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The map label for this gene is 78356824

Identifier: 78356824

GI number: 78356824

Start: 1832880

End: 1834487

Strand: Direct

Name: 78356824

Synonym: Dde_1781

Alternate gene names: NA

Gene position: 1832880-1834487 (Clockwise)

Preceding gene: 78356821

Following gene: 78356825

Centisome position: 49.14

GC content: 52.11

Gene sequence:

>1608_bases
ATGAAAGTTCAATTTCTCGGCGCAGCCCGTACTGTCACTGGTTCATGTTATGTGGTCGAATCCGGCGGTGTCCGCTTTGC
AGTTGATTGCGGCATGCATCAGGGAAACCACGAAATAGAAAAAAGAAACTACGAGACAGATGTATACTCTCCTGAAACGA
TAGATTTTTTTCTGATAACTCACGCTCATATAGACCACACCGGCCTGTTGCCGCGCATGGTGCGCGACGGTTTTACGGGG
CCGGTATATTGTACCGAACCTACCAGAGACCTTCTTGAGATCATGCTGCAGGACAGCGCCAATATACAGGAAATGGAAGC
GGAATGGCAGACCCGCAAGCAAAAACGTAAAGGGCGCAAACCGGTAGACCCGCTGTACACCTTTGCAGATGCAGCGCGGG
TTTCACGTTTTTTCGAGAATGTAGAGTATAACCGGCCTTTTTCTCCTGTGGAAGGGGTTACGGTGACATATAAAGACGCA
GGCCATATTCTGGGTTCCGCGTTTCTTGAAATTGAAGTTTGTGAACACGGGCGCTGCTCACGGTTGATTTTTTCCGGCGA
CCTTGGCAAACCCAACTCGCTCATAGTGCGCGACCCCGAAGCTGCTGCCGCAGCGGATTATCTGTTTGTGGAGTCAACAT
ATGGTGACAGAAACCATAAAGATGAGAGCAACAGCAGGCAGGAGCTGGCAGAAGCCATAGCATACAGTTACCGGCAGGGT
GAAAAGGTCATCATACCCGCCTTTGCGGTTGAGAGAACACAGGAAGTCCTGTACACCCTGTTCCTGCTGCAGAAAGAGGG
GCGTATGCCGGTGGATATGCCCATTTTCCTTGATAGCCCTCTTGCCATCCGTGCCACTGAGATATTCCGCAAGCATCCGC
GCTTCTTTGATGAAGAAATGCAGAAGTTGCTGCTTTCCGGAGAAGACCCGTTTGCCATGCCCAGCCTGCGGCTGACAACA
AAAACACAGGAATCTCAGGCCATCAACAATTACACGGGACCGGCCGTTATCATTTCAGCCAGCGGCATGTGCAACGCCGG
TCGCATCAAGCACCACCTCAGGCACAACATCTGGCGTCCCGGTGCCAGCATTGTCTTTGTGGGGTATCAGGCAGTGGGAA
CCCCCGGCCGCAGAATAGTGGACGGTGCCCGCAGTATCCGTCTCTTCGGCGAAGAGATTGCCATACAGGCAAAAGTCTTT
ACCATAGGCGGTTTTTCGGGGCATGCGGGGCAAAGCCAGATACTGGACTGGGTGGGAAAATTTGCCACCAAAGAGATGAA
AGTGTTTCTTGTGCATGGTGAAGAGAAAGCCCAGCAAGCACTTAAGGCCATACTGGAAGAGAAATATGAGTTGTCTGTTC
ACAGTCCGGGATATCTGGAAGAAATAGAGCTGGAACCGGGGGAGGCTGTTGTCACCACCGGCGACCCGCAGCGCTATCAG
CCGCAGCTTAACTGGGATTTTCTGCTTTCGGAAACAGAGGCACGCATGATGCAGCTGCGCGCCCGCAAAGGCGACATCGA
ACATGCCGACTGGGCGCAGCAGGTTGAAATACGTGACCGTCTGCTTGAATTAAACAACGAAATGCTTGGTATTCTTTCCG
AGCTGTAA

Upstream 100 bases:

>100_bases
AGTCTGTTATTGCAGCCCGCGCAATCGGCTGAAATTACTTGCGCTCGTTCCGCTCTGTGTTCAATATGTCAGTACGCCAT
TTTAACCCAGAGGTTCTCGT

Downstream 100 bases:

>100_bases
CCAGACAAATACTATGAAAATAATAAGCGGAGAGTACGGCGGACGTACTCTGAAAACAACAGTCGGCCCCGGTTACCGGC
CAGCCATGGCAAAAGTACGC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKVQFLGAARTVTGSCYVVESGGVRFAVDCGMHQGNHEIEKRNYETDVYSPETIDFFLITHAHIDHTGLLPRMVRDGFTG
PVYCTEPTRDLLEIMLQDSANIQEMEAEWQTRKQKRKGRKPVDPLYTFADAARVSRFFENVEYNRPFSPVEGVTVTYKDA
GHILGSAFLEIEVCEHGRCSRLIFSGDLGKPNSLIVRDPEAAAAADYLFVESTYGDRNHKDESNSRQELAEAIAYSYRQG
EKVIIPAFAVERTQEVLYTLFLLQKEGRMPVDMPIFLDSPLAIRATEIFRKHPRFFDEEMQKLLLSGEDPFAMPSLRLTT
KTQESQAINNYTGPAVIISASGMCNAGRIKHHLRHNIWRPGASIVFVGYQAVGTPGRRIVDGARSIRLFGEEIAIQAKVF
TIGGFSGHAGQSQILDWVGKFATKEMKVFLVHGEEKAQQALKAILEEKYELSVHSPGYLEEIELEPGEAVVTTGDPQRYQ
PQLNWDFLLSETEARMMQLRARKGDIEHADWAQQVEIRDRLLELNNEMLGILSEL

Sequences:

>Translated_535_residues
MKVQFLGAARTVTGSCYVVESGGVRFAVDCGMHQGNHEIEKRNYETDVYSPETIDFFLITHAHIDHTGLLPRMVRDGFTG
PVYCTEPTRDLLEIMLQDSANIQEMEAEWQTRKQKRKGRKPVDPLYTFADAARVSRFFENVEYNRPFSPVEGVTVTYKDA
GHILGSAFLEIEVCEHGRCSRLIFSGDLGKPNSLIVRDPEAAAAADYLFVESTYGDRNHKDESNSRQELAEAIAYSYRQG
EKVIIPAFAVERTQEVLYTLFLLQKEGRMPVDMPIFLDSPLAIRATEIFRKHPRFFDEEMQKLLLSGEDPFAMPSLRLTT
KTQESQAINNYTGPAVIISASGMCNAGRIKHHLRHNIWRPGASIVFVGYQAVGTPGRRIVDGARSIRLFGEEIAIQAKVF
TIGGFSGHAGQSQILDWVGKFATKEMKVFLVHGEEKAQQALKAILEEKYELSVHSPGYLEEIELEPGEAVVTTGDPQRYQ
PQLNWDFLLSETEARMMQLRARKGDIEHADWAQQVEIRDRLLELNNEMLGILSEL
>Mature_535_residues
MKVQFLGAARTVTGSCYVVESGGVRFAVDCGMHQGNHEIEKRNYETDVYSPETIDFFLITHAHIDHTGLLPRMVRDGFTG
PVYCTEPTRDLLEIMLQDSANIQEMEAEWQTRKQKRKGRKPVDPLYTFADAARVSRFFENVEYNRPFSPVEGVTVTYKDA
GHILGSAFLEIEVCEHGRCSRLIFSGDLGKPNSLIVRDPEAAAAADYLFVESTYGDRNHKDESNSRQELAEAIAYSYRQG
EKVIIPAFAVERTQEVLYTLFLLQKEGRMPVDMPIFLDSPLAIRATEIFRKHPRFFDEEMQKLLLSGEDPFAMPSLRLTT
KTQESQAINNYTGPAVIISASGMCNAGRIKHHLRHNIWRPGASIVFVGYQAVGTPGRRIVDGARSIRLFGEEIAIQAKVF
TIGGFSGHAGQSQILDWVGKFATKEMKVFLVHGEEKAQQALKAILEEKYELSVHSPGYLEEIELEPGEAVVTTGDPQRYQ
PQLNWDFLLSETEARMMQLRARKGDIEHADWAQQVEIRDRLLELNNEMLGILSEL

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=468, Percent_Identity=25.6410256410256, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI33300633, Length=483, Percent_Identity=24.8447204968944, Blast_Score=139, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI32564696, Length=491, Percent_Identity=26.0692464358452, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32566029, Length=478, Percent_Identity=25.7322175732218, Blast_Score=145, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323307, Length=481, Percent_Identity=25.5717255717256, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24648013, Length=455, Percent_Identity=25.0549450549451, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21358523, Length=469, Percent_Identity=25.5863539445629, Blast_Score=138, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 60423; Mature: 60423

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQFLGAARTVTGSCYVVESGGVRFAVDCGMHQGNHEIEKRNYETDVYSPETIDFFLIT
CEEEEEECCEEECCEEEEEECCCEEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEEEE
HAHIDHTGLLPRMVRDGFTGPVYCTEPTRDLLEIMLQDSANIQEMEAEWQTRKQKRKGRK
EECCCCCCCHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
PVDPLYTFADAARVSRFFENVEYNRPFSPVEGVTVTYKDAGHILGSAFLEIEVCEHGRCS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCEEEEEEECCCCCCC
RLIFSGDLGKPNSLIVRDPEAAAAADYLFVESTYGDRNHKDESNSRQELAEAIAYSYRQG
EEEEECCCCCCCCEEEECCCHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
EKVIIPAFAVERTQEVLYTLFLLQKEGRMPVDMPIFLDSPLAIRATEIFRKHPRFFDEEM
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHHHHHHHCCCHHHHHH
QKLLLSGEDPFAMPSLRLTTKTQESQAINNYTGPAVIISASGMCNAGRIKHHLRHNIWRP
HHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
GASIVFVGYQAVGTPGRRIVDGARSIRLFGEEIAIQAKVFTIGGFSGHAGQSQILDWVGK
CCCEEEEEEEECCCCCHHHHHHHHHHEEECCEEEEEEEEEEEECCCCCCCHHHHHHHHHH
FATKEMKVFLVHGEEKAQQALKAILEEKYELSVHSPGYLEEIELEPGEAVVTTGDPQRYQ
HCCCCEEEEEEECHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCEEEECCCCCCCC
PQLNWDFLLSETEARMMQLRARKGDIEHADWAQQVEIRDRLLELNNEMLGILSEL
CCCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MKVQFLGAARTVTGSCYVVESGGVRFAVDCGMHQGNHEIEKRNYETDVYSPETIDFFLIT
CEEEEEECCEEECCEEEEEECCCEEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEEEE
HAHIDHTGLLPRMVRDGFTGPVYCTEPTRDLLEIMLQDSANIQEMEAEWQTRKQKRKGRK
EECCCCCCCHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
PVDPLYTFADAARVSRFFENVEYNRPFSPVEGVTVTYKDAGHILGSAFLEIEVCEHGRCS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCEEEEEEECCCCCCC
RLIFSGDLGKPNSLIVRDPEAAAAADYLFVESTYGDRNHKDESNSRQELAEAIAYSYRQG
EEEEECCCCCCCCEEEECCCHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
EKVIIPAFAVERTQEVLYTLFLLQKEGRMPVDMPIFLDSPLAIRATEIFRKHPRFFDEEM
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHHHHHHHCCCHHHHHH
QKLLLSGEDPFAMPSLRLTTKTQESQAINNYTGPAVIISASGMCNAGRIKHHLRHNIWRP
HHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
GASIVFVGYQAVGTPGRRIVDGARSIRLFGEEIAIQAKVFTIGGFSGHAGQSQILDWVGK
CCCEEEEEEEECCCCCHHHHHHHHHHEEECCEEEEEEEEEEEECCCCCCCHHHHHHHHHH
FATKEMKVFLVHGEEKAQQALKAILEEKYELSVHSPGYLEEIELEPGEAVVTTGDPQRYQ
HCCCCEEEEEEECHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCEEEECCCCCCCC
PQLNWDFLLSETEARMMQLRARKGDIEHADWAQQVEIRDRLLELNNEMLGILSEL
CCCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA