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The map label for this gene is prs [H]

Identifier: 78357169

GI number: 78357169

Start: 2175261

End: 2176202

Strand: Direct

Name: prs [H]

Synonym: Dde_2126

Alternate gene names: 78357169

Gene position: 2175261-2176202 (Clockwise)

Preceding gene: 78357168

Following gene: 78357170

Centisome position: 58.31

GC content: 55.52

Gene sequence:

>942_bases
ATGCATGGCGATTTAAAAATTATTACCGGCACCGCCAATCCGGAATTAGCCAGCGCCATATGCAACCACCTCGGCTGCCA
TCTGACCCCCACGCTGTGCGAAACATTCAGTGACGGTGAAATCAGAATCGAAATAGGCGACAATGTTCGCGGAGATGATG
TTTTCATCGTCCAGCCGACTTGCGCTCCTGTCAACGACAACCTGATTCAGCTCAGCCTGATGCTTGACGCTCTGAAAAGA
GCCAGTGTCGGACGTGTGACTGCGGTTGTCCCCTACTACGGGTACGCCCGTCAGGACCGCAAGGTCAGCCCGCGCGCTCC
CATCAGCGCCAGACTGATGGCGGACCTGCTGGAAGCTGCGGGGATGCACCGGCTTGTCACGGTGGATCTGCACGCGGGAC
AGATTCAGGGATTTTTCAACTGTCCGGTGGACAACCTGTACGCCGCACCTGTCATTCTTGACTACCTGCGTCAGACTGTC
ACCAACGACATTGTTATCGTATCGCCCGATGCGGGCGGTGTGGAACGCGCACGCGCCTATGCCAAACGTCTGGGCGCTTC
TCTTGCAATCATCGACAAACGACGCGATAAACCAAATCAGGCCGAGGCCATGAACGTTATCGGCGAAGTGAAAGGCAAAA
CAGCCATTGTCGTTGATGATATGATCGACACAGCCGGCACCATGGTAGCCGCAGGCAATGTTCTGCTTACCAAGGGAGCC
AAGGAAGTGATGGCTTGCACAACGCACCCTGTCCTGTCCGGACCGGCCATTGAGCGGCTCTGCGAATCTTCTTTCTCGCA
GGTGGTTGTCACCGACACCATTCCGCTCGGGTCCAAACTTCAGGCATGCAGCAAACTGAAGGTACTTTCCGTTGCGGGAT
TGCTGGCAAAGGCCATCCATAATATCCACACGGAATCGTCCGTCAGCGTGCTTTTTGTGTAG

Upstream 100 bases:

>100_bases
GTAAGGCAACGGGTTTTGGTCCCGTCATTCGAGGGTTCAAGTCCTTCCGCCCCTGCCATTTTTTTTGCGTGAACCATAAA
AAAGTCCCGGATCTATTACC

Downstream 100 bases:

>100_bases
CCTGTAAACACCGTATCACACGCGCAGCCAATAAGCGCGACGTTTTTTGAAAGGAGAGAACTTATGTCCCAGCAGATGAC
ACTGAGCGTCCAGAAGCGTG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MHGDLKIITGTANPELASAICNHLGCHLTPTLCETFSDGEIRIEIGDNVRGDDVFIVQPTCAPVNDNLIQLSLMLDALKR
ASVGRVTAVVPYYGYARQDRKVSPRAPISARLMADLLEAAGMHRLVTVDLHAGQIQGFFNCPVDNLYAAPVILDYLRQTV
TNDIVIVSPDAGGVERARAYAKRLGASLAIIDKRRDKPNQAEAMNVIGEVKGKTAIVVDDMIDTAGTMVAAGNVLLTKGA
KEVMACTTHPVLSGPAIERLCESSFSQVVVTDTIPLGSKLQACSKLKVLSVAGLLAKAIHNIHTESSVSVLFV

Sequences:

>Translated_313_residues
MHGDLKIITGTANPELASAICNHLGCHLTPTLCETFSDGEIRIEIGDNVRGDDVFIVQPTCAPVNDNLIQLSLMLDALKR
ASVGRVTAVVPYYGYARQDRKVSPRAPISARLMADLLEAAGMHRLVTVDLHAGQIQGFFNCPVDNLYAAPVILDYLRQTV
TNDIVIVSPDAGGVERARAYAKRLGASLAIIDKRRDKPNQAEAMNVIGEVKGKTAIVVDDMIDTAGTMVAAGNVLLTKGA
KEVMACTTHPVLSGPAIERLCESSFSQVVVTDTIPLGSKLQACSKLKVLSVAGLLAKAIHNIHTESSVSVLFV
>Mature_313_residues
MHGDLKIITGTANPELASAICNHLGCHLTPTLCETFSDGEIRIEIGDNVRGDDVFIVQPTCAPVNDNLIQLSLMLDALKR
ASVGRVTAVVPYYGYARQDRKVSPRAPISARLMADLLEAAGMHRLVTVDLHAGQIQGFFNCPVDNLYAAPVILDYLRQTV
TNDIVIVSPDAGGVERARAYAKRLGASLAIIDKRRDKPNQAEAMNVIGEVKGKTAIVVDDMIDTAGTMVAAGNVLLTKGA
KEVMACTTHPVLSGPAIERLCESSFSQVVVTDTIPLGSKLQACSKLKVLSVAGLLAKAIHNIHTESSVSVLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=47.2668810289389, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=45.6591639871383, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=45.2229299363057, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.016077170418, Blast_Score=287, Evalue=9e-78,
Organism=Homo sapiens, GI194018537, Length=332, Percent_Identity=35.8433734939759, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=32.6589595375723, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=29.9319727891156, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=29.9319727891156, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=29.9319727891156, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=29.9319727891156, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=50.1607717041801, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=45.9807073954984, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=45.9807073954984, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=45.9807073954984, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=46.1038961038961, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=32.5373134328358, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=43.8709677419355, Blast_Score=267, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=42.7652733118971, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=41.3461538461538, Blast_Score=251, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=38.265306122449, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=50, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=46.3022508038585, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=43.1137724550898, Blast_Score=280, Evalue=8e-76,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=32.2128851540616, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=32.2128851540616, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=32.2128851540616, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=32.2128851540616, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651462, Length=376, Percent_Identity=30.8510638297872, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24651464, Length=376, Percent_Identity=30.8510638297872, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI45552010, Length=376, Percent_Identity=30.8510638297872, Blast_Score=180, Evalue=9e-46,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33379; Mature: 33379

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGDLKIITGTANPELASAICNHLGCHLTPTLCETFSDGEIRIEIGDNVRGDDVFIVQPT
CCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEECCC
CAPVNDNLIQLSLMLDALKRASVGRVTAVVPYYGYARQDRKVSPRAPISARLMADLLEAA
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GMHRLVTVDLHAGQIQGFFNCPVDNLYAAPVILDYLRQTVTNDIVIVSPDAGGVERARAY
CCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
AKRLGASLAIIDKRRDKPNQAEAMNVIGEVKGKTAIVVDDMIDTAGTMVAAGNVLLTKGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCCEEECCCEEEECCC
KEVMACTTHPVLSGPAIERLCESSFSQVVVTDTIPLGSKLQACSKLKVLSVAGLLAKAIH
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NIHTESSVSVLFV
HHCCCCCEEEEEC
>Mature Secondary Structure
MHGDLKIITGTANPELASAICNHLGCHLTPTLCETFSDGEIRIEIGDNVRGDDVFIVQPT
CCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEECCC
CAPVNDNLIQLSLMLDALKRASVGRVTAVVPYYGYARQDRKVSPRAPISARLMADLLEAA
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GMHRLVTVDLHAGQIQGFFNCPVDNLYAAPVILDYLRQTVTNDIVIVSPDAGGVERARAY
CCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
AKRLGASLAIIDKRRDKPNQAEAMNVIGEVKGKTAIVVDDMIDTAGTMVAAGNVLLTKGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCCEEECCCEEEECCC
KEVMACTTHPVLSGPAIERLCESSFSQVVVTDTIPLGSKLQACSKLKVLSVAGLLAKAIH
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NIHTESSVSVLFV
HHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA