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The map label for this gene is adk [H]

Identifier: 78357071

GI number: 78357071

Start: 2067413

End: 2068102

Strand: Direct

Name: adk [H]

Synonym: Dde_2028

Alternate gene names: 78357071

Gene position: 2067413-2068102 (Clockwise)

Preceding gene: 78357070

Following gene: 78357075

Centisome position: 55.42

GC content: 54.78

Gene sequence:

>690_bases
ATGACAAGGAGGAATGACGTGAATATACTCATCTTCGGCCCCAACGGTAGCGGTAAGGGAACACAGGGTTCTCTGGTTAA
GCAGAAATACAATCTGGCCCACATCGAATCCGGTGCCATCTTCCGCGAACACATCGGCGGTGGTACGGAGCTTGGTAAAA
AAGCCAAGGAATACATCGATCGCGGCGATCTGGTCCCCGACGAAATCACCATTCCCATGGTTCTTGAAACGCTCAAGAGC
AAGGGTGCCAACGGCTGGCTGCTGGACGGCTTTCCCCGTAACATGGTGCAGGCTGAAAAGCTGTGGGACGCGCTGCAGGC
CGAAAACATGAAACTTGACTACGTCATCGAAATCCTGCTGCCCCGCGAAGTGGCCAAAAACCGCATCATGGGCCGCCGTC
TGTGTGTCAACGACAACAACCACCCCAACAATATTTTCATCGACGCCATCAAGCCCGAAGGCGACAAGTGCCGCGTATGT
GGCGGCGCGCTGAGCAGCCGTGCTGATGATCAGGACGAAGGTGCCATTAACAAGCGTCATGACATCTACTACAACACCGA
AGACGGCACTCTGGCCGCTGCCTACTTCTACAAAGACCTCGCAGCCAAAGGCGCCACCAAATACATTGAACTGAACGGCG
AAGGCGACATCAACTCCATCAAGGAAACCTTGCTGGCCCAGCTCGCCTAG

Upstream 100 bases:

>100_bases
CAGGATACGCCATGGCGGCATATGCTTCTGCCTAACCGCCTGATTCTTTTTTATCCGATTGACAGGGTGCGATTCTTCGC
AGTATGACTTCGTGAAATAA

Downstream 100 bases:

>100_bases
TCTGATCTCTTCCGCCACAAAAAGGCCCCCGCTGAAAGCGGGGGCCTTTTCTTATGCATAACGCACCGACAGCAAGCAGG
CGGTACATGTTCTGCGCGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTRRNDVNILIFGPNGSGKGTQGSLVKQKYNLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDEITIPMVLETLKS
KGANGWLLDGFPRNMVQAEKLWDALQAENMKLDYVIEILLPREVAKNRIMGRRLCVNDNNHPNNIFIDAIKPEGDKCRVC
GGALSSRADDQDEGAINKRHDIYYNTEDGTLAAAYFYKDLAAKGATKYIELNGEGDINSIKETLLAQLA

Sequences:

>Translated_229_residues
MTRRNDVNILIFGPNGSGKGTQGSLVKQKYNLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDEITIPMVLETLKS
KGANGWLLDGFPRNMVQAEKLWDALQAENMKLDYVIEILLPREVAKNRIMGRRLCVNDNNHPNNIFIDAIKPEGDKCRVC
GGALSSRADDQDEGAINKRHDIYYNTEDGTLAAAYFYKDLAAKGATKYIELNGEGDINSIKETLLAQLA
>Mature_228_residues
TRRNDVNILIFGPNGSGKGTQGSLVKQKYNLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDEITIPMVLETLKSK
GANGWLLDGFPRNMVQAEKLWDALQAENMKLDYVIEILLPREVAKNRIMGRRLCVNDNNHPNNIFIDAIKPEGDKCRVCG
GALSSRADDQDEGAINKRHDIYYNTEDGTLAAAYFYKDLAAKGATKYIELNGEGDINSIKETLLAQLA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=180, Percent_Identity=34.4444444444444, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI4502013, Length=180, Percent_Identity=34.4444444444444, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19923437, Length=196, Percent_Identity=36.2244897959184, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI310110345, Length=173, Percent_Identity=35.8381502890173, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI53832003, Length=173, Percent_Identity=35.8381502890173, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI8051579, Length=173, Percent_Identity=35.8381502890173, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI53832001, Length=173, Percent_Identity=35.8381502890173, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI4502011, Length=223, Percent_Identity=27.3542600896861, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=95, Percent_Identity=35.7894736842105, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI28144897, Length=95, Percent_Identity=35.7894736842105, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=35.1598173515982, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17552384, Length=193, Percent_Identity=33.160621761658, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=30.6451612903226, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17567503, Length=129, Percent_Identity=32.5581395348837, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550688, Length=134, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=201, Percent_Identity=35.3233830845771, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=181, Percent_Identity=34.8066298342541, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI22026816, Length=179, Percent_Identity=38.5474860335196, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737899, Length=174, Percent_Identity=37.3563218390805, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645822, Length=174, Percent_Identity=37.3563218390805, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221459597, Length=125, Percent_Identity=30.4, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356893, Length=125, Percent_Identity=30.4, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 25323; Mature: 25192

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRNDVNILIFGPNGSGKGTQGSLVKQKYNLAHIESGAIFREHIGGGTELGKKAKEYID
CCCCCCCEEEEECCCCCCCCCCCCHHHHHCCEEEECCCCCHHHHCCCCHHHHHHHHHHHH
RGDLVPDEITIPMVLETLKSKGANGWLLDGFPRNMVQAEKLWDALQAENMKLDYVIEILL
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHEEEEC
PREVAKNRIMGRRLCVNDNNHPNNIFIDAIKPEGDKCRVCGGALSSRADDQDEGAINKRH
CHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHCCCCCCCCCCCCCCC
DIYYNTEDGTLAAAYFYKDLAAKGATKYIELNGEGDINSIKETLLAQLA
CEEEECCCCCEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TRRNDVNILIFGPNGSGKGTQGSLVKQKYNLAHIESGAIFREHIGGGTELGKKAKEYID
CCCCCCEEEEECCCCCCCCCCCCHHHHHCCEEEECCCCCHHHHCCCCHHHHHHHHHHHH
RGDLVPDEITIPMVLETLKSKGANGWLLDGFPRNMVQAEKLWDALQAENMKLDYVIEILL
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHEEEEC
PREVAKNRIMGRRLCVNDNNHPNNIFIDAIKPEGDKCRVCGGALSSRADDQDEGAINKRH
CHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHCCCCCCCCCCCCCCC
DIYYNTEDGTLAAAYFYKDLAAKGATKYIELNGEGDINSIKETLLAQLA
CEEEECCCCCEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA