Click here to switch to the map view.

The map label for this gene is pth

Identifier: 78357171

GI number: 78357171

Start: 2176984

End: 2177589

Strand: Direct

Name: pth

Synonym: Dde_2128

Alternate gene names: 78357171

Gene position: 2176984-2177589 (Clockwise)

Preceding gene: 78357170

Following gene: 78357172

Centisome position: 58.36

GC content: 56.11

Gene sequence:

>606_bases
ATGAATTTAGACGGCCTGATTGTCGGCCTTGGCAACCCCGGCAAGGAATATGAAAACACCAGACATAATCTGGGGTTCAT
GCTGGCGGACGCCCTACTTGATGAAGTAAGGCGCACCGCGCCCCATGCCGTCACATCACTCGGCACGGGCAAAAAAAAAT
ACGACTTGTGGAAGTGTGCCCCGCTTACCGGCGGGTCGTCCTGGCTGGTGGCAAAGCCGCTTACGTTCATGAACAGAAGC
GGTGATGCCGTTGCTCACATATGCGGATTTTATCGCATACCACCGGAAAAAATACTGGTGCTGCACGACGAGCTGGATCT
GCCGCTGGGCCGCATGAAATTTAAAACGGCAGGAGGACTTGCCGGCCACAACGGGCTGAAGTCCATCGCCGAACGCACCG
GAAGCAAAGATTTTCACCGCCTGCGTCTGGGCATAGGCAAGCCCCAGTCCGGTCAGACCACAGGGTATGTGCTGGGCAGG
TTCGGCAAAGACGAACAGGCACTGGTGGAAAAAGTGCTGCAGGCAGGAGTGGAAGGCATACGGATTTTTGCTCAGCAGGG
AGCCGTGGCCGCCACCCAGTTCATCAACGCTCAAGACATCCAGTAA

Upstream 100 bases:

>100_bases
GGCTCCGTACTACGTGCGGAGCCGCATTCCCTTTTGCCGGAGCAGTTCTGCGTTCTGCTGCTGCCCGTGTGCCTTTCTGT
AGACAGTTCGGACAGACACC

Downstream 100 bases:

>100_bases
CGGAGCAGCAAATAGCCGTAGACTCTCTCGGCCTGTTAGGGTATTATCAAAAGTCCTTACAGCGGCTAGAGAATCCTTCA
AGGAGTACCAAGTGTTTGTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MNLDGLIVGLGNPGKEYENTRHNLGFMLADALLDEVRRTAPHAVTSLGTGKKKYDLWKCAPLTGGSSWLVAKPLTFMNRS
GDAVAHICGFYRIPPEKILVLHDELDLPLGRMKFKTAGGLAGHNGLKSIAERTGSKDFHRLRLGIGKPQSGQTTGYVLGR
FGKDEQALVEKVLQAGVEGIRIFAQQGAVAATQFINAQDIQ

Sequences:

>Translated_201_residues
MNLDGLIVGLGNPGKEYENTRHNLGFMLADALLDEVRRTAPHAVTSLGTGKKKYDLWKCAPLTGGSSWLVAKPLTFMNRS
GDAVAHICGFYRIPPEKILVLHDELDLPLGRMKFKTAGGLAGHNGLKSIAERTGSKDFHRLRLGIGKPQSGQTTGYVLGR
FGKDEQALVEKVLQAGVEGIRIFAQQGAVAATQFINAQDIQ
>Mature_201_residues
MNLDGLIVGLGNPGKEYENTRHNLGFMLADALLDEVRRTAPHAVTSLGTGKKKYDLWKCAPLTGGSSWLVAKPLTFMNRS
GDAVAHICGFYRIPPEKILVLHDELDLPLGRMKFKTAGGLAGHNGLKSIAERTGSKDFHRLRLGIGKPQSGQTTGYVLGR
FGKDEQALVEKVLQAGVEGIRIFAQQGAVAATQFINAQDIQ

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=176, Percent_Identity=34.0909090909091, Blast_Score=85, Evalue=4e-17,
Organism=Escherichia coli, GI1787455, Length=198, Percent_Identity=40.4040404040404, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_DESDG (Q30ZH1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388620.1
- ProteinModelPortal:   Q30ZH1
- SMR:   Q30ZH1
- STRING:   Q30ZH1
- GeneID:   3757137
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2128
- NMPDR:   fig|207559.3.peg.2088
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   DDES207559:DDE_2128-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21751; Mature: 21751

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDGLIVGLGNPGKEYENTRHNLGFMLADALLDEVRRTAPHAVTSLGTGKKKYDLWKCA
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEC
PLTGGSSWLVAKPLTFMNRSGDAVAHICGFYRIPPEKILVLHDELDLPLGRMKFKTAGGL
CCCCCCCEEEECCHHHHCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCCEEEECCCCC
AGHNGLKSIAERTGSKDFHRLRLGIGKPQSGQTTGYVLGRFGKDEQALVEKVLQAGVEGI
CCCHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHH
RIFAQQGAVAATQFINAQDIQ
HHHHHCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNLDGLIVGLGNPGKEYENTRHNLGFMLADALLDEVRRTAPHAVTSLGTGKKKYDLWKCA
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEC
PLTGGSSWLVAKPLTFMNRSGDAVAHICGFYRIPPEKILVLHDELDLPLGRMKFKTAGGL
CCCCCCCEEEECCHHHHCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCCEEEECCCCC
AGHNGLKSIAERTGSKDFHRLRLGIGKPQSGQTTGYVLGRFGKDEQALVEKVLQAGVEGI
CCCHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHH
RIFAQQGAVAATQFINAQDIQ
HHHHHCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA