Click here to switch to the map view.

The map label for this gene is ipdC [H]

Identifier: 78357374

GI number: 78357374

Start: 2349438

End: 2351105

Strand: Reverse

Name: ipdC [H]

Synonym: Dde_2331

Alternate gene names: 78357374

Gene position: 2351105-2349438 (Counterclockwise)

Preceding gene: 78357375

Following gene: 78357373

Centisome position: 63.03

GC content: 60.73

Gene sequence:

>1668_bases
ATGAATCTGACCGAAGCGTTGCTGCATGCTCTCAAAGAGCGTGGCGCCAAAGAAGTGTACGGCATTCCGGGCGACTTTGC
CCTGCCGTATTTCAAGATAATCGAATCCACGGGTATTCTGCCGCTTGTCACGCTGAGCCACGAGCCCGCCGTGGGGTTTG
CCGCCGACGCATCCGCCCGCTTCAGAGGCGGTCTGGGGGTGGCCGCAGTGACATACGGAGCCGGCGCATTGAACATGGTT
AACGCCATAGCGCAGGCATATGCGGAAAAGTCGCCTGTGGTTGTCATTTCCGGCGCGCCGGGAACCCACGAAGGCGGACA
TGGGCTGCTGCTGCACCATCAGGCGAAGCATCTTGACTCGCAGTACCGCATGTACAAAGAAGTCACCTGCGATCAGGCGG
TGCTGGACGATCCGGCCACTGCGCCTGAAACCATAGCCCGTGTGCTGCAGAGCTGTATTGAACATTCCCGCCCTGTGTAT
CTTGAGATTCCGCGTGATCTGCCTGCGGCACCGTGTGCGCCTGTGCCTGCTTTTGCTGCTTCCGGCACGGATGCGGACGC
CGTGGACGCCTGCGCCCGCGACGTGCTGCAGCGCGTGCAGAGCGCCGCGCTGCCCATGATGATGGTGGGGGTTGAGGTGC
GGCGTTACGGCATAGAAGACAAAGTGGCTCTGCTGGCCGAGCGGCTGGGGGTGCCTGTGGTGACCAGCTTTATGGGACGC
GGGTTGCTAGCTTCGGCCAGCTGTCTGGAAGGAACCTATCTGGGCATGGCCGGTGACGAGACACTCAGCGAGGCTGTGGA
ATCTTCCGACGGGCTTCTGCTGCTGGGTGTTATCATGTCGGATACCAATTTCGGCGTGTCCGGAAGCCAGCTGGACCGCA
GGCGTGTGATGCATGCGGAGGACAGACAGGTGCGTGTCGGCTACCATGTGTATCATGACATTCCGCTGGGAGCGCTGGTG
GACCGTCTGCTGGCATTGCTGGATGACGGACAGGAAGCTGACATGGCTCTTTCGGGCTGCGGCGGTTCTTCTGACGACAG
GGCATTGCAGGGGGCGGGACTCGCTGTGAATCCGCGGGGGTTCATGGCAGATGCCGCAGATATCACTCCCACGGATATAG
CCGCGCTGCTTAATGATTTTTTTGCCTCGCACGGAGCAATGCCCGTTGCCAGCGATATAGGCGACTGCCTGTTCACCATG
CTGAGCGTGGATGCCATTCCCATGGTGGCACCGGGGTATTATGCCAGCATGGGCTTCGGGGTGCCGGCGGGCATGGGGCT
GCAGATAACGACAAAGGAGCGTTCGCTCATTCTGGTGGGCGACGGCGCTTTTCAGATGACCGGTATGGAACTGGGCAACT
GCACGCGGCTGGGTATTGATCCCATCGTGCTGGTGTTTAATAATTCGTCGTGGGAAATGCTGCATGTCTTCCAGCCCGAG
ACAGCATACAGCAATCTGGGCGAATGGGATTTTGCCGCGGTGGCTGACGGTCTGGGCGGACGGGGGCACAGGGCCGCCAC
CCGTGCCGAGCTTGCACGTGCGCTGACACAGGCCCATGCCGAACGCGGACGTTTTCAGCTGATTGACGCCCGTCTGGCTC
CGCATAGTCTGTCCCCCACGCTGGCCCGTTTTGTGGAAGGTGTGCGCAGATTCAGTTCGGGGCAATAA

