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The map label for this gene is clpP

Identifier: 78357263

GI number: 78357263

Start: 2261703

End: 2262305

Strand: Reverse

Name: clpP

Synonym: Dde_2220

Alternate gene names: 78357263

Gene position: 2262305-2261703 (Counterclockwise)

Preceding gene: 78357265

Following gene: 78357262

Centisome position: 60.65

GC content: 53.4

Gene sequence:

>603_bases
ATGCCCATCCCCATGGTTATTGAGTCGACGGGCCGTGCCGAACGGGCCTACGATATTTATTCCAGACTGCTGAAAGACCG
TATCATTCTGCTGGGCACCCCCGTGGATGACAATGTTGCTTCACTTATCTGCGCCCAGCTGCTGTTTCTGGAATCGGAAA
ATCCTGAAAAGGAAATTTATCTGTACATCAATTCGCCCGGCGGAGTGGTGACAGCGGGGCTGGCCATATACGACACCATG
CAGTACATTTCCGCGCCTGTGGCCACGTTGTGCATGGGGCAGGCCGCCAGCATGGGGGCTTTTCTGCTGGCCGCAGGTCA
GCCCGGCATGCGGTTTGCGCTGCCCAACAGCCGCATCATGATTCATCAGCCCATGGGCGGTGCTCAGGGGCAGGCCACAG
ACATTGATATTCAGGCTCGGGAAATTCTGCGTCTGAAGGACAGACTGAACGAAATTCTGTCCCGTCACACGGGGCAGCCT
CTTGAAAAAATTGTTGAGCATACCGATCGCGATTATTTCATGGGGCCTGAAAATGCAAAGAACTTCGGTATCATTGACCG
TATTCTCACATCGCGCAAAGATGTGGAAAAAGACGGCAAATAA

Upstream 100 bases:

>100_bases
TGACCTGCCGTCTTTTTGACTTGAACATACATACAAATCCCGATGTCCCGCCGTTCGCTTACGGGCAACAGCCGCATCAT
CACCCAGGAGTTATCATATC

Downstream 100 bases:

>100_bases
CAGGAAGGGCTAATGGATAGAAAAAATGACGGGTCTGCACAGGAGCCCAGATGCTCGTTCTGCCAGAAAGGGCCGGACAG
CGTAAAGCGCCTGATTTCAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MPIPMVIESTGRAERAYDIYSRLLKDRIILLGTPVDDNVASLICAQLLFLESENPEKEIYLYINSPGGVVTAGLAIYDTM
QYISAPVATLCMGQAASMGAFLLAAGQPGMRFALPNSRIMIHQPMGGAQGQATDIDIQAREILRLKDRLNEILSRHTGQP
LEKIVEHTDRDYFMGPENAKNFGIIDRILTSRKDVEKDGK

Sequences:

>Translated_200_residues
MPIPMVIESTGRAERAYDIYSRLLKDRIILLGTPVDDNVASLICAQLLFLESENPEKEIYLYINSPGGVVTAGLAIYDTM
QYISAPVATLCMGQAASMGAFLLAAGQPGMRFALPNSRIMIHQPMGGAQGQATDIDIQAREILRLKDRLNEILSRHTGQP
LEKIVEHTDRDYFMGPENAKNFGIIDRILTSRKDVEKDGK
>Mature_199_residues
PIPMVIESTGRAERAYDIYSRLLKDRIILLGTPVDDNVASLICAQLLFLESENPEKEIYLYINSPGGVVTAGLAIYDTMQ
YISAPVATLCMGQAASMGAFLLAAGQPGMRFALPNSRIMIHQPMGGAQGQATDIDIQAREILRLKDRLNEILSRHTGQPL
EKIVEHTDRDYFMGPENAKNFGIIDRILTSRKDVEKDGK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=64.8936170212766, Blast_Score=258, Evalue=2e-69,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=64.9214659685864, Blast_Score=270, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=196, Percent_Identity=60.7142857142857, Blast_Score=243, Evalue=7e-65,
Organism=Drosophila melanogaster, GI20129427, Length=187, Percent_Identity=63.6363636363636, Blast_Score=253, Evalue=7e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_DESDG (Q30Z79)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388712.1
- ProteinModelPortal:   Q30Z79
- SMR:   Q30Z79
- STRING:   Q30Z79
- MEROPS:   S14.001
- GeneID:   3757230
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2220
- NMPDR:   fig|207559.3.peg.2182
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   DDES207559:DDE_2220-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22109; Mature: 21978

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPMVIESTGRAERAYDIYSRLLKDRIILLGTPVDDNVASLICAQLLFLESENPEKEIY
CCCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGLAIYDTMQYISAPVATLCMGQAASMGAFLLAAGQPGMRFALPNSRIM
EEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCCEEE
IHQPMGGAQGQATDIDIQAREILRLKDRLNEILSRHTGQPLEKIVEHTDRDYFMGPENAK
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
NFGIIDRILTSRKDVEKDGK
CCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PIPMVIESTGRAERAYDIYSRLLKDRIILLGTPVDDNVASLICAQLLFLESENPEKEIY
CCCEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGLAIYDTMQYISAPVATLCMGQAASMGAFLLAAGQPGMRFALPNSRIM
EEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCCEEE
IHQPMGGAQGQATDIDIQAREILRLKDRLNEILSRHTGQPLEKIVEHTDRDYFMGPENAK
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
NFGIIDRILTSRKDVEKDGK
CCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA