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The map label for this gene is hmeD [H]

Identifier: 78357315

GI number: 78357315

Start: 2292525

End: 2294135

Strand: Direct

Name: hmeD [H]

Synonym: Dde_2272

Alternate gene names: 78357315

Gene position: 2292525-2294135 (Clockwise)

Preceding gene: 78357314

Following gene: 78357316

Centisome position: 61.46

GC content: 56.55

Gene sequence:

>1611_bases
ATGCCTAAGGTGCCAACCCCTGAAGAACTGGTCAAAGTAGATTACAGCATGCCTGCAGGCTCTTGGATGGACACCAAACC
GGAGTTCGTCGACGGCAGCTTCTGCTACCCTGCCAAAGCTGAAATCATGGAAGGGCTGGGCATGCCCAACCCGCACACGT
GGAACCCCGCCGAAGAAGACTGGGGCCTGCCCGAAAACTGGGAAGAGATTATCTATAACGCCATGCAGGAGCGGCTGGAA
AAATACCGTTCCTTCAAGGTCTTCATGGATATCTGCGTGCGCTGCGGCGCATGCGCCGACAAGTGTCACTTTTTCATCGG
CACCGGCGACCCCAAAAACATGCCCGTGCTGCGCGCCGAACTGCTGCGCTCGGTCTACCGCCGCGATTTCACCACCGCCG
GTAAAATTCTGGGCAAGCTGGCAGGTGCCAGAAAGCTTGATAAAGACGTGATCAAGGAGTGGTTCTACTACTTCTATCAG
TGCACTGAATGCCGCCGTTGCTCGGTATACTGCCCCTACGGCATCGACACCGCCGAAATAACCATGATGGCGCGTGAGCT
GCTGCATGAACTCGGCCTCGGCATCAACTGGATTATGGAGCCGGTGTCCAACTGTAACCGCACAGGCAACCACCTCGGCA
TCCAGCCGCATGCCTTCAAGGAAATCGTGGAATTCCTGTGTGACGACATCGAAGACATCACAGGCATCCGCATCAATCCC
CCGTTCAACGAACCGGGCCACGAAGTGCTGTTCATCACCCCCTCCGGCGACGTTTTCGCCGATCCGGGTATTTACACCTT
CATGGGATATCTGATGCTCTTCCACGAGATAGGGCTGGACTATACCCTGTCCACCTACGCATCAGAAGGCGGCAACTTCG
GTCTGTTCACGTCAGCTGACATGATGAAAAAGCTGAACGCCAAAATGTACGCCGAAGCCGAGCGTCTGGGTTCCAAATGG
ATTCTGGGCGGCGAATGCGGTCACATGTGGCGTGTGATCAACCAGTACATGGGCACCATGAACGGTTCCACGCCCTCCTG
CATGGAAACTCCCGTCAACCCCATCACCGGCACTGTGTTCCATAACGCAGCCGATACAAAGATGGTGCACATCACCGAGT
TTACTGCAGACCTGATAAAGCACAACAAGCTGCGTCTTGACCCCAGCCGTAACGACCACCTGCGCGTCACGTTCCACGAC
TCGTGCAACCCTGCACGTGCCATGGGTCTTTTTGAAGAACCGCGCGAAGTCATCAAAGCGGTGTGCAACAACTACTTTGA
AATGCCCGAAGGAACCACCCGCGAGCAGACCTTCTGCTGCGGTGCCGGCTCCGGTCTGAATACGGATGAAATAATGGAAC
TGCGCATGCGCGGCGCACTGCCCCGCGGCAATGCCCTGCGGTATGTGCAGCAGAAGCATGACGTAAACGCCATGGCCTGC
ATCTGCGCCATCGACCGTGCCACCCTGATTCCCCTGGCCGACTACTGGGCTCCGGGCGTTTCCATATATGGCACGCACGA
ACTGGTGGCCAACGCACTGGTCATGAAGGGCGAACAGAAGCGTACCGTTGACCTGAGGCAGGAAGATCTGCCGGGCATGG
AGGATGAATAA

Upstream 100 bases:

>100_bases
TTACGAAGAGTACGAGGACGATTTCAGGGAACCCATGTTTGAAGCGGGCCTCCCTCTCATGAAGAAACCTGACGAAGCTT
CCAAGGAGTAAGGAGTAGCC

Downstream 100 bases:

>100_bases
CCATGTATAACAGCAAATACATCATCCCCGGACTGCTCATCTTCGTGGGTCTGGTGACCTTCCCCTTCTGGGTGAATCTG
GTTTCCGCCGAATACAAGCG

Product: reductase, iron-sulfur binding subunit

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MPKVPTPEELVKVDYSMPAGSWMDTKPEFVDGSFCYPAKAEIMEGLGMPNPHTWNPAEEDWGLPENWEEIIYNAMQERLE
KYRSFKVFMDICVRCGACADKCHFFIGTGDPKNMPVLRAELLRSVYRRDFTTAGKILGKLAGARKLDKDVIKEWFYYFYQ
CTECRRCSVYCPYGIDTAEITMMARELLHELGLGINWIMEPVSNCNRTGNHLGIQPHAFKEIVEFLCDDIEDITGIRINP
PFNEPGHEVLFITPSGDVFADPGIYTFMGYLMLFHEIGLDYTLSTYASEGGNFGLFTSADMMKKLNAKMYAEAERLGSKW
ILGGECGHMWRVINQYMGTMNGSTPSCMETPVNPITGTVFHNAADTKMVHITEFTADLIKHNKLRLDPSRNDHLRVTFHD
SCNPARAMGLFEEPREVIKAVCNNYFEMPEGTTREQTFCCGAGSGLNTDEIMELRMRGALPRGNALRYVQQKHDVNAMAC
ICAIDRATLIPLADYWAPGVSIYGTHELVANALVMKGEQKRTVDLRQEDLPGMEDE

Sequences:

>Translated_536_residues
MPKVPTPEELVKVDYSMPAGSWMDTKPEFVDGSFCYPAKAEIMEGLGMPNPHTWNPAEEDWGLPENWEEIIYNAMQERLE
KYRSFKVFMDICVRCGACADKCHFFIGTGDPKNMPVLRAELLRSVYRRDFTTAGKILGKLAGARKLDKDVIKEWFYYFYQ
CTECRRCSVYCPYGIDTAEITMMARELLHELGLGINWIMEPVSNCNRTGNHLGIQPHAFKEIVEFLCDDIEDITGIRINP
PFNEPGHEVLFITPSGDVFADPGIYTFMGYLMLFHEIGLDYTLSTYASEGGNFGLFTSADMMKKLNAKMYAEAERLGSKW
ILGGECGHMWRVINQYMGTMNGSTPSCMETPVNPITGTVFHNAADTKMVHITEFTADLIKHNKLRLDPSRNDHLRVTFHD
SCNPARAMGLFEEPREVIKAVCNNYFEMPEGTTREQTFCCGAGSGLNTDEIMELRMRGALPRGNALRYVQQKHDVNAMAC
ICAIDRATLIPLADYWAPGVSIYGTHELVANALVMKGEQKRTVDLRQEDLPGMEDE
>Mature_535_residues
PKVPTPEELVKVDYSMPAGSWMDTKPEFVDGSFCYPAKAEIMEGLGMPNPHTWNPAEEDWGLPENWEEIIYNAMQERLEK
YRSFKVFMDICVRCGACADKCHFFIGTGDPKNMPVLRAELLRSVYRRDFTTAGKILGKLAGARKLDKDVIKEWFYYFYQC
TECRRCSVYCPYGIDTAEITMMARELLHELGLGINWIMEPVSNCNRTGNHLGIQPHAFKEIVEFLCDDIEDITGIRINPP
FNEPGHEVLFITPSGDVFADPGIYTFMGYLMLFHEIGLDYTLSTYASEGGNFGLFTSADMMKKLNAKMYAEAERLGSKWI
LGGECGHMWRVINQYMGTMNGSTPSCMETPVNPITGTVFHNAADTKMVHITEFTADLIKHNKLRLDPSRNDHLRVTFHDS
CNPARAMGLFEEPREVIKAVCNNYFEMPEGTTREQTFCCGAGSGLNTDEIMELRMRGALPRGNALRYVQQKHDVNAMACI
CAIDRATLIPLADYWAPGVSIYGTHELVANALVMKGEQKRTVDLRQEDLPGMEDE

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 60619; Mature: 60488

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
8.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVPTPEELVKVDYSMPAGSWMDTKPEFVDGSFCYPAKAEIMEGLGMPNPHTWNPAEED
CCCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHC
WGLPENWEEIIYNAMQERLEKYRSFKVFMDICVRCGACADKCHFFIGTGDPKNMPVLRAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
LLRSVYRRDFTTAGKILGKLAGARKLDKDVIKEWFYYFYQCTECRRCSVYCPYGIDTAEI
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHH
TMMARELLHELGLGINWIMEPVSNCNRTGNHLGIQPHAFKEIVEFLCDDIEDITGIRINP
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECC
PFNEPGHEVLFITPSGDVFADPGIYTFMGYLMLFHEIGLDYTLSTYASEGGNFGLFTSAD
CCCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCEEEEECHH
MMKKLNAKMYAEAERLGSKWILGGECGHMWRVINQYMGTMNGSTPSCMETPVNPITGTVF
HHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCEE
HNAADTKMVHITEFTADLIKHNKLRLDPSRNDHLRVTFHDSCNPARAMGLFEEPREVIKA
ECCCCCEEEEEHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHCCHHHHHHHHHH
VCNNYFEMPEGTTREQTFCCGAGSGLNTDEIMELRMRGALPRGNALRYVQQKHDVNAMAC
HHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
ICAIDRATLIPLADYWAPGVSIYGTHELVANALVMKGEQKRTVDLRQEDLPGMEDE
HHHHCCHHCCCCHHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
PKVPTPEELVKVDYSMPAGSWMDTKPEFVDGSFCYPAKAEIMEGLGMPNPHTWNPAEED
CCCCCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHC
WGLPENWEEIIYNAMQERLEKYRSFKVFMDICVRCGACADKCHFFIGTGDPKNMPVLRAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
LLRSVYRRDFTTAGKILGKLAGARKLDKDVIKEWFYYFYQCTECRRCSVYCPYGIDTAEI
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHH
TMMARELLHELGLGINWIMEPVSNCNRTGNHLGIQPHAFKEIVEFLCDDIEDITGIRINP
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECC
PFNEPGHEVLFITPSGDVFADPGIYTFMGYLMLFHEIGLDYTLSTYASEGGNFGLFTSAD
CCCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCEEEEECHH
MMKKLNAKMYAEAERLGSKWILGGECGHMWRVINQYMGTMNGSTPSCMETPVNPITGTVF
HHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCEE
HNAADTKMVHITEFTADLIKHNKLRLDPSRNDHLRVTFHDSCNPARAMGLFEEPREVIKA
ECCCCCEEEEEHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHCCHHHHHHHHHH
VCNNYFEMPEGTTREQTFCCGAGSGLNTDEIMELRMRGALPRGNALRYVQQKHDVNAMAC
HHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
ICAIDRATLIPLADYWAPGVSIYGTHELVANALVMKGEQKRTVDLRQEDLPGMEDE
HHHHCCHHCCCCHHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA