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The map label for this gene is srrA [H]

Identifier: 78357430

GI number: 78357430

Start: 2411516

End: 2412205

Strand: Reverse

Name: srrA [H]

Synonym: Dde_2387

Alternate gene names: 78357430

Gene position: 2412205-2411516 (Counterclockwise)

Preceding gene: 78357431

Following gene: 78357429

Centisome position: 64.67

GC content: 59.13

Gene sequence:

>690_bases
ATGGCGAAGGATCGCTTGCTCGTCGTCGAGGACGACGGGGATATCCTCCAGCTGCTCACATTTACGCTGGAGTCCGCAGG
CTTCGAGGTGTTTTCCGCCATGGACGGAAAAACCGGACTGGAGCTGGCGATGCGTGAGAAACCGGATCTTGTGGTGCTGG
ACCTGATGTTGCCCGGCATGAGCGGACTTGATGTCTGCAAGGATCTGAAAAGAATGCCTGAAACGCAGGAAACGCCCGTT
ATTATGCTGACGGCGCGGGGCGAAGAGGTAGACCGCATCGTAGGGCTGGAGCTGGGCGCTGATGATTATGTCGTCAAGCC
GTTCAGTCCCCGCGAGCTTGTGCTGCGCATCAAGGCGGTGCTTAAGCGCGGGGCGCCGTTTACCGAGCAGGAAGAACGGA
CCCGCTGGCGGGTGAACGGGCTGAGTCTGGATACCGAAGCCCACCGGGTGGAGATTGACGGCGATGAGGTGACCCTGACC
GCCACCGAGTTCAAGCTGCTTTTCGAGCTGGTACGCAACAGGGGACGCGTGCGGACCCGCGACCAGCTGCTGAACACGGT
CTGGGGATATGAATTTGAAGGCTATGCCCGCACTGTGGATACCCACGTGCGCAGGCTGCGCCAGAAAATAGGCGACTATG
CCGGGTATATCGAAACCATACGCGGCGTTGGGTATCGCTTCAGAGAATAA

Upstream 100 bases:

>100_bases
TATGCTGCTCCGGCGTAACGTGATTGTAACCATGTGCCCATCAAGTTGTCACTCTGGGATGTTGTAAGGCATTCCGTAAC
TAACCGGAGGCTTGAACGAT

Downstream 100 bases:

>100_bases
CCGGAGTGACGGTAAGCACATGGCAAGCTTGACAAAGATGCATTCAAAGGGTCTGGACTTTTTTTACGGAGATTTTCAGG
CCCTGCACGACATCAGTCTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MAKDRLLVVEDDGDILQLLTFTLESAGFEVFSAMDGKTGLELAMREKPDLVVLDLMLPGMSGLDVCKDLKRMPETQETPV
IMLTARGEEVDRIVGLELGADDYVVKPFSPRELVLRIKAVLKRGAPFTEQEERTRWRVNGLSLDTEAHRVEIDGDEVTLT
ATEFKLLFELVRNRGRVRTRDQLLNTVWGYEFEGYARTVDTHVRRLRQKIGDYAGYIETIRGVGYRFRE

Sequences:

>Translated_229_residues
MAKDRLLVVEDDGDILQLLTFTLESAGFEVFSAMDGKTGLELAMREKPDLVVLDLMLPGMSGLDVCKDLKRMPETQETPV
IMLTARGEEVDRIVGLELGADDYVVKPFSPRELVLRIKAVLKRGAPFTEQEERTRWRVNGLSLDTEAHRVEIDGDEVTLT
ATEFKLLFELVRNRGRVRTRDQLLNTVWGYEFEGYARTVDTHVRRLRQKIGDYAGYIETIRGVGYRFRE
>Mature_228_residues
AKDRLLVVEDDGDILQLLTFTLESAGFEVFSAMDGKTGLELAMREKPDLVVLDLMLPGMSGLDVCKDLKRMPETQETPVI
MLTARGEEVDRIVGLELGADDYVVKPFSPRELVLRIKAVLKRGAPFTEQEERTRWRVNGLSLDTEAHRVEIDGDEVTLTA
TEFKLLFELVRNRGRVRTRDQLLNTVWGYEFEGYARTVDTHVRRLRQKIGDYAGYIETIRGVGYRFRE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=47.5555555555556, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=39.7379912663755, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=38.961038961039, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=38.2222222222222, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=37.6106194690265, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=40.8695652173913, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=39.4618834080717, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=35.7446808510638, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=37.7777777777778, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=35.1111111111111, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.9148936170213, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=35.2941176470588, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=31.2775330396476, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=37.1900826446281, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788905, Length=133, Percent_Identity=34.5864661654135, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790299, Length=145, Percent_Identity=30.3448275862069, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26183; Mature: 26052

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDRLLVVEDDGDILQLLTFTLESAGFEVFSAMDGKTGLELAMREKPDLVVLDLMLPGM
CCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCEEEEEEECCCC
SGLDVCKDLKRMPETQETPVIMLTARGEEVDRIVGLELGADDYVVKPFSPRELVLRIKAV
CHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHEEEEEECCCCEEECCCCHHHHHHHHHHH
LKRGAPFTEQEERTRWRVNGLSLDTEAHRVEIDGDEVTLTATEFKLLFELVRNRGRVRTR
HHCCCCCCCHHHHHEEEECCEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCCCHH
DQLLNTVWGYEFEGYARTVDTHVRRLRQKIGDYAGYIETIRGVGYRFRE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKDRLLVVEDDGDILQLLTFTLESAGFEVFSAMDGKTGLELAMREKPDLVVLDLMLPGM
CCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCEEEEEEECCCC
SGLDVCKDLKRMPETQETPVIMLTARGEEVDRIVGLELGADDYVVKPFSPRELVLRIKAV
CHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHEEEEEECCCCEEECCCCHHHHHHHHHHH
LKRGAPFTEQEERTRWRVNGLSLDTEAHRVEIDGDEVTLTATEFKLLFELVRNRGRVRTR
HHCCCCCCCHHHHHEEEECCEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCCCHH
DQLLNTVWGYEFEGYARTVDTHVRRLRQKIGDYAGYIETIRGVGYRFRE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA