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The map label for this gene is fabH

Identifier: 78357471

GI number: 78357471

Start: 2449565

End: 2450557

Strand: Direct

Name: fabH

Synonym: Dde_2428

Alternate gene names: 78357471

Gene position: 2449565-2450557 (Clockwise)

Preceding gene: 78357470

Following gene: 78357472

Centisome position: 65.67

GC content: 60.12

Gene sequence:

>993_bases
ATGACCACAAAAAGCTACATTCTCGGATTCGGCTCCCACGCGCCGGAGCGGATTCTCACCAACACCGACATGGAAGCGTT
CGTGGACACCACGGACGAGTGGATCACCACGCGGACCGGCATAAAGCAGCGCCACATAGCCGCCGAAGGCGAAACGACAT
CCGACCTTGGCGCAAAAGCCGCGCTGCAGGCTCTGGCAAATGCCGGACTGCATGCCGACGCACTGACCCACATTCTTGTG
GCCACCTGTACCCCCGACGCCATGTGCCCCAGCACAGCCTGCCTCATCGAGCACAAGCTCGGTGTTTCCGGCCTGATGGC
GCTCGATCTAAACGCCGCCTGTTCCGGCTTTCTGTACGCTCTCAACATGGCACAGGGCATCGTGGCTCTGACCCCCGACG
CCAAGGTGCTTGTTGTGGCTGCAGAAGTGCTGAGCAGGCGCATCAACTGGAACGACCGCTCGACATGCGTTCTGTTCGGC
GATGGCGCCGGCGCCGTCATCGTGGGCAGTCACCCCAACGAGGGACGTGCCGTGGAAGTGGCAGACAGCCTGCTTTCTTC
AGACGGTGCGTTGGGTGATCTTCTGCTCATCAGCGGTGGCGGAACCAGCGTTCCCTACAAACACGGCCAGCCCGTGGGTG
ACGAATTTTTCGTCCGCATGGAAGGCCGTGAAATATTCAAACACGCCGTGCGCAGCATGGCACGCGTGTGCGAAGAACTG
CTTGAGCGCAACGGCATAGCCCGCGAAGACGTGGATATGCTGCTGCCCCATCAGGCAAACCTGCGCATTATCGAAGCGGT
GGGAAAAAAACTGGGTATCCCTGCCGATAAAGTATTTGTGAATCTTCAGGAATACGGCAACACTTCCGCCGCATCGGTGC
CTCTGGCACTGGCCGATGCGGACAGTAAAAACCTGCTGCCCCCCGGGCGCACGGTACTGCTGACCACATTCGGAGGCGGA
TTCACATGGGGTGCAGTGCTGCTGCGCACCTGA

Upstream 100 bases:

>100_bases
AGAGCTGACCAGCTACGGCAAGGCCGTCAAGCAATAACTACCGACCCGTGACGGCGGCGCGTTACCTGCGTCGCCGCTTC
ATGTTTCACGGACCCTGCCA

Downstream 100 bases:

>100_bases
AAAAGCGTGTATAACCGGTAACCTTCCGGAATATAAGATACTCGCTGCCGAAATTCACAATTGAAGTTACACTGTCTTTA
CGGTATAAAGCGGTGCCTTC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTTKSYILGFGSHAPERILTNTDMEAFVDTTDEWITTRTGIKQRHIAAEGETTSDLGAKAALQALANAGLHADALTHILV
ATCTPDAMCPSTACLIEHKLGVSGLMALDLNAACSGFLYALNMAQGIVALTPDAKVLVVAAEVLSRRINWNDRSTCVLFG
DGAGAVIVGSHPNEGRAVEVADSLLSSDGALGDLLLISGGGTSVPYKHGQPVGDEFFVRMEGREIFKHAVRSMARVCEEL
LERNGIAREDVDMLLPHQANLRIIEAVGKKLGIPADKVFVNLQEYGNTSAASVPLALADADSKNLLPPGRTVLLTTFGGG
FTWGAVLLRT

Sequences:

>Translated_330_residues
MTTKSYILGFGSHAPERILTNTDMEAFVDTTDEWITTRTGIKQRHIAAEGETTSDLGAKAALQALANAGLHADALTHILV
ATCTPDAMCPSTACLIEHKLGVSGLMALDLNAACSGFLYALNMAQGIVALTPDAKVLVVAAEVLSRRINWNDRSTCVLFG
DGAGAVIVGSHPNEGRAVEVADSLLSSDGALGDLLLISGGGTSVPYKHGQPVGDEFFVRMEGREIFKHAVRSMARVCEEL
LERNGIAREDVDMLLPHQANLRIIEAVGKKLGIPADKVFVNLQEYGNTSAASVPLALADADSKNLLPPGRTVLLTTFGGG
FTWGAVLLRT
>Mature_329_residues
TTKSYILGFGSHAPERILTNTDMEAFVDTTDEWITTRTGIKQRHIAAEGETTSDLGAKAALQALANAGLHADALTHILVA
TCTPDAMCPSTACLIEHKLGVSGLMALDLNAACSGFLYALNMAQGIVALTPDAKVLVVAAEVLSRRINWNDRSTCVLFGD
GAGAVIVGSHPNEGRAVEVADSLLSSDGALGDLLLISGGGTSVPYKHGQPVGDEFFVRMEGREIFKHAVRSMARVCEELL
ERNGIAREDVDMLLPHQANLRIIEAVGKKLGIPADKVFVNLQEYGNTSAASVPLALADADSKNLLPPGRTVLLTTFGGGF
TWGAVLLRT

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=329, Percent_Identity=44.6808510638298, Blast_Score=267, Evalue=7e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_DESDG (Q30YM1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388920.1
- ProteinModelPortal:   Q30YM1
- SMR:   Q30YM1
- STRING:   Q30YM1
- GeneID:   3757444
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2428
- NMPDR:   fig|207559.3.peg.2786
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- ProtClustDB:   CLSK705098
- BioCyc:   DDES207559:DDE_2428-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34876; Mature: 34745

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 257-257 ACT_SITE 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKSYILGFGSHAPERILTNTDMEAFVDTTDEWITTRTGIKQRHIAAEGETTSDLGAKA
CCCCCEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHCCCHHHEEECCCCCCHHHHHHH
ALQALANAGLHADALTHILVATCTPDAMCPSTACLIEHKLGVSGLMALDLNAACSGFLYA
HHHHHHHCCCCHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHH
LNMAQGIVALTPDAKVLVVAAEVLSRRINWNDRSTCVLFGDGAGAVIVGSHPNEGRAVEV
HHHHCCEEEECCCCEEEEEEHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCEEHH
ADSLLSSDGALGDLLLISGGGTSVPYKHGQPVGDEFFVRMEGREIFKHAVRSMARVCEEL
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
LERNGIAREDVDMLLPHQANLRIIEAVGKKLGIPADKVFVNLQEYGNTSAASVPLALADA
HHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHEEEEHHHHCCCCCCCCEEEEECC
DSKNLLPPGRTVLLTTFGGGFTWGAVLLRT
CCCCCCCCCCEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure 
TTKSYILGFGSHAPERILTNTDMEAFVDTTDEWITTRTGIKQRHIAAEGETTSDLGAKA
CCCCEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHCCCHHHEEECCCCCCHHHHHHH
ALQALANAGLHADALTHILVATCTPDAMCPSTACLIEHKLGVSGLMALDLNAACSGFLYA
HHHHHHHCCCCHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHH
LNMAQGIVALTPDAKVLVVAAEVLSRRINWNDRSTCVLFGDGAGAVIVGSHPNEGRAVEV
HHHHCCEEEECCCCEEEEEEHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCEEHH
ADSLLSSDGALGDLLLISGGGTSVPYKHGQPVGDEFFVRMEGREIFKHAVRSMARVCEEL
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
LERNGIAREDVDMLLPHQANLRIIEAVGKKLGIPADKVFVNLQEYGNTSAASVPLALADA
HHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCHHHEEEEHHHHCCCCCCCCEEEEECC
DSKNLLPPGRTVLLTTFGGGFTWGAVLLRT
CCCCCCCCCCEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA