGGAAGCCATAGAAGAGCCGGAAGCAGGTCCCCTTACCGTGGAACAG GAAGCAATGATCCGCTCCGCCCGCGAACAGAGTGAAAAAATTCTTTCTCTGCGCGGTGTGCCCACTGCAGACATCATGGC CGTACTCAACGGCGTTGATGAACCCGGACGCCTTGCCGACCTTATAGCGGCCAACCTGCGCATGAAGGTGGCCGATGCGC AGACCATTCTTGAATGCACCGACCCTGACGAACGGCTCACGCTGGTTAATGAGCAGCTGGTCAAAGAGGTGGAAGTGGCT GCCATGCAGGCAAAAATCCAGAGCATGGCCAAGGAAGGCATGGACAAGGCACAGAAAGACTATTTTCTGCGCGAACAGAT GAAAGCCATACGCCGTGAACTGGGTGAAGGTCCGGACGGCGACGAAGACATGGACGAGCTCATCGAATCGCTTGCCAAGG CCGGTCTGCCCAAAGATGTGCGCAAAGAAGCCGACAAGCAGCTGCGCCGTCTTTCGGTCATGCATCCGGAATCTTCAGAA GCCACCGTTGTGCGCACCTATCTGGAGTGGCTTGCGGAACTGCCATGGAAAAAACTCTCGCGCGACCGCATAGATATTCC CAGAGCACAGGCAATTCTGGATGAAGACCATTACGGGCTTGAAAAAGTCAAAGACCGTATTCTGGAATATCTTTCCGTGC GCAAGCTCAATCCCAAGTCCAAAGGCCCCATTCTGTGCTTTTCCGGCCCTCCCGGCGTGGGCAAAACTTCGCTCGGACGG TCCATCGCGCGCGCTCTGGGCCGCAAGTTCCAGCGTATATCACTGGGCGGTATGCGTGACGAAGCTGAAATACGCGGACA CCGGCGCACCTATATCGGCGCCATGCCCGGCCGTATCATACAGACCATAAAACAGCTGGGCACGCGCAACCCGGTCATCA TGCTGGACGAAATAGACAAGCTCGGCTCCGACTTCCGCGGAGACCCTTCCTCCGCCCTGCTGGAAGTGCTTGATCCTGAA CAGAACTTCAGCTTCAGCGACCATTACCTGAACGTGCCCTTCGATCTTTCCAAGGTCATGTTCATATGCACGGCGAACCA GCTGGAAACCATTCCCGCACCGCTGCGCGACCGCATGGAGATCATCCGCATTCCCGGTTACACCATGCAGGAAAAAGCAA AAATAGCCCGCCGCTACCTGCTGCCCAGACAGGCCGGAGAAAACGGTCTGAACGAAGACGACGTTCAGATAGCGGACAAC GTGATAACCAAAATCATCGACGAATACACCCGAGAAGCCGGTCTGCGTAATCTTGAACGCGAACTGGGCACCGTGTGCCG CAAACTGGCACGGCGTAAAGCCGAAGGTGAAGACGGCCCGTTCCGCGTTACGGTAAAAGTGCTGGAAAAACTGCTCGGCG CACCGCGGTTCATAGATGAACAGAAAGAACGCGAGCTGCTGCCCGGCGTGGCGCTGGGGCTGGCATGGACTCCATACGGC GGCGAAGTGCTGAACGTGGAAGTAAGCACCATGAAAGGCAAGGGTAAACTTACGCTTACCGGTCAGCTGGGCGACGTGAT GAAAGAAAGCGCACAGGCGGCCGTAAGCTATGTCCGCAGCCATGCGGCAGAACTTGACGTGGACCCCGAGTTTTCTTCCA ACCTCGACATCCACATTCACGTTCCTGCCGGTGCCACGCCCAAAGACGGCCCTTCTGCCGGTGTCACACTGCTCACGGCG CTCATTTCGGCGCTTACCGGACGTTCGGTCAACAGCGACCTGTGCATGACGGGCGAAATAACCCTGCGCGGAAGGGTGCT GCCCGTGGGCGGCATCAAGGAAAAAATTCTGGCCGCGGTGGCACGGGGACTCAGCCATGCCTTTATTCCGCACCAGAACA AAAAAGACCTTGAAGACATTCCCGCCGACCTGCTGCGCAAAATCAACGTGCATCCGGCCGAACACATCAACGACATCCTG CCGCTGGCTCTGGGGCTGGATAAAAAATAA
Upstream 100 bases:
>100_bases ACGCTATGCATCTGCCGCGCCGCGGCAGACCGGCGCAGACGCAACGGGCATTGCCAGCCGCCGGTACAACCGGGAAACGC CGACCCACGGCCCCCGATTA
Downstream 100 bases:
>100_bases CATCAGACGGGCACGGCACTGCCGTGCCCGTTTTTTCGGCACTGCCATGGATATGAAACAGCTCTCCGACATGCACCCGC TGTACAGCAGGCTGACGGGA
Product: Lon-A peptidase
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 809; Mature: 809
Protein sequence:
>809_residues MEGEGMSDRNDAESLDIHESGASIEEAAEHMNELLNDFPAELPVLAVRDIVVFNYMILPLFVGREKSVQAVDAALNGSRY MMICTQHDEAVDDPTGDDLHKTGTVVMIMRMLKMPDGRLKVLVQGISRAKVKNFVSEDPYLLAEVEAIEEPEAGPLTVEQ EAMIRSAREQSEKILSLRGVPTADIMAVLNGVDEPGRLADLIAANLRMKVADAQTILECTDPDERLTLVNEQLVKEVEVA AMQAKIQSMAKEGMDKAQKDYFLREQMKAIRRELGEGPDGDEDMDELIESLAKAGLPKDVRKEADKQLRRLSVMHPESSE ATVVRTYLEWLAELPWKKLSRDRIDIPRAQAILDEDHYGLEKVKDRILEYLSVRKLNPKSKGPILCFSGPPGVGKTSLGR SIARALGRKFQRISLGGMRDEAEIRGHRRTYIGAMPGRIIQTIKQLGTRNPVIMLDEIDKLGSDFRGDPSSALLEVLDPE QNFSFSDHYLNVPFDLSKVMFICTANQLETIPAPLRDRMEIIRIPGYTMQEKAKIARRYLLPRQAGENGLNEDDVQIADN VITKIIDEYTREAGLRNLERELGTVCRKLARRKAEGEDGPFRVTVKVLEKLLGAPRFIDEQKERELLPGVALGLAWTPYG GEVLNVEVSTMKGKGKLTLTGQLGDVMKESAQAAVSYVRSHAAELDVDPEFSSNLDIHIHVPAGATPKDGPSAGVTLLTA LISALTGRSVNSDLCMTGEITLRGRVLPVGGIKEKILAAVARGLSHAFIPHQNKKDLEDIPADLLRKINVHPAEHINDIL PLALGLDKK
Sequences:
>Translated_809_residues MEGEGMSDRNDAESLDIHESGASIEEAAEHMNELLNDFPAELPVLAVRDIVVFNYMILPLFVGREKSVQAVDAALNGSRY MMICTQHDEAVDDPTGDDLHKTGTVVMIMRMLKMPDGRLKVLVQGISRAKVKNFVSEDPYLLAEVEAIEEPEAGPLTVEQ EAMIRSAREQSEKILSLRGVPTADIMAVLNGVDEPGRLADLIAANLRMKVADAQTILECTDPDERLTLVNEQLVKEVEVA AMQAKIQSMAKEGMDKAQKDYFLREQMKAIRRELGEGPDGDEDMDELIESLAKAGLPKDVRKEADKQLRRLSVMHPESSE ATVVRTYLEWLAELPWKKLSRDRIDIPRAQAILDEDHYGLEKVKDRILEYLSVRKLNPKSKGPILCFSGPPGVGKTSLGR SIARALGRKFQRISLGGMRDEAEIRGHRRTYIGAMPGRIIQTIKQLGTRNPVIMLDEIDKLGSDFRGDPSSALLEVLDPE QNFSFSDHYLNVPFDLSKVMFICTANQLETIPAPLRDRMEIIRIPGYTMQEKAKIARRYLLPRQAGENGLNEDDVQIADN VITKIIDEYTREAGLRNLERELGTVCRKLARRKAEGEDGPFRVTVKVLEKLLGAPRFIDEQKERELLPGVALGLAWTPYG GEVLNVEVSTMKGKGKLTLTGQLGDVMKESAQAAVSYVRSHAAELDVDPEFSSNLDIHIHVPAGATPKDGPSAGVTLLTA LISALTGRSVNSDLCMTGEITLRGRVLPVGGIKEKILAAVARGLSHAFIPHQNKKDLEDIPADLLRKINVHPAEHINDIL PLALGLDKK >Mature_809_residues MEGEGMSDRNDAESLDIHESGASIEEAAEHMNELLNDFPAELPVLAVRDIVVFNYMILPLFVGREKSVQAVDAALNGSRY MMICTQHDEAVDDPTGDDLHKTGTVVMIMRMLKMPDGRLKVLVQGISRAKVKNFVSEDPYLLAEVEAIEEPEAGPLTVEQ EAMIRSAREQSEKILSLRGVPTADIMAVLNGVDEPGRLADLIAANLRMKVADAQTILECTDPDERLTLVNEQLVKEVEVA AMQAKIQSMAKEGMDKAQKDYFLREQMKAIRRELGEGPDGDEDMDELIESLAKAGLPKDVRKEADKQLRRLSVMHPESSE ATVVRTYLEWLAELPWKKLSRDRIDIPRAQAILDEDHYGLEKVKDRILEYLSVRKLNPKSKGPILCFSGPPGVGKTSLGR SIARALGRKFQRISLGGMRDEAEIRGHRRTYIGAMPGRIIQTIKQLGTRNPVIMLDEIDKLGSDFRGDPSSALLEVLDPE QNFSFSDHYLNVPFDLSKVMFICTANQLETIPAPLRDRMEIIRIPGYTMQEKAKIARRYLLPRQAGENGLNEDDVQIADN VITKIIDEYTREAGLRNLERELGTVCRKLARRKAEGEDGPFRVTVKVLEKLLGAPRFIDEQKERELLPGVALGLAWTPYG GEVLNVEVSTMKGKGKLTLTGQLGDVMKESAQAAVSYVRSHAAELDVDPEFSSNLDIHIHVPAGATPKDGPSAGVTLLTA LISALTGRSVNSDLCMTGEITLRGRVLPVGGIKEKILAAVARGLSHAFIPHQNKKDLEDIPADLLRKINVHPAEHINDIL PLALGLDKK
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=835, Percent_Identity=40.3592814371258, Blast_Score=585, Evalue=1e-167, Organism=Homo sapiens, GI21396489, Length=689, Percent_Identity=44.7024673439768, Blast_Score=575, Evalue=1e-164, Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=48.8888888888889, Blast_Score=760, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=658, Percent_Identity=40.273556231003, Blast_Score=493, Evalue=1e-139, Organism=Caenorhabditis elegans, GI17556486, Length=538, Percent_Identity=43.8661710037175, Blast_Score=464, Evalue=1e-131, Organism=Saccharomyces cerevisiae, GI6319449, Length=674, Percent_Identity=41.9881305637982, Blast_Score=513, Evalue=1e-146, Organism=Drosophila melanogaster, GI221513036, Length=691, Percent_Identity=43.2706222865412, Blast_Score=551, Evalue=1e-157, Organism=Drosophila melanogaster, GI24666867, Length=691, Percent_Identity=43.2706222865412, Blast_Score=551, Evalue=1e-157,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 89534; Mature: 89534
Theoretical pI: Translated: 5.22; Mature: 5.22
Prosite motif: PS01046 LON_SER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEGEGMSDRNDAESLDIHESGASIEEAAEHMNELLNDFPAELPVLAVRDIVVFNYMILPL CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH FVGREKSVQAVDAALNGSRYMMICTQHDEAVDDPTGDDLHKTGTVVMIMRMLKMPDGRLK HCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH VLVQGISRAKVKNFVSEDPYLLAEVEAIEEPEAGPLTVEQEAMIRSAREQSEKILSLRGV HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC PTADIMAVLNGVDEPGRLADLIAANLRMKVADAQTILECTDPDERLTLVNEQLVKEVEVA CHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHHH AMQAKIQSMAKEGMDKAQKDYFLREQMKAIRRELGEGPDGDEDMDELIESLAKAGLPKDV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHH RKEADKQLRRLSVMHPESSEATVVRTYLEWLAELPWKKLSRDRIDIPRAQAILDEDHYGL HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCH EKVKDRILEYLSVRKLNPKSKGPILCFSGPPGVGKTSLGRSIARALGRKFQRISLGGMRD HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC EAEIRGHRRTYIGAMPGRIIQTIKQLGTRNPVIMLDEIDKLGSDFRGDPSSALLEVLDPE HHHHCCCHHHEECCCCHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCC QNFSFSDHYLNVPFDLSKVMFICTANQLETIPAPLRDRMEIIRIPGYTMQEKAKIARRYL CCCCCCCCEEECCCCHHHHHHHEECCHHHCCCCCHHHCHHEEECCCCCHHHHHHHHHHHH LPRQAGENGLNEDDVQIADNVITKIIDEYTREAGLRNLERELGTVCRKLARRKAEGEDGP CCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC FRVTVKVLEKLLGAPRFIDEQKERELLPGVALGLAWTPYGGEVLNVEVSTMKGKGKLTLT EEEHHHHHHHHHCCCCHHCCHHHHHHCCCHHHHEEECCCCCEEEEEEEEEECCCCCEEEE GQLGDVMKESAQAAVSYVRSHAAELDVDPEFSSNLDIHIHVPAGATPKDGPSAGVTLLTA CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH LISALTGRSVNSDLCMTGEITLRGRVLPVGGIKEKILAAVARGLSHAFIPHQNKKDLEDI HHHHHHCCCCCCCEEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH PADLLRKINVHPAEHINDILPLALGLDKK HHHHHHHCCCCCHHHHHHHHHHHHCCCCC >Mature Secondary Structure MEGEGMSDRNDAESLDIHESGASIEEAAEHMNELLNDFPAELPVLAVRDIVVFNYMILPL CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH FVGREKSVQAVDAALNGSRYMMICTQHDEAVDDPTGDDLHKTGTVVMIMRMLKMPDGRLK HCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH VLVQGISRAKVKNFVSEDPYLLAEVEAIEEPEAGPLTVEQEAMIRSAREQSEKILSLRGV HHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC PTADIMAVLNGVDEPGRLADLIAANLRMKVADAQTILECTDPDERLTLVNEQLVKEVEVA CHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHHH AMQAKIQSMAKEGMDKAQKDYFLREQMKAIRRELGEGPDGDEDMDELIESLAKAGLPKDV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHH RKEADKQLRRLSVMHPESSEATVVRTYLEWLAELPWKKLSRDRIDIPRAQAILDEDHYGL HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCH EKVKDRILEYLSVRKLNPKSKGPILCFSGPPGVGKTSLGRSIARALGRKFQRISLGGMRD HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC EAEIRGHRRTYIGAMPGRIIQTIKQLGTRNPVIMLDEIDKLGSDFRGDPSSALLEVLDPE HHHHCCCHHHEECCCCHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCC QNFSFSDHYLNVPFDLSKVMFICTANQLETIPAPLRDRMEIIRIPGYTMQEKAKIARRYL CCCCCCCCEEECCCCHHHHHHHEECCHHHCCCCCHHHCHHEEECCCCCHHHHHHHHHHHH LPRQAGENGLNEDDVQIADNVITKIIDEYTREAGLRNLERELGTVCRKLARRKAEGEDGP CCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC FRVTVKVLEKLLGAPRFIDEQKERELLPGVALGLAWTPYGGEVLNVEVSTMKGKGKLTLT EEEHHHHHHHHHCCCCHHCCHHHHHHCCCHHHHEEECCCCCEEEEEEEEEECCCCCEEEE GQLGDVMKESAQAAVSYVRSHAAELDVDPEFSSNLDIHIHVPAGATPKDGPSAGVTLLTA CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH LISALTGRSVNSDLCMTGEITLRGRVLPVGGIKEKILAAVARGLSHAFIPHQNKKDLEDI HHHHHHCCCCCCCEEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHH PADLLRKINVHPAEHINDILPLALGLDKK HHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA