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The map label for this gene is uraA [H]

Identifier: 78356494

GI number: 78356494

Start: 1473973

End: 1475217

Strand: Direct

Name: uraA [H]

Synonym: Dde_1449

Alternate gene names: 78356494

Gene position: 1473973-1475217 (Clockwise)

Preceding gene: 78356493

Following gene: 78356500

Centisome position: 39.51

GC content: 57.11

Gene sequence:

>1245_bases
GTGAGCGAATCGACCGAATATTCTTTCAGGCTTAAAGACAGTCTGATAGGTGCGCAGATGCTGTTTGTGGCCTTCGGCGC
GCTGGTGCTTGTGCCCTTGCTTACGGGGCTTGACCCTAACGTGGCGCTGTTCACCGCCGGAGCGGGCACGCTGGTCTTTC
AGCTGATTACCAAACGGCAGGTGCCTATTTTCCTTGCATCTTCGTTTGCATTCATCGCCCCCATCATTCACGGGGTAGCC
ACCTGGGGTATACCTGCAACCATGGGCGGACTTGTTGCGGCGGGGCTGCTGTATGTGCTGCTGGGCACGATGATTAAAAT
TCAGGGTACGCAGATTCTGGACAGAGTGCTGCCCACCATTGTCACCGGTCCCGTCATCATGGTTATCGGGCTGGTGCTGG
CACCTGCAGCGGTGTTCATGGCGCTGGGAAAAACAGGTGACGGTTCGGCGGAGCTTTTTGCGCGCAATGATGCGCTGGTT
GTTTCCATGATTTCGCTTGTTGCCACCATCGGCGCTTCCATGTTCGGCCGCGGTGTCATCCGCCTTATTCCTATCATCTG
TGGTATTGCTGCCGGATACACGGCGGCGCTGGCTTACGGTATGGTGGACTTTACCCGGGTCATAGAAGCCCCGTGGCTGG
CCGTGCCCAGCTTTGTGGCACCCGAGTTTAATATCGAGGCCATCATCTTCATCGTGCCCGTGGCCATTGCCCCCGCCATC
GAGCATGTGGGAGACGTGCTGGCCATCAGTTCGGTGACCGGTAAAAACTACATAGATAAACCCGGCGTGCACCGCACCAT
GATTGGTGACGGCATTGCCACCATGTTTGCCTCTCTGCTGGGCGGTCCTCCCAACACCACCTATTCCGAAGTGACCGGAG
CCGTGGCGCTGACCCGCTCGTTCAACCCCGGCATCATGACATGGGCTGCCATAACCGCCATTCTGCTGGCCTTTGTGGGC
AAGCTCGGCGCGCTGCTGCAGACCATACCCACGCCGGTCATGGGCGGTATCATGATTCTGCTTTTCGGCGCCATTGTTGT
TGTGGGGGTCAATTCGCTGGTGCGTGCTCAGCAGGATCTCATGGAGCCGCGCAACCTTGCCATTATCTCTGTCATACTGG
TTTTCGGCATAGGCGGCATGGCCTTTCATGCCGGTGAGTTTTCCATAAAAGGTATAGGACTGGCCGGTATCACCGGTGTA
GTGCTTAATATGATATTGCCCAAGCCTGCCCGCAGGAAACGCTAG

Upstream 100 bases:

>100_bases
TTTTTGGGCCAAAGGCTGGAATATGAGGGTGGCGCTTTGCGAAAAAGGGCCGCCCTTGCTGTGAGTAACGGATTATCTGG
GTTTACACGGAGGGAGTGTG

Downstream 100 bases:

>100_bases
AAAGCAGATTAACAATAAGGCCCGCTGCAAAGCGGGCTTTGTTGTGTCCGGTAAAAATGCAGGCCGGTCCCGCTGGGGCG
GGACCGGCCGTACGAGGAGC

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSESTEYSFRLKDSLIGAQMLFVAFGALVLVPLLTGLDPNVALFTAGAGTLVFQLITKRQVPIFLASSFAFIAPIIHGVA
TWGIPATMGGLVAAGLLYVLLGTMIKIQGTQILDRVLPTIVTGPVIMVIGLVLAPAAVFMALGKTGDGSAELFARNDALV
VSMISLVATIGASMFGRGVIRLIPIICGIAAGYTAALAYGMVDFTRVIEAPWLAVPSFVAPEFNIEAIIFIVPVAIAPAI
EHVGDVLAISSVTGKNYIDKPGVHRTMIGDGIATMFASLLGGPPNTTYSEVTGAVALTRSFNPGIMTWAAITAILLAFVG
KLGALLQTIPTPVMGGIMILLFGAIVVVGVNSLVRAQQDLMEPRNLAIISVILVFGIGGMAFHAGEFSIKGIGLAGITGV
VLNMILPKPARRKR

Sequences:

>Translated_414_residues
MSESTEYSFRLKDSLIGAQMLFVAFGALVLVPLLTGLDPNVALFTAGAGTLVFQLITKRQVPIFLASSFAFIAPIIHGVA
TWGIPATMGGLVAAGLLYVLLGTMIKIQGTQILDRVLPTIVTGPVIMVIGLVLAPAAVFMALGKTGDGSAELFARNDALV
VSMISLVATIGASMFGRGVIRLIPIICGIAAGYTAALAYGMVDFTRVIEAPWLAVPSFVAPEFNIEAIIFIVPVAIAPAI
EHVGDVLAISSVTGKNYIDKPGVHRTMIGDGIATMFASLLGGPPNTTYSEVTGAVALTRSFNPGIMTWAAITAILLAFVG
KLGALLQTIPTPVMGGIMILLFGAIVVVGVNSLVRAQQDLMEPRNLAIISVILVFGIGGMAFHAGEFSIKGIGLAGITGV
VLNMILPKPARRKR
>Mature_413_residues
SESTEYSFRLKDSLIGAQMLFVAFGALVLVPLLTGLDPNVALFTAGAGTLVFQLITKRQVPIFLASSFAFIAPIIHGVAT
WGIPATMGGLVAAGLLYVLLGTMIKIQGTQILDRVLPTIVTGPVIMVIGLVLAPAAVFMALGKTGDGSAELFARNDALVV
SMISLVATIGASMFGRGVIRLIPIICGIAAGYTAALAYGMVDFTRVIEAPWLAVPSFVAPEFNIEAIIFIVPVAIAPAIE
HVGDVLAISSVTGKNYIDKPGVHRTMIGDGIATMFASLLGGPPNTTYSEVTGAVALTRSFNPGIMTWAAITAILLAFVGK
LGALLQTIPTPVMGGIMILLFGAIVVVGVNSLVRAQQDLMEPRNLAIISVILVFGIGGMAFHAGEFSIKGIGLAGITGVV
LNMILPKPARRKR

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=426, Percent_Identity=22.3004694835681, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI44680143, Length=436, Percent_Identity=22.4770642201835, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788843, Length=387, Percent_Identity=37.984496124031, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87081818, Length=413, Percent_Identity=37.5302663438257, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082181, Length=420, Percent_Identity=25.952380952381, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082178, Length=324, Percent_Identity=25.6172839506173, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790087, Length=370, Percent_Identity=24.3243243243243, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=173, Percent_Identity=30.635838150289, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=174, Percent_Identity=28.735632183908, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356175, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43080; Mature: 42949

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESTEYSFRLKDSLIGAQMLFVAFGALVLVPLLTGLDPNVALFTAGAGTLVFQLITKRQ
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCC
VPIFLASSFAFIAPIIHGVATWGIPATMGGLVAAGLLYVLLGTMIKIQGTQILDRVLPTI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VTGPVIMVIGLVLAPAAVFMALGKTGDGSAELFARNDALVVSMISLVATIGASMFGRGVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RLIPIICGIAAGYTAALAYGMVDFTRVIEAPWLAVPSFVAPEFNIEAIIFIVPVAIAPAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEHHHHHHHHHHHH
EHVGDVLAISSVTGKNYIDKPGVHRTMIGDGIATMFASLLGGPPNTTYSEVTGAVALTRS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECC
FNPGIMTWAAITAILLAFVGKLGALLQTIPTPVMGGIMILLFGAIVVVGVNSLVRAQQDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEPRNLAIISVILVFGIGGMAFHAGEFSIKGIGLAGITGVVLNMILPKPARRKR
CCCCHHHHHHHHHHHCCCHHHEECCCEEECCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SESTEYSFRLKDSLIGAQMLFVAFGALVLVPLLTGLDPNVALFTAGAGTLVFQLITKRQ
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCC
VPIFLASSFAFIAPIIHGVATWGIPATMGGLVAAGLLYVLLGTMIKIQGTQILDRVLPTI
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
VTGPVIMVIGLVLAPAAVFMALGKTGDGSAELFARNDALVVSMISLVATIGASMFGRGVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RLIPIICGIAAGYTAALAYGMVDFTRVIEAPWLAVPSFVAPEFNIEAIIFIVPVAIAPAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEHHHHHHHHHHHH
EHVGDVLAISSVTGKNYIDKPGVHRTMIGDGIATMFASLLGGPPNTTYSEVTGAVALTRS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECC
FNPGIMTWAAITAILLAFVGKLGALLQTIPTPVMGGIMILLFGAIVVVGVNSLVRAQQDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEPRNLAIISVILVFGIGGMAFHAGEFSIKGIGLAGITGVVLNMILPKPARRKR
CCCCHHHHHHHHHHHCCCHHHEECCCEEECCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]