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The map label for this gene is lysA [H]

Identifier: 78357021

GI number: 78357021

Start: 2024103

End: 2025350

Strand: Direct

Name: lysA [H]

Synonym: Dde_1978

Alternate gene names: 78357021

Gene position: 2024103-2025350 (Clockwise)

Preceding gene: 78357020

Following gene: 78357022

Centisome position: 54.26

GC content: 52.24

Gene sequence:

>1248_bases
ATGCATCATTTCACATACCGCGACAATGAACTCTTTGTGGAAAATGTAGCTGTTCAGGAACTTGTGGCCACATACGGAAC
TCCTTTGTACATATACTCCAAAGCGACTTTTCAGCGCCATTTCACAGCGTTTGATTCAGCATTCGGTGCGCTGCCCCACC
TCACCTGCTATTCGGTGAAAGCATGCTCCAACATGCACATTCTGCGCTTTCTCGGCAAAATGGGCGCAGGCATGGACATT
GTATCGGGCGGGGAGCTTTTCAGAGCGTTGCGGGCAGGTATTCAGCCAGCCAAAATCGTTTACAGCGGAGTAGGAAAAAC
ACGCACTGAAATTCTGCAGGCACTGGAAGCTGGCATCCTGATGTTCAATGTGGAATCCATGGGAGAGCTGGAAAAAATAA
GCGAAGTGGCCAACCAGACGGGTCACACAGCCAACGTAGCTCTGCGCATCAACCCCGATGTGGACCCGCATACCCACCCG
TACATATCCACCGGACTGAAAGAAAACAAATTCGGTCTGGACATGGAACAGTCCTATGCGGCTTATATGCGTGCCATGGA
ACTGCCCGCCATCACACCCATGGGTATTGATTGCCATATAGGTTCACAGCTGACCAGTCTGTCACCATTCAGAGAAGCTG
TCGAAAAGATACTTCTTTTCCGGGAAAAGCTGTGCTCTGCAGGACTGTGCATTGACTACATAGATCTGGGCGGAGGACTG
GGAATACCGTATGACACCGAAGAACCGCCTCATCCGCAGGAATTCGGCAAGCTGCTTACTGATATGCTTTCGGGACTTGG
CATCACATTGATACTGGAACCCGGAAGGGTCATTGCAGGCAACGCGGGCATTCTGGTCACCAAAGTCCAGTACACCAAAA
AAACCGCTACCAAAGAATTTGTCATTGTCGATGCCGCCATGAACGATCTTATCAGACCTTCTCTGTACCAGTCACACCAT
CATATTGCCGAAGTCAGCCCCAGAGGCAGGGCAAAACACACGGTGGATGTTGTGGGCCCCATCTGTGAATCGGGCGATTT
TCTGGCACGCGACAGGCTCATGCCTGCGGTGGAACCGCGCGAACTGCTGGCGGTGTTCTCCGCCGGAGCATACGGGTTCA
CCATGAGCTCGCAGTATAACTCGCGGCCTCGTGCCGCTGAAGTTCTGGTGCGGGGTGATACTGCTCACCTCATCAGGCGC
AGAGAGACCTATGAGGACCTCATTGCGCCTGAAGAAACACGTTCTTAA

Upstream 100 bases:

>100_bases
TGGAGATTTGTGGCCAGAAGCACCCACCGCAACGCCCCGTACGGGCTGAGCACCATCAAGATGATGACTTTGCGCTAGCC
GCAGATCAAAAGGAGTTTCC

Downstream 100 bases:

>100_bases
AAGCGGAGGCACTATGAAAGGCCAGCGTAACATCGGCATGGTGGCGCATGACGAACGCAAAGAAGACCTGCTGGACTGGG
TGCAGCACAACCTGCAGGCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MHHFTYRDNELFVENVAVQELVATYGTPLYIYSKATFQRHFTAFDSAFGALPHLTCYSVKACSNMHILRFLGKMGAGMDI
VSGGELFRALRAGIQPAKIVYSGVGKTRTEILQALEAGILMFNVESMGELEKISEVANQTGHTANVALRINPDVDPHTHP
YISTGLKENKFGLDMEQSYAAYMRAMELPAITPMGIDCHIGSQLTSLSPFREAVEKILLFREKLCSAGLCIDYIDLGGGL
GIPYDTEEPPHPQEFGKLLTDMLSGLGITLILEPGRVIAGNAGILVTKVQYTKKTATKEFVIVDAAMNDLIRPSLYQSHH
HIAEVSPRGRAKHTVDVVGPICESGDFLARDRLMPAVEPRELLAVFSAGAYGFTMSSQYNSRPRAAEVLVRGDTAHLIRR
RETYEDLIAPEETRS

Sequences:

>Translated_415_residues
MHHFTYRDNELFVENVAVQELVATYGTPLYIYSKATFQRHFTAFDSAFGALPHLTCYSVKACSNMHILRFLGKMGAGMDI
VSGGELFRALRAGIQPAKIVYSGVGKTRTEILQALEAGILMFNVESMGELEKISEVANQTGHTANVALRINPDVDPHTHP
YISTGLKENKFGLDMEQSYAAYMRAMELPAITPMGIDCHIGSQLTSLSPFREAVEKILLFREKLCSAGLCIDYIDLGGGL
GIPYDTEEPPHPQEFGKLLTDMLSGLGITLILEPGRVIAGNAGILVTKVQYTKKTATKEFVIVDAAMNDLIRPSLYQSHH
HIAEVSPRGRAKHTVDVVGPICESGDFLARDRLMPAVEPRELLAVFSAGAYGFTMSSQYNSRPRAAEVLVRGDTAHLIRR
RETYEDLIAPEETRS
>Mature_415_residues
MHHFTYRDNELFVENVAVQELVATYGTPLYIYSKATFQRHFTAFDSAFGALPHLTCYSVKACSNMHILRFLGKMGAGMDI
VSGGELFRALRAGIQPAKIVYSGVGKTRTEILQALEAGILMFNVESMGELEKISEVANQTGHTANVALRINPDVDPHTHP
YISTGLKENKFGLDMEQSYAAYMRAMELPAITPMGIDCHIGSQLTSLSPFREAVEKILLFREKLCSAGLCIDYIDLGGGL
GIPYDTEEPPHPQEFGKLLTDMLSGLGITLILEPGRVIAGNAGILVTKVQYTKKTATKEFVIVDAAMNDLIRPSLYQSHH
HIAEVSPRGRAKHTVDVVGPICESGDFLARDRLMPAVEPRELLAVFSAGAYGFTMSSQYNSRPRAAEVLVRGDTAHLIRR
RETYEDLIAPEETRS

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=359, Percent_Identity=25.0696378830084, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1789203, Length=438, Percent_Identity=32.4200913242009, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=345, Percent_Identity=24.6376811594203, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24586472, Length=337, Percent_Identity=22.8486646884273, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24586474, Length=390, Percent_Identity=23.5897435897436, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45724; Mature: 45724

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFTYRDNELFVENVAVQELVATYGTPLYIYSKATFQRHFTAFDSAFGALPHLTCYSVK
CCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHEEHH
ACSNMHILRFLGKMGAGMDIVSGGELFRALRAGIQPAKIVYSGVGKTRTEILQALEAGIL
HHCCHHHHHHHHHHCCCCEECCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCEE
MFNVESMGELEKISEVANQTGHTANVALRINPDVDPHTHPYISTGLKENKFGLDMEQSYA
EEEHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
AYMRAMELPAITPMGIDCHIGSQLTSLSPFREAVEKILLFREKLCSAGLCIDYIDLGGGL
HHHHHHHCCCCCCCCCEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYDTEEPPHPQEFGKLLTDMLSGLGITLILEPGRVIAGNAGILVTKVQYTKKTATKEF
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEEEHHHHCCCCEE
VIVDAAMNDLIRPSLYQSHHHIAEVSPRGRAKHTVDVVGPICESGDFLARDRLMPAVEPR
EEEEHHHHHHHCHHHHHCCCHHEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCHH
ELLAVFSAGAYGFTMSSQYNSRPRAAEVLVRGDTAHLIRRRETYEDLIAPEETRS
HHHHHHHCCCCCEEECCCCCCCCCHHEEEEECCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHHFTYRDNELFVENVAVQELVATYGTPLYIYSKATFQRHFTAFDSAFGALPHLTCYSVK
CCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHEEHH
ACSNMHILRFLGKMGAGMDIVSGGELFRALRAGIQPAKIVYSGVGKTRTEILQALEAGIL
HHCCHHHHHHHHHHCCCCEECCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCEE
MFNVESMGELEKISEVANQTGHTANVALRINPDVDPHTHPYISTGLKENKFGLDMEQSYA
EEEHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
AYMRAMELPAITPMGIDCHIGSQLTSLSPFREAVEKILLFREKLCSAGLCIDYIDLGGGL
HHHHHHHCCCCCCCCCEEECCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYDTEEPPHPQEFGKLLTDMLSGLGITLILEPGRVIAGNAGILVTKVQYTKKTATKEF
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEEEHHHHCCCCEE
VIVDAAMNDLIRPSLYQSHHHIAEVSPRGRAKHTVDVVGPICESGDFLARDRLMPAVEPR
EEEEHHHHHHHCHHHHHCCCHHEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCHH
ELLAVFSAGAYGFTMSSQYNSRPRAAEVLVRGDTAHLIRRRETYEDLIAPEETRS
HHHHHHHCCCCCEEECCCCCCCCCHHEEEEECCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]