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The map label for this gene is sul [H]

Identifier: 78356559

GI number: 78356559

Start: 1534051

End: 1534911

Strand: Direct

Name: sul [H]

Synonym: Dde_1514

Alternate gene names: 78356559

Gene position: 1534051-1534911 (Clockwise)

Preceding gene: 78356558

Following gene: 78356560

Centisome position: 41.12

GC content: 58.19

Gene sequence:

>861_bases
ATGCTTCCCCCCATCCATTGGGAAATAGCGGGGGGCAGAGCCATCGGGCCTGCCCCCTTTTTCATTTTCGGTATTGTGAA
TGTCACCCCTGATTCTTTTTATGACGGCGGCAGACATGACGGACCGGACAGTGCTGTGTCTCATGCCCTGCAACTGGCGG
AACAGGGCGCACATGTGCTGGATATCGGCGGTGAATCATCGCGCCCTTATGCCGACCCTGTATCGCAGGAAGATGAAATC
CGGCGGGTGCTGCCCGTGGTGAAGGCCCTGAGGGACCGCACCGGCGGCAACGGTCTGCCTTGGGCGCTTTCTGTCGATAC
CTACAAAAGCGGCACGGCCGCAGCCGTGCTGGAGGCCGGTGCCGGTATTATCAACGATATTTCCGCCTGCTCTTTTGACC
CCGCTCTGAAAGACGTCATCGCGCAGTACAAACCGGGCTATGTGCTGATGCACAGCCCCGGCCGCCCGGAAACCATGCAG
GACAAACCGGCATATGGAAATGTGGTCGAGGAAATTCTGGACTTTTTCGAGAAAAAGCTGAAAGAATTGGTCGTGGCCGG
TGTACCGGAGCAACGCATCATTCTCGATCCCGGTATCGGTTTCGGCAAGCTGCTGGAGCACAATCTGGACATTCTGCGCC
ACATCGACAGATTTATGTCGCTGGGGCGGCCGGTCATGGGAGCATTGTCCAACAAATCCATGTTCGGGCAGTTGCTGGGA
CTGGCTGCCGATGAAAGACAGAATGCCACGCAGGCAGCAACGGCGCTGCTGGCGGCGCGGGGTGTGCGTTTTCACAGGGT
GCATGAGGTGCGGCTTGCGGCACAGACCCTTAACCTGGCTGCGGAACTGTACAACGCATAG

Upstream 100 bases:

>100_bases
TGCTGGAATCGGACGAGGCTGCACGCCCCGCCGCAAAGGACGGGGAGGATGCTCCGGACGGGCAGGAGGAAGATACCACT
GACCGGAGGGAGAAGTAGCA

Downstream 100 bases:

>100_bases
AGGCGCTGCATGACTTTCTGGGCGGATCTGAGCATCACATGGCGGGATGTGCTCGACATCTCTCTGGTGTCTTTGCTGCT
GTACCGTGTCATTGTGATGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLPPIHWEIAGGRAIGPAPFFIFGIVNVTPDSFYDGGRHDGPDSAVSHALQLAEQGAHVLDIGGESSRPYADPVSQEDEI
RRVLPVVKALRDRTGGNGLPWALSVDTYKSGTAAAVLEAGAGIINDISACSFDPALKDVIAQYKPGYVLMHSPGRPETMQ
DKPAYGNVVEEILDFFEKKLKELVVAGVPEQRIILDPGIGFGKLLEHNLDILRHIDRFMSLGRPVMGALSNKSMFGQLLG
LAADERQNATQAATALLAARGVRFHRVHEVRLAAQTLNLAAELYNA

Sequences:

>Translated_286_residues
MLPPIHWEIAGGRAIGPAPFFIFGIVNVTPDSFYDGGRHDGPDSAVSHALQLAEQGAHVLDIGGESSRPYADPVSQEDEI
RRVLPVVKALRDRTGGNGLPWALSVDTYKSGTAAAVLEAGAGIINDISACSFDPALKDVIAQYKPGYVLMHSPGRPETMQ
DKPAYGNVVEEILDFFEKKLKELVVAGVPEQRIILDPGIGFGKLLEHNLDILRHIDRFMSLGRPVMGALSNKSMFGQLLG
LAADERQNATQAATALLAARGVRFHRVHEVRLAAQTLNLAAELYNA
>Mature_286_residues
MLPPIHWEIAGGRAIGPAPFFIFGIVNVTPDSFYDGGRHDGPDSAVSHALQLAEQGAHVLDIGGESSRPYADPVSQEDEI
RRVLPVVKALRDRTGGNGLPWALSVDTYKSGTAAAVLEAGAGIINDISACSFDPALKDVIAQYKPGYVLMHSPGRPETMQ
DKPAYGNVVEEILDFFEKKLKELVVAGVPEQRIILDPGIGFGKLLEHNLDILRHIDRFMSLGRPVMGALSNKSMFGQLLG
LAADERQNATQAATALLAARGVRFHRVHEVRLAAQTLNLAAELYNA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=38.7596899224806, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324073, Length=322, Percent_Identity=30.4347826086957, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30850; Mature: 30850

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPPIHWEIAGGRAIGPAPFFIFGIVNVTPDSFYDGGRHDGPDSAVSHALQLAEQGAHVL
CCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DIGGESSRPYADPVSQEDEIRRVLPVVKALRDRTGGNGLPWALSVDTYKSGTAAAVLEAG
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHC
AGIINDISACSFDPALKDVIAQYKPGYVLMHSPGRPETMQDKPAYGNVVEEILDFFEKKL
CCHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KELVVAGVPEQRIILDPGIGFGKLLEHNLDILRHIDRFMSLGRPVMGALSNKSMFGQLLG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHH
LAADERQNATQAATALLAARGVRFHRVHEVRLAAQTLNLAAELYNA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPPIHWEIAGGRAIGPAPFFIFGIVNVTPDSFYDGGRHDGPDSAVSHALQLAEQGAHVL
CCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DIGGESSRPYADPVSQEDEIRRVLPVVKALRDRTGGNGLPWALSVDTYKSGTAAAVLEAG
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHC
AGIINDISACSFDPALKDVIAQYKPGYVLMHSPGRPETMQDKPAYGNVVEEILDFFEKKL
CCHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KELVVAGVPEQRIILDPGIGFGKLLEHNLDILRHIDRFMSLGRPVMGALSNKSMFGQLLG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHH
LAADERQNATQAATALLAARGVRFHRVHEVRLAAQTLNLAAELYNA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]