Upstream 100 bases:

>100_bases
GCGGCGCTGCCGGATGTGACTTCTTTTTGCACAGGGTGTCCGCCTGCTTATATCTGCGTACCGAACCTGCGCACCGAATG
CGTACCGAGGAGCAAATCAT

Downstream 100 bases:

>100_bases
GCTGTTGTAATTATCAGATGGCGGCTCCGCGCCCGTGCGGAGCCGCTTTGTCAAACCGCCTGTATGCGGTTTCAACCTTG
AACCCAACTCAGGGTGAGCA

Product: putative phenylpyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MNLTEALLHALKERGAKEVYGIPGDFALPYFKIIESTGILPLVTLSHEPAVGFAADASARFRGGLGVAAVTYGAGALNMV
NAIAQAYAEKSPVVVISGAPGTHEGGHGLLLHHQAKHLDSQYRMYKEVTCDQAVLDDPATAPETIARVLQSCIEHSRPVY
LEIPRDLPAAPCAPVPAFAASGTDADAVDACARDVLQRVQSAALPMMMVGVEVRRYGIEDKVALLAERLGVPVVTSFMGR
GLLASASCLEGTYLGMAGDETLSEAVESSDGLLLLGVIMSDTNFGVSGSQLDRRRVMHAEDRQVRVGYHVYHDIPLGALV
DRLLALLDDGQEADMALSGCGGSSDDRALQGAGLAVNPRGFMADAADITPTDIAALLNDFFASHGAMPVASDIGDCLFTM
LSVDAIPMVAPGYYASMGFGVPAGMGLQITTKERSLILVGDGAFQMTGMELGNCTRLGIDPIVLVFNNSSWEMLHVFQPE
TAYSNLGEWDFAAVADGLGGRGHRAATRAELARALTQAHAERGRFQLIDARLAPHSLSPTLARFVEGVRRFSSGQ

Sequences:

>Translated_555_residues
MNLTEALLHALKERGAKEVYGIPGDFALPYFKIIESTGILPLVTLSHEPAVGFAADASARFRGGLGVAAVTYGAGALNMV
NAIAQAYAEKSPVVVISGAPGTHEGGHGLLLHHQAKHLDSQYRMYKEVTCDQAVLDDPATAPETIARVLQSCIEHSRPVY
LEIPRDLPAAPCAPVPAFAASGTDADAVDACARDVLQRVQSAALPMMMVGVEVRRYGIEDKVALLAERLGVPVVTSFMGR
GLLASASCLEGTYLGMAGDETLSEAVESSDGLLLLGVIMSDTNFGVSGSQLDRRRVMHAEDRQVRVGYHVYHDIPLGALV
DRLLALLDDGQEADMALSGCGGSSDDRALQGAGLAVNPRGFMADAADITPTDIAALLNDFFASHGAMPVASDIGDCLFTM
LSVDAIPMVAPGYYASMGFGVPAGMGLQITTKERSLILVGDGAFQMTGMELGNCTRLGIDPIVLVFNNSSWEMLHVFQPE
TAYSNLGEWDFAAVADGLGGRGHRAATRAELARALTQAHAERGRFQLIDARLAPHSLSPTLARFVEGVRRFSSGQ
>Mature_555_residues
MNLTEALLHALKERGAKEVYGIPGDFALPYFKIIESTGILPLVTLSHEPAVGFAADASARFRGGLGVAAVTYGAGALNMV
NAIAQAYAEKSPVVVISGAPGTHEGGHGLLLHHQAKHLDSQYRMYKEVTCDQAVLDDPATAPETIARVLQSCIEHSRPVY
LEIPRDLPAAPCAPVPAFAASGTDADAVDACARDVLQRVQSAALPMMMVGVEVRRYGIEDKVALLAERLGVPVVTSFMGR
GLLASASCLEGTYLGMAGDETLSEAVESSDGLLLLGVIMSDTNFGVSGSQLDRRRVMHAEDRQVRVGYHVYHDIPLGALV
DRLLALLDDGQEADMALSGCGGSSDDRALQGAGLAVNPRGFMADAADITPTDIAALLNDFFASHGAMPVASDIGDCLFTM
LSVDAIPMVAPGYYASMGFGVPAGMGLQITTKERSLILVGDGAFQMTGMELGNCTRLGIDPIVLVFNNSSWEMLHVFQPE
TAYSNLGEWDFAAVADGLGGRGHRAATRAELARALTQAHAERGRFQLIDARLAPHSLSPTLARFVEGVRRFSSGQ

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=565, Percent_Identity=24.4247787610619, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790104, Length=518, Percent_Identity=24.9034749034749, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1787096, Length=560, Percent_Identity=21.7857142857143, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17542570, Length=566, Percent_Identity=22.4381625441696, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321524, Length=566, Percent_Identity=24.5583038869258, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323073, Length=569, Percent_Identity=25.3075571177504, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323163, Length=572, Percent_Identity=25.5244755244755, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320123, Length=570, Percent_Identity=21.0526315789474, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320588, Length=556, Percent_Identity=21.9424460431655, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017765
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 58677; Mature: 58677

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTEALLHALKERGAKEVYGIPGDFALPYFKIIESTGILPLVTLSHEPAVGFAADASAR
CCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCHH
FRGGLGVAAVTYGAGALNMVNAIAQAYAEKSPVVVISGAPGTHEGGHGLLLHHQAKHLDS
HCCCCCEEHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHHHH
QYRMYKEVTCDQAVLDDPATAPETIARVLQSCIEHSRPVYLEIPRDLPAAPCAPVPAFAA
HHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHC
SGTDADAVDACARDVLQRVQSAALPMMMVGVEVRRYGIEDKVALLAERLGVPVVTSFMGR
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCC
GLLASASCLEGTYLGMAGDETLSEAVESSDGLLLLGVIMSDTNFGVSGSQLDRRRVMHAE
CHHHHHHHHCCCEECCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCC
DRQVRVGYHVYHDIPLGALVDRLLALLDDGQEADMALSGCGGSSDDRALQGAGLAVNPRG
CCEEEEEEEEEECCCHHHHHHHHHHHHCCCCHHCEEEECCCCCCCCCHHCCCCEEECCCC
FMADAADITPTDIAALLNDFFASHGAMPVASDIGDCLFTMLSVDAIPMVAPGYYASMGFG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
VPAGMGLQITTKERSLILVGDGAFQMTGMELGNCTRLGIDPIVLVFNNSSWEMLHVFQPE
CCCCCCEEEEECCCEEEEEECCCEEEECCCCCCEEEECCCEEEEEEECCCCEEEEEECCC
TAYSNLGEWDFAAVADGLGGRGHRAATRAELARALTQAHAERGRFQLIDARLAPHSLSPT
HHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
LARFVEGVRRFSSGQ
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLTEALLHALKERGAKEVYGIPGDFALPYFKIIESTGILPLVTLSHEPAVGFAADASAR
CCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCHH
FRGGLGVAAVTYGAGALNMVNAIAQAYAEKSPVVVISGAPGTHEGGHGLLLHHQAKHLDS
HCCCCCEEHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHHHH
QYRMYKEVTCDQAVLDDPATAPETIARVLQSCIEHSRPVYLEIPRDLPAAPCAPVPAFAA
HHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHC
SGTDADAVDACARDVLQRVQSAALPMMMVGVEVRRYGIEDKVALLAERLGVPVVTSFMGR
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCC
GLLASASCLEGTYLGMAGDETLSEAVESSDGLLLLGVIMSDTNFGVSGSQLDRRRVMHAE
CHHHHHHHHCCCEECCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCC
DRQVRVGYHVYHDIPLGALVDRLLALLDDGQEADMALSGCGGSSDDRALQGAGLAVNPRG
CCEEEEEEEEEECCCHHHHHHHHHHHHCCCCHHCEEEECCCCCCCCCHHCCCCEEECCCC
FMADAADITPTDIAALLNDFFASHGAMPVASDIGDCLFTMLSVDAIPMVAPGYYASMGFG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
VPAGMGLQITTKERSLILVGDGAFQMTGMELGNCTRLGIDPIVLVFNNSSWEMLHVFQPE
CCCCCCEEEEECCCEEEEEECCCEEEECCCCCCEEEECCCEEEEEEECCCCEEEEEECCC
TAYSNLGEWDFAAVADGLGGRGHRAATRAELARALTQAHAERGRFQLIDARLAPHSLSPT
HHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
LARFVEGVRRFSSGQ
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8202090 [H]