| Definition | Desulfovibrio desulfuricans subsp. desulfuricans str. G20 chromosome, complete genome. |
|---|---|
| Accession | NC_007519 |
| Length | 3,730,232 |
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The map label for this gene is metE [H]
Identifier: 78357371
GI number: 78357371
Start: 2345409
End: 2347685
Strand: Reverse
Name: metE [H]
Synonym: Dde_2328
Alternate gene names: 78357371
Gene position: 2347685-2345409 (Counterclockwise)
Preceding gene: 78357372
Following gene: 78357369
Centisome position: 62.94
GC content: 59.73
Gene sequence:
>2277_bases ATGATTATTCACAACCTGGGATTTCCCCGCATAGGCGCTTCGCGTGAGCTCAAGTTCGCGCTGGAGTCGTACTGGGCAGA ACGCACCGGTGAAGATGCGCTGCAGTCCGTGGCCGCCGGTTTGCGGCAGCGGAACCTGCAGTGGCAGCAAAAGCTGGACT ATGTGCCTGTGGGCGATTTTTCGCTGTATGATCAGGTGCTGGATATGAGTTTTACCCTCGGCAATGTGCCTGAGCGTGTA AAAAATCTGCCCGGCGGCGATACGGAGGCGTATTTCAGGGTGGCCCGCGGTCGGGCTTCGGCCGGAGACACGCACACTGT ACATGCGGGCGAGATGACCAAATGGTTTGATACCAACTACCACTACATTGTACCGGAATTCACCGCGCAGAGCCGTTTCC GGCTGGATGCAGACCGGCTGACCGGCCAGCTGAAAGAAGCTGCCCGCAGCGGGGTGCAGGCCAAGCCCGTGATCATCGGG CCTGTGACGTACCTGTGGCTGGGCAAGTCCAAAGACGGTTCGGACCGGCTGGCGTTGCTGGAAAAGTTGCTGCCGGTTTA CAGAGAGCTGCTTGAAACTCTGGCGCAGAACGGTGCCGGATGGGTGCAGGTGGATGAACCTGTGCTGGTGACCGAGCTGG AAAAGCCGTGGCTTGATGCGCTGGCTGATGCCTACCGCTATCTTGCCGGCACGCCGGTAAGTATTTTGCTGGCCACCTAT TTCGGCACATTGCAGGGCAATCTCGAAACCCTTGCCGCGCTGCCCGTGGCCGGAGTCCATGTGGATGCCGTGCGCGGCAG GGATGAAGTAGAGCGTCTTGTGGCCGCACTGCCCGGTGAAACTGTTGTTTCGCTTGGTGTCATTGACGGCAGAAACGTCT GGAAGACCGATCTTGCGGCGCTGCTGGACTGGCTGGAACCTGTGGCAGGGCAGCTTAAGGACAGGCTCTGGCTGGCTCCT TCGTGTTCGCTGCTGCATGTGCCGGTAGACCTTGCCGCAGAAGACGCAATGGACAGTGAAGTGCGTTCATGGCTGGCGTT TGCGCTGCAAAAGCTGGAAGAACTGCACACGCTGGGAACAGCCCTGCGCAGCGGAAGAAACGCCGTTGCCGAAGAGCTGG CCCGTAACGCGCGCAGCATCGCTTCCCGCCGCGGTTCGGAGCGGGTGCGCAATGAAGCTGTACGCGCCAGGGTGGCATCG TTGTCCGGTCAGGCGGGAGACCGCAGCCAGCCCTATGAGCAGCGCTCTCTTGTGCAGCGCCGGATGCTGCAACTGCCGCT TTTTCCCACAACGACCATAGGCTCGTTTCCGCAGACGGCGGAGATTCGTGCCGTAAGACAGCAATACCGCAAGGGCGAGC TTTCACTTCAGGAATATGAAGAAGCCATGCGTGCCAACATCAGACATGTGGTGGCGCGGCAGGAAGAGCTTGGGCTGGAT GTGCTTGTTCATGGCGAGGCCGAACGCAACGACATGGTGGAATATTTCGGCGAGCAGCTTTCCGGATACGTCTTCAGCCG TTCCGGCTGGGTGCAGTCCTACGGCTCACGCTGCGTCAAGCCGCCCATCCTGTACGGCGATATCGAGCGGCCTGCTCCCA TGACGGTGAAATGGATAACCTATGCCGCTTCGCTGACCGGAAAGCCGGTGAAGGGTATGCTGACAGGGCCGGTGACCATG CTTAACTGGTCGTTCGTGCGCGATGATCAGCCCCGCGAGGATACCTGCCGTCAGCTTGCCGCGGCCATCCGCGATGAAGT GCTTGATCTTGAGAAGGCAGGTGTGGGCATCATTCAGATAGATGAAGCGGCTCTGCGCGAAGGAATGCCCCTGCGCCGCC CGGAATGGGCGGAATATCTGCGCTGGGCCGTGGAGTCCTTCCGTCTGGCGGCCAACGGCGTGGAGGCGCGGACGCAGGTG CATACGCACATGTGCTATTCGCAGTTCAACGATATCATCGAATCCATCGCCGCCATGGATGCTGATGTCATCACCATCGA GACTTCGCGTTCGGATATGGGGCTGCTCGATGTTTTCGAGCATTTCAGCTACCCCAACGAAATAGGTCCGGGGGTGTATG ACATTCATTCGCCCAACGTGCCTGATGTGGAATCGATGGTGGAATTGCTGTGCAAAGCCGCCCGCCGCATTCCCCCTCAG CGCCTGTGGGTAAACCCTGATTGCGGGCTGAAGACCAGAACATGGCCCGAGACCGTGGCCGCGCTGGAAAATATGGTGGA AGCAGCACGCAGGCTGCGTACCATGTTTGCCGCCTGA
Upstream 100 bases:
>100_bases GACACGTACCGGCGGCAGGTTGCTTGCCTGACCGCTGATGCATCCAGAGCTTGAATGTCGTTGCTCCTTTGATTCAACAC CATAAAAGGAGTGACAGAGC
Downstream 100 bases:
>100_bases CAGTCGCCTGACGGTTTTGCAGTGCGTTGTGTATAAAATGCAATCCGGCAGACCCGCGGGTCTGCCGGATTTTTACGGTC CGGTTGTTGCTGCATGCTGT
Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
Products: NA
Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]
Number of amino acids: Translated: 758; Mature: 758
Protein sequence:
>758_residues MIIHNLGFPRIGASRELKFALESYWAERTGEDALQSVAAGLRQRNLQWQQKLDYVPVGDFSLYDQVLDMSFTLGNVPERV KNLPGGDTEAYFRVARGRASAGDTHTVHAGEMTKWFDTNYHYIVPEFTAQSRFRLDADRLTGQLKEAARSGVQAKPVIIG PVTYLWLGKSKDGSDRLALLEKLLPVYRELLETLAQNGAGWVQVDEPVLVTELEKPWLDALADAYRYLAGTPVSILLATY FGTLQGNLETLAALPVAGVHVDAVRGRDEVERLVAALPGETVVSLGVIDGRNVWKTDLAALLDWLEPVAGQLKDRLWLAP SCSLLHVPVDLAAEDAMDSEVRSWLAFALQKLEELHTLGTALRSGRNAVAEELARNARSIASRRGSERVRNEAVRARVAS LSGQAGDRSQPYEQRSLVQRRMLQLPLFPTTTIGSFPQTAEIRAVRQQYRKGELSLQEYEEAMRANIRHVVARQEELGLD VLVHGEAERNDMVEYFGEQLSGYVFSRSGWVQSYGSRCVKPPILYGDIERPAPMTVKWITYAASLTGKPVKGMLTGPVTM LNWSFVRDDQPREDTCRQLAAAIRDEVLDLEKAGVGIIQIDEAALREGMPLRRPEWAEYLRWAVESFRLAANGVEARTQV HTHMCYSQFNDIIESIAAMDADVITIETSRSDMGLLDVFEHFSYPNEIGPGVYDIHSPNVPDVESMVELLCKAARRIPPQ RLWVNPDCGLKTRTWPETVAALENMVEAARRLRTMFAA
Sequences:
>Translated_758_residues MIIHNLGFPRIGASRELKFALESYWAERTGEDALQSVAAGLRQRNLQWQQKLDYVPVGDFSLYDQVLDMSFTLGNVPERV KNLPGGDTEAYFRVARGRASAGDTHTVHAGEMTKWFDTNYHYIVPEFTAQSRFRLDADRLTGQLKEAARSGVQAKPVIIG PVTYLWLGKSKDGSDRLALLEKLLPVYRELLETLAQNGAGWVQVDEPVLVTELEKPWLDALADAYRYLAGTPVSILLATY FGTLQGNLETLAALPVAGVHVDAVRGRDEVERLVAALPGETVVSLGVIDGRNVWKTDLAALLDWLEPVAGQLKDRLWLAP SCSLLHVPVDLAAEDAMDSEVRSWLAFALQKLEELHTLGTALRSGRNAVAEELARNARSIASRRGSERVRNEAVRARVAS LSGQAGDRSQPYEQRSLVQRRMLQLPLFPTTTIGSFPQTAEIRAVRQQYRKGELSLQEYEEAMRANIRHVVARQEELGLD VLVHGEAERNDMVEYFGEQLSGYVFSRSGWVQSYGSRCVKPPILYGDIERPAPMTVKWITYAASLTGKPVKGMLTGPVTM LNWSFVRDDQPREDTCRQLAAAIRDEVLDLEKAGVGIIQIDEAALREGMPLRRPEWAEYLRWAVESFRLAANGVEARTQV HTHMCYSQFNDIIESIAAMDADVITIETSRSDMGLLDVFEHFSYPNEIGPGVYDIHSPNVPDVESMVELLCKAARRIPPQ RLWVNPDCGLKTRTWPETVAALENMVEAARRLRTMFAA >Mature_758_residues MIIHNLGFPRIGASRELKFALESYWAERTGEDALQSVAAGLRQRNLQWQQKLDYVPVGDFSLYDQVLDMSFTLGNVPERV KNLPGGDTEAYFRVARGRASAGDTHTVHAGEMTKWFDTNYHYIVPEFTAQSRFRLDADRLTGQLKEAARSGVQAKPVIIG PVTYLWLGKSKDGSDRLALLEKLLPVYRELLETLAQNGAGWVQVDEPVLVTELEKPWLDALADAYRYLAGTPVSILLATY FGTLQGNLETLAALPVAGVHVDAVRGRDEVERLVAALPGETVVSLGVIDGRNVWKTDLAALLDWLEPVAGQLKDRLWLAP SCSLLHVPVDLAAEDAMDSEVRSWLAFALQKLEELHTLGTALRSGRNAVAEELARNARSIASRRGSERVRNEAVRARVAS LSGQAGDRSQPYEQRSLVQRRMLQLPLFPTTTIGSFPQTAEIRAVRQQYRKGELSLQEYEEAMRANIRHVVARQEELGLD VLVHGEAERNDMVEYFGEQLSGYVFSRSGWVQSYGSRCVKPPILYGDIERPAPMTVKWITYAASLTGKPVKGMLTGPVTM LNWSFVRDDQPREDTCRQLAAAIRDEVLDLEKAGVGIIQIDEAALREGMPLRRPEWAEYLRWAVESFRLAANGVEARTQV HTHMCYSQFNDIIESIAAMDADVITIETSRSDMGLLDVFEHFSYPNEIGPGVYDIHSPNVPDVESMVELLCKAARRIPPQ RLWVNPDCGLKTRTWPETVAALENMVEAARRLRTMFAA
Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]
COG id: COG0620
COG function: function code E; Methionine synthase II (cobalamin-independent)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]
Homologues:
Organism=Escherichia coli, GI2367304, Length=757, Percent_Identity=56.9352708058124, Blast_Score=851, Evalue=0.0, Organism=Saccharomyces cerevisiae, GI6320936, Length=765, Percent_Identity=46.4052287581699, Blast_Score=680, Evalue=0.0,
Paralogues:
None
Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013215 - InterPro: IPR006276 - InterPro: IPR002629 [H]
Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]
EC number: =2.1.1.14 [H]
Molecular weight: Translated: 84711; Mature: 84711
Theoretical pI: Translated: 5.41; Mature: 5.41
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIIHNLGFPRIGASRELKFALESYWAERTGEDALQSVAAGLRQRNLQWQQKLDYVPVGDF CEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCH SLYDQVLDMSFTLGNVPERVKNLPGGDTEAYFRVARGRASAGDTHTVHAGEMTKWFDTNY HHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCC HYIVPEFTAQSRFRLDADRLTGQLKEAARSGVQAKPVIIGPVTYLWLGKSKDGSDRLALL CEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCCHHHHHHH EKLLPVYRELLETLAQNGAGWVQVDEPVLVTELEKPWLDALADAYRYLAGTPVSILLATY HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHH FGTLQGNLETLAALPVAGVHVDAVRGRDEVERLVAALPGETVVSLGVIDGRNVWKTDLAA HHHHCCCHHHHHHCCCCCCEEHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH LLDWLEPVAGQLKDRLWLAPSCSLLHVPVDLAAEDAMDSEVRSWLAFALQKLEELHTLGT HHHHHHHHHHHHHHCEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ALRSGRNAVAEELARNARSIASRRGSERVRNEAVRARVASLSGQAGDRSQPYEQRSLVQR HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH RMLQLPLFPTTTIGSFPQTAEIRAVRQQYRKGELSLQEYEEAMRANIRHVVARQEELGLD HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE VLVHGEAERNDMVEYFGEQLSGYVFSRSGWVQSYGSRCVKPPILYGDIERPAPMTVKWIT EEEECCCCHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEEECCCCCCCCCEEHHHH YAASLTGKPVKGMLTGPVTMLNWSFVRDDQPREDTCRQLAAAIRDEVLDLEKAGVGIIQI HHHHCCCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE DEAALREGMPLRRPEWAEYLRWAVESFRLAANGVEARTQVHTHMCYSQFNDIIESIAAMD CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC ADVITIETSRSDMGLLDVFEHFSYPNEIGPGVYDIHSPNVPDVESMVELLCKAARRIPPQ CCEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCH RLWVNPDCGLKTRTWPETVAALENMVEAARRLRTMFAA HEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MIIHNLGFPRIGASRELKFALESYWAERTGEDALQSVAAGLRQRNLQWQQKLDYVPVGDF CEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCH SLYDQVLDMSFTLGNVPERVKNLPGGDTEAYFRVARGRASAGDTHTVHAGEMTKWFDTNY HHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCC HYIVPEFTAQSRFRLDADRLTGQLKEAARSGVQAKPVIIGPVTYLWLGKSKDGSDRLALL CEECCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCEEECCEEEEEECCCCCCHHHHHHH EKLLPVYRELLETLAQNGAGWVQVDEPVLVTELEKPWLDALADAYRYLAGTPVSILLATY HHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHH FGTLQGNLETLAALPVAGVHVDAVRGRDEVERLVAALPGETVVSLGVIDGRNVWKTDLAA HHHHCCCHHHHHHCCCCCCEEHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH LLDWLEPVAGQLKDRLWLAPSCSLLHVPVDLAAEDAMDSEVRSWLAFALQKLEELHTLGT HHHHHHHHHHHHHHCEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ALRSGRNAVAEELARNARSIASRRGSERVRNEAVRARVASLSGQAGDRSQPYEQRSLVQR HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH RMLQLPLFPTTTIGSFPQTAEIRAVRQQYRKGELSLQEYEEAMRANIRHVVARQEELGLD HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE VLVHGEAERNDMVEYFGEQLSGYVFSRSGWVQSYGSRCVKPPILYGDIERPAPMTVKWIT EEEECCCCHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEEECCCCCCCCCEEHHHH YAASLTGKPVKGMLTGPVTMLNWSFVRDDQPREDTCRQLAAAIRDEVLDLEKAGVGIIQI HHHHCCCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE DEAALREGMPLRRPEWAEYLRWAVESFRLAANGVEARTQVHTHMCYSQFNDIIESIAAMD CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC ADVITIETSRSDMGLLDVFEHFSYPNEIGPGVYDIHSPNVPDVESMVELLCKAARRIPPQ CCEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCH RLWVNPDCGLKTRTWPETVAALENMVEAARRLRTMFAA HEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA