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The map label for this gene is mprA [H]

Identifier: 78356766

GI number: 78356766

Start: 1780447

End: 1781592

Strand: Reverse

Name: mprA [H]

Synonym: Dde_1723

Alternate gene names: 78356766

Gene position: 1781592-1780447 (Counterclockwise)

Preceding gene: 78356767

Following gene: 78356765

Centisome position: 47.76

GC content: 54.71

Gene sequence:

>1146_bases
ATGCCCGACAGCAGCTCCATCCTGATCGTCGATGATTCGCGTTCTGTCCGCAATGCGCTGGCTTCGCTGCTCAGAAAGAG
CCATGCCATAGAACAGGCGGAAAACGGGGAACAGGCGCTTGCGTCCTATGCGCGCAACCGCCCCGATATCATCCTGCTGG
ATCTGAACATGCCCGGCATGAACGGTCTGGAAGTGCTGCGCACCATCCGCGAAGGCTTCGGTGATGATGAAACATACATT
CTCATTCTCACTGCCGACGACAGTTCGGGCACCAAAACCCGCGGCCTCAGCCTGGGGGCCAACGACTTTCTTTCCAAACC
ATTCGATATCGCAGAACTGAGGGCAAGGGTGGGCGTGGCCGAGCGCCAGCGAAAGCTTACCCGCCAGCTCGTTGATTACG
CCCGTCGCATTCAGAATGAGATAGACCTTGTGGCTTCTCTGCAAAGTAAACTCCTGCCCACTGCAACGCCCTACCTGCAG
GGAATTCATATTGAAAGTCTGTACGAGCCATCCGGTGAAGCCAGCGGTGACTACTATGACTTTTTTCCGGTGCAGGAAGG
CAGAAAAATCCGGACGGTGGTGGCCGATGTGTCCGGCCACGGCGCCCGCGCAGCATTTATCATGAGCATAGTACGCACGG
TATTCCGCATCACACAGTCGCGCTATATGCCGCTTGATGAAACCGTGGCCCTGCTGGAAAATCATCTGATGGATGCCATA
GGGGACGAAGAGGACTTTGTCACTGTATTCACTGCCGATGTGGATTTCACGGATGAACGGCTTGACTACATCAACGCCGG
TCATTGCCCCGGCATCCTCCGCCAGCCTTCGCAAGAGCCTCAGCTGCTCACAGGATCAATGCCCCTGCTGGGCTTTCTCA
AGGCACCGGTAAAAATGCGCAGCATTCCTTTTACAAAAGGAAGCGGGCTGCTGCTTTTCACGGACGGTTTCTATGACTGG
AAAAAGCAGGACGGTACGCTTTTTTCTCTGGAAGATTTCATAGCCGCGGCTACCGGCTGTCTGGGACGCGACGAGCATGT
GCTGAAAAAAATCACCACCACACTGGAAGAAGCCGGCGGCGGAATGCCGGCTTACAGAGATGATCTTACGGCATTGTGGA
TTTTTAATGAAACAACAGCCAGTTAA

Upstream 100 bases:

>100_bases
AGCACCGGTCGGTTTGGTGCGGAAATGTATGTGCAGCTTACCAACTGGGGGCCGGTAACCATCGAACTTTGCGGAAACGC
CCCCGGGGGACAGAACAGCC

Downstream 100 bases:

>100_bases
ATTTACTTTTTGCACCCGCGCCGAGGCGCAGGCATGCCGCGCACTTGTAAAAGGCATAGTGCAGGTTGTCTCGCAGTGGA
TAGTCAGACAACAGCTGCTA

Product: response regulator receiver (CheY-like) modulated serine phosphatase

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MPDSSSILIVDDSRSVRNALASLLRKSHAIEQAENGEQALASYARNRPDIILLDLNMPGMNGLEVLRTIREGFGDDETYI
LILTADDSSGTKTRGLSLGANDFLSKPFDIAELRARVGVAERQRKLTRQLVDYARRIQNEIDLVASLQSKLLPTATPYLQ
GIHIESLYEPSGEASGDYYDFFPVQEGRKIRTVVADVSGHGARAAFIMSIVRTVFRITQSRYMPLDETVALLENHLMDAI
GDEEDFVTVFTADVDFTDERLDYINAGHCPGILRQPSQEPQLLTGSMPLLGFLKAPVKMRSIPFTKGSGLLLFTDGFYDW
KKQDGTLFSLEDFIAAATGCLGRDEHVLKKITTTLEEAGGGMPAYRDDLTALWIFNETTAS

Sequences:

>Translated_381_residues
MPDSSSILIVDDSRSVRNALASLLRKSHAIEQAENGEQALASYARNRPDIILLDLNMPGMNGLEVLRTIREGFGDDETYI
LILTADDSSGTKTRGLSLGANDFLSKPFDIAELRARVGVAERQRKLTRQLVDYARRIQNEIDLVASLQSKLLPTATPYLQ
GIHIESLYEPSGEASGDYYDFFPVQEGRKIRTVVADVSGHGARAAFIMSIVRTVFRITQSRYMPLDETVALLENHLMDAI
GDEEDFVTVFTADVDFTDERLDYINAGHCPGILRQPSQEPQLLTGSMPLLGFLKAPVKMRSIPFTKGSGLLLFTDGFYDW
KKQDGTLFSLEDFIAAATGCLGRDEHVLKKITTTLEEAGGGMPAYRDDLTALWIFNETTAS
>Mature_380_residues
PDSSSILIVDDSRSVRNALASLLRKSHAIEQAENGEQALASYARNRPDIILLDLNMPGMNGLEVLRTIREGFGDDETYIL
ILTADDSSGTKTRGLSLGANDFLSKPFDIAELRARVGVAERQRKLTRQLVDYARRIQNEIDLVASLQSKLLPTATPYLQG
IHIESLYEPSGEASGDYYDFFPVQEGRKIRTVVADVSGHGARAAFIMSIVRTVFRITQSRYMPLDETVALLENHLMDAIG
DEEDFVTVFTADVDFTDERLDYINAGHCPGILRQPSQEPQLLTGSMPLLGFLKAPVKMRSIPFTKGSGLLLFTDGFYDWK
KQDGTLFSLEDFIAAATGCLGRDEHVLKKITTTLEEAGGGMPAYRDDLTALWIFNETTAS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=124, Percent_Identity=34.6774193548387, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=35.8974358974359, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788394, Length=129, Percent_Identity=36.4341085271318, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=131, Percent_Identity=32.0610687022901, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789402, Length=112, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=117, Percent_Identity=34.1880341880342, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=113, Percent_Identity=34.5132743362832, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 42165; Mature: 42034

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSSSILIVDDSRSVRNALASLLRKSHAIEQAENGEQALASYARNRPDIILLDLNMPGM
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCC
NGLEVLRTIREGFGDDETYILILTADDSSGTKTRGLSLGANDFLSKPFDIAELRARVGVA
CHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCHH
ERQRKLTRQLVDYARRIQNEIDLVASLQSKLLPTATPYLQGIHIESLYEPSGEASGDYYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCCCCCEEE
FFPVQEGRKIRTVVADVSGHGARAAFIMSIVRTVFRITQSRYMPLDETVALLENHLMDAI
EEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GDEEDFVTVFTADVDFTDERLDYINAGHCPGILRQPSQEPQLLTGSMPLLGFLKAPVKMR
CCCCCEEEEEEECCCCCHHHHHHCCCCCCCHHHCCCCCCCCEEECCCHHHHHHHCCHHHC
SIPFTKGSGLLLFTDGFYDWKKQDGTLFSLEDFIAAATGCLGRDEHVLKKITTTLEEAGG
CCCCCCCCCEEEEECCCCCHHCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GMPAYRDDLTALWIFNETTAS
CCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PDSSSILIVDDSRSVRNALASLLRKSHAIEQAENGEQALASYARNRPDIILLDLNMPGM
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCC
NGLEVLRTIREGFGDDETYILILTADDSSGTKTRGLSLGANDFLSKPFDIAELRARVGVA
CHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCHH
ERQRKLTRQLVDYARRIQNEIDLVASLQSKLLPTATPYLQGIHIESLYEPSGEASGDYYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCCCCCEEE
FFPVQEGRKIRTVVADVSGHGARAAFIMSIVRTVFRITQSRYMPLDETVALLENHLMDAI
EEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GDEEDFVTVFTADVDFTDERLDYINAGHCPGILRQPSQEPQLLTGSMPLLGFLKAPVKMR
CCCCCEEEEEEECCCCCHHHHHHCCCCCCCHHHCCCCCCCCEEECCCHHHHHHHCCHHHC
SIPFTKGSGLLLFTDGFYDWKKQDGTLFSLEDFIAAATGCLGRDEHVLKKITTTLEEAGG
CCCCCCCCCEEEEECCCCCHHCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GMPAYRDDLTALWIFNETTAS
CCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA